List of works - Mark P. Krebs

A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects.

scientific article

A Mutation in Syne2 Causes Early Retinal Defects in Photoreceptors, Secondary Neurons, and Müller Glia.

scientific article published on June 2015

A high-throughput screening method for small-molecule pharmacologic chaperones of misfolded rhodopsin

scientific article

An allele of microtubule-associated protein 1A (Mtap1a) reduces photoreceptor degeneration in Tulp1 and Tub Mutant Mice

scientific journal article

Authors’ response

scientific article published on 01 August 2011

Biphasic photoreceptor degeneration induced by light in a T17M rhodopsin mouse model of cone bystander damage

scientific article published on 10 January 2009

Bright-Field Imaging and Optical Coherence Tomography of the Mouse Posterior Eye.

scientific article

Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair.

scientific article published on 20 January 2014

Directed synthesis and assembly of nanoparticles using purple membrane

scientific article published in April 2006

Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation

scientific journal article

Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration

scientific journal article

Enhanced retinal pigment epithelium regeneration after injury in MRL/MpJ mice

scientific article published on 6 October 2011

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts

scientific article published on 07 March 2019

Gene profiling of postnatal Mfrprd6 mutant eyes reveals differential accumulation of Prss56, visual cycle and phototransduction mRNAs

scientific article

Genetic modifier loci of mouse Mfrp(rd6) identified by quantitative trait locus analysis

scientific article published on 4 November 2013

Genome sequence of Halobacterium species NRC-1

scientific article

Genomic perspective on the photobiology of Halobacterium species NRC-1, a phototrophic, phototactic, and UV-tolerant haloarchaeon.

scientific article

Identification of a lycopene beta-cyclase required for bacteriorhodopsin biogenesis in the archaeon Halobacterium salinarum.

scientific article

Identification of genes required for eye development by high-throughput screening of mouse knockouts

scientific article published on 21 December 2018

Intramembrane substitutions in helix D of bacteriorhodopsin disrupt the purple membrane

scientific article published in March 1997

Membrane insertion kinetics of a protein domain in vivo. The bacterioopsin n terminus inserts co-translationally

scientific article published on 01 August 1999

Mouse Models of NMNAT1-Leber Congenital Amaurosis (LCA9) Recapitulate Key Features of the Human Disease

scientific article published on 17 May 2016

Mouse models of human ocular disease for translational research

scientific article published on 31 August 2017

Mutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrity

scientific article published on 21 December 2015

Optimization of bacteriorhodopsin for bioelectronic devices.

scientific article

Ordered membrane insertion of an archaeal opsin in vivo.

scientific article

Pathological consequences of long-term mitochondrial oxidative stress in the mouse retinal pigment epithelium ⬇️

scientific article published on June 8, 2012

Proton transport by a bacteriorhodopsin mutant, aspartic acid-85-->asparagine, initiated in the unprotonated Schiff base state.

scientific article

Quality control of integral membrane proteins

scientific article

Rapid high-yield purification and liposome reconstitution of polyhistidine-tagged sensory rhodopsin I

scientific article published on 01 December 1995

Retinoids assist the cellular folding of the autosomal dominant retinitis pigmentosa opsin mutant P23H.

scientific article published on 9 February 2004

Role of helix-helix interactions in assembly of the bacteriorhodopsin lattice

scientific article published on 01 July 1999

Structural determinants of purple membrane assembly.

scientific article

The cobY gene of the archaeon Halobacterium sp. strain NRC-1 is required for de novo cobamide synthesis.

scientific article

Therapeutic potential of valproic acid for retinitis pigmentosa

scientific article published on 20 July 2010

Thermodynamic stability of the bacteriorhodopsin lattice as measured by lipid dilution.

scientific article

Time-resolved Fourier transform infrared spectroscopy of the bacteriorhodopsin mutant Tyr-185-->Phe: Asp-96 reprotonates during O formation; Asp-85 and Asp-212 deprotonate during O decay

scientific article published on 01 December 1992

Transcriptional and translational initiation sites of IS50. Control of transposase and inhibitor expression

scientific article published on 01 December 1986

Translation initiation with GUC codon in the archaeon Halobacterium salinarum: implications for translation of leaderless mRNA and strict correlation between translation initiation and presence of mRNA.

scientific article

Use of a Tn5 derivative that creates lacZ translational fusions to obtain a transposition mutant

scientific article published on 01 March 1988

X-ray diffraction of a cysteine-containing bacteriorhodopsin mutant and its mercury derivative. Localization of an amino acid residue in the loop of an integral membrane protein

scientific article published on 01 November 1993

brp and blh are required for synthesis of the retinal cofactor of bacteriorhodopsin in Halobacterium salinarum

scientific article published on 22 November 2000

List of works by Mark P. Krebs

A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects.

A Mutation in Syne2 Causes Early Retinal Defects in Photoreceptors, Secondary Neurons, and Müller Glia.

A high-throughput screening method for small-molecule pharmacologic chaperones of misfolded rhodopsin

An allele of microtubule-associated protein 1A (Mtap1a) reduces photoreceptor degeneration in Tulp1 and Tub Mutant Mice

Authors’ response

Biphasic photoreceptor degeneration induced by light in a T17M rhodopsin mouse model of cone bystander damage

Bright-Field Imaging and Optical Coherence Tomography of the Mouse Posterior Eye.

Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair.

Directed synthesis and assembly of nanoparticles using purple membrane

Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation

Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration

Enhanced retinal pigment epithelium regeneration after injury in MRL/MpJ mice

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts

Gene profiling of postnatal Mfrprd6 mutant eyes reveals differential accumulation of Prss56, visual cycle and phototransduction mRNAs

Genetic modifier loci of mouse Mfrp(rd6) identified by quantitative trait locus analysis

Genome sequence of Halobacterium species NRC-1

Genomic perspective on the photobiology of Halobacterium species NRC-1, a phototrophic, phototactic, and UV-tolerant haloarchaeon.

Identification of a lycopene beta-cyclase required for bacteriorhodopsin biogenesis in the archaeon Halobacterium salinarum.

Identification of genes required for eye development by high-throughput screening of mouse knockouts

Intramembrane substitutions in helix D of bacteriorhodopsin disrupt the purple membrane

Membrane insertion kinetics of a protein domain in vivo. The bacterioopsin n terminus inserts co-translationally

Mouse Models of NMNAT1-Leber Congenital Amaurosis (LCA9) Recapitulate Key Features of the Human Disease

Mouse models of human ocular disease for translational research

Mutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrity

Optimization of bacteriorhodopsin for bioelectronic devices.

Ordered membrane insertion of an archaeal opsin in vivo.

Pathological consequences of long-term mitochondrial oxidative stress in the mouse retinal pigment epithelium ⬇️

Proton transport by a bacteriorhodopsin mutant, aspartic acid-85-->asparagine, initiated in the unprotonated Schiff base state.

Quality control of integral membrane proteins

Rapid high-yield purification and liposome reconstitution of polyhistidine-tagged sensory rhodopsin I

Retinoids assist the cellular folding of the autosomal dominant retinitis pigmentosa opsin mutant P23H.

Role of helix-helix interactions in assembly of the bacteriorhodopsin lattice

Structural determinants of purple membrane assembly.

The cobY gene of the archaeon Halobacterium sp. strain NRC-1 is required for de novo cobamide synthesis.

Therapeutic potential of valproic acid for retinitis pigmentosa

Thermodynamic stability of the bacteriorhodopsin lattice as measured by lipid dilution.

Time-resolved Fourier transform infrared spectroscopy of the bacteriorhodopsin mutant Tyr-185-->Phe: Asp-96 reprotonates during O formation; Asp-85 and Asp-212 deprotonate during O decay

Transcriptional and translational initiation sites of IS50. Control of transposase and inhibitor expression

Translation initiation with GUC codon in the archaeon Halobacterium salinarum: implications for translation of leaderless mRNA and strict correlation between translation initiation and presence of mRNA.

Use of a Tn5 derivative that creates lacZ translational fusions to obtain a transposition mutant

X-ray diffraction of a cysteine-containing bacteriorhodopsin mutant and its mercury derivative. Localization of an amino acid residue in the loop of an integral membrane protein

brp and blh are required for synthesis of the retinal cofactor of bacteriorhodopsin in Halobacterium salinarum