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List of works by Marcel Leist

1-Methyl-4-Phenylpyridinium Induces Autocrine Excitotoxicity, Protease Activation, and Neuronal Apoptosis ⬇️

scientific article published on November 1, 1998

A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles.

scientific article published on 2 December 2012

A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis.

scientific article published on 08 December 2015

A cytosolic oxygenase activity involved in the bioactivation of 2-aminofluorene

scientific article published on 01 January 1992

A framework program for the teaching of alternative methods (replacement, reduction, refinement) to animal experimentation

scientific article

A high-throughput approach to identify specific neurotoxicants/ developmental toxicants in human neuronal cell function assays

scientific article published on 21 January 2018

A human stem cell-derived test system for agents modifying neuronal N-methyl-D-aspartate-type glutamate receptor Ca<sup>2+</sup>-signalling

scientific article published on 13 March 2021

A novel mechanism of murine hepatocyte death inducible by concanavalin A

scientific article published on 01 December 1996

A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems

scientific article published on January 2013

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.

scientific article published on January 2012

A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption

scientific article published in March 2006

A structure-activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins

scientific article published on 21 November 2017

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

scientific article

Acrylamide alters neurotransmitter induced calcium responses in murine ESC-derived and primary neurons

scientific article published on 12 April 2014

Additive Effects of Caspase Inhibitor and Lazaroid on the Survival of Transplanted Rat and Human Embryonic Dopamine Neurons

scientific article published on 01 July 2000

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

scientific article published on 13 April 2018

Advancing human health risk assessment

scientific article published on 08 July 2019

Adverse outcome pathways: opportunities, limitations and open questions

scientific article published on 19 October 2017

Age-related Macular Degeneration

scientific article published in Journal of Biological Chemistry

Alpha-synuclein binds to the inner membrane of mitochondria in an α-helical conformation

scientific article published on 10 September 2014

Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia

scientific article published on 03 February 2021

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition.

scientific article

Animal testing and its alternatives - the most important omics is economics

scientific article published on 01 January 2018

Animal use for science in Europe.

scientific article

Apoptosis in the absence of poly-(ADP-ribose) polymerase

scientific article published on 01 April 1997

Apoptosis in the dorsal lateral geniculate nucleus after monocular deprivation involves glutamate signaling, NO production, and PARP activation

scientific article published on 01 November 2000

Apoptosis, Excitotoxicity, and Neuropathology ⬇️

scientific article published on March 15, 1998

Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo.

scientific article

Asialoerythropoietin is not effective in the R6/2 line of Huntington's disease mice

scientific article

Assessment of chemical-induced impairment of human neurite outgrowth by multiparametric live cell imaging in high-density cultures

scientific article published on 21 February 2011

Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research

scientific article

Attenuated amyloid-beta aggregation and neurotoxicity owing to methionine oxidation

scientific article

Autocatalytic nitration of prostaglandin endoperoxide synthase-2 by nitrite inhibits prostanoid formation in rat alveolar macrophages

scientific article

Autoproteolytic fragments are intermediates in the oligomerization/aggregation of the Parkinson's disease protein alpha-synuclein as revealed by ion mobility mass spectrometry

scientific article

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

scientific article

Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development

scientific article published on 28 February 2020

Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis

scientific article published on February 2005

Burning up TNF toxicity for cancer therapy

article

CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-alpha release from lipopolysaccharide-treated cells and mice

scientific article

CaFFEE: A program for evaluating time courses of Ca2+ dependent signal changes of complex cells loaded with fluorescent indicator dyes

scientific article published on 01 January 2020

Calcium and neuronal death ⬇️

scientific article published on January 1, 1998

Calpain inhibitors prevent nitric oxide-triggered excitotoxic apoptosis

scientific article published in December 2001

Canagliflozin mediated dual inhibition of mitochondrial glutamate dehydrogenase and complex I: an off-target adverse effect

scientific article published on 14 February 2018

Carbamylated Erythropoietin Decreased Proliferation and Neurogenesis in the Subventricular Zone, but Not the Dentate Gyrus, After Irradiation to the Developing Rat Brain

scientific article published on 12 September 2018

Cascade of caspase activation in potassium-deprived cerebellar granule neurons: targets for treatment with peptide and protein inhibitors of apoptosis

scientific article published in April 2001

Caspase inhibition reduces apoptosis and increases survival of nigral transplants

scientific article

Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury ⬇️

scientific article published on December 3, 2001

Caspase-Mediated Apoptosis in Neuronal Excitotoxicity Triggered by Nitric Oxide ⬇️

scientific article published on November 1, 1997

Cellular resilience

scientific article published on January 2015

Characterization of mouse cell line IMA 2.1 as a potential model system to study astrocyte functions.

scientific article

Chemical concentrations in cell culture compartments (C5) - concentration definitions

scientific article published on 01 January 2019

Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library

scientific article

Combined anti-inflammatory effects of β2-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP.

scientific article published on 17 August 2011

Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells.

scientific article published on 30 December 2016

Comparison of neuroprotective effects of erythropoietin (EPO) and carbamylerythropoietin (CEPO) against ischemia-like oxygen-glucose deprivation (OGD) and NMDA excitotoxicity in mouse hippocampal slice cultures

scientific article published on 8 December 2006

Compound selection for in vitro modeling of developmental neurotoxicity

scientific article published on June 2012

Consensus report on the future of animal-free systemic toxicity testing

scientific article

Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

scientific article published on 12 February 2018

Control of Aβ release from human neurons by differentiation status and RET signaling

scientific article published on 24 April 2012

Conversion of Nonproliferating Astrocytes into Neurogenic Neural Stem Cells: Control by FGF2 and Interferon-γ.

scientific article published on 7 September 2016

Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing

scientific article published on 24 September 2010

Correlation of structural features of novel 1,2,3-triazoles with their neurotoxic and tumoricidal properties

scientific article published on 23 June 2018

Corrigendum to A high-throughput approach to identify specific neurotoxicants / developmental toxicants in human neuronal cell function assays

scientific article published on 01 January 2019

Corrigendum to Chemical concentrations in cell culture compartments (C⁵) - concentration definitions

scientific article published on 01 January 2019

Corrigendum to Essential components of methods papers

scientific article published on 01 January 2019

Corrigendum to Normalization of data for viability and relative cell function curves

scientific article published on 01 January 2019

Corrigendum to Recommendation on test readiness criteria for new approach methods in toxicology: exemplified for developmental neurotoxicity

scientific article published on 01 January 2019

Corrigendum to Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity Toxicol Appl Pharmacol, 354 (2018) 64-80

scientific article published on 16 April 2019

Critical evaluation of the use of dogs in biomedical research and testing in Europe.

scientific article published in January 2011

Current approaches and future role of high content imaging in safety sciences and drug discovery

scientific article published on 14 July 2014

Cytokine-mediated hepatic apoptosis ⬇️

scientific article published on 01 January 1998

Cytoprotection against lipid hydroperoxides correlates with increased glutathione peroxidase activities, but not selenium uptake from different selenocompounds

scientific article published on 01 May 1999

Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia

scientific article published in January 2006

Defined inflammatory states in astrocyte cultures: correlation with susceptibility towards CD95-driven apoptosis

scientific article published on 01 January 2004

Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests

scientific article

Derivatives of erythropoietin that are tissue protective but not erythropoietic

scientific article published in July 2004

Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants

scientific article published on 30 June 2020

Design of a high-throughput human neural crest cell migration assay to indicate potential developmental toxicants

scientific article published on 27 July 2016

Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells.

scientific article published on 21 January 2014

Detectable concentrations of Fas ligand in cerebrospinal fluid after severe head injury

scientific article

Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays

scientific article published on 12 December 2019

Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances

scientific article published on 11 November 2019

Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants

scientific article published on 12 June 2019

Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities

scientific article

Differential effects of Bcl-2 overexpression on fibre outgrowth and survival of embryonic dopaminergic neurons in intracerebral transplants.

scientific article

Differential effects of bcl-2 on cell death triggered under ATP-depleting conditions.

scientific article

Disialoganglioside GD3 is released by microglia and induces oligodendrocyte apoptosis

scientific article

Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation

scientific article

Energy supply and the shape of death in neurons and lymphoid cells

scientific article published on 01 August 1997

Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome

scientific article published on 20 June 2012

Epigenetics and transcriptomics to detect adverse drug effects in model systems of human development.

scientific article published on 03 March 2014

Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion.

scientific article published in December 2002

Erratum to Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

scientific article published on 01 January 2020

Erythropoietin: not just about erythropoiesis

scientific article published on June 2010

Essential components of methods papers

scientific article published on 01 January 2018

Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants.

scientific article published on 14 May 2013

Evaluation of developmental toxicants and signaling pathways in a functional test based on the migration of human neural crest cells

scientific article

Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy.

scientific article published on 15 May 2014

Examination of microcystin neurotoxicity using central and peripheral human neurons

scientific article published on 23 June 2020

Excitotoxicity

scientific article published on 01 August 1997

Execution of apoptosis: converging or diverging pathways?

scientific article

Extensive transcriptional regulation of chromatin modifiers during human neurodevelopment

scientific article

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay

scientific article published on 25 March 2016

Food for thought ... considerations and guidelines for basic test method descriptions in toxicology ⬇️

scientific article published on January 1, 2010

Food for thought ... on education in alternative methods in toxicology.

scientific article published in January 2009

Food for thought ... on the evolution of toxicology and the phasing out of animal testing

scientific article published in January 2008

Food for thought... on the real success of 3R approaches

scientific article

Four deaths and a funeral: from caspases to alternative mechanisms.

scientific article

From smoking guns to footprints: mining for critical events of toxicity pathways in transcriptome data

scientific article published on 8 April 2015

From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects.

scientific article

Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons

scientific article published on 29 March 2021

Functional and immunochemical characterisation of different antibodies against the erythropoietin receptor.

scientific article published on 12 April 2007

Functional and phenotypic differences of pure populations of stem cell-derived astrocytes and neuronal precursor cells

scientific article published on 22 December 2015

Functionalized DNA Hydrogels Produced by Polymerase-Catalyzed Incorporation of Non-Natural Nucleotides as a Surface Coating for Cell Culture Applications

scientific article published on 12 March 2019

GFAP-independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells.

scientific article

Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases.

scientific article published on January 2013

Good Cell Culture Practice for stem cells and stem-cell-derived models.

scientific article published on 23 August 2016

Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling

scientific article published on 31 July 2015

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

scientific article published in Nature Communications

Harnessing the power of novel animal-free test methods for the development of COVID-19 drugs and vaccines

scientific article published on 23 May 2020

High-dose erythropoietin alters platelet reactivity and bleeding time in rodents in contrast to the neuroprotective variant carbamyl-erythropoietin (CEPO)

scientific article published on 01 April 2008

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk

scientific article published on 26 March 2016

Highlight report: towards the replacement of in vivo repeated dose systemic toxicity testing

article

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

scientific article

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

scientific article

Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice

scientific article published in October 1998

Identification and affinity-quantification of ß-amyloid and α-synuclein polypeptides using on-line SAW-biosensor-mass spectrometry.

scientific article published on 21 May 2014

Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration.

scientific article

Impairment of glutamate signaling in mouse central nervous system neurons in vitro by tri-ortho-cresyl phosphate at noncytotoxic concentrations

scientific article published on 8 September 2014

Impairment of human neural crest cell migration by prolonged exposure to interferon-beta.

scientific article

Impairment of neuronal mitochondrial function by L-DOPA in the absence of oxygen-dependent auto-oxidation and oxidative cell damage

scientific article published on 28 June 2021

Improvement of embryonic dopaminergic neurone survival in culture and after grafting into the striatum of hemiparkinsonian rats by CEP-1347.

scientific article

In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities

scientific article published on 4 August 2016

Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies

scientific article published on 07 March 2020

Increased erythropoietin production after myocardial infarction in mice

scientific article published on June 2006

Increasing the Resistance of Living Cells against Oxidative Stress by Nonnatural Surfactants as Membrane Guards

scientific article published on 05 July 2018

Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice

scientific article published on 19 March 2013

Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice

scientific article published in January 2013

Inhibition of microglial inflammation by the MLK inhibitor CEP-1347.

scientific article published on March 2005

Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis

scientific article published on 01 June 1999

Instruments for assessing risk of bias and other methodological criteria of animal studies: omission of well-established methods.

scientific article published on March 2014

International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

scientific article

Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology

scientific article published on 30 April 2020

Intracellular ATP, a switch in the decision between apoptosis and necrosis.

scientific article

Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia†

scientific article published in March 2017

Irradiation-induced progenitor cell death in the developing brain is resistant to erythropoietin treatment and caspase inhibition

scientific article published in November 2004

Lapachol acetylglycosylation enhances its cytotoxic and pro-apoptotic activities in HL60 cells

scientific article published on 11 January 2020

Lineage-specific regulation of epigenetic modifier genes in human liver and brain

scientific article

Locally resolved membrane binding affinity of the N-terminus of α-synuclein.

scientific article published on 30 April 2012

Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism.

scientific article published on 30 January 2016

Lysosomes in cell death

scientific article published on April 2004

Major Histocompatibility Complex class I proteins are critical for maintaining neuronal structural complexity in the aging brain

scientific article

Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift

article

Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing.

scientific article published on January 2010

Measurement of cellular beta-site of APP cleaving enzyme 1 activity and its modulation in neuronal assay systems.

scientific article

Metabolomics in toxicology and preclinical research

scientific article published on January 2013

Mitochondrial signals and energy requirement in cell death

scientific article published on 01 August 1997

Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection

scientific article published in May 2002

Molecular basis for detection of invading pathogens in the brain.

scientific article published on May 2008

Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing

scientific article published on 13 August 2013

Multiparameter toxicity assessment of novel DOPO-derived organophosphorus flame retardants

scientific article published on 29 February 2016

Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals

scientific article published on 30 June 2020

Neuronal cell death: a demise with different shapes.

scientific article

Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells.

scientific article published on 7 May 2015

Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite

scientific article published on 16 November 2010

Neuroprotective properties of memantine in differentin vitroandin vivomodels of excitotoxicity

scientific article (publication date: May 2006)

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors

scientific article published on 29 January 2021

New European Union statistics on laboratory animal use - what really counts!

scientific article published on 01 January 2020

New animal-free concepts and test methods for developmental toxicity and peripheral neurotoxicity.

scientific article published in November 2017

Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release

scientific article

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

scientific article

Nonhematopoietic erythropoietin derivatives prevent motoneuron degeneration in vitro and in vivo

scientific article

Normalization of data for viability and relative cell function curves

scientific article published on 01 January 2018

Novel technologies and an overall strategy to allow hazard assessment and risk prediction of chemicals, cosmetics, and drugs with animal-free methods.

scientific article

OECD/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes.

scientific article published in January 2017

Optimizing drug discovery by Investigative Toxicology: Current and future trends

scientific article published on 20 December 2018

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

scientific article

Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.

scientific article published on 19 March 2013

Pathological apoptosis in the developing brain

scientific article published on May 2007

Peroxynitrite and nitric oxide donors induce neuronal apoptosis by eliciting autocrine excitotoxicity

scientific article published on July 1997

Pharmacological LRH-1/Nr5a2 inhibition limits pro-inflammatory cytokine production in macrophages and associated experimental hepatitis

scientific article published on 28 February 2020

Poly(ADP-ribose) glycohydrolase as a target for neuroprotective intervention: assessment of currently available pharmacological tools

scientific article

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

scientific article published on 27 June 2019

Preferential Extracellular Generation of the Active Parkinsonian Toxin MPP+ by Transporter-Independent Export of the Intermediate MPDP+.

scientific article

Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress

scientific article published on 02 November 2018

Prevention of the degeneration of human dopaminergic neurons in an astrocyte co-culture system allowing endogenous drug metabolism

scientific article

Profiling of drugs and environmental chemicals for functional impairment of neural crest migration in a novel stem cell-based test battery

scientific article

Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway.

scientific article published on July 2005

Quantification of Metabolic Rearrangements During Neural Stem Cells Differentiation into Astrocytes by Metabolic Flux Analysis

scientific article published on 12 April 2016

Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line.

scientific article published on 13 April 2011

Rapid, noninflammatory and PS-dependent phagocytic clearance of necrotic cells ⬇️

scientific article published on October 1, 2003

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

scientific article published on 23 February 2018

Reduced Aβ secretion by human neurons under conditions of strongly increased BACE activity

scientific article published on 26 September 2018

Reduced functional deficits, neuroinflammation, and secondary tissue damage after treatment of stroke by nonerythropoietic erythropoietin derivatives

scientific article published on 12 July 2006

Reduced immunoproteasome formation and accumulation of immunoproteasomal precursors in the brains of lymphocytic choriomeningitis virus-infected mice

scientific article published on 29 September 2010

Reductive modification of genetically encoded 3-nitrotyrosine sites in alpha synuclein expressed in E.coli

scientific article published on 10 June 2019

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use.

scientific article

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes

article

Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells

scientific article published on 30 July 2009

Reverse-transcription quantitative PCR directly from cells without RNA extraction and without isothermal reverse-transcription: a 'zero-step' RT-qPCR protocol

scientific article published on 01 January 2017

SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging

scientific article published on 01 January 2019

Selective nitration of prostacyclin synthase and defective vasorelaxation in atherosclerotic bovine coronary arteries.

scientific article published on May 1999

Selective proteolysis of the nuclear replication factor MCM3 in apoptosis

scientific article published on 01 February 1998

Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure

scientific article

Sensitization to the lysosomal cell death pathway upon immortalization and transformation

scientific article published on August 2004

Shortened derivatives from native antimicrobial peptide LyeTx I: In vitro and in vivo biological activity assessment

scientific article published on 11 November 2020

Simultaneous IR-Spectroscopic Observation of α-Synuclein, Lipids, and Solvent Reveals an Alternative Membrane-Induced Oligomerization Pathway

scientific article published on 5 October 2017

Simultaneous release of adenylate kinase and cytochrome c in cell death

scientific article published on 01 December 1998

Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis

scientific article

Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347.

scientific article

Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity.

scientific article published on 23 December 2017

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

scientific article

Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity.

scientific article published on 21 December 2016

Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants

scientific article published on March 2016

Strategy to replace animal-derived ECM by a modular and highly defined matrix

scientific article published on 04 June 2020

Switching from astrocytic neuroprotection to neurodegeneration by cytokine stimulation

scientific article published on 06 April 2016

Systems Toxicology: The Future of Risk Assessment

scientific article published on 23 March 2015

TLR2 hypersensitivity of astrocytes as functional consequence of previous inflammatory episodes.

scientific article published on 31 January 2011

Targeting chelatable iron as a therapeutic modality in Parkinson's disease

scientific article

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

scientific article published on 01 January 2019

Test systems of developmental toxicity: state-of-the art and future perspectives.

scientific article published in December 2013

The Center for Alternatives to Animal Testing - Europe (CAAT-EU): a transatlantic bridge for the paradigm shift in toxicology.

scientific article published in January 2010

The Current Status and Work of Three Rs Centres and Platforms in Europe*

scientific article published in November 2022

The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

scientific article published on 01 June 2020

The Influence of Structural Gradients in Large Pore Organosilica Materials on the Capabilities for Hosting Cellular Communities

The NOX1/4 inhibitor GKT136901 as selective and direct scavenger of peroxynitrite.

scientific article published on January 2014

The Rise of Three Rs Centres and Platforms in Europe*

scientific article published in March 2022

The Sonic hedgehog pathway mediates carbamylated erythropoietin-enhanced proliferation and differentiation of adult neural progenitor cells

scientific article published on 05 September 2007

The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy

scientific article published on January 2008

The dawning of a new age of toxicology.

scientific article published on January 2008

The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditions.

scientific article published on 20 September 2006

The expression of plasma membrane Ca2+ pump isoforms in cerebellar granule neurons is modulated by Ca2+

scientific article (publication date: 15 January 1999)

The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function.

scientific article

The network formation assay: a spatially standardized neurite outgrowth analytical display for neurotoxicity screening

scientific article published on 4 January 2010

The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin

The novel SAR-binding domain of scaffold attachment factor A (SAF-A) is a target in apoptotic nuclear breakdown.

scientific article published in December 1997

The shape of cell death.

scientific article published on July 1997

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

scientific article

The synthetic peptide LyeTxI-b derived from Lycosa erythrognatha spider venom is cytotoxic to U-87 MG glioblastoma cells

scientific article published on 17 November 2018

The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans

scientific article published in January 2012

Time and space-resolved quantification of plasma membrane sialylation for measurements of cell function and neurotoxicity

scientific article published on 11 December 2019

Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP.

scientific article

Tolerance against tumor necrosis factor alpha (TNF)-induced hepatotoxicity in mice: the role of nitric oxide

scientific article published on 01 December 1995

Toward Good In Vitro Reporting Standards

scientific article published on 01 January 2019

Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project

scientific article published on 28 November 2019

Toxicity of organic and inorganic mercury species in differentiated human neurons and human astrocytes

scientific article published on 15 July 2015

Toxicity testing in the 21st century beyond environmental chemicals

scientific article published in January 2015

Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone

scientific article published on 28 June 2018

Toxicogenomics directory of chemically exposed human hepatocytes

scientific article

Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

scientific article published on 03 December 2018

Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+)

scientific article

Translating neurobehavioural endpoints of developmental neurotoxicity tests into in vitro assays and readouts

scientific article

Tributyltin-induced apoptosis requires glycolytic adenosine trisphosphate production

scientific article published on 01 October 1999

Triggering of apoptosis by cathepsins

scientific article published on 01 April 2001

Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins

scientific article published on 01 March 1997

Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice

scientific article published on 01 July 1995

Tunicamycin potently inhibits tumor necrosis factor-induced hepatocyte apoptosis.

scientific article published on January 1995

Uncoupling of ATP-depletion and cell death in human dopaminergic neurons

scientific article published on 19 December 2011

Vesicular monoamine transporter 2 regulates the sensitivity of rat dopaminergic neurons to disturbed cytosolic dopamine levels.

scientific article published on 21 September 2007

Wide spectrum modulation by KP-544 in models relevant for neuronal survival

scientific article

[What can a chair on alternatives to animal experimentation effectuate?]

scientific article published on 01 January 2006

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