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List of works by Nigel P Minton

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The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome

scientific article
The role of toxin A and toxin B in Clostridium difficile infection

scientific article
The pMTL nic- cloning vectors. I. Improved pUC polylinker regions to facilitate the use of sonicated DNA for nucleotide sequencing

scientific article published in August 1988
The ClosTron: a universal gene knock-out system for the genus Clostridium

scientific article published on 18 June 2007
The ClosTron: Mutagenesis in Clostridium refined and streamlined.

scientific article published on 3 November 2009
A modular system for Clostridium shuttle plasmids

scientific article
Improved plasmid vectors for the isolation of translational lac gene fusions

scientific article published on 01 November 1984
Conjugative transfer of clostridial shuttle vectors from Escherichia coli to Clostridium difficile through circumvention of the restriction barrier

scientific article published in October 2002
Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes

scientific article published on 22 May 2007
Precise manipulation of the Clostridium difficile chromosome reveals a lack of association between the tcdC genotype and toxin production.

scientific article published on 20 April 2012
Femtomolar sensitivity of a NO sensor from Clostridium botulinum.

scientific article published on 7 October 2004
Multiple factors modulate biofilm formation by the anaerobic pathogen Clostridium difficile

scientific article published on 21 November 2012
Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment

scientific article published on 01 August 1997
Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain

scientific article published on 09 August 2013
Integration of DNA into bacterial chromosomes from plasmids without a counter-selection marker

scientific article published on 18 January 2012
Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.

scientific article published on December 1995
Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after single and multiple doses in healthy volunteers

scientific article published in September 2004
The complete amino acid sequence of the Clostridium botulinum type A neurotoxin, deduced by nucleotide sequence analysis of the encoding gene

scientific article published on April 1990
Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis

scientific article published in February 2002
A mariner-based transposon system for in vivo random mutagenesis of Clostridium difficile

scientific article
Spores of Clostridium difficile clinical isolates display a diverse germination response to bile salts

scientific article
Expanding the repertoire of gene tools for precise manipulation of the Clostridium difficile genome: allelic exchange using pyrE alleles

scientific article
Multiple orphan histidine kinases interact directly with Spo0A to control the initiation of endospore formation in Clostridium acetobutylicum

scientific article
Regulation of neurotoxin production and sporulation by a Putative agrBD signaling system in proteolytic Clostridium botulinum.

scientific article published on 7 May 2010
Clostridia in cancer therapy

scientific article
The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia

scientific article
Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo

scientific article published on 3 October 2006
Molecular cloning of the Clostridium botulinum structural gene encoding the type B neurotoxin and determination of its entire nucleotide sequence.

scientific article published on 01 August 1992
Reconsidering the sporulation characteristics of hypervirulent Clostridium difficile BI/NAP1/027.

scientific article
The complete nucleotide sequence of the Pseudomonas gene coding for carboxypeptidase G2.

scientific article published in November 1984
Targeted mutagenesis of the Clostridium acetobutylicum acetone-butanol-ethanol fermentation pathway.

scientific article
The role of flagella in Clostridium difficile pathogenesis: comparison between a non-epidemic and an epidemic strain

scientific article
A novel approach to generate a recombinant toxoid vaccine against Clostridium difficile.

scientific article published on 29 April 2013
The complete amino acid sequence of the Clostridium botulinum type-E neurotoxin, derived by nucleotide-sequence analysis of the encoding gene

scientific article published on March 1992
CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii.

scientific article published on 23 May 2016
Molecular cloning of the Pseudomonas carboxypeptidase G2 gene and its expression in Escherichia coli and Pseudomonas putida

scientific article published on December 1, 1983
Anaerobic bacteria as a delivery system for cancer gene therapy: in vitro activation of 5-fluorocytosine by genetically engineered clostridia.

scientific article
Both, toxin A and toxin B, are important in Clostridium difficile infection

scientific article published on July 1, 2011
Physical characterisation of the replication region of the Streptococcus faecalis plasmid pAM beta 1.

scientific article published on March 1990
AnagrQuorum Sensing System That Regulates Granulose Formation and Sporulation in Clostridium acetobutylicum

scientific article published on December 16, 2011
The diverse sporulation characteristics of Clostridium difficile clinical isolates are not associated with type

scientific article published on 13 October 2010
Characterization of a region of the Enterococcus faecalis plasmid pAM beta 1 which enhances the segregational stability of pAM beta 1-derived cloning vectors in Bacillus subtilis

scientific article published in November 1991
Sporulation studies in Clostridium difficile

scientific article
The analysis of para-cresol production and tolerance in Clostridium difficile 027 and 012 strains

scientific article
CRISPR/Cas9-Based Efficient Genome Editing in Clostridium ljungdahlii, an Autotrophic Gas-Fermenting Bacterium

scientific article published on 8 June 2016
Functional Intestinal Bile Acid 7α-Dehydroxylation by Clostridium scindens Associated with Protection from Clostridium difficile Infection in a Gnotobiotic Mouse Model

scientific article (publication date: 2016)
Disruption of the acetate kinase (ack) gene of Clostridium acetobutylicum results in delayed acetate production

scientific article (publication date: May 2012)
Genome sequencing shows that European isolates of Francisella tularensis subspecies tularensis are almost identical to US laboratory strain Schu S4.

scientific article
Cloning, expression and complete nucleotide sequence of the Bacillus stearothermophilus L-lactate dehydrogenase gene

scientific article published on 01 January 1986
Release of TcdA and TcdB from Clostridium difficile cdi 630 is not affected by functional inactivation of the tcdE gene.

scientific article

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