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List of works by Miguel A. Valvano

A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation.

scientific article published on 27 April 2016

A Burkholderia cenocepacia MurJ (MviN) homolog is essential for cell wall peptidoglycan synthesis and bacterial viability

scientific article published on 31 March 2014

A Burkholderia cenocepacia gene encoding a non-functional tyrosine phosphatase is required for the delayed maturation of the bacteria-containing vacuoles in macrophages.

scientific article published on 12 April 2014

A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo.

scientific article published on March 2006

A decade of Burkholderia cenocepacia virulence determinant research

scientific article

A general protein O-glycosylation machinery conserved in Burkholderia species improves bacterial fitness and elicits glycan immunogenicity in humans

scientific article published on 26 July 2019

A glycoengineered antigen exploiting a conserved protein O-glycosylation pathway in the Burkholderia genus for detection of glanders infections

scientific article published on 01 December 2021

A markerless deletion method for genetic manipulation of Burkholderia cenocepacia and other multidrug-resistant gram-negative bacteria

scientific article published on 01 January 2014

A minor catalase/peroxidase from Burkholderia cenocepacia is required for normal aconitase activity

scientific article published in June 2005

A putative gene cluster for aminoarabinose biosynthesis is essential for Burkholderia cenocepacia viability

scientific article

A quorum-quenching approach to investigate the conservation of quorum-sensing-regulated functions within the Burkholderia cepacia complex

scientific article

A system for the construction of targeted unmarked gene deletions in the genus Burkholderia

scientific article published on 13 March 2008

A two-tier model of polymyxin B resistance in Burkholderia cenocepacia

scientific article published on 8 November 2010

Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepacia

scientific article

Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia

scientific article

Akt-mediated proinflammatory response of mononuclear phagocytes infected with Burkholderia cenocepacia occurs by a novel GSK3β-dependent, IκB kinase-independent mechanism.

scientific article

Aminoarabinose is essential for lipopolysaccharide export and intrinsic antimicrobial peptide resistance inBurkholderia cenocepacia†

scientific article published on 18 July 2012

An Escherichia coli undecaprenyl-pyrophosphate phosphatase implicated in undecaprenyl phosphate recycling.

scientific article published in August 2007

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

scientific article (publication date: July 2003)

An evolutionary conserved detoxification system for membrane lipid-derived peroxyl radicals in Gram-negative bacteria

scientific article published on 17 May 2022

An expression vector containing a rhamnose-inducible promoter provides tightly regulated gene expression in Burkholderia cenocepacia

scientific article published on 31 May 2005

An in vitro screen of bacterial lipopolysaccharide biosynthetic enzymes identifies an inhibitor of ADP-heptose biosynthesis.

scientific article

Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance

scientific article published on 14 March 2017

Antimicrobial heteroresistance: an emerging field in need of clarity.

scientific article published on January 2015

ArnT proteins that catalyze the glycosylation of lipopolysaccharide share common features with bacterial N-oligosaccharyltransferases.

scientific article published on 29 October 2015

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance

scientific article published on 17 September 2009

Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis.

scientific article

BcsKC is an essential protein for the type VI secretion system activity in Burkholderia cenocepacia that forms an outer membrane complex with BcsLB

scientific article published on 20 August 2010

Biological efficacy of electroless-deposited silver on plasma activated polyurethane

scientific article published on 01 July 2003

Biosynthesis and structure of the Burkholderia cenocepacia K56-2 lipopolysaccharide core oligosaccharide: truncation of the core oligosaccharide leads to increased binding and sensitivity to polymyxin B

scientific article

Biosynthesis of inner core lipopolysaccharide in enteric bacteria identification and characterization of a conserved phosphoheptose isomerase

scientific article published in February 1996

Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli

scientific article

Burkholderia cenocepacia BC2L-C Is a Super Lectin with Dual Specificity and Proinflammatory Activity

scientific article

Burkholderia cenocepacia C5424 produces a pigment with antioxidant properties using a homogentisate intermediate.

scientific article

Burkholderia cenocepacia Lipopolysaccharide Modification and Flagellin Glycosylation Affect Virulence but Not Innate Immune Recognition in Plants

scientific article published on 4 June 2015

Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages.

scientific article published on 22 December 2010

Burkholderia cenocepacia and Salmonella enterica ArnT proteins that transfer 4-amino-4-deoxy-l-arabinose to lipopolysaccharide share membrane topology and functional amino acids.

scientific article published on June 2015

Burkholderia cenocepacia disrupts host cell actin cytoskeleton by inactivating Rac and Cdc42

scientific article published on 15 November 2011

Burkholderia cenocepacia requires a periplasmic HtrA protease for growth under thermal and osmotic stress and for survival in vivo

scientific article published on 12 January 2007

Burkholderia cenocepacia requires the RpoN sigma factor for biofilm formation and intracellular trafficking within macrophages

scientific article published on 14 January 2008

Burkholderia cenocepacia-induced delay of acidification and phagolysosomal fusion in cystic fibrosis transmembrane conductance regulator (CFTR)-defective macrophages

scientific article published in December 2008

Burkholderia cepacia complex isolates survive intracellularly without replication within acidic vacuoles of Acanthamoeba polyphaga

scientific article published in December 2004

Burkholderia multivorans survival and trafficking within macrophages.

scientific article

Characterization of the AtsR hybrid sensor kinase phosphorelay pathway and identification of its response regulator in Burkholderia cenocepacia.

scientific article published on 6 September 2013

Characterization of the exopolysaccharide biosynthesis pathway in Myxococcus xanthus

scientific article published on 04 August 2020

Characterization of the highly conserved VFMGD motif in a bacterial polyisoprenyl-phosphate N-acetylaminosugar-1-phosphate transferase.

scientific article

Chemical communication of antibiotic resistance by a highly resistant subpopulation of bacterial cells

scientific article (publication date: 2013)

Cofactor- and substrate-binding domains in flavin-dependent N-hydroxylating enzymes

scientific article published on 01 November 1998

Common themes in glycoconjugate assembly using the biogenesis of O-antigen lipopolysaccharide as a model system.

scientific article published on July 2011

Communication is key: do bacteria use a universal 'language' to spread resistance?

scientific article

Construction and evaluation of plasmid vectors optimized for constitutive and regulated gene expression in Burkholderia cepacia complex isolates.

scientific article published on December 2002

Construction of aminoglycoside-sensitive Burkholderia cenocepacia strains for use in studies of intracellular bacteria with the gentamicin protection assay.

scientific article published on 26 March 2010

Contributions of two UDP-glucose dehydrogenases to viability and polymyxin B resistance of Burkholderia cenocepacia

scientific article published on 21 April 2009

Current Advances in <i>Burkholderia</i> Vaccines Development

scientific article published on 11 December 2020

Dam Methylation Participates in the Regulation of PmrA/PmrB and RcsC/RcsD/RcsB Two Component Regulatory Systems in Salmonella enterica Serovar Enteritidis ⬇️

scientific article published on February 13, 2013

Dam methylation controls O-antigen chain length in Salmonella enterica serovar enteritidis by regulating the expression of Wzz protein

scientific article published on 28 August 2009

Depletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr ΔF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery

scientific journal article

Different sugar residues of the lipopolysaccharide outer core are required for early interactions of Salmonella enterica serovars Typhi and Typhimurium with epithelial cells

scientific article published on 12 November 2010

Diphenylamine increases cloacin DF13 sensitivity in avian septicemic strains of Escherichia coli

scientific article published on September 1, 1992

Distinct functional domains of the Salmonella enterica WbaP transferase that is involved in the initiation reaction for synthesis of the O antigen subunit

scientific article published in February 2008

Diverse pathogenicity of Burkholderia cepacia complex strains in the Caenorhabditis elegans host model

scientific article published on 01 September 2005

Draft Genome Sequence of a Pseudomonas aeruginosa Sequence Type 3351 Strain Exhibiting High-Level Resistance to Polymyxins in a Pediatric Patient with Cystic Fibrosis in Mexico

scientific article published on 09 January 2020

Elucidation of the Burkholderia cenocepacia hopanoid biosynthesis pathway uncovers functions for conserved proteins in hopanoid-producing bacteria. ⬇️

scientific article published on 24 June 2014

Engineering N-linked protein glycosylation with diverse O antigen lipopolysaccharide structures in Escherichia coli.

scientific article

Escherichia coli and Pseudomonas aeruginosa lipopolysaccharide O-antigen ligases share similar membrane topology and biochemical properties

scientific article published on 03 October 2018

Export of O-specific lipopolysaccharide.

scientific article

Extreme antimicrobial peptide and polymyxin B resistance in the genus Burkholderia.

scientific article

Functional analysis of predicted coiled-coil regions in the Escherichia coli K-12 O-antigen polysaccharide chain length determinant Wzz.

scientific article published on 18 January 2008

Functional analysis of the C-terminal domain of the WbaP protein that mediates initiation of O antigen synthesis in Salmonella enterica

scientific article published on 29 June 2010

Functional analysis of the glycero-manno-heptose 7-phosphate kinase domain from the bifunctional HldE protein, which is involved in ADP-L-glycero-D-manno-heptose biosynthesis

scientific article

Functional analysis of the large periplasmic loop of the Escherichia coli K-12 WaaL O-antigen ligase

scientific article published on 10 October 2008

Functional characterization and membrane topology of Escherichia coli WecA, a sugar-phosphate transferase initiating the biosynthesis of enterobacterial common antigen and O-antigen lipopolysaccharide

scientific article

Functional characterization of the initiation enzyme of S-layer glycoprotein glycan biosynthesis in Geobacillus stearothermophilus NRS 2004/3a

scientific article published on 19 January 2007

Global changes in gene expression by the opportunistic pathogen Burkholderia cenocepacia in response to internalization by murine macrophages

scientific article

Growth-phase regulation of lipopolysaccharide O-antigen chain length influences serum resistance in serovars of Salmonella.

scientific article published in August 2008

High confidence prediction of essential genes in Burkholderia cenocepacia ⬇️

scientific article

Hopanoid production is required for low-pH tolerance, antimicrobial resistance, and motility in Burkholderia cenocepacia

scientific article published on 30 September 2011

Identification and molecular analysis of cable pilus biosynthesis genes in Burkholderia cepacia

scientific article published in April 2003

Identification of Burkholderia cenocepacia genes required for bacterial survival in vivo

scientific article published on July 2004

Identification of a UDP-Gal: GlcNAc-R galactosyltransferase activity in Escherichia coli VW187.

scientific article

Identification of a general secretory pathway in a human isolate of Burkholderia vietnamiensis (formerly B. cepacia complex genomovar V) that is required for the secretion of hemolysin and phospholipase C activities

scientific article published on 01 May 2002

Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia.

scientific article published on 22 June 2015

Identification of the Wzx flippase, Wzy polymerase and sugar-modifying enzymes for spore coat polysaccharide biosynthesis in Myxococcus xanthus

scientific article published on 16 February 2020

Identification of the flagellin glycosylation system in Burkholderia cenocepacia and the contribution of glycosylated flagellin to evasion of human innate immune responses

scientific article

Identification of the lipopolysaccharide O-antigen biosynthesis priming enzyme and the O-antigen ligase in Myxococcus xanthus: critical role of LPS O-antigen in motility and development

scientific article published on 30 July 2019

Inactivation of macrophage Rab7 by Burkholderia cenocepacia.

scientific article

Infections by Burkholderia spp.: the psychodramatic life of an opportunistic pathogen

scientific article published on 01 August 2006

Interplay of the Wzx translocase and the corresponding polymerase and chain length regulator proteins in the translocation and periplasmic assembly of lipopolysaccharide o antigen

scientific article

Intracellular survival of Burkholderia cepacia complex in phagocytic cells

scientific article published on 30 June 2015

Lipopolysaccharide modification in Gram-negative bacteria during chronic infection.

scientific article published on 12 April 2016

Loss of O-Linked Protein Glycosylation in Burkholderia cenocepacia Impairs Biofilm Formation and Siderophore Activity and Alters Transcriptional Regulators

scientific article published on 13 November 2019

Macrophage dysfunction in cystic fibrosis: Nature or nurture?

scientific article published on 17 July 2020

Membrane Topology and Identification of Critical Amino Acid Residues in the Wzx O-Antigen Translocase from Escherichia coli O157:H7.

scientific article published in March 2011

Membrane topology and identification of critical amino acid residues in the Wzx O-antigen translocase from Escherichia coli O157:H4.

scientific article published on 24 September 2010

Mitochondrial proteins Bnip3 and Bnip3L are involved in anthrax lethal toxin-induced macrophage cell death.

scientific article

Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues

scientific article published on 27 May 2019

Nasal immunization with Burkholderia multivorans outer membrane proteins and the mucosal adjuvant adamantylamide dipeptide confers efficient protection against experimental lung infections with B. multivorans and B. cenocepacia

scientific article published on 12 February 2007

Non-genetic mechanisms communicating antibiotic resistance: rethinking strategies for antimicrobial drug design.

scientific article published on 04 August 2012

Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections.

scientific article published on 25 November 2017

O-antigen modal chain length in Shigella flexneri 2a is growth-regulated through RfaH-mediated transcriptional control of the wzy gene

scientific article published in October 2007

Phage life cycles behind bacterial biodiversity.

scientific article

Phenotypic characterization of an international Pseudomonas aeruginosa reference panel: strains of cystic fibrosis (CF) origin show less in vivo virulence than non-CF strains.

scientific article

Physico-chemical characterization of a recombinant cytoplasmic form of lysine: N6-hydroxylase

scientific article

Polysaccharide co-polymerases: the enigmatic conductors of the O-antigen assembly orchestra.

scientific article published on 24 October 2012

Prevalence of indeterminate genetic species of Burkholderia cepacia complex in a cystic fibrosis center in Argentina

scientific article published on 16 January 2008

Putrescine reduces antibiotic-induced oxidative stress as a mechanism of modulation of antibiotic resistance in Burkholderia cenocepacia.

scientific article published on 12 May 2014

Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.

scientific article published on 11 September 2015

Reconstitution of O-specific lipopolysaccharide expression in Burkholderia cenocepacia strain J2315, which is associated with transmissible infections in patients with cystic fibrosis

scientific article

RpoS and RpoN are involved in the growth-dependent regulation of rfaH transcription and O antigen expression in Salmonella enterica serovar Typhi

scientific article published in January 2004

Structural and kinetic characterization of the LPS biosynthetic enzyme D-alpha,beta-D-heptose-1,7-bisphosphate phosphatase (GmhB) from Escherichia coli

scientific article

Structural–Functional Studies of Burkholderia cenocepacia d -Glycero-β- d -manno-heptose 7-Phosphate Kinase (HldA) and Characterization of Inhibitors with Antibiotic Adjuvant and Antivirulence Properties

scientific article

Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants

scientific article

Structure of O-Antigen and Hybrid Biosynthetic Locus in Burkholderia cenocepacia Clonal Variants Recovered from a Cystic Fibrosis Patient.

scientific article

Structure-guided investigation of lipopolysaccharide O-antigen chain length regulators reveals regions critical for modal length control

scientific article published on 3 June 2011

Subdivision of the bacterioferritin comigratory protein family of bacterial peroxiredoxins based on catalytic activity

scientific article

Subfunctionalization influences the expansion of bacterial multidrug antibiotic resistance.

scientific article

Substrate specificity of bacterial oligosaccharyltransferase suggests a common transfer mechanism for the bacterial and eukaryotic systems

scholarly article

Surface expression of O-specific lipopolysaccharide in Escherichia coli requires the function of the TolA protein

scientific article published on 01 October 2000

Survival and persistence of opportunistic Burkholderia species in host cells.

scientific article

Synthetic Phosphodiester-Linked 4-Amino-4-deoxy-l-arabinose Derivatives Demonstrate that ArnT is an Inverting Aminoarabinosyl Transferase

scientific article published on 22 October 2019

The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium

scientific article published in PLoS ONE

The Burkholderia cenocepacia peptidoglycan-associated lipoprotein is involved in epithelial cell attachment and elicitation of inflammation

scientific article

The Burkholderia cenocepacia sensor kinase hybrid AtsR is a global regulator modulating quorum-sensing signalling

scientific article published on 26 July 2012

The C-terminal domain of the Salmonella enterica WbaP (UDP-galactose:Und-P galactose-1-phosphate transferase) is sufficient for catalytic activity and specificity for undecaprenyl monophosphate

scientific article published on 19 August 2011

The GalF protein of Escherichia coli is not a UDP-glucose pyrophosphorylase but interacts with the GalU protein possibly to regulate cellular levels of UDP-glucose.

scientific article published in December 1996

The LpxL acyltransferase is required for normal growth and penta-acylation of lipid A in Burkholderia cenocepacia

scientific article published on 13 January 2017

The N-terminal region of the Escherichia coli WecA (Rfe) protein, containing three predicted transmembrane helices, is required for function but not for membrane insertion.

scientific article

The Type VI secretion system of Burkholderia cenocepacia affects multiple Rho family GTPases disrupting the actin cytoskeleton and the assembly of NADPH oxidase complex in macrophages.

scientific article

The WaaL O-antigen lipopolysaccharide ligase has features in common with metal ion-independent inverting glycosyltransferases.

scientific article

The activity of a putative polyisoprenol-linked sugar translocase (Wzx) involved in Escherichia coli O antigen assembly is independent of the chemical structure of the O repeat

scientific article (publication date: 3 December 1999)

The cellular level of O-antigen polymerase Wzy determines chain length regulation by WzzB and WzzpHS-2 in Shigella flexneri 2a.

scientific article published on 25 June 2009

The mgtC gene of Burkholderia cenocepacia is required for growth under magnesium limitation conditions and intracellular survival in macrophages.

scientific article published on October 2006

The normal chain length distribution of the O antigen is required for the interaction of Shigella flexneri 2a with polarized Caco-2 cells

scientific article published on 01 January 2012

The outer core lipopolysaccharide of Salmonella enterica serovar Typhi is required for bacterial entry into epithelial cells.

scientific article published on March 2006

The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose

scientific article

The suhB gene of Burkholderia cenocepacia is required for protein secretion, biofilm formation, motility and polymyxin B resistance.

scientific article published on 5 July 2012

The temperate Burkholderia phage AP3 of the Peduovirinae shows efficient antimicrobial activity against B. cenocepacia of the IIIA lineage.

scientific article

The unexpected discovery of a novel low-oxygen-activated locus for the anoxic persistence of Burkholderia cenocepacia

scientific article published on 14 March 2013

The wbbD gene of E. coli strain VW187 (O7:K1) encodes a UDP-Gal: GlcNAc{alpha}-pyrophosphate-R {beta}1,3-galactosyltransferase involved in the biosynthesis of O7-specific lipopolysaccharide

scientific article published on 29 December 2004

Topological analysis of the Escherichia coli WcaJ protein reveals a new conserved configuration for the polyisoprenyl-phosphate hexose-1-phosphate transferase family.

scientific article

Transcriptional responses of Burkholderia cenocepacia to polymyxin B in isogenic strains with diverse polymyxin B resistance phenotypes.

scientific article

Two distinct but interchangeable mechanisms for flipping of lipid-linked oligosaccharides

scientific journal article

Tyrosine Phosphorylation and Dephosphorylation in Burkholderia cenocepacia Affect Biofilm Formation, Growth under Nutritional Deprivation, and Pathogenicity

scientific article

Undecaprenyl phosphate recycling comes out of age.

scientific article

Validation of membrane protein topology models by oxidative labeling and mass spectrometry.

scientific article published on 13 March 2012

Vitamin E Increases Antimicrobial Sensitivity by Inhibiting Bacterial Lipocalin Antibiotic Binding

scientific article published in 2018

Wzx proteins involved in biosynthesis of O antigen function in association with the first sugar of the O-specific lipopolysaccharide subunit

scientific article published in December 2004

tolQ is required for cloacin DF13 susceptibility in Escherichia coli expressing the aerobactin/cloacin DF13 receptor IutA.

scientific article published in March 1992

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