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List of works by Alan Morgan

A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action

article by Shi Quan Wong et al published 1 November 2018 in Journal of Neuroscience Methods

A Caenorhabditis elegans model of autosomal dominant adult-onset neuronal ceroid lipofuscinosis identifies ethosuximide as a potential therapeutic

scholarly article

A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells

scientific article

A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3

scientific article published on 01 January 2008

A major role for protein kinase C in calcium-activated exocytosis in permeabilised adrenal chromaffin cells

scientific article published on 01 September 1988

A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ-aminobutyric acidergic anticonvulsant

scientific article published on 14 August 2020

A protein-protein binding assay using coated microtitre plates: increased throughput, reproducibility and speed compared to bead-based assays.

scientific article published in July 2004

A random mutagenesis approach to isolate dominant-negative yeast sec1 mutants reveals a functional role for domain 3a in yeast and mammalian Sec1/Munc18 proteins

scientific article

A synthetic peptide of the N-terminus of ADP-ribosylation factor (ARF) inhibits regulated exocytosis in adrenal chromaffin cells

scientific article

A systematic analysis of protein palmitoylation in Caenorhabditis elegans

scientific article

Amisyn Regulates Exocytosis and Fusion Pore Stability by Both Syntaxin-dependent and Syntaxin-independent Mechanisms

scientific article published on 20 July 2005

Analysis of NSF mutants reveals residues involved in SNAP binding and ATPase stimulation

scientific article published in April 2002

Analysis of regulated exocytosis in adrenal chromaffin cells: insights into NSF/SNAP/SNARE function

scientific article published on April 1998

Analysis of the brain palmitoyl-proteome using both acyl-biotin exchange and acyl-resin-assisted capture methods

scientific article

Analysis of the interacting partners of the neuronal calcium-binding proteins L-CaBP1, hippocalcin, NCS-1 and neurocalcin delta

scientific journal article

Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans

scientific article published in February 2009

Biochemical analysis of the Saccharomyces cerevisiae SEC18 gene product: implications for the molecular mechanism of membrane fusion

scientific article

Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.

scientific article

Caenorhabditis elegans: a useful tool to decipher neurodegenerative pathways

scientific article published on April 2010

Calcium sensors in regulated exocytosis

scientific article

Calcium-dependent regulation of exocytosis

scientific article

Calorie restriction reduces rDNA recombination independently of rDNA silencing

scientific article

Chaperoning the SNAREs: a role in preventing neurodegeneration?

scientific article published on 01 January 2011

Classic clues to NSF function

scientific article published in August 1996

Control of membrane fusion dynamics during regulated exocytosis.

scientific article

Cysteine string protein (CSP) and its role in preventing neurodegeneration

scientific article published on 21 March 2015

Distinct effects of alpha-SNAP, 14-3-3 proteins, and calmodulin on priming and triggering of regulated exocytosis

scientific article published on September 1995

Editorial: Molecular neuroprotection

scientific article published in April 2015

Epilepsy research methods update: Understanding the causes of epileptic seizures and identifying new treatments using non-mammalian model organisms.

scientific article published on 13 October 2014

Erratum to: Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression

scientific article published on 23 October 2015

Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression

scientific article

Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components

scientific article

Functional analysis of epilepsy-associated variants in STXBP1/Munc18-1 using humanized Caenorhabditis elegans

scientific article published on 29 February 2020

Identification of a key domain in annexin and 14-3-3 proteins that stimulate calcium-dependent exocytosis in permeabilized adrenal chromaffin cells

scientific article published on April 1993

Is NSF a fusion protein?

scientific article published on 01 September 1995

Low molecular mass GTP-binding proteins of adrenal chromaffin cells are present on the secretory granule.

scientific article

Membrane Trafficking: Three Steps to Fusion

scientific article published on 01 April 2007

Membrane traffic: controlling membrane fusion by modifying NSF.

scientific article

Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions

scientific article

NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in Yeast

scientific article

NSF and SNAPs

Neurotransmitter release mechanisms studied in Caenorhabditis elegans

scientific article published on 20 April 2012

New links between SOD1 and metabolic dysfunction from a yeast model of amyotrophic lateral sclerosis

scientific article

PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion.

scientific article

Phosphomimetic mutation of Ser-187 of SNAP-25 increases both syntaxin binding and highly Ca2+-sensitive exocytosis.

scientific article

Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch

scientific article published on 5 July 2016

Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis

scientific article

Phosphorylation of cysteine string protein in the brain: developmental, regional and synaptic specificity.

scientific article published in May 2005

Phosphorylation of cysteine string protein on Serine 10 triggers 14-3-3 protein binding.

scientific article

Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I.

scientific article published on June 2002

Physiological regulation of Munc18/nSec1 phosphorylation on serine-313

scientific article (publication date: September 2003)

Presynaptic targets for acute ethanol sensitivity

scientific article published on February 2010

Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size.

scientific article published on 21 October 2005

Protein phosphorylation and the regulation of synaptic membrane traffic

scientific article

Proteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension

scientific article published in 2021

Proximity labelling reveals effects of disease-causing mutation on the DNAJC5/cysteine string protein α interactome

scientific article published in 2024

Regulation of exocytosis by protein kinase C.

scientific article

Regulation of the exocytotic machinery by cAMP-dependent protein kinase: implications for presynaptic plasticity

scientific article

Regulation of the fusion pore conductance during exocytosis by cyclin-dependent kinase 5.

scientific article

S-nitrosylation of syntaxin 1 at Cys(145) is a regulatory switch controlling Munc18-1 binding

scientific article

Selective stimulation of the D1 ATPase domain of N -ethylmaleimide-sensitive fusion protein (NSF) by soluble NSF attachment proteins

scientific article published on 01 February 1998

Sequential appearance of cytoskeletal components during the early stages of neurite outgrowth from cerebellar granule cells in vitro

scientific article

Similar effects of α- and β-SNAP on Ca 2+ -regulated exocytosis

scientific article published on 01 September 1996

Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis

scientific article

Stimulation of NSF ATPase activity during t-SNARE priming

scientific article published on 01 September 1998

Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis

scientific article

Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone

scientific article

The DNA helicase activity of yeast Sgs1p is essential for normal lifespan but not for resistance to topoisomerase inhibitors

scientific article

The contribution of multicellular model organisms to neuronal ceroid lipofuscinosis research

scientific article published on 26 November 2019

The control of cytoskeletal actin and exocytosis in intact and permeabilized adrenal chromaffin cells: role of calcium and protein kinase C.

scientific article

The control of free arachidonic acid levels

scientific article published on October 1990

The functions of Munc18-1 in regulated exocytosis

scientific article

Tying everything together: the multiple roles of cysteine string protein (CSP) in regulated exocytosis

scientific article

UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans

scientific article published on 15 October 2008

Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases

scientific article

Using Caenorhabditis elegans to fight human neurodegenerative diseases

scientific article published on 13 September 2013

Yeast Nhp6A/B and mammalian Hmgb1 facilitate the maintenance of genome stability

scientific article published in January 2005

nSec-1 (munc-18) interacts with both primed and unprimed syntaxin 1A and associates in a dimeric complex on adrenal chromaffin granules

scientific article published in September 1999

α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy

article

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