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List of works by Rakesh P. Patel

A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure.

scientific article

A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury.

scholarly article

A novel model of chronic wounds: importance of redox imbalance and biofilm-forming bacteria for establishment of chronicity

scientific article

A randomized clinical trial testing the anti-inflammatory effects of preemptive inhaled nitric oxide in human liver transplantation

scientific article

ABO blood group is associated with response to inhaled nitric oxide in neonates with respiratory failure

scientific article

Activation of c-Jun N-terminal kinase and apoptosis in endothelial cells mediated by endogenous generation of hydrogen peroxide

scientific article published in March 2002

Acyloxy nitroso compounds as nitroxyl (HNO) donors: kinetics, reactions with thiols, and vasodilation properties

scientific article

Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality

scientific article

Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivo ⬇️

scientific article published on November 16, 2012

Antioxidant mechanisms of isoflavones in lipid systems: paradoxical effects of peroxyl radical scavenging

scientific article published in December 2001

Assessing NO-dependent vasodilatation using vessel bioassays at defined oxygen tensions.

scientific article published in January 2005

Assessment of ICAM-1 N-glycoforms in mouse and human models of endothelial dysfunction

scientific article published on 24 March 2020

Assessment of endothelial glycocalyx disruption in term parturients receiving a fluid bolus before spinal anesthesia: a prospective observational study

scientific article published on 7 June 2014

Biochemical aspects of the reaction of hemoglobin and NO: implications for Hb-based blood substitutes.

scientific article

Biochemical characterization of human S-nitrosohemoglobin. Effects on oxygen binding and transnitrosation

scientific article published on 01 May 1999

Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin

scientific article published on 4 November 2007

Characterization of Storage-Induced Red Blood Cell Hemolysis Using Raman Spectroscopy

scientific article published on 01 October 2018

Chlorination and nitration of soy isoflavones

scientific article published on 01 August 1999

Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting endothelial nitric oxide synthase-dependent signaling

scientific article

Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis

scholarly article

Control of mitochondrial respiration by NO*, effects of low oxygen and respiratory state

scientific article published on 4 June 2003

Cytoprotection against oxidative stress and the regulation of glutathione synthesis.

scientific article

Developmental changes in circulating IL-8/CXCL8 isoforms in neonates.

scientific article published on 15 February 2009

Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels.

scientific article

Dipyridamole enhances ischaemia-induced arteriogenesis through an endocrine nitrite/nitric oxide-dependent pathway

scientific article

Dipyridamole reverses peripheral ischemia and induces angiogenesis in the Db/Db diabetic mouse hind-limb model by decreasing oxidative stress.

scientific article published on 9 November 2010

Effects of Erythrocyte Aging on Nitric Oxide and Nitrite Metabolism ⬇️

scientific article published on 04 March 2013

Effects of S-nitrosation and cross-linking of hemoglobin on hypoxic pulmonary vasoconstriction in isolated rat lungs

scientific article published in October 2002

Effects of S-nitrosation on hemoglobin-induced microvascular damage

scientific article

Effects of T- and R-state stabilization on deoxyhemoglobin-nitrite reactions and stimulation of nitric oxide signaling.

scientific article published on 26 January 2011

Effects of sodium nitrite on ischemia-reperfusion injury in the rat kidney

scientific article published on 8 November 2005

Effects of venous needle turbulence during ex vivo hemodialysis on endothelial morphology and nitric oxide formation

scientific article published on 11 December 2006

Elevated levels of NO are localized to distal airways in asthma

scientific article

Encapsulation of hemoglobin inside liposomes surface conjugated with poly(ethylene glycol) attenuates their reactions with gaseous ligands and regulates nitric oxide dependent vasodilation.

scientific article published on 30 March 2012

Endothelial NOS-dependent activation of c-Jun NH2- terminal kinase by oxidized low-density lipoprotein ⬇️

scientific article published on December 1, 2001

Endothelial heterogeneity and adhesion molecules N-glycosylation: implications in leukocyte trafficking in inflammation.

scientific article published on 27 February 2013

Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control

scientific article

Erythrocyte storage increases rates of NO and nitrite scavenging: implications for transfusion-related toxicity

scientific article published on September 2012

Erythrocyte-dependent regulation of human skeletal muscle blood flow: role of varied oxyhemoglobin and exercise on nitrite, S-nitrosohemoglobin, and ATP.

scientific article

Fatty acid transduction of nitric oxide signaling. Nitrolinoleic acid is a hydrophobically stabilized nitric oxide donor

scientific article

Formation of nanomolar concentrations of S-nitroso-albumin in human plasma by nitric oxide

scientific article published in September 2001

Formation of the NO donors glyceryl mononitrate and glyceryl mononitrite from the reaction of peroxynitrite with glycerol ⬇️

scientific article published on December 1, 1997

Haemoglobin: NO transporter, NO inactivator or NOne of the above?

scientific article

Hemoglobin mediated nitrite activation of soluble guanylyl cyclase.

scientific article published on 2 June 2005

Hemoglobin oxygen fractional saturation regulates nitrite-dependent vasodilation of aortic ring bioassays

scientific article published on 31 August 2007

Heterogenic Endothelial Responses to Inflammation: Role for Differential N ‐Glycosylation and Vascular Bed of Origin ⬇️

scientific article published on July 30, 2013

High-mannose intercellular adhesion molecule-1 enhances CD16+ monocyte adhesion to the endothelium

scientific article published on 09 August 2019

Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation

scientific article published on 29 September 2005

ICAM-1 cross-linking stimulates endothelial glutathione synthesis.

scientific article

ICAM-1 cytoplasmic tail regulates endothelial glutathione synthesis through a NOX4/PI3-kinase-dependent pathway.

scientific article published on 13 July 2010

Identification of a high-mannose ICAM-1 glycoform: effects of ICAM-1 hypoglycosylation on monocyte adhesion and outside in signaling

scientific article published on 22 May 2013

Increased sensitivity of Apolipoprotein E knockout mice to swainsonine dependent immunomodulation

scientific article

Induction of glutathione synthesis by oxidized low-density lipoprotein and 1-palmitoyl-2-arachidonyl phosphatidylcholine: protection against quinone-mediated oxidative stress

scientific article published in February 2002

Inhalation of nitric oxide prevents ischemic brain damage in experimental stroke by selective dilatation of collateral arterioles

scientific article

Intercellular adhesion molecule-1 (ICAM-1) regulates endothelial cell motility through a nitric oxide-dependent pathway

scientific article published on 24 February 2004

Is methemoglobin an inert bystander, biomarker or a mediator of oxidative stress--The example of anemia?

scientific article published on 26 January 2013

Isoflavones and PPAR Signaling: A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease ⬇️

scientific article published on January 1, 2010

L-Arginine inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemia

scientific article published in March 2004

Losing control over adenosine 5′-triphosphate release: Implications for the red blood cell storage lesion* ⬇️

scientific article published on November 1, 2011

Low intensity shear stress increases endothelial ELR+ CXC chemokine production via a focal adhesion kinase-p38{beta} MAPK-NF-{kappa}B pathway.

scientific article

Mass spectrometric methods for the analysis of chlorinated and nitrated isoflavonoids: a novel class of biological metabolites

scientific article published in July 2003

Measurement of mitochondrial respiratory thresholds and the control of respiration by nitric oxide

scientific article published in January 2002

Measuring nitrate reductase activity from human and rodent tongues

scientific article published on 5 April 2017

Mechanisms of cystic fibrosis transmembrane conductance regulator activation by S-nitrosoglutathione

scientific article published on 17 January 2006

Mechanisms of the interaction of nitroxyl with mitochondria

scientific article published on April 2004

Mechanisms of the pro- and anti-oxidant actions of nitric oxide in atherosclerosis.

scientific article

Membrane attack complex generation increases as a function of time in stored blood

scientific article published on 4 March 2014

Metabolic and cardiac signaling effects of inhaled hydrogen sulfide and low oxygen in male rats ⬇️

scientific article published on March 8, 2012

Metabolism of phytoestrogen conjugates

scientific article published in January 2005

Microvascular response to red blood cell transfusion in trauma patients.

scientific article

Mitigation of chlorine gas lung injury in rats by postexposure administration of sodium nitrite ⬇️

scientific article published on December 10, 2010

Modulation of pulmonary endothelial endothelin B receptor expression and signaling: implications for experimental hepatopulmonary syndrome.

scientific article

Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor

scientific journal article

Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species.

scientific article

Neutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant properties

scientific article

Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators

scientific article

Nitric oxide donor generation from reactions of peroxynitrite

scientific article published on 01 January 1999

Nitric oxide formation versus scavenging: the red blood cell balancing act.

scientific article published on 11 June 2012

Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation

scientific article published on 02 November 2003

Nitrite therapy improves survival postexposure to chlorine gas

scientific article

Nitrosation of uric acid by peroxynitrite. Formation of a vasoactive nitric oxide donor

scientific article published on 01 September 1998

Over-the-counter mouthwash use and risk of pre-diabetes/diabetes.

scientific article

Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype

scientific article published on 14 August 2012

Oxidant regulation of gene expression and neural tube development: Insights gained from diabetic pregnancy on molecular causes of neural tube defects ⬇️

scientific article published on March 26, 2003

Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease ⬇️

scientific article published on December 18, 2001

Pentoxifylline attenuation of experimental hepatopulmonary syndrome.

scientific article

Peroxiredoxin-2 recycling is inhibited during erythrocyte storage

scientific article

Physiologic, pathologic and therapeutic implications for hemoglobin interactions with nitric oxide

scientific article published in February 2004

Polyphenols, Inflammatory Response, and Cancer Prevention: Chlorination of Isoflavones by Human Neutrophils ⬇️

scientific article published on November 1, 2003

Potential for chlorine gas-induced injury in the extrapulmonary vasculature.

scientific article published on July 2010

Predicting storage-dependent damage to red blood cells using nitrite oxidation kinetics, peroxiredoxin-2 oxidation, and hemoglobin and free heme measurements

scientific article

Preserving vessel function during ischemic disease: new possibilities of inorganic nitrite therapy.

scientific article published on October 2008

Red blood cell age and potentiation of transfusion-related pathology in trauma patients.

scientific article

Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma-hemorrhage

scientific article published on 29 April 2015

Redox therapeutics in hepatic ischemia reperfusion injury

scientific article

Regulation of endothelial glutathione by ICAM-1 governs VEGF-A-mediated eNOS activity and angiogenesis

scientific article published on 16 December 2006

Regulation of endothelial glutathione by ICAM-1: implications for inflammation.

scientific article

Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation

scientific article published on 13 March 2009

Revealing anti-inflammatory mechanisms of soy isoflavones by flow: modulation of leukocyte-endothelial cell interactions

scientific article

Role of endothelial N-glycan mannose residues in monocyte recruitment during atherogenesis.

scientific article published on 21 June 2012

Role of heme in lung bacterial infection after trauma hemorrhage and stored red blood cell transfusion: A preclinical experimental study.

scientific article

Role of the b93cys, ATP and adenosine in red cell dependent hypoxic vasorelaxation ⬇️

scientific article published on March 8, 2013

S-Nitrosothiol biology and therapeutic potential in metabolic disease ⬇️

scientific article published on October 1, 2010

SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilation

scientific article published on 30 May 2008

SOD2 acetylation and deacetylation: Another tale of Jekyll and Hyde in cancer

scientific article published on 06 November 2019

Sildenafil promotes ischemia-induced angiogenesis through a PKG-dependent pathway.

scientific article published on 21 June 2007

Single-dose pharmacokinetics of different oral sodium nitrite formulations in diabetes patients

scientific article

Sodium nitrite protects against kidney injury induced by brain death and improves post-transplant function.

scientific article published on 25 April 2012

Targeting endothelial adhesion molecule mRNA to control inflammation: novel insights into potential anti-inflammatory effects of IL-19. Focus on "Interleukin-19 decreases leukocyte-endothelial cell interactions by reduction in endothelial cell adhes

scientific article published on 8 May 2013

The deleterious effect of red blood cell storage on microvascular response to transfusion.

scientific article

The detection of the nitrite reductase and NO-generating properties of haemoglobin by mitochondrial inhibition ⬇️

scientific article published on October 14, 2010

The emerging biology of the nitrite anion

scientific article published on 01 November 2005

The globin-based free radical of ferryl hemoglobin is detected in normal human blood

scientific article published on 01 March 1997

The induction of GSH synthesis by nanomolar concentrations of NO in endothelial cells: a role for γ-glutamylcysteine synthetase and γ-glutamyl transpeptidase

scientific article published on 9 April 1999

The level of complement activation fragments is higher in red blood cell units than segments

scientific article

The potential role of the red blood cell in nitrite-dependent regulation of blood flow.

scientific article published on 14 October 2010

The red blood cell and vascular function in health and disease.

scientific article

The role of red blood cells and hemoglobin-nitric oxide interactions on blood flow

scientific article published in February 2008

The role of redox-dependent mechanisms in heme release from hemoglobin and erythrocyte hemolysates

scientific article published on 05 December 2018

The transcription factor E26 transformation-specific sequence-1 mediates neointima formation in arteriovenous fistula

scientific article

Things We "kNOw" and Do Not "kNOw" about Pulmonary Hypertension

scientific article published on 01 July 2018

Transduction of NO-bioactivity by the red blood cell in sepsis: novel mechanisms of vasodilation during acute inflammatory disease

scientific article published on 18 May 2004

Vasoactivity of S-nitrosohemoglobin: role of oxygen, heme, and NO oxidation states

scientific article

Weight loss and race modulate nitric oxide metabolism in overweight women

scientific article

Working with nitric oxide and hydrogen sulfide in biological systems

scientific article

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