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List of works by Lezanne Ooi

A Simple Differentiation Protocol for Generation of Induced Pluripotent Stem Cell-Derived Basal Forebrain-Like Cholinergic Neurons for Alzheimer's Disease and Frontotemporal Dementia Disease Modeling

scientific article published on 02 September 2020

A Simple Microplate Assay for Reactive Oxygen Species Generation and Rapid Cellular Protein Normalization

A postmortem analysis of NMDA ionotropic and group 1 metabotropic glutamate receptors in the nucleus accumbens in schizophrenia

scientific article

A quick, convenient and economical method for the reliable determination of methylglyoxal in millimolar concentrations: the N-acetyl-l-cysteine assay

scientific article published on 14 May 2012

An Optimized Direct Lysis Gene Expression Microplate Assay and Applications for Disease, Differentiation, and Pharmacological Cell-Based Studies

Anti-inflammatory effects of five commercially available mushroom species determined in lipopolysaccharide and interferon-γ activated murine macrophages

scientific article published on 14 October 2013

Astrocytic modulation of cortical oscillations

scientific article published on 01 August 2018

Automated Liquid Handling for Microplate Assays: a Simplified User Interface for the Hamilton Microlab STAR

BRG1 chromatin remodeling activity is required for efficient chromatin binding by repressor element 1-silencing transcription factor (REST) and facilitates REST-mediated repression

scientific article published on 4 October 2006

Chromatin crosstalk in development and disease: lessons from REST

scientific article

Chromatin switching and transcriptional regulation in disease

scientific article published in August 2008

Chronic Adolescent CDPPB Treatment Alters Short-Term, but not Long-Term, Glutamatergic Receptor Expression

scientific article published on 23 June 2018

Chronic inflammation alters production and release of glutathione and related thiols in human U373 astroglial cells

scientific article

Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research

scientific article

Comparison of effects of anandamide at recombinant and endogenous rat vanilloid receptors

scientific article published in December 2002

Consumption of pomegranates improves synaptic function in a transgenic mice model of Alzheimer's disease

scientific article published on 28 July 2016

Cross-Linking Cellular Prion Protein Induces Neuronal Type 2-Like Hypersensitivity

scientific article published on 30 July 2021

Cytoprotective properties of traditional Chinese medicinal herbal extracts in hydrogen peroxide challenged human U373 astroglia cells

scientific article

DC and AC magnetic fields increase neurite outgrowth of SH-SY5Y neuroblastoma cells with and without retinoic acid

Determination of anti-inflammatory activities of standardised preparations of plant- and mushroom-based foods

scientific article published on 8 May 2013

Development of a high-performance liquid chromatography method for the simultaneous quantitation of glutathione and related thiols

scientific article

Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis

scientific article published on 05 April 2019

Edaravone and mitochondrial transfer as potential therapeutics for vanishing white matter disease astrocyte dysfunction

Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells

scientific article published on 12 September 2013

Effects of short- and long-term aripiprazole treatment on Group I mGluRs in the nucleus accumbens: Comparison with haloperidol

scientific article published on 21 November 2017

Electrochemical biosensing strategies for DNA methylation analysis.

scientific article published on 17 February 2017

Evaluation of Skin Fibroblasts from Amyotrophic Lateral Sclerosis Patients for the Rapid Study of Pathological Features.

scientific article

Generation and characterization of a human induced pluripotent stem cell line UOWi005-A from dermal fibroblasts derived from a CCNFS621G familial amyotrophic lateral sclerosis patient using mRNA reprogramming

scientific article published on 14 August 2019

Generation and characterization of human induced pluripotent stem cell lines from a familial Alzheimer's disease PSEN1 A246E patient and a non-demented family member bearing wild-type PSEN1

scientific article published on 13 August 2018

Generation of APOE knock-down SK-N-SH human neuroblastoma cells using CRISPR/Cas9: a novel cellular model relevant to Alzheimer's disease research

scientific article published in 2021

Generation of hydrogen peroxide-resistant murine neuroblastoma cells: a target discovery platform for novel neuroprotective genes

scientific article published on 20 February 2013

Getting to NO Alzheimer's Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide

scientific article

Identification and High-Resolution Imaging of α-Tocopherol from Human Cells to Whole Animals by TOF-SIMS Tandem Mass Spectrometry

scientific article published on 12 June 2018

Identification of repurposable cytoprotective drugs in vanishing white matter disease patient-derived cells

Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication ⬇️

scientific article published on 09 August 2006

Identifying transcriptional regulatory regions using reporter genes and DNA-protein interactions by chromatin immunoprecipitation

scientific article published in January 2008

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

scientific article published on 13 April 2020

Impairments in Motor Neurons, Interneurons and Astrocytes Contribute to Hyperexcitability in ALS: Underlying Mechanisms and Paths to Therapy

scientific article published on 3 February 2017

Increased Tau Phosphorylation in Motor Neurons From Clinically Pure Sporadic Amyotrophic Lateral Sclerosis Patients

scientific article published on 01 July 2019

Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer's disease

scientific article published on 13 June 2012

Innovations advancing our understanding of microglia in Alzheimer's disease: From in vitro to in vivo models

Lipoic Acid as an Anti-Inflammatory and Neuroprotective Treatment for Alzheimer’s Disease

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice

scientific article published on 01 October 2019

M-Type K+ Channel as Plasma Membrane Nitric Oxide and Reactive Oxygen Species Sensor

Mammalian expression systems and transfection techniques

scientific article published in January 2013

Modeling Emergent Properties in the Brain Using Tissue Models to Investigate Neurodegenerative Disease

scientific article published on 13 September 2019

Molecular and Functional Characterization of Neurogenin-2 Induced Human Sensory Neurons

scientific article published on 04 December 2020

More than a Corepressor: The Role of CoREST Proteins in Neurodevelopment

scientific article published on 10 March 2020

Multiple chromatin modifications important for gene expression changes in cardiac hypertrophy

scientific article published in December 2006

Nanotechnology and its medical applications: revisiting public policies from a regulatory perspective in Australia

article

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells

scientific article published on 13 July 2020

Neurodevelopmental Expression Profile of Dimeric and Monomeric Group 1 mGluRs: Relevance to Schizophrenia Pathogenesis and Treatment

scientific article published on 10 October 2016

Neuronal hyperexcitability in Alzheimer’s disease: what are the drivers behind this aberrant phenotype?

scientific article published in 2022

Neuroprotection of Neuro2a cells and the cytokine suppressive and anti-inflammatory mode of action of resveratrol in activated RAW264.7 macrophages and C8-B4 microglia

scientific article published on 29 October 2015

Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease

scientific article published on 12 August 2016

New drugs under development for Alzheimer’s disease

article

Nitric Oxide: A Regulator of Cellular Function in Health and Disease.

scientific article

Novel dual-action prodrug triggers apoptosis in glioblastoma cells by releasing a glutathione quencher and lysine-specific histone demethylase 1A inhibitor

scientific article published on 03 February 2019

P2Y2 and P2X4 Receptors Mediate Ca2+ Mobilization in DH82 Canine Macrophage Cells

scientific article published on 13 November 2020

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

scientific article published on 12 September 2019

Pharmacological and genetic characterisation of the canine P2X4 receptor

scientific article published on 04 February 2020

Proenergetic effects of resveratrol in the murine neuronal cell line Neuro2a

scientific article published on 12 August 2013

Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons

scientific article

Redox and nitric oxide-mediated regulation of sensory neuron ion channel function

scientific article

Regulation Of Kcnq2/3 Channels By The Transcriptional Repressor REST In Nociception

Regulation of gene expression in the nervous system

scientific article published on September 2008

Reversing increased neuronal nitric oxide synthase in Alzheimer’s disease prevents aberrant glutamatergic calcium responses

Role of EphA4 in Mediating Motor Neuron Death in MND

scientific article published in 2021

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

scientific article

Selective ferroptosis vulnerability due to familial Alzheimer's disease presenilin mutations

Sensitive Detection of Motor Neuron Disease Derived Exosomal miRNA Using Electrocatalytic Activity of Gold‐Loaded Superparamagnetic Ferric Oxide Nanocubes

Substance P and Bradykinin Activate Alternative Gq/11-Coupled Signalling Cascades and Impose Opposite Effects on M Current in DRG Neurons

TRPV3 is a temperature-sensitive vanilloid receptor-like protein.

scientific article published on 23 June 2002

The P2X4 Receptor: Cellular and Molecular Characteristics of a Promising Neuroinflammatory Target

scientific article published in 2022

The Thiol Antioxidant Lipoic Acid and Alzheimer’s Disease

The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Differentiation

scientific article published on 13 June 2019

The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels

scientific article

The heat shock response in neurons and astroglia and its role in neurodegenerative diseases.

scientific article published on 18 September 2017

The mRNA-based reprogramming of fibroblasts from a SOD1E101G familial amyotrophic lateral sclerosis patient to induced pluripotent stem cell line UOWi007

scientific article published on 16 January 2020

The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS

scientific article published on 03 April 2019

The repressor element 1-silencing transcription factor regulates heart-specific gene expression using multiple chromatin-modifying complexes

scientific article published on 19 March 2007

The role of amyloid oligomers in neurodegenerative pathologies

scientific article published in 2021

The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis

scientific article published on 2 February 2018

The transcriptional repressor REST is a critical regulator of the neurosecretory phenotype

scientific article published on September 2006

Transcriptional control of KCNQ channel genes and the regulation of neuronal excitability ⬇️

scientific article published on October 2010

Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury

scientific article published on 23 February 2011

Transgene and Chemical Transdifferentiation of Somatic Cells for Rapid and Efficient Neurological Disease Cell Models

Treatment of microglia with Anti-PrP monoclonal antibodies induces neuronal apoptosis in vitro

Triple cysteine module within M-type K+ channels mediates reciprocal channel modulation by nitric oxide and reactive oxygen species

scientific article published on April 2013

Unbiased Label-Free Quantitative Proteomics of Cells Expressing Amyotrophic Lateral Sclerosis (ALS) Mutations in CCNF Reveals Activation of the Apoptosis Pathway: A Workflow to Screen Pathogenic Gene Mutations

Understanding inflammatory pain: ion channels contributing to acute and chronic nociception

scientific article published on 17 February 2010

Understanding the Role of ApoE Fragments in Alzheimer's Disease

scientific article published on 17 September 2018

Understanding the pathology of psychiatric disorders in refugees

scientific article published on 24 December 2020

Viral-free generation and characterization of a human induced pluripotent stem cell line from dermal fibroblasts

Walking the tightrope: proteostasis and neurodegenerative disease

scientific article published on 12 February 2016

Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.

scientific article

Wnt is here! Could Wnt signalling be promoted to protect against Alzheimer disease?

scientific article published on 26 January 2018

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