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List of works by Arwen R Pearson

3D-MiXD: 3D-printed X-ray-compatible microfluidic devices for rapid, low-consumption serial synchrotron crystallography data collection in flow

scientific article published on 16 January 2020

A comparative analysis of the fluorescence properties of the wild-type and active site mutants of the hepatitis C virus autoprotease NS2-3

scientific article

A new on-axis multimode spectrometer for the macromolecular crystallography beamlines of the Swiss Light Source

scientific article published on 25 February 2009

Active site aspartate residues are critical for tryptophan tryptophylquinone biogenesis in methylamine dehydrogenase

scientific article published on 25 February 2005

All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding

scientific article

Applying broadband terahertz time-domain spectroscopy to the analysis of crystalline proteins: a dehydration study

Calculation of terahertz active normal modes in organic crystals

Catching catalysis in the act: using single crystal kinetics to trap methylamine dehydrogenase reaction intermediates

scientific article published in April 2003

Combining X-ray crystallography and single-crystal spectroscopy to probe enzyme mechanisms

scientific article published on April 2009

Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies.

scientific article published on 3 March 2018

Cryocrystallography of metalloprotein reaction intermediates

scientific article

Crystal structure of a domain-swapped photoactivatable sfGFP variant provides evidence for GFP folding pathway

scientific article published on 20 March 2019

Crystallization and preliminary X-ray analysis of a bifunctional catalase-phenol oxidase from Scytalidium thermophilum

scientific article published on 24 April 2009

Directed Assembly of Homopentameric Cholera Toxin B-Subunit Proteins into Higher-Order Structures Using Coiled-Coil Appendages

scientific article published on 21 March 2019

Dissecting the mechanism of oxygen trafficking in a metalloenzyme

scientific article published in January 2011

Dynamic structural science: recent developments in time-resolved spectroscopy and X-ray crystallography.

scientific article

Effect of molecular size and particle shape on the terahertz absorption of a homologous series of tetraalkylammonium salts

scientific article published on 6 August 2013

Evaluation of fluoropyruvate as nucleophile in reactions catalysed by N-acetyl neuraminic acid lyase variants: scope, limitations and stereoselectivity ⬇️

scientific article published on 5 November 2015

Exploring Molecular Oxygen Pathways in Hansenula polymorpha Copper-containing Amine Oxidase

scientific article

Exploring the Roles of the Metal Ions in Escherichia coli Copper Amine Oxidase ,

scientific article

Expression, purification, crystallization and preliminary X-ray diffraction of a novel Nitrosomonas europaea cytochrome, cytochrome P460.

scientific article published on 25 March 2006

Extending enzyme molecular recognition with an expanded amino acid alphabet ⬇️

scientific article

Fixed target combined with spectral mapping: approaching 100% hit rates for serial crystallography

scientific article

Fixed target matrix for femtosecond time-resolved and in situ serial micro-crystallography

scientific article published on 18 August 2015

Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation

scientific article

Human Cellular Retinaldehyde-Binding Protein Has Secondary Thermal 9- cis -Retinal Isomerase Activity

scientific article

Identification of the site of oxidase substrate binding in Scytalidium thermophilum catalase ⬇️

scientific article published on 02 October 2018

Improving Escherichia coli alkaline phosphatase efficacy by additional mutations inside and outside the catalytic pocket.

scientific article

In pursuit of an accurate spatial and temporal model of biomolecules at the atomistic level: a perspective on computer simulation

scientific article

Investigating the active centre of theScytalidium thermophilumcatalase

scientific article

Isolation of an Asymmetric RNA Uncoating Intermediate for a Single-Stranded RNA Plant Virus

scientific article

Isotope labeling studies reveal the order of oxygen incorporation into the tryptophan tryptophylquinone cofactor of methylamine dehydrogenase

scientific article published on September 2006

Light-induced Trpin/Metout Switching During BLUF Domain Activation in ATP-bound Photoactivatable Adenylate Cyclase OaPAC

scientific article published in 2024

Limits of Structural Plasticity in a Picornavirus Capsid Revealed by a Massively Expanded Equine Rhinitis A Virus Particle ⬇️

scientific article

Liquid application method for time-resolved analyses by serial synchrotron crystallography

scientific article published on 16 September 2019

MauG, a novel diheme protein required for tryptophan tryptophylquinone biogenesis

scientific article

MauG-dependent in vitro biosynthesis of tryptophan tryptophylquinone in methylamine dehydrogenase

scientific article published in June 2005

Mechanistic Possibilities in MauG-Dependent Tryptophan Tryptophylquinone Biosynthesis†

scientific article published on 01 November 2006

Microspectrophotometry for structural enzymology

scientific article

Multi and serial data collection and processing

scientific article published on 26 February 2019

Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design

scientific article published in 2024

Nature of the Ferryl Heme in Compounds I and II

scientific article

Nature of the ferryl heme in Compounds I and II.

scientific article published in May 2011

Oxygen Activation Switch in the Copper Amine Oxidase of Escherichia coli ⬇️

scientific article published on 24 August 2018

Packaging signals in single-stranded RNA viruses: nature's alternative to a purely electrostatic assembly mechanism ⬇️

scientific article published on March 2013

Pathological macromolecular crystallographic data affected by twinning, partial-disorder and exhibiting multiple lattices for testing of data processing and refinement tools

scientific article published in Scientific Reports

Preface to Special Topic: Transactions from the 66th Annual Meeting of the American Crystallographic Association

scientific article published on May 2017

Probing temperature- and solvent-dependent protein dynamics using terahertz time-domain spectroscopy ⬇️

article

Probing the molecular mechanisms in copper amine oxidases by generating heterodimers ⬇️

scientific article published on 21 January 2015

Reaction Mechanism of N -Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, QM/MM Simulation, and Mutagenesis ⬇️

scientific article

Revealing low-dose radiation damage using single-crystal spectroscopy

scientific article

Sequence-Specific, RNA–Protein Interactions Overcome Electrostatic Barriers Preventing Assembly of Satellite Tobacco Necrosis Virus Coat Protein

scientific article

Structural Insight into Methyl-Coenzyme M Reductase Chemistry Using Coenzyme B Analogues,

scientific article

Structural Insights into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution

scientific article

Structural Insights into the Recovery of Aldolase Activity inN-Acetylneuraminic Acid Lyase by Replacement of the Catalytically Active Lysine with γ-Thialysine by Using a Chemical Mutagenesis Strategy

scientific article

Structural Kinetics of MsbA Investigated by Stopped-Flow Time-Resolved Small-Angle X-Ray Scattering

scientific article published on 30 December 2019

Structure of a xenon derivative ofEscherichia colicopper amine oxidase: confirmation of the proposed oxygen-entry pathway

scientific article

Structure of anEscherichia coli N-acetyl-D-neuraminic acid lyase mutant, E192N, in complex with pyruvate at 1.45 Å resolution

scientific article

Structure, recombinant expression and mutagenesis studies of the catalase with oxidase activity from Scytalidium thermophilum ⬇️

scientific article

Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release

scientific article

Terahertz spectral measurements of a homologous organic series

Terahertz time-domain spectroscopy of lysozyme and mouse urinary protein single crystals ⬇️

Terahertz time-domain spectroscopy of protein single crystals

The Crystal Structure of Cytochrome P460 of Nitrosomonas europaea Reveals a Novel Cytochrome Fold and Heme−Protein Cross-link † , ‡

scientific article

The HARE chip for efficient time-resolved serial synchrotron crystallography

scientific article published on 27 February 2020

The Mechanism of Regulation of Pantothenate Biosynthesis by the PanD-PanZ·AcCoA Complex Reveals an Additional Mode of Action for the Antimetabolite N-Pentyl Pantothenamide (N5-Pan). ⬇️

scientific article published on 23 August 2017

The structure of the PanD/PanZ protein complex reveals negative feedback regulation of pantothenate biosynthesis by coenzyme A. ⬇️

scientific article published on April 2015

Threonine 57 is required for the post-translational activation ofEscherichia coliaspartate α-decarboxylase ⬇️

scientific article

Time-resolved crystallography using the Hadamard transform

scientific article

Topological Dissection of the Membrane Transport Protein Mhp1 Derived from Cysteine Accessibility and Mass Spectrometry ⬇️

scientific article published on 20 July 2017

Tracking X-ray-derived redox changes in crystals of a methylamine dehydrogenase/amicyanin complex using single-crystal UV/Vis microspectrophotometry

scientific article

Understanding quinone cofactor biogenesis in methylamine dehydrogenase through novel cofactor generation

scientific article published in March 2003

Understanding the influence of morphology on the terahertz spectra of a powdered ionic crystalline system ⬇️

Using synchrotrons and XFELs for time-resolved X-ray crystallography and solution scattering experiments on biomolecules

scientific article

X-ray crystallography marries spectroscopy to unveil structure and function of biological macromolecules

scientific article published on 01 June 2011

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

scientific article

X-ray-excited optical luminescence of protein crystals: a new tool for studying radiation damage during diffraction data collection

scientific article

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