List of works - Helena Mertlíková-Kaiserová

2´-deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine: a comparative study of hypomethylating potential

scientific article published on June 2011

9-Norbornyl-6-chloropurine is a novel antileukemic compound interacting with cellular GSH.

scientific article

Amidate prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine as inhibitors of adenylate cyclase toxin from Bordetella pertussis

scientific article published on 21 October 2013

Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone

scientific article

Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity

scientific article published on 26 September 2006

Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening

scientific article published on 28 August 2012

Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases

scientific article published on 24 October 2016

Determination of the antioxidative activity of substituted 5-aminopyrimidines

scientific article

Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.

scientific article published on 22 June 2010

Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action

scientific article

In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity ⬇️

scientific article published on November 3, 2010

Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates

scientific article published on February 1, 2012

New iron chelators in anthracycline-induced cardiotoxicity

scientific article published on January 2007

Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG.

scientific article published on 14 April 2011

Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells

scientific article published on July 1, 2010

SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors

scientific article

Synthesis of novel purine-based coxsackievirus inhibitors bearing polycylic substituents at the N-9 position

scientific article

Synthesis of α-branched acyclic nucleoside phosphonates as potential inhibitors of bacterial adenylate cyclases

scientific article published on 13 December 2017

The effect of new lipophilic chelators on the activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics: studies in vitro.

scientific article published in January 2004

Transport mechanisms of a novel antileukemic and antiviral compound 9-norbornyl-6-chloropurine

scientific article published on 31 March 2014

List of works by Helena Mertlíková-Kaiserová

2´-deoxy-5,6-dihydro-5-azacytidine - a less toxic alternative of 2´-deoxy-5-azacytidine: a comparative study of hypomethylating potential

9-Norbornyl-6-chloropurine is a novel antileukemic compound interacting with cellular GSH.

Amidate prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine as inhibitors of adenylate cyclase toxin from Bordetella pertussis

Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone

Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity

Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening

Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases

Determination of the antioxidative activity of substituted 5-aminopyrimidines

Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.

Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action

In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity ⬇️

Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates

New iron chelators in anthracycline-induced cardiotoxicity

Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG.

Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells

SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors

Synthesis of novel purine-based coxsackievirus inhibitors bearing polycylic substituents at the N-9 position

Synthesis of α-branched acyclic nucleoside phosphonates as potential inhibitors of bacterial adenylate cyclases

The effect of new lipophilic chelators on the activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics: studies in vitro.

Transport mechanisms of a novel antileukemic and antiviral compound 9-norbornyl-6-chloropurine