List of works - Conrad Kunick

1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: a new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines

scientific article published on March 2007

2-(3-aryl-3-oxopropen-1-yl)-9-tert-butyl-paullones: a new antileishmanial chemotype

scientific article published on 11 January 2008

2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines

scientific article published on 14 April 2012

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3

scientific article

4-Arylthieno[2,3-b]pyridine-2-carboxamides Are a New Class of Antiplasmodial Agents

scientific article published on 13 July 2020

5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms

scientific article

9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma

scientific article

A new Heck reaction modification using ketone Mannich bases as enone precursors: parallel synthesis of anti-leishmanial chalcones

scientific article

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition

scientific article published on December 2006

Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential

scientific article published on April 2003

Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages

scientific article

Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer

scientific article published on 14 August 2018

Darpones and water-soluble aminobutoxylated darpone derivatives are distinguished by matrix COMPARE analysis

scientific article published on 24 January 2007

Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH).

scientific article

Dual IGF-1R/SRC inhibitors based on a N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure

scientific article published on 6 April 2011

Epoxide-containing side chains enhance antiproliferative activity of paullones

scientific article published on 7 April 2005

Functional inactivation of Plasmodium falciparum glycogen synthase kinase GSK3 modulates erythrocyte invasion and blocks gametocyte maturation

scientific article published in 2022

Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites

scientific article

Identification of 2-anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as dual PLK1/VEGF-R2 kinase inhibitor chemotypes by structure-based lead generation

scientific article

Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening

scientific article

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design.

scientific article published on 24 January 2018

Inhibitors of the RET tyrosine kinase based on a 2-(alkylsulfanyl)-4-(3-thienyl)nicotinonitrile scaffold

scientific article published on 19 March 2010

Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

scientific article published on 01 December 2020

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.

scientific article

Novel molecular targets in cancer chemotherapy waiting for discovery

scientific article published in September 2004

Parenteral formulation of an antileishmanial drug candidate--tackling poor solubility, chemical instability, and polymorphism

scientific article

Paullones as inhibitors of protein kinases

scientific article published on January 2011

Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors

scientific article (publication date: 11 March 2004)

Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.

scientific article published on 15 May 2009

Selective inhibitors of Plasmodium falciparum glycogen synthase-3 (PfGSK-3): New antimalarial agents?

scientific article (publication date: October 2015)

Structure-activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines

scientific article published on 21 March 2019

Structure-aided optimization of kinase inhibitors derived from alsterpaullone.

scientific article published on March 2005

Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).

scientific article

[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors

scientific article published on 13 November 2019

List of works by Conrad Kunick

1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: a new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines

2-(3-aryl-3-oxopropen-1-yl)-9-tert-butyl-paullones: a new antileishmanial chemotype

2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3

4-Arylthieno[2,3-b]pyridine-2-carboxamides Are a New Class of Antiplasmodial Agents

5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms

9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma

A new Heck reaction modification using ketone Mannich bases as enone precursors: parallel synthesis of anti-leishmanial chalcones

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition

Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential

Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages

Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer

Darpones and water-soluble aminobutoxylated darpone derivatives are distinguished by matrix COMPARE analysis

Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH).

Dual IGF-1R/SRC inhibitors based on a N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure

Epoxide-containing side chains enhance antiproliferative activity of paullones

Functional inactivation of Plasmodium falciparum glycogen synthase kinase GSK3 modulates erythrocyte invasion and blocks gametocyte maturation

Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites

Identification of 2-anilino-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-ones as dual PLK1/VEGF-R2 kinase inhibitor chemotypes by structure-based lead generation

Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design.

Inhibitors of the RET tyrosine kinase based on a 2-(alkylsulfanyl)-4-(3-thienyl)nicotinonitrile scaffold

Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype.

Novel molecular targets in cancer chemotherapy waiting for discovery

Parenteral formulation of an antileishmanial drug candidate--tackling poor solubility, chemical instability, and polymorphism

Paullones as inhibitors of protein kinases

Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors

Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.

Selective inhibitors of Plasmodium falciparum glycogen synthase-3 (PfGSK-3): New antimalarial agents?

Structure-activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines

Structure-aided optimization of kinase inhibitors derived from alsterpaullone.

Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).

[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors