List of works - Apirat Chaikuad

A new class of small molecule inhibitor of BMP signaling

scientific article

A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis

scientific article

An Unusual Binding Model of the Methyl 9-Anilinothiazolo[5,4-f] quinazoline-2-carbimidates (EHT 1610 and EHT 5372) Confers High Selectivity for Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases

scientific article

Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells

scientific article

Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis

scientific article

Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases

scientific article

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

scientific article published on 23 March 2015

Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure

scientific article

Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening

scientific article

Modulation of the Chromatin Phosphoproteome by the Haspin Protein Kinase

scientific article

Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents

scientific article

Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket

scientific article published on 7 November 2016

Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation

scientific article published on 3 November 2014

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

scientific article

Structural Basis of Intracellular TGF-β Signaling: Receptors and Smads

scientific article

Structural Comparison of Human Mammalian Ste20-Like Kinases

scientific article published on 6 August 2010

Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates

scientific article

Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase

scientific article

Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS

scientific article

Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.

scientific article published on 26 February 2015

Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies

scientific article

Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family

scientific article

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva

scientific article

Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain

scientific article published on 5 January 2016

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

scientific article

The ins and outs of selective kinase inhibitor development

scientific article published on October 2015

UDP-glucose dehydrogenase: structure and function of a potential drug target

scientific article published on October 2010

List of works by Apirat Chaikuad

A new class of small molecule inhibitor of BMP signaling

A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis

An Unusual Binding Model of the Methyl 9-Anilinothiazolo[5,4-f] quinazoline-2-carbimidates (EHT 1610 and EHT 5372) Confers High Selectivity for Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases

Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells

Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis

Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure

Identification of CLK1 Inhibitors by a Fragment-linking Based Virtual Screening

Modulation of the Chromatin Phosphoproteome by the Haspin Protein Kinase

Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents

Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket

Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

Structural Basis of Intracellular TGF-β Signaling: Receptors and Smads

Structural Comparison of Human Mammalian Ste20-Like Kinases

Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates

Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase

Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS

Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.

Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies

Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva

Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

The ins and outs of selective kinase inhibitor development

UDP-glucose dehydrogenase: structure and function of a potential drug target