List of works - Thomas S. Peat

300-Fold Increase in Production of the Zn2+-Dependent Dechlorinase TrzN in Soluble Form via Apoenzyme Stabilization

scientific article

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.

scientific article published on 24 November 2017

A Nondenaturing Purification Scheme for the DNA-Binding Domain of Poly(ADP-Ribose) Polymerase, a Structure-Specific DNA-Binding Protein ⬇️

scientific article published on October 1, 1998

A PMMA microfluidic droplet platform for in vitro protein expression using crude E. coli S30 extract

scientific article published in October 2009

A drunken search in crystallization space

scientific article

A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo

scientific article

A new crystal form of human vascular adhesion protein 1

scientific article

A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. strain ADP

scientific article published in PLoS ONE

A structural genomics approach to the study of quorum sensing: crystal structures of three LuxS orthologs

scientific article

A β-Alanine Catabolism Pathway Containing a Highly Promiscuous ω-Transaminase in the 12-Aminododecanate-Degrading Pseudomonas sp. Strain AAC.

scientific article published on 22 April 2016

An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets

scientific article

An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme.

scientific article published on 9 March 2018

Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects

scientific article published on 21 May 2019

Characterization of crystals of the thermostable DNA polymerase I fromthermus aquaticus

scientific article published on 01 September 1995

Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling.

scientific article published on 25 June 2013

Cryo-EM structure of the active, G-protein complexed, human CGRP receptor

scientific article published in Nature

Crystal Structure of an Indole-3-Acetic Acid Amido Synthetase from Grapevine Involved in Auxin Homeostasis ⬇️

scientific article published on November 6, 2012

Crystal structure of YIGZ, a conserved hypothetical protein from Escherichia coli k12 with a novel fold

scientific article

Crystal structure of a putrescine aminotransferase from Pseudomonas sp. strain AAC.

scientific article published on January 2017

Crystal structures of human ENPP1 in apo and bound forms

scientific article published on 17 August 2020

Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site

scientific article

Crystallization and preliminary X-ray analysis of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.

scientific article published on 30 April 2010

Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II.

scientific article published on 26 August 2009

Crystallization and preliminary X-ray diffraction analysis of the amidase domain of allophanate hydrolase from Pseudomonas sp. strain ADP.

scientific article published on 19 February 2014

Crystallization of an apo form of human arginase: using all the tools in the toolbox simultaneously

scientific article published on 23 December 2010

Crystallization reports are the backbone of Acta Cryst. F, but do they have any spine?

scientific article published on 30 June 2013

Crystallization: digging into the past to learn lessons for the future.

scientific article published on January 2015

Cyanuric acid hydrolase: evolutionary innovation by structural concatenation

scientific article published in June 2013

Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology

scientific article published on 09 April 2018

Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects

scientific article published on 19 May 2018

Determination of the Structure of the Catabolic N-Succinylornithine Transaminase (AstC) from Escherichia coli

scientific article

Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.

scientific article published on 10 August 2017

Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action

scientific article published on 20 February 2020

Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK

scientific article

Expression, purification, crystallization and preliminary X-ray diffraction analysis of a lactococcal bacteriophage small terminase subunit

scientific article published on 22 February 2013

Fragment screening for a protein-protein interaction inhibitor to WDR5

scientific article published on 14 November 2019

From information management to protein annotation: preparing protein structures for drug discovery.

scientific article

High-Resolution X-Ray Structures of Two Functionally Distinct Members of the Cyclic Amide Hydrolase Family of Toblerone Fold Enzymes.

scientific article published on 24 February 2017

How to fabricate robust microfluidic systems for a dollar

scientific article published on 7 December 2013

Identification and characterization of two families of F420H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation

scientific article

Identification of a Highly Conserved Allosteric Binding Site on Mnk1 and Mnk2.

scientific article published on 12 August 2015

Identification of a New Zinc Binding Chemotype by Fragment Screening.

scientific article published on 17 August 2017

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

scientific article published in Nature

Intermolecular cleavage by UmuD-like enzymes: identification of residues required for cleavage and substrate specificity

scientific article published in February 1999

Interrogating HIV integrase for compounds that bind- a SAMPL challenge

scientific article

Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors.

scientific article published on 28 November 2016

Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state

scientific article

On the need for an international effort to capture, share and use crystallization screening data

scientific article (publication date: March 2012)

Over the rainbow: structural characterization of the chromoproteins gfasPurple, amilCP, spisPink and eforRed

scientific article published in 2022

Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?

scientific article

Phoenito experiments: combining the strengths of commercial crystallization automation.

scientific article published on 31 October 2008

Practical aspects of the SAMPL challenge: providing an extensive experimental data set for the modeling community

scientific article

Rational engineering of a mesohalophilic carbonic anhydrase to an extreme halotolerant biocatalyst.

scientific article

Solution structure of Pyrobaculum aerophilum DsrC, an archaeal homologue of the gamma subunit of dissimilatory sulfite reductase ⬇️

scientific article published on November 1, 2001

Some of the most interesting CASP11 targets through the eyes of their authors

scientific article

Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli

scientific article

Structural analysis of a set of proteins resulting from a bacterial genomics project.

scientific article

Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses

scientific article

Structural and biochemical analyses of a Clostridium perfringens sortase D transpeptidase

scientific article

Structural and biochemical characterization of the biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841.

scientific article published on 9 February 2018

Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design

scientific article

Structural basis for ligand recognition by a Cache chemosensory domain that mediates carboxylate sensing in Pseudomonas syringae

scientific article (publication date: 13 October 2016)

Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus.

scientific article

Structure of S. aureus HPPK and the Discovery of a New Substrate Site Inhibitor ⬇️

scientific article published on January 19, 2012

Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus

scientific article

Structures of the transcriptional regulator BgaR, a lactose sensor

scientific article published on 26 June 2019

Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity

scientific article published on 05 August 2019

Synthesis, structure and bioactivity of primary sulfamate-containing natural products

scientific article published on 16 April 2018

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein.

scientific article published on 31 July 2017

Tapping the Protein Data Bank for crystallization information

scientific article published on 19 November 2005

The 1.59 A resolution crystal structure of TM0096, a flavin mononucleotide binding protein from Thermotoga maritima

scientific article

The DINGO dataset: a comprehensive set of data for the SAMPL challenge

scientific article

The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors—A Spin-Off Discovery from Fragment Screening

scientific article published in 2021

The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein

scientific article published on 25 November 2020

The evolving story of AtzT, a periplasmic binding protein

scientific article published on 31 October 2019

The nanoscience behind the art of in-meso crystallization of membrane proteins

scientific article

The structure of the hexameric atrazine chlorohydrolase AtzA

scientific article

The structure of vanin 1: a key enzyme linking metabolic disease and inflammation

scientific article

Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits

scientific article

X-Ray Structure and Mutagenesis Studies of the N-Isopropylammelide Isopropylaminohydrolase, AtzC

scientific article

X-ray crystal structure of a malonate-semialdehyde dehydrogenase from Pseudomonas sp. strain AAC.

scientific article published in January 2017

X-ray crystallography of Epacadostat in adduct with Carbonic Anhydrase IX

scientific article published on 14 February 2020

X-ray structure of the amidase domain of AtzF, the allophanate hydrolase from the cyanuric acid-mineralizing multienzyme complex

scientific article

List of works by Thomas S. Peat

300-Fold Increase in Production of the Zn2+-Dependent Dechlorinase TrzN in Soluble Form via Apoenzyme Stabilization

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.

A Nondenaturing Purification Scheme for the DNA-Binding Domain of Poly(ADP-Ribose) Polymerase, a Structure-Specific DNA-Binding Protein ⬇️

A PMMA microfluidic droplet platform for in vitro protein expression using crude E. coli S30 extract

A drunken search in crystallization space

A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo

A new crystal form of human vascular adhesion protein 1

A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. strain ADP

A structural genomics approach to the study of quorum sensing: crystal structures of three LuxS orthologs

A β-Alanine Catabolism Pathway Containing a Highly Promiscuous ω-Transaminase in the 12-Aminododecanate-Degrading Pseudomonas sp. Strain AAC.

An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets

An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme.

Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects

Characterization of crystals of the thermostable DNA polymerase I fromthermus aquaticus

Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling.

Cryo-EM structure of the active, G-protein complexed, human CGRP receptor

Crystal Structure of an Indole-3-Acetic Acid Amido Synthetase from Grapevine Involved in Auxin Homeostasis ⬇️

Crystal structure of YIGZ, a conserved hypothetical protein from Escherichia coli k12 with a novel fold

Crystal structure of a putrescine aminotransferase from Pseudomonas sp. strain AAC.

Crystal structures of human ENPP1 in apo and bound forms

Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site

Crystallization and preliminary X-ray analysis of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.

Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II.

Crystallization and preliminary X-ray diffraction analysis of the amidase domain of allophanate hydrolase from Pseudomonas sp. strain ADP.

Crystallization of an apo form of human arginase: using all the tools in the toolbox simultaneously

Crystallization reports are the backbone of Acta Cryst. F, but do they have any spine?

Crystallization: digging into the past to learn lessons for the future.

Cyanuric acid hydrolase: evolutionary innovation by structural concatenation

Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology

Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects

Determination of the Structure of the Catabolic N-Succinylornithine Transaminase (AstC) from Escherichia coli

Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.

Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action

Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK

Expression, purification, crystallization and preliminary X-ray diffraction analysis of a lactococcal bacteriophage small terminase subunit

Fragment screening for a protein-protein interaction inhibitor to WDR5

From information management to protein annotation: preparing protein structures for drug discovery.

High-Resolution X-Ray Structures of Two Functionally Distinct Members of the Cyclic Amide Hydrolase Family of Toblerone Fold Enzymes.

How to fabricate robust microfluidic systems for a dollar

Identification and characterization of two families of F420H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation

Identification of a Highly Conserved Allosteric Binding Site on Mnk1 and Mnk2.

Identification of a New Zinc Binding Chemotype by Fragment Screening.

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Intermolecular cleavage by UmuD-like enzymes: identification of residues required for cleavage and substrate specificity

Interrogating HIV integrase for compounds that bind- a SAMPL challenge

Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors.

Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state

On the need for an international effort to capture, share and use crystallization screening data

Over the rainbow: structural characterization of the chromoproteins gfasPurple, amilCP, spisPink and eforRed

Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?

Phoenito experiments: combining the strengths of commercial crystallization automation.

Practical aspects of the SAMPL challenge: providing an extensive experimental data set for the modeling community

Rational engineering of a mesohalophilic carbonic anhydrase to an extreme halotolerant biocatalyst.

Solution structure of Pyrobaculum aerophilum DsrC, an archaeal homologue of the gamma subunit of dissimilatory sulfite reductase ⬇️

Some of the most interesting CASP11 targets through the eyes of their authors

Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli

Structural analysis of a set of proteins resulting from a bacterial genomics project.

Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses

Structural and biochemical analyses of a Clostridium perfringens sortase D transpeptidase

Structural and biochemical characterization of the biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841.

Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design

Structural basis for ligand recognition by a Cache chemosensory domain that mediates carboxylate sensing in Pseudomonas syringae

Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus.

Structure of S. aureus HPPK and the Discovery of a New Substrate Site Inhibitor ⬇️

Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus

Structures of the transcriptional regulator BgaR, a lactose sensor

Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity

Synthesis, structure and bioactivity of primary sulfamate-containing natural products

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein.

Tapping the Protein Data Bank for crystallization information

The 1.59 A resolution crystal structure of TM0096, a flavin mononucleotide binding protein from Thermotoga maritima

The DINGO dataset: a comprehensive set of data for the SAMPL challenge

The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors—A Spin-Off Discovery from Fragment Screening

The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein

The evolving story of AtzT, a periplasmic binding protein

The nanoscience behind the art of in-meso crystallization of membrane proteins

The structure of the hexameric atrazine chlorohydrolase AtzA

The structure of vanin 1: a key enzyme linking metabolic disease and inflammation

Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits