List of works - Joachim Jose

1st Joint European Conference on Therapeutic Targets and Medicinal Chemistry (TTMC 2015)

scientific article

4,5,7-Trisubstituted indeno[1,2-b]indole inhibits CK2 activity in tumor cells equivalent to CX-4945 and shows strong anti-migratory effects

scientific article published on 18 December 2021

A Regenerative Immunoaffinity Layer Based on the Outer Membrane of Z-Domains Autodisplaying for Immunoassays and Immunosensors

scientific article published on 19 November 2018

A magnetite suspension-based washing method for immunoassays using Escherichia coli cells with autodisplayed Z-domains.

scientific article published on 9 June 2016

A new family of densely functionalized fused-benzoquinones as potent human protein kinase CK2 inhibitors.

scientific article published on 18 December 2017

A π-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors

scientific article published on 17 February 2018

Activity control of autodisplayed proteins on the same outer membrane layer of E. coli by using Z-domain/streptavidin/and lipase/foldase systems.

scientific article published on 4 October 2016

An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2.

scientific article published on 23 March 2017

Autodisplay of 60-kDa Ro/SS-A antigen and development of a surface display enzyme-linked immunosorbent assay for systemic lupus erythematosus patient sera screening ⬇️

scientific article published on 06 August 2010

Autodisplay of Human Hyaluronidase Hyal-1 on Escherichia coli and Identification of Plant-Derived Enzyme Inhibitors.

scientific article published on 26 August 2015

Autodisplay of catalytically active human hyaluronidase hPH-20 and testing of enzyme inhibitors ⬇️

scientific article published on November 12, 2010

Autodisplay of functional CYP106A2 in Escherichia coli.

scientific article published on 8 March 2012

Autodisplay of glucose-6-phosphate dehydrogenase for redox cofactor regeneration at the cell surface

scientific article published on 12 April 2017

Autodisplay of nitrilase from Klebsiella pneumoniae and whole-cell degradation of oxynil herbicides and related compounds ⬇️

scientific article published on September 18, 2012

Autodisplay of streptavidin ⬇️

scientific article published on December 22, 2010

Autodisplay of the La/SSB protein on LPS-free E. coli for the diagnosis of Sjögren's syndrome.

scientific article published on 24 January 2017

Bacterial Cell-Surface Display of Semisynthetic Cyclic Peptides

scientific article published on 30 October 2018

Casein α s1 Is Expressed by Human Monocytes and Upregulates the Production of GM-CSF via p38 MAPK ⬇️

scientific article published on 06 December 2010

Cell density-dependent auto-inducible promoters for expression of recombinant proteins in Pseudomonas putida

scientific article published on 25 June 2019

Cellular surface display of dimeric Adx and whole cell P450-mediated steroid synthesis on E. coli.

scientific article

Chirality-dependent cell adhesion and enrichment in Janus nanocomposite hydrogels.

scientific article published on 8 November 2017

Co-autodisplay of Z-domains and bovine caseins on the outer membrane of E. coli.

scientific article published on 23 September 2015

Cryptotanshinone from Salvia miltiorrhiza Roots Reduces Cytokeratin CK1/10 Expression in Keratinocytes by Activation of Peptidyl-prolyl-cis-trans-isomerase FKBP1A

scientific article published on 23 July 2018

Design and biological testing of peptidic dimerization inhibitors of human Hsp90 that target the C-terminal domain.

scientific article published on 13 January 2016

Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2 Inhibitors and Database Mining

scientific article published on 9 January 2017

Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization

scientific article published on 27 April 2022

Development of a wash-free immunoassay using Escherichia coli cells with autodisplayed Z-domains.

scientific article published on 12 April 2017

Development of an in vitro screening assay for PIP5K1α lipid kinase and identification of potent inhibitors

scientific article published on 26 December 2019

Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α' Structures

scientific article published on 19 March 2019

Direct optical density determination of bacterial cultures in microplates for high-throughput screening applications

scientific article published on 03 July 2018

Human casein alpha s1 induces proinflammatory cytokine expression in monocytic cells by TLR4 signaling.

scientific article

Human αS1-casein induces IL-8 secretion by binding to the ecto-domain of the TLR4/MD2 receptor complex

scientific article published on 13 December 2018

Hyal-1 inhibitors from the leaves of Phyllanthus muellerianus (Kuntze) Excell

scientific article published on 12 March 2019

Identification of a Potent Allosteric Inhibitor of Human Protein Kinase CK2 by Bacterial Surface Display Library Screening

scientific article

Immobilization of E. coli with autodisplayed Z-domains to a surface-modified microplate for immunoassay ⬇️

scientific article published on September 16, 2011

Improving the activity of surface displayed cytochrome P450 enzymes by optimizing the outer membrane linker

scientific article

Improving the autotransporter-based surface display of enzymes in Pseudomonas putida KT2440

scientific article published on 02 May 2019

In Silico Identification and In Vitro Evaluation of Natural Inhibitors of Leishmania major Pteridine Reductase I.

scientific article published on 6 December 2017

In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase.

scientific article published on 3 September 2015

In Vitro and in Silico Evaluation of Bikaverin as a Potent Inhibitor of Human Protein Kinase CK2

scientific article published on 08 April 2019

Inhibition of Shiga toxin-converting bacteriophage development by novel antioxidant compounds.

scientific article published in December 2018

Isoflavonoids with inhibiting effects on human hyaluronidase-1 and norneolignan clitorienolactone B from Ononis spinosa L. root extract

scientific article published on 01 September 2018

Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles

scientific article published on 19 January 2021

Monitoring the Cellular Surface Display of Recombinant Proteins by Cysteine Labeling and Flow Cytometry ⬇️

scientific article published on May 9, 2003

Phytochemical Characterization of Low Molecular Weight Constituents from Marshmallow Roots (Althaea officinalis) and Inhibiting Effects of the Aqueous Extract on Human Hyaluronidase-1.

scientific article published on 27 January 2017

Purification-independent immunoreagents obtained by displaying nanobodies on bacteria surface

scientific article published on 15 April 2019

QSAR Model of Indeno[1,2-b]indole Derivatives and Identification of N-isopentyl-2-methyl-4,9-dioxo-4,9-Dihydronaphtho[2,3-b]furan-3-carboxamide as a Potent CK2 Inhibitor

scientific article published on 26 December 2019

Refolding of autodisplayed anti-NEF scFv through oxidation with glutathione for immunosensors.

scientific article published on 8 December 2017

Root Extracts From Ononis spinosa Inhibit IL-8 Release via Interactions With Toll-Like Receptor 4 and Lipopolysaccharide

scientific article published on 12 June 2020

Self-Assembled Supramolecular Nanoparticles Improve the Cytotoxic Efficacy of CK2 Inhibitor THN7.

scientific article

Ser71 of αS1-Casein is Phosphorylated in Breast Milk-Evidence from Targeted Mass Analysis.

scientific article published on 8 August 2017

Sesquiterpene Lactones with Dual Inhibitory Activity against the Trypanosoma brucei Pteridine Reductase 1 and Dihydrofolate Reductase

scientific article published on 28 December 2021

Site-Specific Labeling of Protein Kinase CK2: Combining Surface Display and Click Chemistry for Drug Discovery Applications.

scientific article published on 27 June 2016

Synthesis and biological evaluation of 2,6-di(furan-3-yl)anthracene-9, 10-dione as an inhibitor of human protein kinase CK2.

scientific article

Synthesis and biological evaluation of novel 2 (4`-hydroxynaphthyl) chromen-4-one as a CK2 inhibitor.

scientific article published in April 2018

Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response

scientific article published on 03 May 2018

Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction

scientific article published on 2 December 2015

The Neisseria gonorrhoeae gene aniA encodes an inducible nitrite reductase ⬇️

scientific article published on 01 November 1997

The integration site of the iga gene in commensal Neisseria sp ⬇️

scientific article published on April 29, 2003

The workability of Escherichia coli BL21 (DE3) and Pseudomonas putida KT2440 expression platforms with autodisplayed cellulases: a comparison.

scientific article

Thermophoretic diagnosis of autoimmune diseases based on Escherichia coli with autodisplayed autoantigens

scientific article published on 21 December 2018

Toward selective CK2alpha and CK2alpha' inhibitors: Development of a novel whole-cell kinase assay by Autodisplay of catalytic CK2alpha'.

scientific article published on 8 January 2016

Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α'.

scientific article published on 13 December 2017

List of works by Joachim Jose

1st Joint European Conference on Therapeutic Targets and Medicinal Chemistry (TTMC 2015)

4,5,7-Trisubstituted indeno[1,2-b]indole inhibits CK2 activity in tumor cells equivalent to CX-4945 and shows strong anti-migratory effects

A Regenerative Immunoaffinity Layer Based on the Outer Membrane of Z-Domains Autodisplaying for Immunoassays and Immunosensors

A magnetite suspension-based washing method for immunoassays using Escherichia coli cells with autodisplayed Z-domains.

A new family of densely functionalized fused-benzoquinones as potent human protein kinase CK2 inhibitors.

A π-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors

Activity control of autodisplayed proteins on the same outer membrane layer of E. coli by using Z-domain/streptavidin/and lipase/foldase systems.

An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2.

Autodisplay of 60-kDa Ro/SS-A antigen and development of a surface display enzyme-linked immunosorbent assay for systemic lupus erythematosus patient sera screening ⬇️

Autodisplay of Human Hyaluronidase Hyal-1 on Escherichia coli and Identification of Plant-Derived Enzyme Inhibitors.

Autodisplay of catalytically active human hyaluronidase hPH-20 and testing of enzyme inhibitors ⬇️

Autodisplay of functional CYP106A2 in Escherichia coli.

Autodisplay of glucose-6-phosphate dehydrogenase for redox cofactor regeneration at the cell surface

Autodisplay of nitrilase from Klebsiella pneumoniae and whole-cell degradation of oxynil herbicides and related compounds ⬇️

Autodisplay of streptavidin ⬇️

Autodisplay of the La/SSB protein on LPS-free E. coli for the diagnosis of Sjögren's syndrome.

Bacterial Cell-Surface Display of Semisynthetic Cyclic Peptides

Casein α s1 Is Expressed by Human Monocytes and Upregulates the Production of GM-CSF via p38 MAPK ⬇️

Cell density-dependent auto-inducible promoters for expression of recombinant proteins in Pseudomonas putida

Cellular surface display of dimeric Adx and whole cell P450-mediated steroid synthesis on E. coli.

Chirality-dependent cell adhesion and enrichment in Janus nanocomposite hydrogels.

Co-autodisplay of Z-domains and bovine caseins on the outer membrane of E. coli.

Cryptotanshinone from Salvia miltiorrhiza Roots Reduces Cytokeratin CK1/10 Expression in Keratinocytes by Activation of Peptidyl-prolyl-cis-trans-isomerase FKBP1A

Design and biological testing of peptidic dimerization inhibitors of human Hsp90 that target the C-terminal domain.

Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2 Inhibitors and Database Mining

Development of a First-in-Class Small-Molecule Inhibitor of the C-Terminal Hsp90 Dimerization

Development of a wash-free immunoassay using Escherichia coli cells with autodisplayed Z-domains.

Development of an in vitro screening assay for PIP5K1α lipid kinase and identification of potent inhibitors

Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α' Structures

Direct optical density determination of bacterial cultures in microplates for high-throughput screening applications

Human casein alpha s1 induces proinflammatory cytokine expression in monocytic cells by TLR4 signaling.

Human αS1-casein induces IL-8 secretion by binding to the ecto-domain of the TLR4/MD2 receptor complex

Hyal-1 inhibitors from the leaves of Phyllanthus muellerianus (Kuntze) Excell

Identification of a Potent Allosteric Inhibitor of Human Protein Kinase CK2 by Bacterial Surface Display Library Screening

Immobilization of E. coli with autodisplayed Z-domains to a surface-modified microplate for immunoassay ⬇️

Improving the activity of surface displayed cytochrome P450 enzymes by optimizing the outer membrane linker

Improving the autotransporter-based surface display of enzymes in Pseudomonas putida KT2440

In Silico Identification and In Vitro Evaluation of Natural Inhibitors of Leishmania major Pteridine Reductase I.

In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase.

In Vitro and in Silico Evaluation of Bikaverin as a Potent Inhibitor of Human Protein Kinase CK2

Inhibition of Shiga toxin-converting bacteriophage development by novel antioxidant compounds.

Isoflavonoids with inhibiting effects on human hyaluronidase-1 and norneolignan clitorienolactone B from Ononis spinosa L. root extract

Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles

Monitoring the Cellular Surface Display of Recombinant Proteins by Cysteine Labeling and Flow Cytometry ⬇️

Phytochemical Characterization of Low Molecular Weight Constituents from Marshmallow Roots (Althaea officinalis) and Inhibiting Effects of the Aqueous Extract on Human Hyaluronidase-1.

Purification-independent immunoreagents obtained by displaying nanobodies on bacteria surface

QSAR Model of Indeno[1,2-b]indole Derivatives and Identification of N-isopentyl-2-methyl-4,9-dioxo-4,9-Dihydronaphtho[2,3-b]furan-3-carboxamide as a Potent CK2 Inhibitor

Refolding of autodisplayed anti-NEF scFv through oxidation with glutathione for immunosensors.

Root Extracts From Ononis spinosa Inhibit IL-8 Release via Interactions With Toll-Like Receptor 4 and Lipopolysaccharide

Self-Assembled Supramolecular Nanoparticles Improve the Cytotoxic Efficacy of CK2 Inhibitor THN7.

Ser71 of αS1-Casein is Phosphorylated in Breast Milk-Evidence from Targeted Mass Analysis.

Sesquiterpene Lactones with Dual Inhibitory Activity against the Trypanosoma brucei Pteridine Reductase 1 and Dihydrofolate Reductase

Site-Specific Labeling of Protein Kinase CK2: Combining Surface Display and Click Chemistry for Drug Discovery Applications.

Synthesis and biological evaluation of 2,6-di(furan-3-yl)anthracene-9, 10-dione as an inhibitor of human protein kinase CK2.

Synthesis and biological evaluation of novel 2 (4`-hydroxynaphthyl) chromen-4-one as a CK2 inhibitor.

Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response

Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction

The Neisseria gonorrhoeae gene aniA encodes an inducible nitrite reductase ⬇️

The integration site of the iga gene in commensal Neisseria sp ⬇️

The workability of Escherichia coli BL21 (DE3) and Pseudomonas putida KT2440 expression platforms with autodisplayed cellulases: a comparison.

Thermophoretic diagnosis of autoimmune diseases based on Escherichia coli with autodisplayed autoantigens

Toward selective CK2alpha and CK2alpha' inhibitors: Development of a novel whole-cell kinase assay by Autodisplay of catalytic CK2alpha'.

Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α'.