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List of works by Juan C. Laguna

Action of Ebselen on rat hepatic microsomal enzyme-catalyzed fatty acid chain elongation, desaturation, and drug biotransformation

scientific article published on 01 February 1989

Ageing introduces a complex pattern of changes in several rat brain transcription factors depending on gender and anatomical localization

scientific article published on 4 April 2006

Agonist-induced activation releases peroxisome proliferator-activated receptor beta/delta from its inhibition by palmitate-induced nuclear factor-kappaB in skeletal muscle cells.

scientific article

Aspirin increases CD36, SR-BI, and ABCA1 expression in human THP-1 macrophages

scientific article (publication date: April 2005)

Atorvastatin improves peroxisome proliferator-activated receptor signaling in cardiac hypertrophy by preventing nuclear factor-kappa B activation.

scientific article published in February 2005

Atorvastatin inhibits GSK-3beta phosphorylation by cardiac hypertrophic stimuli.

scientific article published on 12 November 2007

Atorvastatin prevents carbohydrate response element binding protein activation in the fructose-fed rat by activating protein kinase A

scientific journal article

Atorvastatin reduces CD68, FABP4, and HBP expression in oxLDL-treated human macrophages

scientific article published on May 2004

Atorvastatin reverses age-related reduction in rat hepatic PPARalpha and HNF-4

scientific article

Atorvastatin treatment induced peroxisome proliferator-activated receptor alpha expression and decreased plasma nonesterified fatty acids and liver triglyceride in fructose-fed rats

scientific article

Avasimibe and atorvastatin synergistically reduce cholesteryl ester content in THP-1 macrophages

scientific article published in September 2002

Cholesterol regulation of genes involved in sterol trafficking in human THP-1 macrophages

scientific article published in May 2005

Chronic Liquid Fructose, but not Glucose, Supplementation Selectively Induces Visceral Adipose Tissue Leptin Resistance and Hypertrophy in Female Sprague-Dawley Rats

scientific article published on 11 October 2018

Chronic fructose intake does not induce liver steatosis and inflammation in female Sprague–Dawley rats, but causes hypertriglyceridemia related to decreased VLDL receptor expression

scientific article published on 07 March 2018

Cytosolic lipogenic enzymes: Effect of fibric acid derivatives in vitro

scientific article published on 01 January 1993

Dabigatran etexilate: Another Double-Edged Drug? ⬇️

scientific article published on 01 October 2012

Decreased susceptibility to copper-induced oxidation of rat-lipoproteins after fibrate treatment: influence of fatty acid composition.

scientific article published on March 1996

Different response of senescent female Sprague-Dawley rats to gemfibrozil and rosiglitazone administration

scientific article published in July 2005

Differential effects of high consumption of fructose or glucose on mesenteric arterial function in female rats

scientific article published on 03 April 2018

Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages

scientific article published in May 2003

Differential induction of stearoyl-CoA desaturase and acyl-CoA oxidase genes by fibrates in HepG2 cells.

scientific article

Differential inhibition of long-chain acyl-CoA hydrolases by hypolipidemic drugs in vitro.

scientific article published in February 1992

Disruption of rat hepatic microsomal electron transport chains by the selenium-containing anti-inflammatory agent Ebselen

scientific article published on 01 February 1989

Down-regulation of acyl-CoA oxidase gene expression and increased NF-kappaB activity in etomoxir-induced cardiac hypertrophy.

scientific article

Down-regulation of acyl-CoA oxidase gene expression in heart of troglitazone-treated mice through a mechanism involving chicken ovalbumin upstream promoter transcription factor II.

scientific article published in September 2003

Effects of a Low Dose of Caffeine Alone or as Part of a Green Coffee Extract, in a Rat Dietary Model of Lean Non-Alcoholic Fatty Liver Disease without Inflammation

scientific article published on 23 October 2020

Effects of rosiglitazone and atorvastatin on the expression of genes that control cholesterol homeostasis in differentiating monocytes

scientific article published on 18 January 2006

Etomoxir, Sodium 2-[6-(4-Chlorophenoxy)hexyl]oxirane-2-carboxylate, Up-Regulates Uncoupling Protein-3 mRNA Levels in Primary Culture of Rat Preadipocytes

article

Fatty acid composition in low-density lipoproteins from renal transplant recipients

scientific article published in September 1999

Fatty acid composition of low-density lipoprotein in renal transplant recipients treated with cyclosporine.

scientific article published in February 2002

Fibrates modify rat hepatic fatty acid chain elongation and desaturation in vitro

scientific article published on 01 November 1993

Fibrates modify the expression of key factors involved in bile-acid synthesis and biliary-lipid secretion in gallstone patients

scientific article published on 18 December 2003

Fructose during pregnancy provokes fetal oxidative stress: The key role of the placental heme oxygenase-1.

scientific article

Fructose only in pregnancy provokes hyperinsulinemia, hypoadiponectinemia, and impaired insulin signaling in adult male, but not female, progeny.

scientific article published on 26 March 2015

Fructose supplementation impairs rat liver autophagy through mTORC activation without inducing endoplasmic reticulum stress

scientific article published on 9 November 2014

Fructose, but not glucose, impairs insulin signaling in the three major insulin-sensitive tissues

scientific article published on 19 May 2016

Gemfibrozil increases the specific binding of rat-cortex nuclear extracts to a PPRE probe

scientific article published on October 2003

Hepatoprotective activity of polyphenolic compounds from Cynara scolymus against CCl4 toxicity in isolated rat hepatocytes

scientific article published on 01 July 1987

Human hepatic lipase overexpression in mice induces hepatic steatosis and obesity through promoting hepatic lipogenesis and white adipose tissue lipolysis and fatty acid uptake

scientific article published on 15 December 2017

Hypercholesterolemia and neurodegeneration. Comparison of hippocampal phenotypes in LDLr knockout and APPswe/PS1dE9 mice

scientific article published on 20 March 2015

Hypertriglyceridemia and hepatic steatosis in senescence-accelerated mouse associate to changes in lipid-related gene expression.

scientific article published in November 2007

Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone

scientific journal article

Impairment of hepatic Stat-3 activation and reduction of PPARalpha activity in fructose-fed rats

scientific article published in March 2007

In vitro effect of clofibric acid derivatives on rat hepatic microsomal electron transport chains

scientific article published on 01 October 1991

Increased Akt protein expression is associated with decreased ceramide content in skeletal muscle of troglitazone-treated mice

scientific article

Increased reactive oxygen species production down-regulates peroxisome proliferator-activated alpha pathway in C2C12 skeletal muscle cells

scientific article published on 15 January 2002

Influence of lipid profile and fatty acid composition on the oxidation behavior of rat and guinea pig low density lipoprotein.

scientific article published in February 1998

Lack of hypotriglyceridemic effect of gemfibrozil as a consequence of age-related changes in rat liver PPARalpha

scientific article

Leptin down-regulates peroxisome proliferator-activated receptor γ (PPARγ) mRNA levels in primary human monocyte-derived macrophages

scientific article published on 01 July 2005

Lipoprotein composition and oxidative modification during therapy with gemfibrozil and lovastatin in patients with combined hyperlipidaemia.

scientific article published on March 1998

Liquid fructose down-regulates liver insulin receptor substrate 2 and gluconeogenic enzymes by modifying nutrient sensing factors in rats

scientific article published on 22 November 2013

Liquid fructose downregulates Sirt1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells

scientific article published on 13 January 2014

Liquid fructose in Western-diet-fed mice impairs liver insulin signaling and causes cholesterol and triglyceride loading without changing calorie intake and body weight

scientific article published on 2 November 2016

Liquid fructose in pregnancy exacerbates fructose-induced dyslipidemia in adult female offspring.

scientific article published on 23 March 2016

Liquid fructose supplementation in LDL-R−/− mice fed a western-type diet enhances lipid burden and atherosclerosis despite identical calorie consumption

Liver AMP/ATP ratio and fructokinase expression are related to gender differences in AMPK activity and glucose intolerance in rats ingesting liquid fructose

scientific article published on 5 November 2010

Metabolic alterations and increased liver mTOR expression precede the development of autoimmune disease in a murine model of lupus erythematosus

scientific article

Monocyte gene-expression profile in men with familial combined hyperlipidemia and its modification by atorvastatin treatment

scientific article

Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy

scientific journal article

Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells

scientific article

Opposite fates of fructose in the development of metabolic syndrome ⬇️

scientific article published on September 7, 2012

Oxidation of low-density lipoproteins in renal transplant recipients

scientific article published in September 1999

Oxidation of low-density lipoproteins in renal transplant recipients treated with tacrolimus.

scientific article published in February 2002

PGC-1beta down-regulation is associated with reduced ERRalpha activity and MCAD expression in skeletal muscle of senescence-accelerated mice.

scientific article

Palmitate-induced interleukin 6 production is mediated by protein kinase C and nuclear-factor kappaB activation and leads to glucose transporter 4 down-regulation in skeletal muscle cells.

scientific article

Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha in skeletal muscle cells involves MEK1/2 and nuclear factor-kappaB activation

scientific article published on 01 October 2006

Peroxisome proliferator-activated receptor alpha down-regulation is associated with enhanced ceramide levels in age-associated cardiac hypertrophy

scientific article published on 01 December 2007

Prevention of age-related changes in rat cortex transcription factor activator protein-1 by hypolipidemic drugs

scientific article published in October 2004

Princesa de África

2008 film

Randomized crossover study of gemfibrozil versus lovastatin in familial combined hyperlipidemia: additive effects of combination treatment on lipid regulation.

scientific article

Reduction of intracellular cholesterol accumulation in THP-1 macrophages by a combination of rosiglitazone and atorvastatin

scientific article

Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment

scientific article published on 29 November 2010

Reductions in plasma cholesterol levels after fenofibrate treatment are negatively correlated with resistin expression in human adipose tissue.

scientific article published in March 2003

Regulation of Gene Expression in Atherosclerosis: Insights from Microarray Studies in Monocytes/Macrophages ⬇️

scientific article published on March 1, 2012

Relationship between plasma lipids and palmitoyl-CoA hydrolase and synthetase activities with peroxisomal proliferation in rats treated with fibrates.

scientific article published on June 1994

Ritonavir increases CD36, ABCA1 and CYP27 expression in THP-1 macrophages

scientific article published on 10 October 2008

Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism

scientific article published on 16 August 2004

Selective modification of rat hepatic microsomal fatty acid chain elongation and desaturation by fibrates: relationship with peroxisome proliferation

scientific article

Sexual dimorphism in lipid metabolic phenotype associated with old age in Sprague–Dawley rats

scientific article published on 01 September 2004

Simple sugar intake and hepatocellular carcinoma: epidemiological and mechanistic insight

scientific article

Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women. A randomized crossover trial.

scientific article published in April 2000

Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism

scientific article published on November 2008

TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model

scientific article

The Addition of Liquid Fructose to a Western-Type Diet in LDL-R-/- Mice Induces Liver Inflammation and Fibrogenesis Markers without Disrupting Insulin Receptor Signalling after an Insulin Challenge

scientific article published on 15 March 2017

The p65 subunit of NF-kappaB binds to PGC-1alpha, linking inflammation and metabolic disturbances in cardiac cells.

scientific article

Tissue factor pathway inhibitor 2 is induced by thrombin in human macrophages

scientific article published on 15 April 2011

Type II interleukin-1 receptor expression is reduced in monocytes/macrophages and atherosclerotic lesions

scientific article published on 12 June 2011

Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats

scientific article published on 6 December 2016

Way back for fructose and liver metabolism: bench side to molecular insights

scientific article

[Emergency care of patients with upper gastrointestinal bleeding in regional hospitals in Catalonia]

scientific article published on 14 October 2011

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