List of works - Andrew M Gulick

1.2 Å resolution crystal structure of the periplasmic aminotransferase PvdN from Pseudomonas aeruginosa.

scientific article published on 22 April 2016

Aerobactin Synthesis Proteins as Antivirulence Targets in Hypervirulent Klebsiella pneumoniae

scientific article published on 29 April 2019

Aerobactin mediates virulence and accounts for increased siderophore production under iron-limiting conditions by hypervirulent (hypermucoviscous) Klebsiella pneumoniae

scientific article

Alteration of the Flexible Loop in 1-Deoxy- d -xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by Fosmidomycin

scientific article

An Open and Shut Case: The Interaction of Magnesium with MST Enzymes

scientific article

Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site.

scientific article

Analysis of the linker region joining the adenylation and carrier protein domains of the modular nonribosomal peptide synthetases.

scientific article

Biochemical and Crystallographic Analysis of Substrate Binding and Conformational Changes in Acetyl-CoA Synthetase † , ‡

scientific article

Biochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Nonribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis,

scientific article

Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones

scientific article published on 23 January 2013

Cloning of the Orange Light-Producing Luciferase from Photinus scintillans-A New Proposal on how Bioluminescence Color is Determined.

scientific article published on 18 November 2016

Computational Screening of the Human TF-Glycome Provides a Structural Definition for the Specificity of Anti-Tumor Antibody JAA-F11

scientific article

Crystal Structure of Firefly Luciferase in a Second Catalytic Conformation Supports a Domain Alternation Mechanism

scientific article

Crystal Structure of the Siderophore Binding Protein BauB Bound to an Unusual 2:1 Complex Between Acinetobactin and Ferric Iron

scientific article published on 15 November 2018

Crystal structure of 4-chlorobenzoate:CoA ligase/synthetase in the unliganded and aryl substrate-bound states

scientific article published in July 2004

Development of a High-Throughput Biochemical Assay to Screen for Inhibitors of Aerobactin Synthetase IucA

scientific article published on 10 July 2018

Enzymes engineered to trap reaction intermediates

scientific article published on 01 January 2019

Evolution of Enzymatic Activities in the Enolase Superfamily: Crystal Structure of (D)-Glucarate Dehydratase from Pseudomonas putida, ⬇️

scientific article published on October 13, 1998

Evolution of enzymatic activities in the enolase superfamily: crystal structures of the L-Ala-D/L-Glu epimerases from Escherichia coli and Bacillus subtilis

scientific article

Evolution of enzymatic activities in the enolase superfamily: crystallographic and mutagenesis studies of the reaction catalyzed by D-glucarate dehydratase from Escherichia coli

scientific article

Examining Reaction Specificity in PvcB, a Source of Diversity in Isonitrile-Containing Natural Products

scientific article

Experimental Support for a Single Electron-Transfer Oxidation Mechanism in Firefly Bioluminescence.

scientific article published on 12 June 2015

Expression of tandem glutathione S-transferase recombinant genes in COS cells for analysis of efficiency of protein expression and associated drug resistance

scientific article published on 01 April 1991

Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme.

scientific article

High-level production and purification of biologically active proteins from bacterial and mammalian cells using the tandem pGFLEX expression system.

scientific article published in July 1997

Human Glycerol 3-Phosphate Dehydrogenase: X-ray Crystal Structures That Guide the Interpretation of Mutagenesis Studies

scientific article published on 31 January 2019

Identification of a small molecule inhibitor of Pseudomonas aeruginosa PvdQ acylase, an enzyme involved in siderophore pyoverdine synthesis

scientific article published on 10 May 2013

Identification of inhibitors of PvdQ, an enzyme involved in the synthesis of the siderophore pyoverdine

scientific article published on 21 May 2014

Insights into resistance against lincosamide antibiotics

scientific article published in December 2009

Ironing out a new siderophore synthesis strategy

scientific article

Mammalian glutathione S-transferase: regulation of an enzyme system to achieve chemotherapeutic efficacy.

scientific article

Mechanistic Roles of Tyrosine 149 and Serine 124 in UDP-galactose 4-Epimerase from Escherichia coli ⬇️

scientific article published on September 2, 1997

Molecular structures of the S124A, S124T, and S124V site-directed mutants of UDP-galactose 4-epimerase from Escherichia coli

scientific article

Mutagenesis and Structural Studies Reveal the Basis for the Activity and Stability Properties That Distinguish the Photinus Luciferases scintillans and pyralis

scientific article published on 10 October 2019

Mutational substitution of residues implicated by crystal structure in binding the substrate glutathione to human glutathione S-transferase pi

scientific article published on 01 July 1992

Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii

scientific article published on 13 March 2013

Pentaerythritol propoxylate: a new crystallization agent and cryoprotectant induces crystal growth of 2-methylcitrate dehydratase

scientific article published on 24 January 2002

Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

scientific article

Structural Biology of Nonribosomal Peptide Synthetases

scientific article published on January 2016

Structural Characterization and High-Throughput Screening of Inhibitors of PvdQ, an NTN Hydrolase Involved in Pyoverdine Synthesis

scientific article

Structural and Functional Characterization of Aerobactin Synthetase IucA from a Hypervirulent Pathotype of Klebsiella pneumoniae

scientific article published on 02 June 2016

Structural and Functional Investigation of the Intermolecular Interaction between NRPS Adenylation and Carrier Protein Domains

scientific article

Structural and bioinformatic characterization of an Acinetobacter baumannii type II carrier protein

scientific article

Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae.

scientific article published on 4 April 2018

Structural insight into the necessary conformational changes of modular nonribosomal peptide synthetases

scientific article published on 24 September 2016

Structural studies on human glutathione S-transferase pi. Family of native-specific monoclonal antibodies used to block catalysis

scientific article published on 01 September 1992

Structural studies on human glutathione S-transferase pi. Substitution mutations to determine amino acids necessary for binding glutathione

scientific article published on 01 September 1992

Structural studies on myosin II: Communication between distant protein domains ⬇️

scientific article published on July 1, 1997

Structure determination of the functional domain interaction of a chimeric nonribosomal peptide synthetase from a challenging crystal with noncrystallographic translational symmetry

scientific article

Structure of PA1221, a Nonribosomal Peptide Synthetase Containing Adenylation and Peptidyl Carrier Protein Domains

scientific article

Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions

scientific article published on 27 August 2019

Structure of the EntB multidomain nonribosomal peptide synthetase and functional analysis of its interaction with the EntE adenylation domain.

scientific article

Structure-Function Studies of Hydrophobic Residues That Clamp a Basic Glutamate Side Chain during Catalysis by Triosephosphate Isomerase

scientific article published on 05 May 2016

Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-Like Proteins Support a Highly Dynamic Domain Architecture

scientific article

Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

scientific article published on January 2016

Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ.

scientific article published on 10 February 2017

The 1.75 A crystal structure of acetyl-CoA synthetase bound to adenosine-5'-propylphosphate and coenzyme A

scientific article (publication date: 18 March 2003)

The 1.8 A crystal structure of PA2412, an MbtH-like protein from the pyoverdine cluster of Pseudomonas aeruginosa

scientific article

The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition

scientific article published on 23 May 2018

The role of phosphate in a multistep enzymatic reaction: reactions of the substrate and intermediate in pieces

scientific article published on 10 February 2015

The structural basis of N-acyl-α-amino-β-lactone formation catalyzed by a nonribosomal peptide synthetase

scientific article published on 31 July 2019

The structure of S. lividans acetoacetyl-CoA synthetase shows a novel interaction between the C-terminal extension and the N-terminal domain

scientific article

Three-dimensional Structures of Pseudomonas aeruginosa PvcA and PvcB, Two Proteins Involved in the Synthesis of 2-Isocyano-6,7-dihydroxycoumarin

scientific article

Trapping interactions between catalytic domains and carrier proteins of modular biosynthetic enzymes with chemical probes

scientific article published on 01 November 2018

X-ray Structures of the MgADP, MgATPγS, and MgAMPPNP Complexes of the Dictyostelium discoideum Myosin Motor Domain, ⬇️

scientific article published on September 30, 1997

X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution

scientific article

X-ray structures of the Dictyostelium discoideum myosin motor domain with six non-nucleotide analogs

scientific article

List of works by Andrew M Gulick

1.2 Å resolution crystal structure of the periplasmic aminotransferase PvdN from Pseudomonas aeruginosa.

Aerobactin Synthesis Proteins as Antivirulence Targets in Hypervirulent Klebsiella pneumoniae

Aerobactin mediates virulence and accounts for increased siderophore production under iron-limiting conditions by hypervirulent (hypermucoviscous) Klebsiella pneumoniae

Alteration of the Flexible Loop in 1-Deoxy- d -xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by Fosmidomycin

An Open and Shut Case: The Interaction of Magnesium with MST Enzymes

Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site.

Analysis of the linker region joining the adenylation and carrier protein domains of the modular nonribosomal peptide synthetases.

Biochemical and Crystallographic Analysis of Substrate Binding and Conformational Changes in Acetyl-CoA Synthetase † , ‡

Biochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Nonribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis,

Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones

Cloning of the Orange Light-Producing Luciferase from Photinus scintillans-A New Proposal on how Bioluminescence Color is Determined.

Computational Screening of the Human TF-Glycome Provides a Structural Definition for the Specificity of Anti-Tumor Antibody JAA-F11

Crystal Structure of Firefly Luciferase in a Second Catalytic Conformation Supports a Domain Alternation Mechanism

Crystal Structure of the Siderophore Binding Protein BauB Bound to an Unusual 2:1 Complex Between Acinetobactin and Ferric Iron

Crystal structure of 4-chlorobenzoate:CoA ligase/synthetase in the unliganded and aryl substrate-bound states

Development of a High-Throughput Biochemical Assay to Screen for Inhibitors of Aerobactin Synthetase IucA

Enzymes engineered to trap reaction intermediates

Evolution of Enzymatic Activities in the Enolase Superfamily: Crystal Structure of (D)-Glucarate Dehydratase from Pseudomonas putida, ⬇️

Evolution of enzymatic activities in the enolase superfamily: crystal structures of the L-Ala-D/L-Glu epimerases from Escherichia coli and Bacillus subtilis

Evolution of enzymatic activities in the enolase superfamily: crystallographic and mutagenesis studies of the reaction catalyzed by D-glucarate dehydratase from Escherichia coli

Examining Reaction Specificity in PvcB, a Source of Diversity in Isonitrile-Containing Natural Products

Experimental Support for a Single Electron-Transfer Oxidation Mechanism in Firefly Bioluminescence.

Expression of tandem glutathione S-transferase recombinant genes in COS cells for analysis of efficiency of protein expression and associated drug resistance

Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme.

High-level production and purification of biologically active proteins from bacterial and mammalian cells using the tandem pGFLEX expression system.

Human Glycerol 3-Phosphate Dehydrogenase: X-ray Crystal Structures That Guide the Interpretation of Mutagenesis Studies

Identification of a small molecule inhibitor of Pseudomonas aeruginosa PvdQ acylase, an enzyme involved in siderophore pyoverdine synthesis

Identification of inhibitors of PvdQ, an enzyme involved in the synthesis of the siderophore pyoverdine

Insights into resistance against lincosamide antibiotics

Ironing out a new siderophore synthesis strategy

Mammalian glutathione S-transferase: regulation of an enzyme system to achieve chemotherapeutic efficacy.

Mechanistic Roles of Tyrosine 149 and Serine 124 in UDP-galactose 4-Epimerase from Escherichia coli ⬇️

Molecular structures of the S124A, S124T, and S124V site-directed mutants of UDP-galactose 4-epimerase from Escherichia coli

Mutagenesis and Structural Studies Reveal the Basis for the Activity and Stability Properties That Distinguish the Photinus Luciferases scintillans and pyralis

Mutational substitution of residues implicated by crystal structure in binding the substrate glutathione to human glutathione S-transferase pi

Non-nucleoside inhibitors of BasE, an adenylating enzyme in the siderophore biosynthetic pathway of the opportunistic pathogen Acinetobacter baumannii

Pentaerythritol propoxylate: a new crystallization agent and cryoprotectant induces crystal growth of 2-methylcitrate dehydratase

Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

Structural Biology of Nonribosomal Peptide Synthetases

Structural Characterization and High-Throughput Screening of Inhibitors of PvdQ, an NTN Hydrolase Involved in Pyoverdine Synthesis

Structural and Functional Characterization of Aerobactin Synthetase IucA from a Hypervirulent Pathotype of Klebsiella pneumoniae

Structural and Functional Investigation of the Intermolecular Interaction between NRPS Adenylation and Carrier Protein Domains

Structural and bioinformatic characterization of an Acinetobacter baumannii type II carrier protein

Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae.

Structural insight into the necessary conformational changes of modular nonribosomal peptide synthetases

Structural studies on human glutathione S-transferase pi. Family of native-specific monoclonal antibodies used to block catalysis

Structural studies on human glutathione S-transferase pi. Substitution mutations to determine amino acids necessary for binding glutathione

Structural studies on myosin II: Communication between distant protein domains ⬇️

Structure determination of the functional domain interaction of a chimeric nonribosomal peptide synthetase from a challenging crystal with noncrystallographic translational symmetry

Structure of PA1221, a Nonribosomal Peptide Synthetase Containing Adenylation and Peptidyl Carrier Protein Domains

Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions

Structure of the EntB multidomain nonribosomal peptide synthetase and functional analysis of its interaction with the EntE adenylation domain.

Structure-Function Studies of Hydrophobic Residues That Clamp a Basic Glutamate Side Chain during Catalysis by Triosephosphate Isomerase

Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-Like Proteins Support a Highly Dynamic Domain Architecture

Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ.

The 1.75 A crystal structure of acetyl-CoA synthetase bound to adenosine-5'-propylphosphate and coenzyme A

The 1.8 A crystal structure of PA2412, an MbtH-like protein from the pyoverdine cluster of Pseudomonas aeruginosa

The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition

The role of phosphate in a multistep enzymatic reaction: reactions of the substrate and intermediate in pieces

The structural basis of N-acyl-α-amino-β-lactone formation catalyzed by a nonribosomal peptide synthetase

The structure of S. lividans acetoacetyl-CoA synthetase shows a novel interaction between the C-terminal extension and the N-terminal domain

Three-dimensional Structures of Pseudomonas aeruginosa PvcA and PvcB, Two Proteins Involved in the Synthesis of 2-Isocyano-6,7-dihydroxycoumarin

Trapping interactions between catalytic domains and carrier proteins of modular biosynthetic enzymes with chemical probes

X-ray Structures of the MgADP, MgATPγS, and MgAMPPNP Complexes of the Dictyostelium discoideum Myosin Motor Domain, ⬇️

X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution

X-ray structures of the Dictyostelium discoideum myosin motor domain with six non-nucleotide analogs