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List of works by Richard Callaghan

A Novel Class of N-Sulfonyl and N-Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells

scientific article published on 12 November 2019

A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene

scientific article

A model of quiescent tumour microregions for evaluating multicellular resistance to chemotherapeutic drugs.

scientific article

Accumulation and distribution of doxorubicin in tumour spheroids: the influence of acidity and expression of P-glycoprotein

scientific article published on 15 March 2011

Acetoacetate is a more efficient energy-yielding substrate for human mesenchymal stem cells than glucose and generates fewer reactive oxygen species.

scientific article

Can P-glycoprotein influence the bioavailability of iminosugar-based glucosylceramide synthase inhibitors?

scientific article published on 3 January 2006

Collateral sensitivity of multidrug resistant cells to narcotic analgesics is due to effects on the plasma membrane

scientific article published on May 1995

Communication between the nucleotide binding domains of P-glycoprotein occurs via conformational changes that involve residue 508.

scientific article published on July 2003

Comparative efficacy of novel platinum(IV) compounds with established chemotherapeutic drugs in solid tumour models

scientific article

Cytosolic region of TM6 in P-glycoprotein: topographical analysis and functional perturbation by site directed labeling

scientific article

Definition of the domain boundaries is critical to the expression of the nucleotide-binding domains of P-glycoprotein

scientific article published on 26 June 2003

Diffusivity and distribution of vinblastine in three-dimensional tumour tissue: experimental and mathematical modelling.

scientific article published on 9 August 2006

Drug binding sites on P-glycoprotein are altered by ATP binding prior to nucleotide hydrolysis

scientific article published on 01 October 2000

Dual effects of the PI3K inhibitor ZSTK474 on multidrug efflux pumps in resistant cancer cells

scientific article

Elemental tomography of cancer-cell spheroids reveals incomplete uptake of both platinum(II) and platinum(IV) complexes.

scientific article

Fabrication of psoralen-loaded lipid-polymer hybrid nanoparticles and their reversal effect on drug resistance of cancer cells

scientific article published on 14 June 2018

Factors affecting the hepatic elimination of oxidized and of glucoronidated high clearance drugs following acute administration of carbon tetrachloride

scientific article published on 01 June 1994

Generating inhibitors of P-glycoprotein: where to, now?

scientific article published on 01 January 2010

Hepatic enzyme activity is the major factor determining elimination rate of high-clearance drugs in cirrhosis

scientific article published on 01 July 1993

How can we best use structural information on P-glycoprotein to design inhibitors?

scientific article published on 18 November 2006

Improving the stability and function of purified ABCB1 and ABCA4: the influence of membrane lipids.

scientific article

Inhibition of P-glycoprotein function by XR9576 in a solid tumour model can restore anticancer drug efficacy

scientific article published in March 2004

Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells

scientific article

Inhibition of the multidrug resistance P-glycoprotein: time for a change of strategy?

scientific article published on 03 February 2014

Interaction of tamoxifen with the multidrug resistance P-glycoprotein.

scientific article

Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein

scientific article

Mamma Mia, P-glycoprotein binds again

scientific article published on 06 October 2020

Metabolic alterations during the growth of tumour spheroids

scientific article published on April 2014

Methods of reconstitution to investigate membrane protein function

scientific article published on 15 February 2018

Modulation of the BK channel by estrogens: examination at single channel level

scientific article published on 01 September 2006

Multidrug efflux pumps: drug binding--gates or cavity?

scientific article published on 03 December 2009

Multidrug efflux pumps: the big issues

scientific article published on 03 December 2009

Multiple drugbinding sites on the R482G isoform of the ABCG2 transporter.

scientific article

Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors

scientific article published on 9 September 2015

Overcoming P-Glycoprotein-Mediated Drug Resistance with Noscapine Derivatives

scientific article published on 26 November 2018

P-glycoprotein retains function when reconstituted into a sphingolipid- and cholesterol-rich environment

scientific article published on 16 July 2004

P-glycoprotein: a role in the export of amyloid-β in Alzheimer's disease?

scientific article published on 09 December 2019

Providing a molecular mechanism for P-glycoprotein; why would I bother?

scientific article

Psoralen-loaded lipid-polymer hybrid nanoparticles enhance doxorubicin efficacy in multidrug-resistant HepG2 cells

scientific article published on 27 March 2019

Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2.

scientific article published on November 2006

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

scientific article

Residue G346 in transmembrane segment six is involved in inter-domain communication in P-glycoprotein

scientific article published on 14 August 2007

Role of GSH in estrone sulfate binding and translocation by the multidrug resistance protein 1 (MRP1/ABCC1).

scientific article published on 24 March 2006

SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1.

scientific article

Survivin isoform Delta Ex3 regulates tumor spheroid formation.

scientific article published on 8 December 2011

Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents

scientific article published on 14 September 2018

The "pushmi-pullyu" of resistance to chloroquine in malaria

scientific article published on February 2017

The Effects of Severe Hypoxia on Glycolytic Flux and Enzyme Activity in a Model of Solid Tumors

scientific article

The binding of auxin to the Arabidopsis auxin influx transporter AUX1.

scientific article

The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis

scientific article published on April 2014

The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment.

scientific article published on July 2005

The expression of P-glycoprotein does influence the distribution of novel fluorescent compounds in solid tumour models ⬇️

scientific article published on October 20, 2003

The functional purification of P-glycoprotein is dependent on maintenance of a lipid-protein interface

scientific article published on 01 September 1997

The influence of tumour microenvironmental factors on the efficacy of cisplatin and novel platinum(IV) complexes

scientific article published on 01 October 2005

The lipid translocase, ABCA4: seeing is believing.

scientific article

The multi-drug resistance reversal agent SR33557 and modulation of vinca alkaloid binding to P-glycoprotein by an allosteric interaction.

scientific article published on October 1997

The nucleotide-binding domains of P-glycoprotein. Functional symmetry in the isolated domain demonstrated by N-ethylmaleimide labelling

scientific article published in April 2003

The stabilisation of purified, reconstituted P-glycoprotein by freeze drying with disaccharides.

scientific article published on 17 October 2008

The synthesis and biological evaluation of multifunctionalised derivatives of noscapine as cytotoxic agents

scientific article published on 11 December 2013

The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein.

scientific article published on 10 June 2004

The translocation mechanism of P-glycoprotein.

scientific article

Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.

scientific article published on 13 October 2004

Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding

scientific article published on 25 December 2002

Transmembrane helix 12 modulates progression of the ATP catalytic cycle in ABCB1.

scientific article

Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1.

scientific article published on 20 August 2010

Transport kinetics of four- and six-coordinate platinum compounds in the multicell layer tumour model.

scientific article

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