List of works - Stefan Zahler

A novel approach to prevent endothelial hyperpermeability: the Crataegus extract WS® 1442 targets the cAMP/Rap1 pathway.

scientific article

A novel role for inhibitor of apoptosis (IAP) proteins as regulators of endothelial barrier function by mediating RhoA activation

scientific article published on 26 December 2013

A novel technique for selective NF-kappaB inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion.

scientific article published on 25 May 2009

A role for Syk-kinase in the control of the binding cycle of the beta2 integrins (CD11/CD18) in human polymorphonuclear neutrophils

scientific article

A small molecule inhibits protein disulfide isomerase and triggers the chemosensitization of cancer cells

scientific article

ACE-inhibition attenuates cardiac cell damage and preserves release of NO in the postischemic heart

scientific article published on October 1999

ACE-inhibition prevents postischemic coronary leukocyte adhesion and leukocyte-dependent reperfusion injury

scientific article published in December 1997

Actin stabilizing compounds show specific biological effects due to their binding mode

scientific article published on 05 July 2019

Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass

scientific article published on 01 March 1999

Adenosine endogenously released during early reperfusion mitigates postischemic myocardial dysfunction by inhibiting platelet adhesion

scientific article published in July 1998

An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.

scientific article

Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases

scientific article published on 13 April 2011

Antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury ⬇️

scientific article published in October 2009

Anti‐angiogenic effects of the tubulysin precursor pretubulysin and of simplified pretubulysin derivatives ⬇️

scientific article published on November 1, 2012

Application of peptides containing the cleavage sequence of pro-TNFalpha in assessing TACE activity of whole cells.

scientific article published on November 2002

Assessment of human MAPCs for stem cell transplantation and cardiac regeneration after myocardial infarction in SCID mice

scientific article

Atrial natriuretic peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD(P)H oxidase/Nox2-activation

scientific article published on 29 November 2004

Atrial natriuretic peptide protects against histamine-induced endothelial barrier dysfunction in vivo

scientific article published on 15 April 2008

Atrial natriuretic peptide, a regulator of nuclear factor-kappaB activation in vivo.

scientific article published on 28 September 2006

Beneficial effect of sodium nitroprusside after coronary artery bypass surgery: pump function correlates inversely with cardiac release of proinflammatory cytokines

scientific article published on 01 September 2003

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

scientific article

Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells

scientific article published on 04 September 2012

C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms

scientific article published on 6 June 2012

Calpains: a physiological regulator of the endothelial barrier?

scientific article published on 22 December 2005

Cardioprotection by cyclosporine A in experimental ischemia and reperfusion--evidence for a nitric oxide-dependent mechanism mediated by endothelin

scientific article published in February 1997

Cardiovascular actions of adenosine. Granulocyte and blood platelet adhesion in the reperfused myocardium

scientific article published on 01 January 1998

Ccl2 and Ccl3 mediate neutrophil recruitment via induction of protein synthesis and generation of lipid mediators.

scientific article published on 16 July 2009

Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2.

scientific article

Chivosazole A Modulates Protein-Protein Interactions of Actin

scientific article published on 01 July 2019

Components of the plasminogen activation system promote engraftment of porous polyethylene biomaterial via common and distinct effects

scientific article

Crucial role of local peroxynitrite formation in neutrophil-induced endothelial cell activation

scientific article published in March 2003

Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis.

scientific article

Dexamethasone-induced expression of endothelial mitogen-activated protein kinase phosphatase-1 involves activation of the transcription factors activator protein-1 and 3',5'-cyclic adenosine 5'-monophosphate response element-binding protein and the

scientific article published on 10 April 2008

Disparate effects of adhesion and degranulation of platelets on myocardial and coronary function in postischaemic hearts

scientific article published in May 1998

Effects of ACE-inhibition on redox status and expression of P-selectin of endothelial cells subjected to oxidative stress

scientific article published on 01 November 1997

Endothelial alpha-parvin controls integrity of developing vasculature and is required for maintenance of cell-cell junctions

scientific article published on 29 April 2015

Endothelial function and hemostasis

scientific journal article

Endothelial glycocalyx as an additional barrier determining extravasation of 6% hydroxyethyl starch or 5% albumin solutions in the coronary vascular bed.

scientific article published in May 2004

Endothelial preconditioning by transient oxidative stress reduces inflammatory responses of cultured endothelial cells to TNF-alpha

scientific article published on 01 March 2000

Evidence for inflammatory responses of the lungs during coronary artery bypass grafting with cardiopulmonary bypass

scientific article published on 01 January 2001

Flavopiridol protects against inflammation by attenuating leukocyte-endothelial interaction via inhibition of cyclin-dependent kinase 9

scientific article published on 18 November 2010

Gap-junctional coupling between neutrophils and endothelial cells: a novel modulator of transendothelial migration

scientific article published on 01 January 2003

Ginkgo biloba extract EGb 761 exerts anti-angiogenic effects via activation of tyrosine phosphatases

scientific article published on 23 October 2008

Ginkgo biloba extract EGb 761 increases endothelial nitric oxide production in vitro and in vivo.

scientific article published on July 2007

Halothane, isoflurane, and sevoflurane reduce postischemic adhesion of neutrophils in the coronary system

scientific article published on January 1997

Hemodynamic effects of isoprostanes (8-iso-prostaglandin F2alpha and E2) in isolated guinea pig hearts

scientific article published in June 1997

In vitro and in vivo characterization of the actin polymerizing compound chondramide as an angiogenic inhibitor.

scientific article published on 19 September 2014

Indirect enhancement of neutrophil activity and adhesion to cultured human umbilical vein endothelial cells by isoprostanes (iPF2alpha-III and iPE2-III)

scientific article published on 01 July 1999

Indirubin derivative 6BIO suppresses metastasis

scientific article published on 14 August 2013

Influence of intact left atrial appendage on hemodynamic parameters of isolated guinea pig heart

scientific article

Inhibition of neutrophil activation by volatile anesthetics decreases adhesion to cultured human endothelial cells

scientific article published in May 1999

Inhibitor of apoptosis proteins as novel targets in inflammatory processes.

scientific article

Insights from knock-out models concerning postischemic release of TNFalpha from isolated mouse hearts

scientific article

Interaction of adenosine with leukocytes and thrombocytes

scientific article published in January 1996

Intracoronary formation and retention of micro aggregates of leukocytes and platelets contribute to postischemic myocardial dysfunction

scientific article published on 10 June 2005

Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets.

scientific article

Inverse in silico screening for identification of kinase inhibitor targets.

scientific article published on November 2007

Investigation of the marine compound spongistatin 1 links the inhibition of PKCalpha translocation to nonmitotic effects of tubulin antagonism in angiogenesis

scientific article published on 04 December 2008

Ketamine does not inhibit inflammatory responses of cultured human endothelial cells but reduces chemotactic activation of neutrophils

scientific article published in November 1999

MAPK phosphatase-1 represents a novel anti-inflammatory target of glucocorticoids in the human endothelium.

scientific article

Magnetofection--a highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo

scientific article published on May 2003

Micropatterning as a tool to identify regulatory triggers and kinetics of actin-mediated endothelial mechanosensing

scientific article published on 29 May 2018

Modified phosphatidylethanolamine as the active component of oxidized low density lipoprotein promoting platelet prothrombinase activity

scientific article

Multimodal therapy for synergic inhibition of tumour cell invasion and tumour-induced angiogenesis

scientific article

Nitric oxide enhances de novo formation of endothelial gap junctions

scientific article published in November 2003

Nonuniform behavior of intravenous anesthetics on postischemic adhesion of neutrophils in the guinea pig heart

scientific article published in June 2000

Novel tubulin antagonist pretubulysin displays antivascular properties in vitro and in vivo

scientific article published on 27 November 2013

Nuclear factor-kappa B-independent anti-inflammatory action of salicylate in human endothelial cells: induction of heme oxygenase-1 by the c-jun N-terminal kinase/activator protein-1 pathway

scientific article (publication date: July 2006)

Optical Manipulation of F-Actin with Photoswitchable Small Molecules

scientific article published on 11 May 2020

PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation

scientific article

Persistent inhibition of pore-based cell migration by sub-toxic doses of miuraenamide, an actin filament stabilizer

scientific article published on 27 November 2017

Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death.

scientific article

Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.

scientific article

Platelet-associated tissue factor contributes to the collagen-triggered activation of blood coagulation

scientific article published on 01 February 2001

Porosity and mechanically optimized PLGA based in situ hardening systems

scientific article published on 28 August 2012

Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides

scientific article

Reactive oxygen species and nitric oxide in myocardial ischemia and reperfusion

scientific article published in January 2000

Reciprocal activation between CD4+ T cells and Kupffer cells during hepatic ischemia-reperfusion.

scientific article

Reduction of pro-inflammatory cytokine levels and cellular adhesion in CABG procedures with separated pulmonary and systemic extracorporeal circulation without an oxygenator

scientific article published on 01 June 2000

Regulation of endothelial signaling and migration by v-ATPase

scientific article published on 20 November 2013

Release of TNF-alpha during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers

scientific article published on December 2003

Retention of leucocytes in reperfused, isolated hearts does not cause haemodynamically relevant permanent capillary plugging

scientific article published on April 1997

Roscovitine blocks leukocyte extravasation by inhibition of cyclin-dependent kinases 5 and 9.

scientific article published on July 2011

S(+)-ketamine, but not R(-)-ketamine, reduces postischemic adherence of neutrophils in the coronary system of isolated guinea pig hearts

scientific article published on May 1999

Selectin-mediated rolling of neutrophils is essential for their activation and retention in the reperfused coronary system

scientific article

Sevoflurane and isoflurane protect the reperfused guinea pig heart by reducing postischemic adhesion of polymorphonuclear neutrophils

scientific article published on August 1999

Significant leukocyte and platelet retention during pulmonary passage after declamping of the aorta in CABG patients

scientific article published on May 1999

Sodium nitroprusside during coronary artery bypass grafting: evidence for an antiinflammatory action

scientific article published on 01 April 1999

Sodium nitroprusside in patients with compromised left ventricular function undergoing coronary bypass: reduction of cardiac proinflammatory substances

scientific article published on 01 March 2000

Stimulation of endothelial adenosine A1 receptors enhances adhesion of neutrophils in the intact guinea pig coronary system

scientific article published on 01 September 1994

Subcellular localization and in vivo subunit interactions of ubiquitous mu-calpain.

scientific article published on 18 February 2003

Sustained platelet activation following intracoronary beta irradiation

scientific article published in December 2002

Targeting actin inhibits repair of doxorubicin-induced DNA damage: a novel therapeutic approach for combination therapy

scientific article published on 03 April 2019

Targeting cyclin dependent kinase 5 in hepatocellular carcinoma--A novel therapeutic approach.

scientific article published on 7 February 2015

The Crataegus extract WS 1442 inhibits balloon catheter-induced intimal hyperplasia in the rat carotid artery by directly influencing PDGFR-beta

scientific article published on 14 April 2010

The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.

scientific article

The actin targeting compound Chondramide inhibits breast cancer metastasis via reduction of cellular contractility

scientific article (publication date: 2014)

The biophysical properties of Basal lamina gels depend on the biochemical composition of the gel

scientific article

The function of neutrophils isolated by a magnetic antibody cell separation technique is not altered in comparison to a density gradient centrifugation method

scientific article published on January 1997

The marine compound spongistatin 1 targets pancreatic tumor progression and metastasis

scientific article published in September 2010

The selective P-TEFb inhibitor CAN508 targets angiogenesis.

scientific article

The vascular barrier-protecting hawthorn extract WS® 1442 raises endothelial calcium levels by inhibition of SERCA and activation of the IP3 pathway

scientific article

Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/β-catenin signaling

scientific article published on 5 January 2012

Tissue plasminogen activator promotes postischemic neutrophil recruitment via its proteolytic and nonproteolytic properties

scientific article published on 24 April 2014

Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors

scientific article

Tumor necrosis factor-alpha contributes to ischemia- and reperfusion-induced endothelial activation in isolated hearts

scientific article published on 01 March 1999

Twice switched at birth: Cell cycle-independent roles of the “neuron-specific” cyclin-dependent kinase 5 (Cdk5) in non-neuronal cells ⬇️

scientific article published on June 30, 2011

Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via Mac-1, but independently of urokinase-type plasminogen activator receptor

scientific article published on 03 October 2011

Volatile anaesthetics reduce adhesion of blood platelets under low-flow conditions in the coronary system of isolated guinea pig hearts

scientific article published in September 1998

Zn-triggered self-assembly of Gonadorelin [6-D-Phe] to produce nanostructures and fibrils

scientific article published in Scientific Reports

[Plasma lactate concentration in post-ischemic reperfusion of human hearts under treatment with sodium nitroprusside]

scientific article published on 01 April 1999

List of works by Stefan Zahler

A novel approach to prevent endothelial hyperpermeability: the Crataegus extract WS® 1442 targets the cAMP/Rap1 pathway.

A novel role for inhibitor of apoptosis (IAP) proteins as regulators of endothelial barrier function by mediating RhoA activation

A novel technique for selective NF-kappaB inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion.

A role for Syk-kinase in the control of the binding cycle of the beta2 integrins (CD11/CD18) in human polymorphonuclear neutrophils

A small molecule inhibits protein disulfide isomerase and triggers the chemosensitization of cancer cells

ACE-inhibition attenuates cardiac cell damage and preserves release of NO in the postischemic heart

ACE-inhibition prevents postischemic coronary leukocyte adhesion and leukocyte-dependent reperfusion injury

Actin stabilizing compounds show specific biological effects due to their binding mode

Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass

Adenosine endogenously released during early reperfusion mitigates postischemic myocardial dysfunction by inhibiting platelet adhesion

An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.

Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases

Antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury ⬇️

Anti‐angiogenic effects of the tubulysin precursor pretubulysin and of simplified pretubulysin derivatives ⬇️

Application of peptides containing the cleavage sequence of pro-TNFalpha in assessing TACE activity of whole cells.

Assessment of human MAPCs for stem cell transplantation and cardiac regeneration after myocardial infarction in SCID mice

Atrial natriuretic peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD(P)H oxidase/Nox2-activation

Atrial natriuretic peptide protects against histamine-induced endothelial barrier dysfunction in vivo

Atrial natriuretic peptide, a regulator of nuclear factor-kappaB activation in vivo.

Beneficial effect of sodium nitroprusside after coronary artery bypass surgery: pump function correlates inversely with cardiac release of proinflammatory cytokines

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells

C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms

Calpains: a physiological regulator of the endothelial barrier?

Cardioprotection by cyclosporine A in experimental ischemia and reperfusion--evidence for a nitric oxide-dependent mechanism mediated by endothelin

Cardiovascular actions of adenosine. Granulocyte and blood platelet adhesion in the reperfused myocardium

Ccl2 and Ccl3 mediate neutrophil recruitment via induction of protein synthesis and generation of lipid mediators.

Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2.

Chivosazole A Modulates Protein-Protein Interactions of Actin

Components of the plasminogen activation system promote engraftment of porous polyethylene biomaterial via common and distinct effects

Crucial role of local peroxynitrite formation in neutrophil-induced endothelial cell activation

Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis.

Dexamethasone-induced expression of endothelial mitogen-activated protein kinase phosphatase-1 involves activation of the transcription factors activator protein-1 and 3',5'-cyclic adenosine 5'-monophosphate response element-binding protein and the

Disparate effects of adhesion and degranulation of platelets on myocardial and coronary function in postischaemic hearts

Effects of ACE-inhibition on redox status and expression of P-selectin of endothelial cells subjected to oxidative stress

Endothelial alpha-parvin controls integrity of developing vasculature and is required for maintenance of cell-cell junctions

Endothelial function and hemostasis

Endothelial glycocalyx as an additional barrier determining extravasation of 6% hydroxyethyl starch or 5% albumin solutions in the coronary vascular bed.

Endothelial preconditioning by transient oxidative stress reduces inflammatory responses of cultured endothelial cells to TNF-alpha

Evidence for inflammatory responses of the lungs during coronary artery bypass grafting with cardiopulmonary bypass

Flavopiridol protects against inflammation by attenuating leukocyte-endothelial interaction via inhibition of cyclin-dependent kinase 9

Gap-junctional coupling between neutrophils and endothelial cells: a novel modulator of transendothelial migration

Ginkgo biloba extract EGb 761 exerts anti-angiogenic effects via activation of tyrosine phosphatases

Ginkgo biloba extract EGb 761 increases endothelial nitric oxide production in vitro and in vivo.

Halothane, isoflurane, and sevoflurane reduce postischemic adhesion of neutrophils in the coronary system

Hemodynamic effects of isoprostanes (8-iso-prostaglandin F2alpha and E2) in isolated guinea pig hearts

In vitro and in vivo characterization of the actin polymerizing compound chondramide as an angiogenic inhibitor.

Indirect enhancement of neutrophil activity and adhesion to cultured human umbilical vein endothelial cells by isoprostanes (iPF2alpha-III and iPE2-III)

Indirubin derivative 6BIO suppresses metastasis

Influence of intact left atrial appendage on hemodynamic parameters of isolated guinea pig heart

Inhibition of neutrophil activation by volatile anesthetics decreases adhesion to cultured human endothelial cells

Inhibitor of apoptosis proteins as novel targets in inflammatory processes.

Insights from knock-out models concerning postischemic release of TNFalpha from isolated mouse hearts

Interaction of adenosine with leukocytes and thrombocytes

Intracoronary formation and retention of micro aggregates of leukocytes and platelets contribute to postischemic myocardial dysfunction

Intravascular tissue factor initiates coagulation via circulating microvesicles and platelets.

Inverse in silico screening for identification of kinase inhibitor targets.

Investigation of the marine compound spongistatin 1 links the inhibition of PKCalpha translocation to nonmitotic effects of tubulin antagonism in angiogenesis

Ketamine does not inhibit inflammatory responses of cultured human endothelial cells but reduces chemotactic activation of neutrophils

MAPK phosphatase-1 represents a novel anti-inflammatory target of glucocorticoids in the human endothelium.

Magnetofection--a highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo

Micropatterning as a tool to identify regulatory triggers and kinetics of actin-mediated endothelial mechanosensing

Modified phosphatidylethanolamine as the active component of oxidized low density lipoprotein promoting platelet prothrombinase activity

Multimodal therapy for synergic inhibition of tumour cell invasion and tumour-induced angiogenesis

Nitric oxide enhances de novo formation of endothelial gap junctions

Nonuniform behavior of intravenous anesthetics on postischemic adhesion of neutrophils in the guinea pig heart

Novel tubulin antagonist pretubulysin displays antivascular properties in vitro and in vivo

Nuclear factor-kappa B-independent anti-inflammatory action of salicylate in human endothelial cells: induction of heme oxygenase-1 by the c-jun N-terminal kinase/activator protein-1 pathway

Optical Manipulation of F-Actin with Photoswitchable Small Molecules

PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation

Persistent inhibition of pore-based cell migration by sub-toxic doses of miuraenamide, an actin filament stabilizer

Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death.

Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.

Platelet-associated tissue factor contributes to the collagen-triggered activation of blood coagulation

Porosity and mechanically optimized PLGA based in situ hardening systems

Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides

Reactive oxygen species and nitric oxide in myocardial ischemia and reperfusion

Reciprocal activation between CD4+ T cells and Kupffer cells during hepatic ischemia-reperfusion.

Reduction of pro-inflammatory cytokine levels and cellular adhesion in CABG procedures with separated pulmonary and systemic extracorporeal circulation without an oxygenator