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List of works by Florian Nigsch

A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi.

scientific article published on 7 December 2017

A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space

scientific article

A novel hybrid ultrafast shape descriptor method for use in virtual screening.

scientific article published on 18 February 2008

Activity-aware clustering of high throughput screening data and elucidation of orthogonal structure-activity relationships

scientific article

Analysis of Iterative Screening with Stepwise Compound Selection Based on Novartis In-house HTS Data

scientific article

Causal Network Models for Predicting Compound Targets and Driving Pathways in Cancer

scientific article published on 11 February 2014

CellSIUS provides sensitive and specific detection of rare cell populations from complex single-cell RNA-seq data

scientific article published on 17 July 2019

Classifying large chemical data sets: using a regularized potential function method

scientific article

Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia.

scientific article published on 14 November 2016

Computational methods for early predictive safety assessment from biological and chemical data

scientific article

Computational toxicology: an overview of the sources of data and of modelling methods

article

Corrigendum: The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size

scientific article published in October 2016

Data-Driven Derivation of an "Informer Compound Set" for Improved Selection of Active Compounds in High-Throughput Screening

scientific article

Determination of minimal transcriptional signatures of compounds for target prediction

scientific article published on 10 May 2012

Evidence-Based and Quantitative Prioritization of Tool Compounds in Phenotypic Drug Discovery

scientific article published on 9 July 2016

Farnesoid X Receptor Agonism, Acetyl-Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model

scientific article published on 08 November 2019

Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy

scientific article published on 21 December 2017

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

scientific article

How to winnow actives from inactives: introducing molecular orthogonal sparse bigrams (MOSBs) and multiclass Winnow.

scientific article published on 26 January 2008

IRF2 is a master regulator of human keratinocyte stem cell fate

scientific article published on 14 October 2019

In vitro models for processes involved in intestinal absorption

scientific article published on August 2007

Ligand-target prediction using Winnow and naive Bayesian algorithms and the implications of overall performance statistics

scientific article published in December 2008

Melting point prediction employing k-nearest neighbor algorithms and genetic parameter optimization

scientific article

Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization

scientific article

Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information

scientific article (publication date: June 2011)

Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information

scientific article published in 2011

Predicting the mechanism of phospholipidosis

scientific article published on 26 January 2012

Recent trends and observations in the design of high-quality screening collections

scientific article

Rethinking molecular similarity: comparing compounds on the basis of biological activity.

scientific article published on 31 May 2012

Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology

scholarly article published 6 January 2017

Simultaneous feature selection and parameter optimisation using an artificial ant colony: case study of melting point prediction.

scientific article published on 29 October 2008

Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis

scientific article published on 29 September 2021

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

scientific article published on 18 April 2016

The multidimensional perturbation value: a single metric to measure similarity and activity of treatments in high-throughput multidimensional screens

scientific article

Total synthesis of (+)-crocacin D.

scientific article

Toxicological relationships between proteins obtained from protein target predictions of large toxicity databases

scientific article

Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite during progression into dormancy

scientific article published on 27 December 2018

Why are some properties more difficult to predict than others? A study of QSPR models of solubility, melting point, and Log P.

scientific article

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

scientific article published on 09 May 2019

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