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List of works by Michael P. Brown

A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

scientific article published on 4 January 2013

A phase 2 study of tasisulam sodium (LY573636 sodium) as second-line treatment for patients with unresectable or metastatic melanoma

scientific article

A phase I study of the GM-CSF antagonist E21R

scientific article published on 03 July 2002

A preliminary assessment of oral monepantel's tolerability and pharmacokinetics in individuals with treatment-refractory solid tumors

scientific article published on 22 September 2020

A randomized, controlled phase III trial of nab-Paclitaxel versus dacarbazine in chemotherapy-naïve patients with metastatic melanoma.

scientific article published on 26 September 2015

A simplified suite of methods to evaluate chelator conjugation of antibodies: effects on hydrodynamic radius and biodistribution

scientific article

APOMAB, a La-specific monoclonal antibody, detects the apoptotic tumor response to life-prolonging and DNA-damaging chemotherapy

scientific article

Adenovector-induced expression of human-CD40-ligand (hCD40L) by multiple myeloma cells. A model for immunotherapy.

scientific article

An empirical approach towards the efficient and optimal production of influenza-neutralizing ovine polyclonal antibodies demonstrates that the novel adjuvant CoVaccine HT™ is functionally superior to Freund's adjuvant

scientific article

An open-label, multicentre safety study of vemurafenib in patients with BRAFV600-mutant metastatic melanoma: final analysis and a validated prognostic scoring system

scientific article published on 20 December 2018

Antigen-specific T-cell responses to a recombinant fowlpox virus are dependent on MyD88 and interleukin-18 and independent of Toll-like receptor 7 (TLR7)- and TLR9-mediated innate immune recognition

scientific article published on 19 January 2011

Autoimmune limbic encephalitis with anti-contactin-associated protein-like 2 antibody secondary to pembrolizumab therapy.

scientific article published on 18 January 2017

Autoradiography imaging in targeted alpha therapy with Timepix detector

scientific article

Breast cancer stem cells: treatment resistance and therapeutic opportunities

scientific article published on 10 February 2011

CD40 is not detected on human prostate cancer cells by immunohistologic techniques

scientific article

CD40 ligand (CD154) improves the durability of respiratory syncytial virus DNA vaccination in BALB/c mice

scientific article published in June 2003

Can cancer registries show whether treatment is contributing to survival increases for melanoma of the skin at a population level?

scientific article

Chemotherapy synergizes with radioimmunotherapy targeting La autoantigen in tumors

scientific article

Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 study

scientific article published on 27 March 2018

Complement-fixing CD45 monoclonal antibodies to facilitate stem cell transplantation in mouse and man.

scientific article published in May 2003

Could bystander killing contribute significantly to the antitumor activity of brentuximab vedotin given with standard first-line chemotherapy for Hodgkin lymphoma?

scientific article published in January 2014

Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancy

scientific article published in June 2009

Current and emerging immunotherapeutic approaches to treat and prevent peanut allergy

scientific article published on December 2012

Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.

scientific article

Dasatinib alters the metastatic phenotype of B16-OVA melanoma in vivo

scientific article published on October 2010

Dasatinib inhibits recombinant viral antigen-specific murine CD4+ and CD8+ T-cell responses and NK-cell cytolytic activity in vitro and in vivo

scientific article

Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome

scientific article published on 22 June 2016

Detection of TNF alpha and Fas ligand mRNA within synovial mononuclear cells by fluorescence in-cell labeling PCR (FICL-PCR).

scientific article published on November 1998

Development of a transmission alpha particle dosimetry technique using A549 cells and a Ra-223 source for targeted alpha therapy.

scientific article published on November 2016

Different cytokine and stimulation conditions influence the expansion and immune phenotype of third-generation chimeric antigen receptor T cells specific for tumor antigen GD2.

scientific article

Do Human Lymphocyte Antigens Play a Role in the Clinical Antimelanoma Activity of Ipilimumab? ⬇️

scientific article published on 01 May 2011

Dose selection, pharmacokinetics, and pharmacodynamics of BRAF inhibitor dabrafenib (GSK2118436).

scientific article published on 23 June 2014

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

scientific article published in 2021

Eosinophilic fasciitis as a paraneoplastic phenomenon associated with metastatic colorectal carcinoma

scientific article

Exploring the epidemiological characteristics of cancers of unknown primary site in an Australian population: implications for research and clinical care

scientific article published in August 2008

Expression of Drosophila Ca2+ permeable transient receptor potential-like channel protein in a prostate cancer cell line decreases cell survival.

scientific article published in August 2003

Feasibility and kinetics of CD34+ hematopoietic progenitor cell mobilization in response to a single administration of docetaxel chemotherapy and pegfilgrastim in a contemporary cohort of patients with metastatic breast cancer

scientific article published on 21 September 2016

Feasibility of adding everolimus to carboplatin and paclitaxel, with or without bevacizumab, for treatment-naive, advanced non-small cell lung cancer

scientific article

First-in-Man Dose-Escalation Study of the Selective BRAF Inhibitor RG7256 in Patients with BRAF V600-Mutated Advanced Solid Tumors.

scientific article published on 27 August 2015

Flt3 ligand expands dendritic cell numbers in normal and malignant murine prostate

scientific article published on 01 August 2002

GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade

scientific article published on 29 March 2016

Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma

scientific article published on 16 May 2014

Hematopoietic and immunomodulatory effects of lytic CD45 monoclonal antibodies in patients with hematologic malignancy

scientific article published on 01 April 2003

Human Flt-3 ligand-mobilized dendritic cells require additional activation to drive effective immune responses

article

Immunotargeting of Functional Nanoparticles for MRI detection of Apoptotic Tumor Cells

scientific article published on 01 February 2009

Immunotherapy of high-risk acute leukemia with a recipient (autologous) vaccine expressing transgenic human CD40L and IL-2 after chemotherapy and allogeneic stem cell transplantation.

scientific article published on 25 October 2005

Improving vaccines by incorporating immunological coadjuvants

scientific article published on August 2007

In vivo targeting of dead tumor cells in a murine tumor model using a monoclonal antibody specific for the La autoantigen

scientific article

Induction of both cellular and humoral immunity following a rational prime-boost immunization regimen that incorporates recombinant ovine atadenovirus and fowlpox virus

scientific article published on September 2010

Innate immune recognition of poxviral vaccine vectors

scientific article published on October 2011

Is the Induction of Tumor Cell Senescence the Key to a Good Irradiated Tumor Vaccine? ⬇️

scientific article published on May 1, 2012

Monte Carlo simulations of dose distributions with necrotic tumor targeted radioimmunotherapy

scientific article published on 12 March 2014

Multifunctional core-shell magnetic cisplatin nanocarriers

scientific article

Nutlin-3a efficacy in sarcoma predicted by transcriptomic and epigenetic profiling

scientific article published on 13 December 2013

Nutlin-3a is a potential therapeutic for ewing sarcoma

scientific article published on 23 November 2010

Open-label, multicentre safety study of vemurafenib in 3219 patients with BRAFV600 mutation-positive metastatic melanoma: 2-year follow-up data and long-term responders' analysis.

scientific article

Phase I study evaluating the safety and efficacy of oral panobinostat in combination with radiotherapy or chemoradiotherapy in patients with inoperable stage III non-small-cell lung cancer

scientific article

Phase II study evaluating efficacy and safety of everolimus with letrozole for management of advanced (unresectable or metastatic) non-small cell lung cancer after failure of platinum-based treatment: a preliminary analysis of toxicity.

scientific article published on 11 December 2014

Phase II trial of continuous once-daily dosing of sunitinib as first-line treatment in patients with metastatic renal cell carcinoma.

scientific article published on 6 September 2011

Postchemotherapy and Tumor-Selective Targeting with the La-Specific DAB4 Monoclonal Antibody Relates to Apoptotic Cell Clearance

scientific article published on 27 March 2014

Pre-activation of the p53 pathway through Nutlin-3a sensitises sarcomas to drozitumab therapy

scientific article published on 13 May 2013

Prolonged and severe myelosuppression in two patients after low-dose temozolomide treatment- case study and review of literature.

scientific article published on 26 May 2007

Rare and novel epidermal growth factor receptor mutations in non-small-cell lung cancer and lack of clinical response to gefitinib in two cases.

scientific article

Recombinant fowlpox virus elicits transient cytotoxic T cell responses due to suboptimal innate recognition and recruitment of T cell help

scientific article published on 27 May 2008

Risk of cumulative toxicity after complete melanoma response with pembrolizumab

scientific article published in February 2017

Scrutinizing calcium flux oscillations in T lymphocytes to deduce the strength of stimulus.

scientific article published on 14 January 2015

Sentinel node biopsy for melanoma: The medical oncology perspective

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

scientific journal article

Suppression of androgen receptor signaling in prostate cancer cells by an inhibitory receptor variant.

scientific article published on 19 January 2006

T-cell recognition of a prostate specific antigen is not sufficient to induce prostate tissue destruction

article

Targeted α-therapy using 227Th-APOMAB and cross-fire antitumour effects: preliminary in-vivo evaluation.

scientific article published on December 2014

The La Autoantigen Is a Malignancy-Associated Cell Death Target That Is Induced by DNA-Damaging Drugs

scientific article published on 01 September 2007

The La antigen is over-expressed in lung cancer and is a selective dead cancer cell target for radioimmunotherapy using the La-specific antibody APOMAB®.

scientific article published on 04 January 2014

The atypical chemokine receptor CCX-CKR regulates metastasis of mammary carcinoma via an effect on EMT.

scientific article published on 15 July 2014

The inducible caspase-9 suicide gene system as a "safety switch" to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells.

scientific article

The potential role of fowlpox virus in rational vaccine design

scientific article published on August 2006

The use of vemurafenib in Australian patients with unresectable or metastatic melanoma containing the V600 BRAF gene mutation

scientific article published on April 2014

Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice

scientific article

Transforming growth factor-β-mediated signaling in T lymphocytes impacts on prostate-specific immunity and early prostate tumor progression

Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor

scientific article published on 5 April 2013

Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436).

scientific article published on 05 July 2013

Unravelling the complexity of cancer-immune system interplay

scientific article published on June 2010

Vedolizumab: a novel treatment for ipilimumab-induced colitis

scientific article published on 18 August 2016

Vemurafenib in patients with BRAF(V600) mutated metastatic melanoma: an open-label, multicentre, safety study.

scientific article

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