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List of works by Joel L. Sussman

3-D structure of serum paraoxonase 1 sheds light on its activity, stability, solubility and crystallizability

scientific article published in September 2007

3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates

scientific article

6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase

scientific article

A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides

scientific article published on 06 March 2020

A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica

scientific article

A paradigm for single nucleotide polymorphism analysis: the case of the acetylcholinesterase gene

scientific article published on November 2004

A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase.

scientific article

A server and database for dipole moments of proteins.

scientific article

A structure-based design approach to the development of novel, reversible AChE inhibitors

scientific article

Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity

scientific article

Acetylcholinesterase in motion: Visualizing conformational changes in crystal structures by a morphing procedure

scientific article published on 01 March 2003

Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology

scientific article

Acetylcholinesterase: From 3D structure to function

scientific article

Acetylcholinesterase: Substrate traffic and inhibition

scientific article published on 07 March 2012

Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease

scientific article published on January 2003

Acetylcholinesterase: how is structure related to function?

scientific article published on 06 June 2008

Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy

scientific article

Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica 1 1Edited by R. Huber

scientific article published on 01 February 2000

Adenine-guanine base pairing ribosomal RNA.

scientific article published on April 1982

Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization

scientific article published on 8 October 2008

An NMR approach to tRNA tertiary structure in solution ⬇️

scientific article published on April 1, 1977

An encyclopedic effort to make 3D structures easier to understand

scientific article published on 18 February 2009

An idea whose time has come

scientific article

An unusual halotolerant alpha-type carbonic anhydrase from the alga Dunaliella salina functionally expressed in Escherichia coli

scientific article published in March 2003

Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations

scientific article published on April 2005

Apotheosis, not apocalypse: methods in protein crystallography

scientific article published on 01 November 2000

Assessment of CASP8 structure predictions for template free targets

scientific article

Assessment of disorder predictions in CASP8

scientific article published on 01 January 2009

AutoDep: a web-based system for deposition and validation of macromolecular structural information

scientific article published on 01 July 2000

Backbone and side chain NMR assignments for the intrinsically disordered cytoplasmic domain of human neuroligin-3.

scientific article published on 7 June 2011

Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations

scientific article

Biochemical Evaluation of Photolabile Precursors of Choline and of Carbamylcholine for Potential Time-Resolved Crystallographic Studies on Cholinesterases†

scientific article published on 01 August 1996

Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3.

scientific article

Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors.

scientific article published on January 2007

Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme

scientific article

Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1

scientific article

Characterization of gene-activated human acid- -glucosidase: Crystal structure, glycan composition, and internalization into macrophages

scientific article

Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies

scientific article published on 19 September 2006

Comparison of a molecular dynamics model with the X-ray structure of the N370S acid-beta-glucosidase mutant that causes Gaucher disease

scientific article

Complexes of Alkylene-Linked Tacrine Dimers withTorpedo californicaAcetylcholinesterase: Binding of Bis(5)-tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge

scientific article published on 01 September 2006

Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis

scientific article

Constrained-restrained least-squares (CORELS) refinement of proteins and nucleic acids

scientific article published on 01 January 1985

Context-dependent resistance to proteolysis of intrinsically disordered proteins

scientific article published on 08 June 2011

Control of the rate of evaporation in protein crystallization by the 'microbatch under oil' method

scientific article published on 30 August 2008

Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis ⬇️

scientific article published on November 15, 1992

Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly

scientific article published on 11 December 2018

Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase

scientific article published on 01 August 2005

Crystal Structure of Thioflavin T Bound to the Peripheral Site of Torpedo californica Acetylcholinesterase Reveals How Thioflavin T Acts as a Sensitive Fluorescent Reporter of Ligand Binding to the Acylation Site

scientific article

Crystal structure of YagE, a putative DHDPS-like protein from Escherichia coli K12

scientific article

Crystal structure of a eukaryotic initiator tRNA ⬇️

scientific article published on March 8, 1979

Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level

scientific article

Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease

scientific article

Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime

scientific article

Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues

scientific article

Design and synthesis of peptides that bind alpha-bungarotoxin with high affinity and mimic the three-dimensional structure of the binding-site of acetylcholine receptor

scientific article

Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase

scientific article published on 30 July 2009

Detection of alpha/beta-hydrolase fold in the cell surface esterases of Acinetobacter species using an analysis of 3D profiles

scientific article

Directed evolution of hydrolases for prevention of G-type nerve agent intoxication

article by Rinkoo Devi Gupta et al published February 2011 in Nature Chemical Biology

Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization

scientific article

Dynamic mechanism of E2020 binding to acetylcholinesterase: a steered molecular dynamics simulation

scientific article published in December 2005

Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro

scientific article published on 30 January 2014

Eukaryotic expression: developments for structural proteomics.

scientific article published on 19 September 2006

Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation

article

Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification

scientific article published on 01 April 2012

Expression of protein complexes using multiple Escherichia coli protein co-expression systems: a benchmarking study

scientific article published on 5 March 2011

External and internal electrostatic potentials of cholinesterase models

scientific article published in October 1997

First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.

scientific article published on 19 September 2006

Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics

scientific article published on 23 May 2008

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations

scientific article

FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded

scientific article

From SPINE to SPINE-2 complexes and beyond ⬇️

scientific article published on May 17, 2011

Function and structure of inherently disordered proteins

scientific article

G protein-coupled receptors show unusual patterns of intrinsic unfolding

scientific article published on 01 February 2005

HalX: an open-source LIMS (Laboratory Information Management System) for small- to large-scale laboratories

scientific article published on 26 May 2005

Histochemical method for characterization of enzyme crystals: application to crystals of Torpedo californica acetylcholinesterase.

scientific article published on 23 August 2001

How Does Ammonium Interact with Aromatic Groups? A Density Functional Theory (DFT/B3LYP) Investigation

How does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations

scientific article

Hydrogen bonding in yeast phenylalanine transfer RNA ⬇️

scientific article published on December 1, 1975

Identification, cDNA cloning, expression, crystallization and preliminary X-ray analysis of an exceptionally halotolerant carbonic anhydrase from Dunaliella salina

scientific article published on 23 May 2003

In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases

scientific article

Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design

scientific article published in April 2008

Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.

scientific article published on 28 October 2005

Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine

scientific article

Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase

scientific article

Molecular basis of reduced glucosylceramidase activity in the most common Gaucher disease mutant, N370S

scientific article

Natural protein engineering: a uniquely salt-tolerant, but not halophilic, alpha-type carbonic anhydrase from algae proliferating in low- to hyper-saline environments

scientific article published on 13 February 2004

New directions in the treatment of Gaucher disease

scientific article published on March 2004

New trends in protein expression

scientific article published on 04 August 2010

Noncovalent interaction or chemical bonding between alkaline earth cations and benzene? A quantum chemistry study using MP2 and density-functional theory methods

scholarly article by Xiao Jian Tan et al published November 2001 in Chemical Physics Letters

Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.

scientific article published in March 2008

Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system

scientific article

Protein Data Bank Deposits

scientific article published on 01 December 1998

Protein Data Bank archives of three-dimensional macromolecular structures.

scientific article

Protein production and purification

scientific article

Proteomic signatures: amino acid and oligopeptide compositions differentiate among phyla

scientific article published in January 2004

Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules

scientific article

Proteopedia: A collaborative, virtual 3D web-resource for protein and biomolecule structure and function

scientific article published in September 2010

Proteopedia: a status report on the collaborative, 3D web-encyclopedia of proteins and other biomolecules

scientific article

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase

scientific article

RIKEN aids international structural genomics efforts

scientific article published in January 2007

Refined crystal structures of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin

scientific article

Shedding UV light on the phase problem

scientific article published in April 2006

Shoot-and-Trap: Use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography

scientific article

Site-directed mutagenesis of active-site-related residues in Torpedo acetylcholinesterase Presence of a glutamic acid in the catalytic triad

scientific article published on 01 September 1992

Site-directed mutants designed to test back-door hypotheses of acetylcholinesterase function.

scientific article

Solvent behaviour in flash-cooled protein crystals at cryogenic temperatures.

scientific article published in April 2001

Specific protein dynamics near the solvent glass transition assayed by radiation-induced structural changes

scientific article

Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers.

scientific article

Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase.

scientific article published on 26 June 2012

Structural comparison of differently glycosylated forms of acid-β-glucosidase, the defective enzyme in Gaucher disease

scientific article published on 23 November 2006

Structural disorder serves as a weak signal for intracellular protein degradation.

scientific article

Structural insights into substrate traffic and inhibition in acetylcholinesterase

scientific article published on 8 June 2006

Structural proteomics: from the molecule to the system.

scientific article

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes

scientific article

Structure of Estradiol Metal Chelate and Estrogen Receptor Complex: The Basis for Designing a New Class of Selective Estrogen Receptor Modulators

scientific article

Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution

scientific article

Structure of recombinant human carboxylesterase 1 isolated from whole cabbage looper larvae

scientific article

The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase

scientific article

The binding site of acetylcholine receptor: from synthetic peptides to solution and crystal structure

scientific article

The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad

scientific article

The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action

scientific article

The effect of binding of metal ions on the three-dimensional structure of demetallized concanavalin A.

scientific article published in November 1978

The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded.

scientific article

The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties

scientific article published on October 2009

The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy.

scientific article

The structure of the complex between avidin and the dye, 2-(4'-hydroxyazobenzene) benzoic acid (HABA)

scientific article published on 01 August 1993

The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix

scientific article

Three-dimensional structure determination of proteins related to human health in their functional context at The Israel Structural Proteomics Center (ISPC). This paper was presented at ICCBM10.

scientific article

Three-dimensional structure of a complex of E2020 with acetylcholinesterase from Torpedo californica

scientific article published on 01 June 1998

Three-dimensional structure of a halotolerant algal carbonic anhydrase predicts halotolerance of a mammalian homolog

scientific article

Three-dimensional structures of bulge-containing DNA fragments

scientific article

Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG+ strategy

scientific article published on 28 September 2005

Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography

scientific article

X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease

scientific article published on 6 April 2005

X-ray structure of human acid-β-glucosidase, the defective enzyme in Gaucher disease

scientific article

[9] Crystal forms of avidin

scientific article published on 01 January 1990

eMovie: a storyboard-based tool for making molecular movies

scientific article published on 19 April 2007

pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins

scientific article

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