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List of works by Carlo Ballatore

1,2,4-Triazolo[1,5-a]pyrimidines in drug design

scientific article published on 14 January 2019

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model

scientific article published on 07 November 2018

A facile route to paclitaxel C-10 carbamates

scientific article published on 01 May 2005

Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes.

scientific article

Aminothienopyridazine inhibitors of tau aggregation: evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties.

scientific article

Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation ⬇️

scientific article published on February 26, 2013

Aminothienopyridazines as imaging probes of tau pathology: a patent evaluation of WO2013090497.

scientific article published on 3 January 2014

Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D

scientific article

Brain-Penetrant Triazolopyrimidine and Phenylpyrimidine Microtubule Stabilizers as Potential Leads to Treat Human African Trypanosomiasis

scientific article published on 07 August 2018

Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies ⬇️

scientific article published on August 1, 2012

Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies

scientific article

Carboxylic acid (bio)isosteres in drug design

scientific article published on 29 January 2013

Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro

scientific article published on 31 October 2020

Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists

scientific article

Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR

scientific article

Design, Synthesis, and Evaluation of An Anti‐trypanosomal [1,2,4]Triazolo[1,5‐<i>a</i>]pyrimidine Probe for Photoaffinity Labeling Studies

scientific article published in 2024

Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines

scientific article published on 05 May 2018

Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as new glycogen synthase kinase-3β inhibitors

scientific article

Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs

scientific article published on 01 February 2000

Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy ⬇️

scientific article published on October 13, 2010

Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-<i>a</i>]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies

scientific article published on 07 January 2021

Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group

scientific article published on 23 July 2014

High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation

scientific article

Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening

scientific article published on August 2009

Kinase-mediated trapping of bi-functional conjugates of paclitaxel or vinblastine with thymidine in cancer cells.

scientific article published on 25 July 2006

Lactate cannot substitute for alanine in d4T-based anti-HIV nucleotide prodrugs--despite efficient esterase-mediated hydrolysis.

scientific article published on November 1998

Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies

scientific article published on 28 September 2012

Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease

scientific article

Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies

scientific article published on January 2011

Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies

scientific article published on 29 November 2016

Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies

scientific article published on 25 April 2007

Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine

scientific article published on 14 March 2015

Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists

scientific article published on 24 July 2014

Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase

scientific article published on 04 February 2020

Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes

scientific article

Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture.

scientific article

Solid phase synthesis of 2-aminobenzothiazoles

scientific article

Structure Property Relationships of Carboxylic Acid Isosteres

scientific article published on 11 March 2016

Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.

scientific article published in April 2001

Targeting heat shock proteins on cancer cells: selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand

scientific article published in August 2006

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

scientific article (publication date: September 2007)

The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice ⬇️

scientific article published on March 14, 2012

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies ⬇️

scientific article published on December 14, 2010

The design, synthesis, and evaluation of two universal doxorubicin-linkers: preparation of conjugates that retain topoisomerase II activity

scientific article published on 18 October 2005

The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship.

scientific article

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