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List of works by Alessandro Pezzella

14,15N beam from cyanide compounds

17beta-Estradiol nitration by peroxidase/H2O2/NO2-: a chemical assessment

scientific article

5,6-Dihydroxyindole Chemistry: Unexplored Opportunities Beyond Eumelanin

5,6-Dihydroxyindole oxidation in phosphate buffer/polyvinyl alcohol: a new model system for studies of visible chromophore development in synthetic eumelanin polymers

scientific article published on 16 April 2010

5,6-Dihydroxyindole-2-carboxylic Acid–TiO2 Charge Transfer Complexes in the Radical Polymerization of Melanogenic Precursor(s)

article published in 2016

5,6-Dihydroxyindoles and Indole-5,6-diones

5,6-dihydroxyindole tetramers with "anomalous" interunit bonding patterns by oxidative coupling of 5,5',6,6'-tetrahydroxy-2,7'-biindolyl: emerging complexities on the way toward an improved model of eumelanin buildup

scientific article published on 2 November 2007

6,7-Dihydroxy-1,2,3,4-tetrahydroisoquinoline formation by iron mediated dopamine oxidation: a novel route to endogenous neurotoxins under oxidative stress conditions

scholarly article by Alessandra Napolitano et al published April 1999 in Tetrahedron Letters

A novel fluoride-sensing scaffold by a peculiar acid-promoted trimerization of 5,6-dihydroxyindole

Acid-Promoted Reaction of the Stilbene Antioxidant Resveratrol with Nitrite Ions: Mild Phenolic Oxidation at the 4‘-Hydroxystiryl Sector Triggering Nitration, Dimerization, and Aldehyde-Forming Routes

scientific article published on 01 May 2006

An electrochemical study of natural and chemically controlled eumelanin

An expedient one-pot entry to catecholestrogens and other catechol compounds via IBX-mediated phenolic oxygenation

article published in 2005

An integrated approach to the structure of Sepia melanin. Evidence for a high proportion of degraded 5,6-dihydroxyindole-2-carboxylic acid units in the pigment backbone

Anomalous evolution of broadband optical absorption reveals dynamic solid state reorganization during eumelanin build-up in thin films

scientific article published on 31 March 2017

Antimicrobial activity of eumelanin-based hybrids: The role of TiO2 in modulating the structure and biological performance

scientific article published on 12 February 2017

Aqueous photo(electro)catalysis with eumelanin thin films

article by Ludovico Migliaccio et al published 2018 in Materials Horizons

Atropodiastereoselectivity in solid state BINOL synthesis: Leads from the estradiol platform

scientific article published on 15 February 2012

Atropoisomeric melanin intermediates by oxidation of the melanogenic precursor 5,6-dihydroxyindole-2-carboxylic acid under biomimetic conditions

Bioinspired hybrid eumelanin–TiO2 antimicrobial nanostructures: the key role of organo–inorganic frameworks in tuning eumelanin's biocide action mechanism through membrane interaction

scholarly article in RSC Advances, vol. 8 no. 50, 2018

Boosting, probing and switching-off visible light-induced photocurrents in eumelanin-porous silicon hybrids

scholarly article in RSC Advances, vol. 5 no. 70, 2015

Bottom-up approach to eumelanin photoprotection: emission dynamics in parallel sets of water-soluble 5,6-dihydroxyindole-based model systems

scientific article

Chemical and structural diversity in eumelanins: unexplored bio-optoelectronic materials

scientific article published on January 2009

Chemical, pulse radiolysis and density functional studies of a new, labile 5,6-indolequinone and its semiquinone

scientific article

Cyclic structural motifs in 5,6-dihydroxyindole polymerization uncovered: biomimetic modular buildup of a unique five-membered macrocycle

scientific article published on July 2010

Disentangling eumelanin "black chromophore": visible absorption changes as signatures of oxidation state- and aggregation-dependent dynamic interactions in a model water-soluble 5,6-dihydroxyindole polymer

scientific article published in October 2009

Dopaquinone redox exchange with dihydroxyindole and dihydroxyindole carboxylic acid

scientific article

Effect of substrate temperature on MAPLE deposition of synthetic eumelanin films

Efficient synthesis of 5,6-dihydroxyindole dimers, key eumelanin building blocks, by a unified o-ethynylaniline-based strategy for the construction of 2-linked biindolyl scaffolds

scientific article published in September 2009

Eumelanin 3D Architectures: Electrospun PLA Fiber Templating for Mammalian Pigment Microtube Fabrication.

scientific article published on 16 April 2015

Eumelanin Coated PLA Electrospun Micro Fibers as Bioinspired Cradle for SH-SY5Y Neuroblastoma Cells Growth and Maturation

scientific article published on 30 October 2017

Eumelanin Coating of Silica Aerogel by Supercritical Carbon Dioxide Deposition of a 5,6-Dihydroxyindole Thin Film

Eumelanin buildup on the nanoscale: aggregate growth/assembly and visible absorption development in biomimetic 5,6-dihydroxyindole polymerization

scientific article published on 17 July 2012

Eumelanin from the Black Soldier Fly as Sustainable Biomaterial: Characterisation and Functional Benefits in Tissue-Engineered Composite Scaffolds

scientific article published in 2022

Eumelanin-Based Organic Bioelectronics: Myth or Reality?

Eumelanin-PEDOT:PSS Complementing En Route to Mammalian-Pigment-Based Electrodes: Design and Fabrication of an ITO-Free Organic Light-Emitting Device

Eumelanin: An Old Natural Pigment and a New Material for Organic Electronics - Chemical, Physical, and Structural Properties in Relation to Potential Applications

Excited-State Proton-Transfer Processes of DHICA Resolved: From Sub-Picoseconds to Nanoseconds.

scientific article published on 10 April 2013

Exploring the frontiers of synthetic eumelanin polymers by high-resolution matrix-assisted laser/desorption ionization mass spectrometry

scientific article

First synthetic entry to the trimer stage of 5,6-dihydroxyindole polymerization: ortho-alkynylaniline-based access to the missing 2,7':2',7''-triindole

scientific article published on 6 August 2010

Formation of novel tetrahydroisoquinoline retinoids by Pictet–Spengler reaction of dopamine and retinaldehyde under conditions of relevance to biological environments

scholarly article by Alessandro Pezzella & Giuseppe Prota published September 2002 in Tetrahedron Letters

Free radical coupling of o-semiquinones uncovered

scientific article published on 31 July 2013

Functionality of epidermal melanin pigments: current knowledge on UV-dissipative mechanisms and research perspectives

scientific article

Generation of the Neurotoxin 6-Hydroxydopamine by Peroxidase/H2O2 Oxidation of Dopamine

scientific article published on 01 March 1995

Glycosylated Eumelanin Building Blocks by Thioglycosylation of 5,6-Diacetoxyindole with an Expedient Selenium-Based Dynamic-Mixture Methodology

Heparin conjugated silica nanoparticle synthesis

Identification of a new small bioactive peptide from Lactobacillus gasseri supernatant.

scientific article published on 8 November 2016

Impact of Eumelanin-PEDOT Blending: Increased PEDOT Crystalline Order and Packing-Conductivity Relationship in Ternary PEDOT:PSS:Eumelanin Thin Films

In Situ Formation of Dendrites in Eumelanin Thin Films between Gold Electrodes

In-situ sol-gel synthesis and characterization of bioactive pHEMA/SiO2 blend hybrids

scientific article

Intermolecular π-electron perturbations generate extrinsic visible contributions to eumelanin black chromophore in model polymers with interrupted interring conjugation.

scientific article published on 2 November 2012

Iron-Mediated Generation of the Neurotoxin 6-Hydroxydopamine Quinone by Reaction of Fatty Acid Hydroperoxides with Dopamine: A Possible Contributory Mechanism for Neuronal Degeneration in Parkinson's Disease

scholarly article by Alessandro Pezzella et al published July 1997 in Journal of Medicinal Chemistry

Irreversible evolution of eumelanin redox states detected by an organic electrochemical transistor: en route to bioelectronics and biosensing

article

Lack of visible chromophore development in the pulse radiolysis oxidation of 5,6-dihydroxyindole-2-carboxylic acid oligomers: DFT investigation and implications for eumelanin absorption properties

scientific article published in May 2009

Matrix assisted pulsed laser deposition of melanin thin films

Measurement of 1323 and 1487 keV resonances inN15(α,γ)F19with the recoil separator ERNA ⬇️

scholarly article

Melanin Biopolymers: Tailoring Chemical Complexity for Materials Design

scientific article published on 23 December 2019

Melanin-Inspired Organic Electronics: Electroluminescence in Asymmetric Triazatruxenes

scientific article published on 04 March 2015

Melanin-based flexible supercapacitors

article published in 2016

Melanins and melanogenesis: from pigment cells to human health and technological applications

scientific article

Melanins and melanogenesis: methods, standards, protocols

scientific article published on 21 June 2013

Mild and efficient iodination of aromatic and heterocyclic compounds with the NaClO2/NaI/HCl system

Neuroglobin modification by reactive quinone species

scientific article published on 11 November 2013

New Reaction Pathways of Dopamine under Oxidative Stress Conditions: Nonenzymatic Iron-Assisted Conversion to Norepinephrine and the Neurotoxins 6-Hydroxydopamine and 6,7-Dihydroxytetrahydroisoquinoline

scientific article published on 01 November 1999

New directions in Parkinson’s research and treatment

scholarly article by Alessandra Napolitano et al published October 1998 in Expert Opinion on Therapeutic Patents

New insight into the oxidative chemistry of noradrenaline: competitive o-quinone cyclisation and chain fission routes leading to an unusual 4-[bis-(1H-5,6-dihydroxyindol-2-yl)methyl]-1,2-dihydroxybenzene derivative

New pyrrole acids by oxidative degradation of eumelanins with hydrogen peroxide. Further hints to the mechanism of pigment breakdown

Oxidative chemistry of 2-nitro and 4-nitroestradiol: Dichotomous behavior of radical intermediates and novel potential routes for oxyfunctionalization and B-ring fission of steroidal scaffolds

scientific article published on 29 March 2005

Oxidative chemistry of hydroxytyrosol: isolation and characterisation of novel methanooxocinobenzodioxinone derivatives

article published in 2003

Oxidative chemistry of the natural antioxidant hydroxytyrosol: hydrogen peroxide-dependent hydroxylation and hydroxyquinone/o-quinone coupling pathways

Oxidative coupling of 17beta-estradiol: inventory of oligomer products and configuration assignment of atropoisomeric c4-linked biphenyl-type dimers and trimers

scientific article

Oxidative degradation of melanins to pyrrole acids: A model study

Oxidative polymerisation of 5,6-dihydroxyindole-2-carboxylic acid to melanin: A new insight

Photovoltaic properties of PSi impregnated with eumelanin

scientific article published on 9 July 2012

Physical and Chemical Control of Interface Stability in Porous Si–Eumelanin Hybrids

Plant catechols and their S-glutathionyl conjugates as antinitrosating agents: expedient synthesis and remarkable potency of 5-S-glutathionylpiceatannol.

scientific article published in December 2008

Practical one-pot conversion of 17β-estradiol to 10β-hydroxy- (p-quinol) and 10β-chloro-17β-hydroxyestra-1,4-dien-3-one

scientific article published on 30 May 2006

Probing the Eumelanin-Silica Interface in Chemically Engineered Bulk Hybrid Nanoparticles for Targeted Subcellular Antioxidant Protection.

scientific article published on 12 October 2017

Protonic and Electronic Transport in Hydrated Thin Films of the Pigment Eumelanin

article published in 2015

Reaction of dihydrolipoic acid with juglone and related naphthoquinones: unmasking of a spirocyclic 1,3-dithiane intermediate en route to naphtho[1,4]dithiepines

Regioselective Phenol or Carbinol Glycosidation of 17β-Estradiol and Derivatives Thereof

Relation between Local Structure, Electric Dipole, and Charge Carrier Dynamics in DHICA Melanin: A Model for Biocompatible Semiconductors

scientific article published on 27 January 2020

Role of solvent, pH, and molecular size in excited-state deactivation of key eumelanin building blocks: implications for melanin pigment photostability

scientific article

Room-temperature surface-assisted reactivity of a melanin precursor: silver metal–organic coordination versus covalent dimerization on gold

article

Self-assembly of 5,6-dihydroxyindole-2-carboxylic acid: polymorphism of a eumelanin building block on Au(111)

scientific article published on 01 March 2019

Sequential Proton-Coupled Electron Transfer Mediates Excited-State Deactivation of a Eumelanin Building Block.

scientific article published on 14 February 2017

Short-Lived Quinonoid Species from 5,6-Dihydroxyindole Dimers en Route to Eumelanin Polymers: Integrated Chemical, Pulse Radiolytic, and Quantum Mechanical Investigation

scientific article published on 01 December 2006

Spontaneous wrinkle emergence in nascent eumelanin thin films

scientific article published on 29 October 2019

Stem cell-compatible eumelanin biointerface fabricated by chemically controlled solid state polymerization

Structural effects on the electronic absorption properties of 5,6-dihydroxyindole oligomers: the potential of an integrated experimental and DFT approach to model eumelanin optical properties

scientific article published in May 2008

Structure of Melanins

Superior Photoprotective Motifs and Mechanisms in Eumelanins Uncovered

scientific article published on 11 August 2014

Supplementing π-systems: eumelanin and graphene-like integration towards highly conductive materials for the mammalian cell culture bio-interface

article

Surface-Functionalization of Nanostructured Cellulose Aerogels by Solid State Eumelanin Coating

scientific article published on 6 January 2016

Synthesis of optically active tetrameric melanin intermediates by oxidation of the melanogenic precursor 5,6-dihydroxyindole-2-carboxylic acid under biomimetic conditions

Synthesis, structure and bioactivity of pHEMA/SiO2 hybrids derived through in situ sol–gel process

THz spectroscopy on graphene-like materials for bio-compatible devices

The First 5,6-Dihydroxyindole Tetramer by Oxidation of 5,5‘,6,6‘-Tetrahydroxy- 2,4‘-biindolyl and an Unexpected Issue of Positional Reactivity en Route to Eumelanin-Related Polymers

scientific article published on 09 March 2007

The Toluene o-Xylene Monooxygenase Enzymatic Activity for the Biosynthesis of Aromatic Antioxidants

scientific article

The first characterisation of a transient 5,6-indolequinone

The first entry to 5,6-dihydroxy-3-mercaptoindole, 5-hydroxy-3-mercaptoindole and their 2-carbomethoxy derivatives by a mild thiocyanation/reduction methodology

The role of residue Thr249 in modulating the catalytic efficiency and substrate specificity of catechol-2,3-dioxygenase from Pseudomonas stutzeri OX1.

scientific article

Titania as a driving agent for DHICA polymerization: a novel strategy for the design of bioinspired antimicrobial nanomaterials

scientific article published on 02 March 2015

Towards the development of a novel bioinspired functional material: Synthesis and characterization of hybrid TiO2/DHICA-melanin nanoparticles

article

Trichocyanines: a Red-Hair-Inspired Modular Platform for Dye-Based One-Time-Pad Molecular Cryptography.

scientific article published on 5 February 2015

Tuning the specificity of the recombinant multicomponent toluene o-xylene monooxygenase from Pseudomonas sp. strain OX1 for the biosynthesis of tyrosol from 2-phenylethanol

scientific article published on 10 June 2011

Tyrosinase-catalyzed oxidation of 17beta-estradiol: structure elucidation of the products formed beyond catechol estrogen quinones

scientific article published in September 2005

UV-dissipation mechanisms in the eumelanin building block DHICA.

scientific article published on August 2010

Ultrafast excited state dynamics of 5,6-dihydroxyindole, a key eumelanin building block: nonradiative decay mechanism

scientific article published in September 2009

π-Electron Manipulation of the 5,6-Dihydroxyindole/Quinone System by 3-Alkynylation: Mild Acid-Mediated Entry to (Cross)-Conjugated Scaffolds and Paradigms for Medium-Tunable Chromophores

scientific article published on 10 May 2011

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