List of works - Raffaele De Palma

A chemical investigation of the Antarctic spongeLyssodendoryx flabellata

scientific article published on 06 October 2011

A new mouse model of Peyronie's disease: An increased expression of hypoxia-inducible factor-1 target genes during the development of penile changes

scientific article published on 28 May 2008

A simple twist of phosphate: Immunological synapse formation and T cell receptor signaling outcome in regulatory T cells.

scientific article published in December 2017

Activation of protease-activated receptor-2 reduces airways inflammation in experimental allergic asthma

scientific article published in October 2007

Adoptive transfer of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T cells with in vitro antitumor activity boosts LMP2-specific immune response in a patient with EBV-related nasopharyngeal carcinoma.

scientific article published in January 2004

Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis.

scientific article

Analysis of the antigen specific T cell repertoires in HIV infection

scientific article published in November 2001

Anti-epidermal growth factor receptor monoclonal antibodies in cancer therapy.

scientific article published on October 2009

Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells

scientific article published on 29 May 2013

Antitumour efficacy of MEK inhibitors in human lung cancer cells and their derivatives with acquired resistance to different tyrosine kinase inhibitors

scientific article

Autoimmune B-cell lymphopenia after successful adoptive therapy with telomerase-specific T lymphocytes.

scientific article

C-reactive protein induces tissue factor expression and promotes smooth muscle and endothelial cell proliferation

scientific article published in October 2005

C-reactive protein is released in the coronary circulation and causes endothelial dysfunction in patients with acute coronary syndromes.

scientific article

Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia.

scientific article published on 19 December 2002

Comparative analysis of new innovative vaccine formulations based on the use of procaryotic display systems

scientific article published on 5 December 2006

Cytokine mRNA expression in chronically rejected human renal allografts

scientific article published in October 2004

Cytotoxic molecule mRNA expression in chronically rejected human kidney allografts

scientific article published in July 2005

Demethylation of the RORC2 and IL17A in human CD4+ T lymphocytes defines Th17 origin of nonclassic Th1 cells.

scientific article published on 4 March 2015

Dendritic cells pulsed with polyomavirus BK antigen induce ex vivo polyoma BK virus-specific cytotoxic T-cell lines in seropositive healthy individuals and renal transplant recipients.

scientific article published on December 2003

Distinctive features of classic and nonclassic (Th17 derived) human Th1 cells

scientific article published on 25 October 2012

Early Systemic Sclerosis: Serum Profiling of Factors Involved in Endothelial, T-cell, and Fibroblast Interplay is Marked by Elevated Interleukin-33 Levels

scientific article published on 24 April 2014

Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis

scientific article published on 01 August 2011

Expression of functional tissue factor in activated T-lymphocytes in vitro and in vivo: A possible contribution of immunity to thrombosis?

scientific article published on 3 May 2016

Fat: a matter of disturbance for the immune system.

scientific article

Human T cells interacting with HNSCC-derived mesenchymal stromal cells acquire Tissue-Resident memory like properties

scientific article published on 22 May 2020

Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate.

scholarly article

Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.

scientific article published on 28 July 2008

Human naive CD4 T-cell clones specific for HIV envelope persist for years in vivo in the absence of antigenic challenge

scientific article published on October 2005

Human urotensin II induces tissue factor and cellular adhesion molecules expression in human coronary endothelial cells: an emerging role for urotensin II in cardiovascular disease.

scientific article published on 12 February 2008

Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation

scientific article

IL-4-induced gene 1 maintains high Tob1 expression that contributes to TCR unresponsiveness in human T helper 17 cells.

scientific article

Identification of T cells responding to a self-protein modified by an external agent.

scientific article

Identification of new Th peptides from the cytomegalovirus protein pp65 to design a peptide library for generation of CD4 T cell lines for cellular immunoreconstitution.

scientific article published on 29 March 2004

Increased TGF-α as a mechanism of acquired resistance to the anti-EGFR inhibitor cetuximab through EGFR-MET interaction and activation of MET signaling in colon cancer cells

scientific article published on 11 October 2013

Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells ⬇️

scientific article published on May 8, 2012

Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate.

scientific article

Local cytokine production in patients with Acute Coronary Syndromes: a look into the eye of the perfect (cytokine) storm.

scientific article published on 17 May 2014

Major histocompatibility complex-independent recognition of a distinctive pollen antigen, most likely a carbohydrate, by human CD8+ alpha/beta T cells

scientific article published on September 1997

NF-κB-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells ⬇️

scientific article published on January 31, 2011

Neopterin induces pro-atherothrombotic phenotype in human coronary endothelial cells.

scientific article

New Role of Adult Lung c-kit+ Cells in a Mouse Model of Airway Hyperresponsiveness

scientific article published on 20 December 2016

Nobiletin inhibits oxidized-LDL mediated expression of Tissue Factor in human endothelial cells through inhibition of NF-κB.

scientific article published on 22 December 2016

Patients With Acute Coronary Syndrome Show Oligoclonal T-Cell Recruitment Within Unstable Plaque

scientific article published on 7 February 2006

Perianal Crohn's disease and hidradenitis suppurativa: a possible common immunological scenario.

scientific article published on 22 July 2015

Peripheral T cells from patients with early systemic sclerosis kill autologous fibroblasts in co-culture: is T-cell response aimed to play a protective role?

scientific article published on 23 April 2010

Peripheral T lymphocytes from patients with early systemic sclerosis co-cultured with autologous fibroblasts undergo an oligoclonal expansion similar to that occurring in the skin

Posttransplant human herpes virus 8 infection and seroconversion in a Kaposi's sarcoma affected kidney recipient transplanted from a human herpes virus 8 positive living related donor.

scientific article published in August 1998

Pregnancy-associated plasma protein-A promotes TF procoagulant activity in human endothelial cells by Akt-NF-κB axis.

scientific article

Primary and Acquired Resistance of Colorectal Cancer to Anti-EGFR Monoclonal Antibody Can Be Overcome by Combined Treatment of Regorafenib with Cetuximab.

scientific article published on 2 April 2015

Rarity of Human T Helper 17 Cells Is due to Retinoic Acid Orphan Receptor-Dependent Mechanisms that Limit Their Expansion

scientific article published on 09 February 2012

Restricted and conserved T-cell repertoires involved in allorecognition of class II major histocompatibility complex.

scientific article

Senescence and NFκB: A trojan horse in tumors?

scientific article published on December 2012

Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum

scientific article published on 18 October 2005

Sphingosine-1-Phosphate/Sphingosine Kinase Pathway Is Involved in Mouse Airway Hyperresponsiveness

scientific article published on 22 February 2007

Synergistic effects of metformin treatment in combination with gefitinib, a selective EGFR tyrosine kinase inhibitor, in LKB1 wild-type NSCLC cell lines.

scientific article published on 21 May 2013

Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse.

scientific article published on 25 June 2009

TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells.

scientific article

Th17 and regulatory T lymphocytes in primary biliary cirrhosis and systemic sclerosis as models of autoimmune fibrotic diseases

scientific article published on 23 May 2012

Th17 cells in multiple sclerosis express higher levels of JAK2, which increases their surface expression of IFN-γR2.

scientific article published on 4 January 2012

Th22 cells are expanded in multiple sclerosis and are resistant to IFN-β.

scientific article published on 5 August 2014

The involvement of sensory neuropeptides in airway hyper-responsiveness in rabbits sensitized and challenged to Parietaria judaica

scientific article

The transcription factor RFX protects MHC class II genes against epigenetic silencing by DNA methylation.

scientific article

Therapeutic effectiveness of recombinant cancer vaccines is associated with a prevalent T-cell receptor alpha usage by melanoma-specific CD8+ T lymphocytes.

scientific article published in November 2004

Tissue factor is induced by resistin in human coronary artery endothelial cells by the NF-ĸB-dependent pathway

scientific article published on 14 July 2010

Transcoronary Th-17 lymphocytes and acute coronary syndromes: new evidence from the crime scene?

scientific article published on 11 October 2011

beta(3) Integrin subunit mediates the bone-resorbing function exerted by cultured myeloma plasma cells

scientific article published on 4 August 2009

List of works by Raffaele De Palma

A chemical investigation of the Antarctic spongeLyssodendoryx flabellata

A new mouse model of Peyronie's disease: An increased expression of hypoxia-inducible factor-1 target genes during the development of penile changes

A simple twist of phosphate: Immunological synapse formation and T cell receptor signaling outcome in regulatory T cells.

Activation of protease-activated receptor-2 reduces airways inflammation in experimental allergic asthma

Adoptive transfer of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T cells with in vitro antitumor activity boosts LMP2-specific immune response in a patient with EBV-related nasopharyngeal carcinoma.

Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis.

Analysis of the antigen specific T cell repertoires in HIV infection

Anti-epidermal growth factor receptor monoclonal antibodies in cancer therapy.

Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells

Antitumour efficacy of MEK inhibitors in human lung cancer cells and their derivatives with acquired resistance to different tyrosine kinase inhibitors

Autoimmune B-cell lymphopenia after successful adoptive therapy with telomerase-specific T lymphocytes.

C-reactive protein induces tissue factor expression and promotes smooth muscle and endothelial cell proliferation

C-reactive protein is released in the coronary circulation and causes endothelial dysfunction in patients with acute coronary syndromes.

Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia.

Comparative analysis of new innovative vaccine formulations based on the use of procaryotic display systems

Cytokine mRNA expression in chronically rejected human renal allografts

Cytotoxic molecule mRNA expression in chronically rejected human kidney allografts

Demethylation of the RORC2 and IL17A in human CD4+ T lymphocytes defines Th17 origin of nonclassic Th1 cells.

Dendritic cells pulsed with polyomavirus BK antigen induce ex vivo polyoma BK virus-specific cytotoxic T-cell lines in seropositive healthy individuals and renal transplant recipients.

Distinctive features of classic and nonclassic (Th17 derived) human Th1 cells

Early Systemic Sclerosis: Serum Profiling of Factors Involved in Endothelial, T-cell, and Fibroblast Interplay is Marked by Elevated Interleukin-33 Levels

Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis

Expression of functional tissue factor in activated T-lymphocytes in vitro and in vivo: A possible contribution of immunity to thrombosis?

Fat: a matter of disturbance for the immune system.

Human T cells interacting with HNSCC-derived mesenchymal stromal cells acquire Tissue-Resident memory like properties

Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate.

Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.

Human naive CD4 T-cell clones specific for HIV envelope persist for years in vivo in the absence of antigenic challenge

Human urotensin II induces tissue factor and cellular adhesion molecules expression in human coronary endothelial cells: an emerging role for urotensin II in cardiovascular disease.

Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation

IL-4-induced gene 1 maintains high Tob1 expression that contributes to TCR unresponsiveness in human T helper 17 cells.

Identification of T cells responding to a self-protein modified by an external agent.

Identification of new Th peptides from the cytomegalovirus protein pp65 to design a peptide library for generation of CD4 T cell lines for cellular immunoreconstitution.

Increased TGF-α as a mechanism of acquired resistance to the anti-EGFR inhibitor cetuximab through EGFR-MET interaction and activation of MET signaling in colon cancer cells

Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells ⬇️

Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate.

Local cytokine production in patients with Acute Coronary Syndromes: a look into the eye of the perfect (cytokine) storm.

Major histocompatibility complex-independent recognition of a distinctive pollen antigen, most likely a carbohydrate, by human CD8+ alpha/beta T cells

NF-κB-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells ⬇️

Neopterin induces pro-atherothrombotic phenotype in human coronary endothelial cells.

New Role of Adult Lung c-kit+ Cells in a Mouse Model of Airway Hyperresponsiveness

Nobiletin inhibits oxidized-LDL mediated expression of Tissue Factor in human endothelial cells through inhibition of NF-κB.

Patients With Acute Coronary Syndrome Show Oligoclonal T-Cell Recruitment Within Unstable Plaque

Perianal Crohn's disease and hidradenitis suppurativa: a possible common immunological scenario.

Peripheral T cells from patients with early systemic sclerosis kill autologous fibroblasts in co-culture: is T-cell response aimed to play a protective role?

Peripheral T lymphocytes from patients with early systemic sclerosis co-cultured with autologous fibroblasts undergo an oligoclonal expansion similar to that occurring in the skin

Posttransplant human herpes virus 8 infection and seroconversion in a Kaposi's sarcoma affected kidney recipient transplanted from a human herpes virus 8 positive living related donor.

Pregnancy-associated plasma protein-A promotes TF procoagulant activity in human endothelial cells by Akt-NF-κB axis.

Primary and Acquired Resistance of Colorectal Cancer to Anti-EGFR Monoclonal Antibody Can Be Overcome by Combined Treatment of Regorafenib with Cetuximab.

Rarity of Human T Helper 17 Cells Is due to Retinoic Acid Orphan Receptor-Dependent Mechanisms that Limit Their Expansion

Restricted and conserved T-cell repertoires involved in allorecognition of class II major histocompatibility complex.

Senescence and NFκB: A trojan horse in tumors?

Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum

Sphingosine-1-Phosphate/Sphingosine Kinase Pathway Is Involved in Mouse Airway Hyperresponsiveness

Synergistic effects of metformin treatment in combination with gefitinib, a selective EGFR tyrosine kinase inhibitor, in LKB1 wild-type NSCLC cell lines.

Systemic administration of sphingosine-1-phosphate increases bronchial hyperresponsiveness in the mouse.

TGF-beta indirectly favors the development of human Th17 cells by inhibiting Th1 cells.

Th17 and regulatory T lymphocytes in primary biliary cirrhosis and systemic sclerosis as models of autoimmune fibrotic diseases

Th17 cells in multiple sclerosis express higher levels of JAK2, which increases their surface expression of IFN-γR2.

Th22 cells are expanded in multiple sclerosis and are resistant to IFN-β.

The involvement of sensory neuropeptides in airway hyper-responsiveness in rabbits sensitized and challenged to Parietaria judaica

The transcription factor RFX protects MHC class II genes against epigenetic silencing by DNA methylation.

Therapeutic effectiveness of recombinant cancer vaccines is associated with a prevalent T-cell receptor alpha usage by melanoma-specific CD8+ T lymphocytes.

Tissue factor is induced by resistin in human coronary artery endothelial cells by the NF-ĸB-dependent pathway

Transcoronary Th-17 lymphocytes and acute coronary syndromes: new evidence from the crime scene?

beta(3) Integrin subunit mediates the bone-resorbing function exerted by cultured myeloma plasma cells