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List of works by John R. Falck

(Z)-alpha-haloacrylates: an exceptionally stereoselective preparation via Cr(II)-mediated olefination of aldehydes with trihaloacetates

scientific article published on 01 March 2003

11(R),12(S),15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid: an endothelium-derived 15-lipoxygenase metabolite that relaxes rabbit aorta

scientific article

11,12,20-Trihydroxy-eicosa-8(Z)-enoic acid: a selective inhibitor of 11,12-EET-induced relaxations of bovine coronary and rat mesenteric arteries ⬇️

scientific article published on February 3, 2012

11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression

scientific article published in November 2003

11,12-epoxyeicosatrienoic acid stimulates heme-oxygenase-1 in endothelial cells

scientific article published on 30 August 2006

14,15-Dihydroxy-eicosa-5(Z)-enoic Acid Selectively Inhibits 14,15-Epoxyeicosatrienoic Acid-Induced Relaxations in Bovine Coronary Arteries ⬇️

scientific article published on September 29, 2010

14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries.

scientific article published on June 2004

14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries

scientific article

14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.

scientific article published on August 2009

14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries

scientific article published on 2 September 2003

14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries

scientific article published on 7 February 2005

16(R)-hydroxy-5,8,11,14-eicosatetraenoic acid, a new arachidonate metabolite in human polymorphonuclear leukocytes

scientific article published on 01 August 2000

17(R),18(S)-epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: structure-activity relationships and stable analogues

scientific article

19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension

scientific article published on 13 August 2019

2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion.

scientific article

20-HETE and F2-isoprostanes in the metabolic syndrome: the effect of weight reduction

scientific article

20-HETE can act as a nonhypoxic regulator of HIF-1alpha in human microvascular endothelial cells.

scientific article

20-HETE contributes to myogenic activation of skeletal muscle resistance arteries in Brown Norway and Sprague-Dawley rats

scientific article published in February 2001

20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells.

scientific article published on 22 February 2008

20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells

scientific article published on 09 January 2009

20-HETE mediates the effect of parathyroid hormone and protein kinase C on renal phosphate transport.

scientific article published on March 1998

20-HETE pathway antagonists inhibit rat small mesenteric artery tone

scientific article published in September 2002

20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt.

scientific article

20-Hydroxyeicosatetraenoic acid is a potent dilator of mouse basilar artery: role of cyclooxygenase

scientific article published on 16 June 2006

20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: Photoaffinity Labeling of a 14,15-Epoxyeicosatrienoic Acid Receptor ⬇️

scientific article published on April 15, 2011

20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors alpha and gamma

scientific article published on 15 June 2006

20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling

scientific article

20-hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells.

scientific article

20-hydroxyeicosatetraenoic acid (20-HETE): structural determinants for renal vasoconstriction

scientific article published on July 2003

20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling.

scientific article

3(S)-hydroxy-leukotriene B4 is a potent granulocyte chemotaxin in the guinea pig dermis

scientific article published on 01 August 1995

5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation.

scientific article published on 27 February 2013

5,6-epoxyeicosatrienoic acid mediates the enhanced renal vasodilation to arachidonic acid in the SHR.

scientific article published on 25 August 2003

8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier.

scientific article published on June 2009

9L gliosarcoma cell proliferation and tumor growth in rats are suppressed by N-hydroxy-N'-(4-butyl-2-methylphenol) formamidine (HET0016), a selective inhibitor of CYP4A.

scientific article published on 13 December 2005

A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats.

scientific article published on September 2008

A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of the Sirtuin 3-NLRP3 Pathway

scientific article published on 24 July 2020

A biosynthetic pathway generating 12-hydroxy-5,8,14-eicosatrienoic acid from arachidonic acid is active in mouse skin microsomes

scientific article published on 16 September 2005

A convenient preparation of 3-substituted furans: synthesis of perillene and dendrolasin

scientific article published on 01 April 2002

A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid

scientific article published on January 2012

A one-pot synthesis of pyrido[2,3-b][1,4]oxazin-2-ones

scientific article published in October 2003

A role for heterocellular coupling and EETs in dilation of rat cremaster arteries

scientific article published in March 2006

A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels.

scientific article published on 3 December 2011

A tagging-via-substrate technology for detection and proteomics of farnesylated proteins

scientific article

A tagging-via-substrate technology for genome-wide detection and identification of farnesylated proteins

scientific article published on 01 January 2006

Abdominal Surgical Incision Induces Remote Preconditioning of Trauma (RPCT) via Activation of Bradykinin Receptors (BK2R) and the Cytochrome P450 Epoxygenase Pathway in Canine Hearts ⬇️

scientific article published on December 1, 2011

Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation.

scientific article published on 8 January 2007

Acylation of glucosaminyl phosphatidylinositol revisited. Palmitoyl-CoA dependent palmitoylation of the inositol residue of a synthetic dioctanoyl glucosaminyl phosphatidylinositol by hamster membranes permits efficient mannosylation of the glucosam

scientific article published on 01 October 1996

Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ

scientific article

Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway

scientific journal article

Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ Channels.

scientific article published on February 2008

Aging increases cytochrome P450 4A modulation of alpha1-adrenergic vasoconstriction in mesenteric arteries

scientific article published in March 2008

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension

scientific article

Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats

scientific article

Alternative pathways for Heck intermediates: palladium-catalyzed oxyarylation of homoallylic alcohols

scientific article published on 8 June 2011

Amide-directed tandem C-C/C-N bond formation through C-H activation.

scientific article published on 11 April 2012

An Economic and Practical Synthesis of the 2-Tetrahydrofuranyl Ether Protective Group

scientific article published on July 2006

An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase

scientific article published on 01 January 1997

An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase.

scientific article

Analysis of oxidized glycerophosphocholine lipids using electrospray ionization mass spectrometry and microderivatization techniques

scientific article published on 01 February 2000

Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs.

scientific article

Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.

scientific article published on 20 May 2008

Arachidonic acid directly activates members of the mitogen-activated protein kinase superfamily in rabbit proximal tubule cells

scientific article

Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways.

scientific article published on 16 April 2008

Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding

scientific article published on February 1999

Association of the inositol (1,4,5)-trisphosphate receptor ligand binding site with phosphatidylinositol (4,5)-bisphosphate and adenophostin A

scientific article published on 01 March 2000

Asymmetric synthesis of the stereoisomers of 11,12,15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid, a potent endothelium-derived vasodilator

scientific article published in October 2004

Asymmetric total synthesis of (+)-fostriecin

scientific article published on 01 March 2002

Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases.

scientific article

Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids

scientific article

Bromo-boronolactonization of olefins

scientific article published on 01 October 2001

CYP2J2 overexpression protects against arrhythmia susceptibility in cardiac hypertrophy

scientific article

CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET)

scientific article

CYP450 4A inhibition attenuates O2 induced arteriolar constriction in chronic but not acute Goldblatt hypertension.

scientific article published on 15 September 2009

CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent

scientific article

Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity

scientific article

Calcium influx factor, further evidence it is 5, 6-epoxyeicosatrienoic acid

scientific article published in January 1999

Carbon monoxide and biliverdin prevent endothelial cell sloughing in rats with type I diabetes

scientific article published on 20 March 2006

Carbon monoxide signaling in promoting angiogenesis in human microvessel endothelial cells

scientific article published on 01 May 2005

Cardioprotective effect of a dual acting epoxyeicosatrienoic acid analogue towards ischaemia reperfusion injury

scientific article

Cascade synthesis of (E)-2-alkylidenecyclobutanols

scientific article published on October 2009

Catalyst-Controlled Diastereoselective Synthesis of Cyclic Amines via C-H Functionalization.

scientific article published on 28 November 2017

Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes

scientific journal article

Changes in renal haemodynamics induced by indomethacin in the rat involve cytochrome P450 arachidonic acid-dependent epoxygenases

scientific article published in October 2004

Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding

scientific article published on 27 February 2007

Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids

scientific article published on 24 May 2005

Characterization of epoxyeicosatrienoic acid binding site in U937 membranes using a novel radiolabeled agonist, 20-125i-14,15-epoxyeicosa-8(Z)-enoic acid

scientific article published on 2 January 2008

Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs).

scientific article published on August 2005

Chiral alpha,beta-dialkoxy- and alpha-alkoxy-beta-aminostannanes: preparation and copper-mediated cross-coupling

scientific article published on 01 December 2003

Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites

scientific article published on 24 January 2006

Chromium vinylidene carbenoids: generation, characterization, and reactivity. First evidence for an internal proton return phenomenon with vinylidene carbenoids

scientific article published on 01 September 2001

Chromium vinylidene carbenoids: stereospecific synthesis of (Z)-2-chloroalk-2-en-1-ols

scientific article published on 01 December 2001

Chromium-carbyne complexes: intermediates for organic synthesis

scientific article published on 01 January 2007

Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD

scientific article published on 07 January 2009

Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats.

scientific article

Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock

scientific article published on 14 May 2013

Contribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase-2 inhibitor, NS-398, on endotoxin-induced hypotension in rats.

scientific article

Contributions of nitric oxide, EDHF, and EETs to endothelium-dependent relaxation in renal afferent arterioles

scientific article published in June 2003

Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.

scientific article

Convenient syntheses of [20,20,20-H(3)]-arachidonic acid and [20,20-H(2)]-20-hydroxyeicosatetraenoic acid

scientific article published on March 2006

Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes.

scientific article

Cu(II)-Mediated N-H and N-Alkyl Aryl Amination and Olefin Aziridination

scientific article published on 01 March 2019

Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited.

scientific article

Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling

scientific article

Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis.

scientific article

Cytochrome P450 epoxygenases provide a novel mechanism for penile erection

scientific article

Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer

scientific article

Cytochrome P4502C9-derived epoxyeicosatrienoic acids induce the expression of cyclooxygenase-2 in endothelial cells

scientific article published on 29 November 2004

Decreased levels of cytochrome P450 2E1-derived eicosanoids sensitize renal arteries to constrictor agonists in spontaneously hypertensive rats

scientific article published on 29 November 2004

Determination of 14,15-epoxyeicosatrienoic acid and 14,15-dihydroxyeicosatrienoic acid by fluoroimmunoassay

scientific article published on 01 March 1997

Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs

scientific article published in May 2001

Determination of trans-arachidonic acid isomers in human blood plasma

scientific article

Development of Robust 17(R),18(S)-Epoxyeicosatetraenoic Acid (17,18-EEQ) Analogues as Potential Clinical Antiarrhythmic Agents

scientific article published on 19 November 2019

Development of epoxyeicosatrienoic acid analogs with in vivo anti-hypertensive actions

scientific article

Differential Cleavage of Arylmethyl Ethers: Reactivity of 2,6-Dimethoxybenzyl Ethers Financial support was provided by the Robert A. Welch Foundation, NIH (GM31278, DK38226), CNRS, Instituts de Recherche Pierre Fabre (to R.B.), and an unrestricted g

Differential effect of cytochrome P-450 omega-hydroxylase inhibition on O2-induced constriction of arterioles in SHR with early and established hypertension

scientific article published in December 2001

Dimethylthiocarbamate (DMTC): an alcohol protecting group

scientific article published on 01 December 2003

Diphospho-myo-inositol phosphates in Dictyostelium and Polysphondylium: identification of a new bisdiphospho-myo-inositol tetrakisphosphate

scientific article published on 01 April 1998

Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism.

scientific article

Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism.

scientific article published on September 2007

EET agonist prevents adiposity and vascular dysfunction in rats fed a high fat diet via a decrease in Bach 1 and an increase in HO-1 levels

scientific article published on 24 December 2011

EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides

scientific article

Effect of human 15-lipoxygenase-1 metabolites on vascular function in mouse mesenteric arteries and hearts.

scientific article published on 16 July 2013

Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle

article

Effects of a 20-HETE antagonist and agonists on cerebral vascular tone

scientific article published on February 2004

Effects of high-salt diet on CYP450-4A omega-hydroxylase expression and active tone in mesenteric resistance arteries

scientific article published on 2 December 2004

Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection

scientific article

Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.

scientific article

Efficient iridium-catalyzed C-H functionalization/silylation of heteroarenes

scientific article published on January 2008

Eicosanoid Regulation of Vascular Endothelial Growth Factor Expression and Angiogenesis in Microvessel Endothelial Cells

scientific article published on 18 March 2002

Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats.

scientific article published on 24 October 2008

Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids.

scientific article published on 25 July 2006

Enalapril treatment alters the contribution of epoxyeicosatrienoic acids but not gap junctions to endothelium-derived hyperpolarizing factor activity in mesenteric arteries of spontaneously hypertensive rats

scientific article published on May 2009

Endogenously produced 20-HETE modulates myogenic and TGF response in microperfused afferent arterioles.

scientific article

Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice

scientific article

Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice.

scientific article

Endothelial nitric oxide synthase activation leads to dilatory H2O2 production in mouse cerebral arteries

scientific article published on 13 October 2006

Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries

scientific article published on 4 November 2004

Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid

scientific article

Epoxyeicosanoids promote organ and tissue regeneration.

scientific article published on 29 July 2013

Epoxyeicosatrienoic acid agonist regulates human mesenchymal stem cell-derived adipocytes through activation of HO-1-pAKT signaling and a decrease in PPARγ

scientific article

Epoxyeicosatrienoic acid prevents postischemic electrocardiogram abnormalities in an isolated heart model

scientific article published on 10 October 2008

Epoxyeicosatrienoic acid-dependent cerebral vasodilation evoked by metabotropic glutamate receptor activation in vivo.

scientific article

Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis.

scientific article published on 11 September 2008

Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury

scientific article

Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells.

scientific article

Epoxyeicosatrienoic acids mediate adenosine-induced vasodilation in rat preglomerular microvessels (PGMV) via A2A receptors.

scientific article

Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response

scientific article published on 24 October 2013

Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells

scientific article published on 13 September 2007

Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition

scientific article

Epoxygenase metabolites contribute to nitric oxide-independent afferent arteriolar vasodilation in response to bradykinin

scientific article published in May 2001

Epoxygenation of arachidonic acid by rat anterior pituitary microsomal fractions

scientific article published in December 1984

Estrogen elicits cytochrome P450--mediated flow-induced dilation of arterioles in NO deficiency: role of PI3K-Akt phosphorylation in genomic regulation.

scientific article

Evaluation of cytochrome P450 4 family as mediator of phospholipase D activation in aortic vascular smooth muscle cells

scientific article published on July 2005

Evaluation of cytochrome P450-4A omega-hydroxylase and 20-hydroxyeicosatetraenoic acid as an O2 sensing mechanism in the microcirculation

scientific article published in January 2004

Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.

scientific article

Exaggerated response to adenosine in kidneys from high salt-fed rats: role of epoxyeicosatrienoic acids

scientific article published on 5 April 2005

Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction

scientific article published on 9 March 2012

Failure to upregulate the adenosine2A receptor-epoxyeicosatrienoic acid pathway contributes to the development of hypertension in Dahl salt-sensitive rats.

scientific article published on October 2008

Fe(0)-mediated synthesis of tri- and tetra-substituted olefins from carbonyls: an environmentally friendly alternative to Cr(II).

scientific article published on October 2006

Functional coupling of phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate receptor

scientific article published in June 1998

Generation of Nucleophilic Chromium Acetylides from gem-Trichloroalkanes and Chromium Chloride: Synthesis of Propargyl Alcohols

scientific article

Global identification of O-GlcNAc-modified proteins

scientific article published in January 2006

Glomerular autacoids stimulated by bradykinin regulate efferent arteriole tone

scientific article published in March 2003

Glomerular cytochrome P-450 and cyclooxygenase metabolites regulate efferent arteriole resistance

scientific article published on 17 October 2005

Heme oxygenase (HO-1) rescue of adipocyte dysfunction in HO-2 deficient mice via recruitment of epoxyeicosatrienoic acids (EETs) and adiponectin

scientific article published on March 2012

Heme oxygenase metabolites inhibit tubuloglomerular feedback in vivo ⬇️

scientific article published on January 14, 2011

Heme oxygenase-derived carbon monoxide restores vascular function in type 1 diabetes

scientific article

Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers.

scientific article

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

scientific article published in Journal of Biological Chemistry

High dietary salt reduces the contribution of 20-HETE to arteriolar oxygen responsiveness in skeletal muscle

scientific article

Highly stereoselective synthesis of (Z,E)-1-halo-1,3-dienol esters via rearrangement of Fischer chromium chloro-carbenes using microwave irradiation

scientific article published on 19 March 2009

Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta

scientific article

Identification of 5,6-trans-epoxyeicosatrienoic acid in the phospholipids of red blood cells

scientific article

Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue

scientific journal article

Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta

scientific article published on 01 November 1998

Impaired endothelial function and microvascular asymmetrical dimethylarginine in angiotensin II-infused rats: effects of tempol.

scientific article

Impairment of flow-induced dilation of skeletal muscle arterioles with elevated oxygen in normotensive and hypertensive rats

scientific article published on 01 July 2000

Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer.

scientific article

Increases in plasma trans-EETs and blood pressure reduction in spontaneously hypertensive rats.

scientific article

Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats

journal article published in 2007

Induction of angiotensin-converting enzyme and activation of the renin-angiotensin system contribute to 20-hydroxyeicosatetraenoic acid-mediated endothelial dysfunction.

scientific article published on 21 June 2012

Inhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulation

scientific article published on 8 April 2005

Inhibition of 20-HETE synthesis and action protects the kidney from ischemia/reperfusion injury

scientific article published on 20 October 2010

Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists.

scientific article

Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1.

scientific article published on 17 August 2006

Inhibition of telomerase by BIBR 1532 and related analogues

scientific article published on 01 April 2003

Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex

scientific article published on 23 May 2008

Intramolecular N-Me and N-H aminoetherification for the synthesis of <i>N</i>-unprotected 3-amino-O-heterocycles

scientific article published on 05 January 2021

Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats.

scientific article

Introgression of Brown Norway CYP4A genes on to the Dahl salt-sensitive background restores vascular function in SS-5(BN) consomic rats

scientific article published on March 2013

Iridium-catalyzed (Z)-trialkylsilylation of terminal olefins.

scientific article published on March 2010

Liquid chromatographic-electrospray ionization-mass spectrometric analysis of cytochrome P450 metabolites of arachidonic acid

scientific article published in November 2001

Lysine propionylation and butyrylation are novel post-translational modifications in histones

scientific article

Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides

scientific article

Measurement of 20-hydroxyeicosatetraenoic acid in human urine by gas chromatography-mass spectrometry

scientific article

Mechanism and signal transduction of 14 (R), 15 (S)-epoxyeicosatrienoic acid (14,15-EET) binding in guinea pig monocytes

scientific article published on 01 October 2000

Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid

scientific article published in April 2006

Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells.

scientific article

Mechanisms of carbon monoxide attenuation of tubuloglomerular feedback.

scientific article

Metabolism of 12(R)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(R)-HETE) in corneal tissues: formation of novel metabolites

scientific article published on 01 November 1991

Metabolism of 12(R)-hydroxyeicosatetraenoic acid by rat liver microsomes

scientific article published on 01 January 1992

Metabolism of 12-hydroperoxyeicosatetraenoic acid to vasodilatory trioxilin C3 by rabbit aorta

scientific article (publication date: 20 June 2003)

Metabolism of arachidonic acid by canine polymorphonuclear leukocytes synthesis of lipoxygenase and omega-oxidized metabolites.

scientific article

Metabolism of arachidonic acid to epoxyeicosatrienoic acids by human granulosa cells may mediate steroidogenesis

scientific article published on 01 June 1993

Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis.

scientific article published in January 1995

Microsomal cytochrome P450 and eicosanoid metabolism

scientific article published on 01 May 2002

Mild and rapid hydroxylation of aryl/heteroaryl boronic acids and boronate esters with N-oxides

scientific article published on 26 June 2012

Modulation by cytochrome P450-4A ω-hydroxylase enzymes of adrenergic vasoconstriction and response to reduced PO₂ in mesenteric resistance arteries of Dahl salt-sensitive rats

scientific article published on October 2010

Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.

scientific article

Modulation of V1-receptor-mediated renal vasoconstriction by epoxyeicosatrienoic acids.

scientific article published on 26 February 2004

Modulation of vascular O2 responses by cytochrome 450-4A omega-hydroxylase metabolites in Dahl salt-sensitive rats

scientific article published on 16 February 2009

Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform

scientific article

Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes.

scientific article published on May 1997

Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia.

scientific article published on 30 November 2007

N-acylsulfonamide assisted tandem C-H olefination/annulation: synthesis of isoindolinones

scientific article published on 8 February 2011

NO and NO-independent mechanisms mediate ETB receptor buffering of ET-1-induced renal vasoconstriction in the rat.

scientific article published on 23 December 2004

NS-398 reverses hypotension in endotoxemic rats: Contribution of eicosanoids, NO, and peroxynitrite ⬇️

scientific article published on 05 September 2012

Not so EEZE: the 'EDHF' antagonist 14, 15 epoxyeicosa-5(Z)-enoic acid has vasodilator properties in mesenteric arteries

scientific article published in December 2004

Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat.

scientific article published on 19 January 2005

Novel orally active epoxyeicosatrienoic acid (EET) analogs attenuate cisplatin nephrotoxicity.

scientific article published on 19 April 2013

Oligomerization controls in tissue-specific manner ligand binding of native, affinity-purified p42(IP4)/centaurin alpha1 and cytohesins-proteins with high affinity for the messengers D-inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol 3,4,5-tr

scientific article published in September 2003

Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4.

scientific article

Orally active epoxyeicosatrienoic acid analog attenuates kidney injury in hypertensive Dahl salt-sensitive rat.

scientific article published on 26 August 2013

Ovariectomy, but not estrogen deficiency, increases CYP4A modulation of alpha(1)-adrenergic vasoconstriction in aging female rats.

scientific article published on 17 April 2008

Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production

scientific article published on 03 July 2006

P2X receptor-stimulated calcium responses in preglomerular vascular smooth muscle cells involves 20-hydroxyeicosatetraenoic acid

scientific article published on 17 August 2004

P450BM-3: absolute configuration of the primary metabolites of palmitic acid

scientific article published on 01 June 1999

Pd-catalyzed cross-coupling of α-(acyloxy)-tri-n-butylstannanes with alkenyl, aryl, and heteroaryl electrophiles

scientific article published on 9 December 2010

Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis.

scientific article published on 3 April 2007

Phosphatidylinositol (3,4,5)-trisphosphate stimulates phosphorylation of pleckstrin in human platelets

scientific article published on 01 September 1995

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.

scientific article

Phospholipase A 2 -mediated activation of mitogen-activated protein kinase by angiotensin II ⬇️

scientific article published on July 7, 1998

Phosphorylation of a synaptic vesicle-associated protein by an inositol hexakisphosphate-regulated protein kinase

scientific article

Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase

scientific article published on 01 December 1995

Picolinate-Directed Arene meta-C-H Amination via FeCl3 Catalysis

scientific article published on 04 March 2020

Post-receptor signal transduction and regulation of 14(R),15(S)-epoxyeicosatrienoic acid (14,15-EET) binding in U-937 cells ⬇️

scientific article published on July 1, 1997

Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z), 11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity

scientific article published in November 2003

Preparation of L-alpha-phosphatidyl-D-myo-inositol 3-phosphate (3-PIP) and 3,5-bisphosphate (3,5-PIP2)

scientific article published on 01 August 2000

Preparation of N-tBoc L-glutathione dimethyl and di-tert-butyl esters: versatile synthetic building blocks

scientific article published on 25 October 2006

Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats.

scientific article published on 23 November 2011

Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels

scientific article

Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury

scientific article

Protective effect of 20-HETE inhibition in a model of oxygen-glucose deprivation in hippocampal slice cultures.

scientific article published on 13 January 2012

Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation

scientific article published on 07 November 2006

Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress

scientific article

ROS-sensitive cytochrome P450 activity maintains endothelial dilatation in ageing but is transitory in dyslipidaemic mice.

scientific article published in April 2006

Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry

scientific article

Rapid detection, discovery, and identification of post-translationally myristoylated proteins during apoptosis using a bio-orthogonal azidomyristate analog

scientific article

Recombinant p42IP4, a brain-specific 42-kDa high-affinity Ins(1,3,4,5)P4 receptor protein, specifically interacts with lipid membranes containing Ptd-Ins(3,4,5)P3.

scientific article published on April 1999

Red blood cells: reservoirs of cis- and trans-epoxyeicosatrienoic acids

scientific article published in January 2005

Reductive olefination of aldehydes via chromium Brook rearrangement

scientific article published on July 2006

Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase

scientific article

Regulation of vascular tone during pregnancy: a novel role for the pregnane X receptor.

scientific article

Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation.

scientific article published on 23 December 2011

Relative contributions of cyclooxygenase- and cytochrome P450 omega-hydroxylase-dependent pathways to hypoxic dilation of skeletal muscle resistance arteries

scientific article published in July 2001

Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced by L-NAME treatment in pregnant rats

scientific article published on 5 July 2005

Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells

scientific article published on November 2007

Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13BN rats

scientific article

Rhodium catalyzed C-H olefination of N-benzoylsulfonamides with internal alkenes

scientific article published on 21 December 2011

Rhodium catalyzed synthesis of isoindolinones via C-H activation of N-benzoylsulfonamides

scientific article published on 4 September 2012

Rhodium(I)-catalyzed N-CN bond cleavage: intramolecular β-cyanation of styrenes

scientific article published on 14 June 2013

Rhodium-catalyzed annulation of N-benzoylsulfonamide with isocyanide through C-H activation

scientific article published on 4 October 2011

Ring expansion/homologation--aldehyde condensation cascade using tert-trihalomethylcarbinols

scientific article published on September 2006

Role of B-type natriuretic peptide in epoxyeicosatrienoic acid-mediated improved post-ischaemic recovery of heart contractile function.

scientific article published on 28 April 2009

Role of SK(Ca) and IK(Ca) in endothelium-dependent hyperpolarizations of the guinea-pig isolated carotid artery

scientific article published on February 2005

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav ⬇️

scientific article published on January 23, 1998

Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries ⬇️

scientific article published on December 30, 2010

Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells.

scientific article

Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier.

scientific article

Role of epoxyeicosatrienoic acids as autocrine metabolites in glutamate-mediated K+ signaling in perivascular astrocytes

scientific article

Role of phospholipase C and diacylglyceride lipase pathway in arachidonic acid release and acetylcholine-induced vascular relaxation in rabbit aorta

scientific article published on 15 July 2005

Role of prostanoids and 20-HETE in mediating oxygen-induced constriction of skeletal muscle resistance arteries

scientific article published in November 2001

Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function

scientific article

Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension.

scientific article published on 27 June 2007

Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.

scientific article published on 14 December 2010

Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels

scientific article published on 11 December 2003

Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles.

scientific article

Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension

scientific article published in May 2008

Stable 5,6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation

scientific article published on 7 February 2005

Stable EET urea agonist and soluble epoxide hydrolase inhibitor regulate rat pulmonary arteries through TRPCs

scientific article

Stereocontrolled synthesis of α-amino-α'-alkoxy ketones by a copper-catalyzed cross-coupling of peptidic thiol esters and α-alkoxyalkylstannanes.

scientific article

Stereoselective transformations of trihalomethylcarbinols induced by chromous chloride

scientific article published on 01 March 2005

Stereospecific Stille Cross-Couplings Using Mn(II)Cl2.

scientific article published on 10 January 2018

Stereospecific Suzuki cross-coupling of alkyl alpha-cyanohydrin triflates.

scientific article published on March 2010

Stereospecific cross-coupling of alpha-(thiocarbamoyl)organostannanes with alkenyl, aryl, and heteroaryl iodides

scientific article published on January 2007

Stereospecific synthesis of trans-arachidonic acids

scientific article

Steroid-producing cells regulate arterial tone of adrenal cortical arteries.

scientific article

Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding

scientific article

Structural characterization of monohydroxyeicosatetraenoic acids and dihydroxy- and trihydroxyeicosatrienoic acids by ESI-FTICR.

scientific article published on 31 January 2008

Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3.

scientific article published in March 2001

Studies of anandamide accumulation inhibitors in cerebellar granule neurons: comparison to inhibition of fatty acid amide hydrolase

scientific article

Synthesis and stereochemical assignment of FR252921, a promising immunosuppressant

scientific article published on 01 January 2007

Synthesis of enantioenriched alpha-(hydroxyalkyl)-tri-n-butylstannanes

scientific article published on January 2008

Synthesis, structural identification and biological activity of 11,12-dihydroxyeicosatetraenoic acids formed in human platelets

scientific article published in February 1991

Tagging-via-substrate strategy for probing O-GlcNAc modified proteins.

scientific article published on May 2005

Targeting QseC signaling and virulence for antibiotic development

scientific article

The Cytochrome P450 Inhibitor Ketoconazole Potentiates 5-Hydroxytryptamine-Induced Contraction in Rat Aorta

scientific article published on 08 August 2007

The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production

scientific article published on 16 July 2018

The Roles of Intrarenal 20-Hydroxyeicosatetraenoic and Epoxyeicosatrienoic Acids in the Regulation of Renal Function in Hypertensive Ren-2 Transgenic Rats

scientific article published on 30 August 2007

The contribution of TRPV1 channel to 20-HETE-Aggravated ischemic neuronal injury

scientific article published on 06 July 2018

The cytochrome P450 4A/F-20-hydroxyeicosatetraenoic acid system: a regulator of endothelial precursor cells derived from human umbilical cord blood

scientific article

The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase

scientific article

The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3

scientific article published in 1996

The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C.

scientific article published on March 1997

The mechanism of oleic acid nitration by *NO(2).

scientific article published on 20 April 2008

The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity

scientific article published in December 2004

The synthesis of 20-HETE in small porcine coronary arteries antagonizes EDHF-mediated relaxation

scientific article published in February 2005

The vasodilator 17,18-epoxyeicosatetraenoic acid targets the pore-forming BK alpha channel subunit in rodents.

scientific article published on 3 August 2007

Total Synthesis of (±)-Halomon by a Johnson-Claisen Rearrangement

scientific article published on 01 August 1998

Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration

scientific article published on 27 November 2005

Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor.

scientific article published on February 1999

Transfection of cytochrome P4504B1 into the cornea increases angiogenic activity of the limbal vessels

scientific article published on 11 July 2005

Two distinct pathways account for EDHF-dependent dilatation in the gracilis artery of dyslipidaemic hApoB+/+ mice.

scientific article published on May 2005

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