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List of works by Wilfred van der Donk

18O Kinetic Isotope Effects Reveal an Associative Transition State for Phosphite Dehydrogenase Catalyzed Phosphoryl Transfer

scientific article published on 12 December 2018

A catalytic role for methionine revealed by a combination of computation and experiments on phosphite dehydrogenase

A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase.

scientific article published on 26 February 2015

A general method for fluorescent labeling of the N-termini of lanthipeptides and its application to visualize their cellular localization

scientific article published on 08 July 2013

A lanthipeptide library used to identify a protein-protein interaction inhibitor.

scientific article published on 5 March 2018

A price to pay for relaxed substrate specificity: a comparative kinetic analysis of the class II lanthipeptide synthetases ProcM and HalM2.

scientific article

An engineered azurin variant containing a selenocysteine copper ligand

scientific article published in March 2002

An engineered lantibiotic synthetase that does not require a leader peptide on its substrate ⬇️

scientific article

An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase

scientific article published in November 2012

An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis

scientific article

An unusual isotope effect on substrate inhibition in the oxidation of arachidonic acid by lipoxygenase

scientific article published in July 2003

Answers to the carbon-phosphorus lyase conundrum.

scientific article published on 14 February 2012

Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage

scientific article published on 02 September 2015

Arabidopsis thaliana fatty acid alpha-dioxygenase-1: evaluation of substrates, inhibitors and amino-terminal function

scientific article published in May 2006

Assessing the Flexibility of the Prochlorosin 2.8 Scaffold for Bioengineering Applications

scientific article published on 08 May 2019

Aziridine-2-carboxylic acid-containing peptides: application to solution- and solid-phase convergent site-selective peptide modification

scientific article published in May 2005

Bacillus anthracis spore interactions with mammalian cells: relationship between germination state and the outcome of in vitro

scientific article

Bacteria Do It Differently: An Alternative Path to Squalene

scientific article published on 8 May 2015

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

scientific article published on 13 November 2019

Biochemistry: Positive and radical

scientific article published in April 2013

Biomimetic stereoselective formation of methyllanthionine

scientific article published on 01 April 2002

Biomimetic studies on the mechanism of stereoselective lanthionine formation

scientific article published in October 2003

Biosynthesis and mode of action of lantibiotics.

scientific article

Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways.

scientific article published on 10 June 2008

Biosynthesis of fosfazinomycin is a convergent process.

scientific article

Biosynthesis of phosphonic and phosphinic acid natural products.

scientific article published on January 2009

Biosynthesis of rhizocticins, antifungal phosphonate oligopeptides produced by Bacillus subtilis ATCC6633

scientific article

Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate

scientific article

Biosynthesis of the class III lantipeptide catenulipeptin ⬇️

scientific article

Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin

scientific article published on 4 October 2016

Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes ⬇️

scientific article published on 15 March 2016

Cameo appearances of aminoacyl-tRNA in natural product biosynthesis

scientific article published on 3 September 2016

Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria

scientific article

Catalytic promiscuity of a bacterial α‐N‐methyltransferase ⬇️

scientific article published on July 25, 2012

Chapter 21. In vitro studies of lantibiotic biosynthesis

scientific article published in January 2009

Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ.

scientific article

Characterization and structure of DhpI, a phosphonateO-methyltransferase involved in dehydrophos biosynthesis

scientific article

Characterization of Leader Peptide Binding During Catalysis by the Nisin Dehydratase NisB

scientific article published on 20 March 2018

Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads.

scientific article published on 15 December 2016

Characterization of a Dehydratase and Methyltransferase in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides in Lachnospiraceae

scientific article published on 04 November 2019

Characterization of a Substrate-Derived Radical Detected during the Inactivation of Ribonucleotide Reductase from <i>Escherichia coli</i> by 2‘-Fluoromethylene-2‘-deoxycytidine 5‘-Diphosphate

scientific article published in 1998

Characterization of chlorovinylcobalamin, a putative intermediate in reductive degradation of chlorinated ethylenes

scientific article published in April 2003

Characterization of glutamyl-tRNA-dependent dehydratases using nonreactive substrate mimics

scientific article published on 13 August 2019

Characterization of the stereochemical configuration of lanthionines formed by the lanthipeptide synthetase GeoM.

scientific article published on 14 May 2016

Chemical and enzymatic synthesis of fluorinated-dehydroalanine-containing peptides

scientific article published in November 2003

Chemical rescue and inhibition studies to determine the role of Arg301 in phosphite dehydrogenase

scientific article

Chemical synthesis and biological activity of analogues of the lantibiotic epilancin 15X.

scientific article

Chemical synthesis of the lantibiotic lacticin 481 reveals the importance of lanthionine stereochemistry.

scientific article published on 03 May 2013

Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products

scientific article published on 6 June 2017

Comparison of the properties of prostaglandin H synthase-1 and -2.

scientific article

Conjugation to albumin-binding molecule tags as a strategy to improve both efficacy and pharmacokinetic properties of the complement inhibitor compstatin

scientific article

Convergent synthesis of peptide conjugates using dehydroalanines for chemoselective ligations

scientific article published on 01 April 2001

Converging on a mechanism for choline degradation

scientific article published on 14 December 2012

Crystal Structures of Phosphite Dehydrogenase Provide Insights into Nicotinamide Cofactor Regeneration

scientific article

Cyclooxygenase reaction mechanism of PGHS--evidence for a reversible transition between a pentadienyl radical and a new tyrosyl radical by nitric oxide trapping

scientific article published on March 2011

Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects

scientific article

CylA is a sequence-specific protease involved in toxin biosynthesis

scientific article published on 27 November 2018

Dehydroalanine-containing peptides: preparation from phenylselenocysteine and utility in convergent ligation strategies

scientific article published on 01 January 2006

Detection of a new substrate-derived radical during inactivation of ribonucleotide reductase from Escherichia coli by gemcitabine 5'-diphosphate

scientific article published on 01 May 1998

Development and Application of Yeast and Phage Display of Diverse Lanthipeptides.

scientific article published on 28 March 2018

Dichloroacetylene is not the precursor to dichlorinated vinylcobaloxime and vinylcobalamin in cobalt catalyzed dechlorination of perchloro- and trichloroethylene

scientific article published in November 2002

Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species. ⬇️

scientific article

Discovery and Biosynthesis of Phosphonate and Phosphinate Natural Products

scientific article published on 01 January 2012

Discovery and Characterization of Bicereucin, an Unusual d-Amino Acid-Containing Mixed Two-Component Lantibiotic

scientific article published on 13 April 2016

Discovery and Characterization of a Class IV Lanthipeptide with a Nonoverlapping Ring Pattern

scientific article published on 01 May 2020

Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic

scientific article published on 3 November 2006

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

scientific article published on 31 August 2015

Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection.

scientific article published on 13 March 2013

Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights

scientific article

Discovery, biosynthesis, and engineering of lantipeptides

scientific article

Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry.

scientific article published on September 2009

Efficient synthesis of suitably protected beta-difluoroalanine and gamma-difluorothreonine from L-ascorbic acid

scientific article published on January 2007

Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin

scientific article published on 26 July 2018

Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase

scientific article published in October 2006

Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids

scientific article published on December 2003

Evolution of lanthipeptide synthetases

scientific article

Evolutionary radiation of lanthipeptides in marine cyanobacteria.

scientific article

Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in actinobacteria

scientific article published on 17 April 2015

Expressed protein ligation for metalloprotein design and engineering

scientific article published on January 2009

Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy Acid

scientific article published on June 2015

Facile chemoselective synthesis of dehydroalanine-containing peptides

scientific article published on 01 November 2000

Follow the leader: the use of leader peptides to guide natural product biosynthesis.

scientific article published on January 2010

Genetic and biochemical characterization of a pathway for the degradation of 2-aminoethylphosphonate in Sinorhizobium meliloti 1021.

scientific article

Genome mining for ribosomally synthesized natural products

scientific article

Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kinamycin

scientific article published in Nature Communications

Go it alone: four-electron oxidations by mononuclear non-heme iron enzymes.

scientific article

Haloduracin α binds the peptidoglycan precursor lipid II with 2:1 stoichiometry

scientific article published on 17 October 2011

Heterologous expression and purification of SpaB involved in subtilin biosynthesis.

scientific article

Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa

scientific article

Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster

scientific article

Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli ⬇️

scientific article published on November 18, 2012

High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis.

scientific article

Homemade cofactors: self-processing in galactose oxidase

scientific article

Hydroperoxylation by hydroxyethylphosphonate dioxygenase.

scientific article

Identification of an active site residue of the R1 subunit of ribonucleotide reductase from Escherichia coli: characterization of substrate-induced polypeptide cleavage by C225SR1.

scientific article published on August 1996

Identification of essential catalytic residues of the cyclase NisC involved in the biosynthesis of nisin.

scientific article published on 19 May 2007

In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide Thiomuracin

scientific article published on 17 December 2015

In vitro activity of the nisin dehydratase NisB.

scientific article

In vitro characterization of a heterologously expressed nonribosomal Peptide synthetase involved in phosphinothricin tripeptide biosynthesis

scientific article published in June 2009

In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids

scientific article published in September 2009

In vitro reconstitution and substrate specificity of a lantibiotic protease.

scientific article published on 21 June 2008

Inactivation of ribonucleotide reductase by (E)-2'-fluoromethylene-2'-deoxycytidine 5'-diphosphate: a paradigm for nucleotide mechanism-based inhibitors.

scientific article

Incorporation of Nonproteinogenic Amino Acids in Class I and II Lantibiotics.

scientific article published on 13 February 2018

Inhibition and pH dependence of phosphite dehydrogenase

scientific article published in May 2005

Inhibition of Bacillus anthracis spore outgrowth by nisin

scientific article published on 22 September 2008

Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease

scientific article published on 14 January 2019

Insights into the Biosynthesis of Duramycin.

scientific article

Insights into the evolution of lanthipeptide biosynthesis

scientific article published on 18 September 2013

Insights into the mode of action of the two-peptide lantibiotic haloduracin

scientific article

Introduction: Unusual Enzymology in Natural Product Synthesis

scientific article published in April 2017

Investigation of Amide Bond Formation during Dehydrophos Biosynthesis

scientific article published on 5 January 2018

Investigation of Substrate Recognition and Biosynthesis in Class IV Lanthipeptide Systems.

scientific article published on 10 April 2018

Investigation of the role of Arg301 identified in the X-ray structure of phosphite dehydrogenase

scientific article published on 17 May 2012

Investigation of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids

scientific article published on March 2009

Investigations into the Mechanism of Action of Sublancin

scientific article published on 08 January 2019

Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases

scientific article published on 12 June 2008

Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2.

scientific article published on September 2009

Kinetic isotope effects in the oxidation of arachidonic acid by soybean lipoxygenase-1.

scientific article published on 31 August 2008

Lacticin 481 synthetase as a general serine/threonine kinase.

scientific article published on May 2009

Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production

scientific article published in November 2005

Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity

scientific article

LanCL proteins are not Involved in Lanthionine Synthesis in Mammals

scientific article published on 20 January 2017

LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

scientific article published on 30 April 2021

Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt.

scientific article

Lanthionine synthetase C-like protein 2 (LanCL2) is important for adipogenic differentiation

scientific article published on 07 June 2018

Lantibiotics from Geobacillus thermodenitrificans.

scientific article

Lantibiotics: peptides of diverse structure and function.

scientific article published on January 2007

Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis.

scientific article published on 28 April 2016

Mechanism and applications of phosphite dehydrogenase.

scientific article

Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase

scientific article

Mechanism of a Class C Radical S-Adenosyl-l-methionine Thiazole Methyl Transferase.

scientific article

Mechanism of inhibition of Bacillus anthracis spore outgrowth by the lantibiotic nisin.

scientific article

Mechanistic Studies of the Kinase Domains of Class IV Lanthipeptide Synthetases

scientific article published on 24 June 2019

Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes

scientific article published on 30 January 2017

Mechanistic investigation of a highly active phosphite dehydrogenase mutant and its application for NADPH regeneration.

scientific article published on August 2005

Mechanistic investigation of a novel vitamin B(12)-catalyzed carbon [bond] carbon bond forming reaction, the reductive dimerization of arylalkenes

scientific article published on 01 February 2002

Mechanistic investigation of methylphosphonate synthase, a non-heme iron-dependent oxygenase.

scientific article

Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid.

scientific article

Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis.

scientific article published on 25 April 2007

Mechanistic studies of Ser/Thr dehydration catalyzed by a member of the LanL lanthionine synthetase family

scientific article published on 13 January 2011

Mechanistic studies on the substrate-tolerant lanthipeptide synthetase ProcM

scientific article

Michael-type cyclizations in lantibiotic biosynthesis are reversible.

scientific article published on 10 March 2015

MicroED in natural product and small molecule research

scientific article published on 17 September 2020

Minimum Information about a Biosynthetic Gene cluster.

scientific article published on August 2015

Mode of action and structure-activity relationship studies of geobacillin I.

scientific article published on 30 October 2013

Model studies of the Cu(B) site of cytochrome c oxidase utilizing a Zn(II) complex containing an imidazole-phenol cross-linked ligand

scientific article published on 20 April 2006

Model studies of the histidine-tyrosine cross-link in cytochrome C oxidase reveal the flexible substituent effect of the imidazole moiety

scientific article

Modulating the Copper-Sulfur Interaction in Type 1 Blue Copper Azurin by Replacing Cys112 with Nonproteinogenic Homocysteine.

scientific article published on February 2014

Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster

scientific article

Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity.

scientific article published on 5 May 2007

NMR Structure of the S-Linked Glycopeptide Sublancin 168

scientific article

New Insights into the Biosynthesis of Fosfazinomycin

scientific article published on 06 May 2016

New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products

scientific article published on January 2016

New developments in RiPP discovery, enzymology and engineering

scientific article published on 16 September 2020

New developments in lantibiotic biosynthesis and mode of action.

scientific article

New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin

scientific article published on 23 November 2006

Nine post-translational modifications during the biosynthesis of cinnamycin

scientific article

Non-proteinogenic amino acids in lacticin 481 analogues result in more potent inhibition of peptidoglycan transglycosylation.

scientific article

Nonribosomal Peptide Extension by a Peptide Amino-Acyl tRNA Ligase

scientific article published on 09 December 2019

Novel cofactors via post-translational modifications of enzyme active sites

scientific article

O-H Activation by an Unexpected Ferryl Intermediate during Catalysis by 2-Hydroxyethylphosphonate Dioxygenase

scientific article published on 16 January 2017

O-Methyltransferase-Mediated Incorporation of a β-Amino Acid in Lanthipeptides

scientific article published on 15 October 2019

Oligosaccharide-peptide ligation of glycosyl thiolates with dehydropeptides: synthesis of S-linked mucin-related glycopeptide conjugates

scientific article published in December 2003

On the regioselectivity of thioether formation by lacticin 481 synthetase

scientific article published on 25 July 2007

On the role of alkylcobalamins in the vitamin B12-catalyzed reductive dehalogenation of perchloroethylene and trichloroethylene

scientific article published on 20 December 2005

On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase

scientific article

On the substrate specificity of dehydration by lacticin 481 synthetase

scientific article published in February 2007

Optimizing a biocatalyst for improved NAD(P)H regeneration: directed evolution of phosphite dehydrogenase

scientific article published in May 2006

Oxygen-18 Kinetic Isotope Effects of Nonheme Iron Enzymes HEPD and MPnS Support Iron(III) Superoxide as the Hydrogen Abstraction Species

scientific article published on 12 August 2015

Phosphite dehydrogenase: a versatile cofactor-regeneration enzyme

scientific article

Phosphite dehydrogenase: an unusual phosphoryl transfer reaction

scientific article published in March 2001

Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology

scientific article published on 17 July 2013

Photochemical cleavage of leader peptides.

scientific article

Post-translational Introduction of D-Alanine into Ribosomally Synthesized Peptides by the Dehydroalanine Reductase NpnJ

scientific article

Post-translational modifications during lantibiotic biosynthesis

scientific article published in October 2004

Pre-steady-state studies of phosphite dehydrogenase demonstrate that hydride transfer is fully rate limiting

scientific article published on 20 October 2007

Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family

scientific article published on 03 June 2020

Probing the role of the backbone carbonyl interaction with the CuA center in azurin by replacing the peptide bond with an ester linkage

scientific article published on 5 December 2016

Product Formation by the Promiscuous Lanthipeptide Synthetase ProcM is under Kinetic Control

scientific article published on 7 April 2015

Production of lantipeptides in Escherichia coli.

scientific article

Properties and reactivity of chlorovinylcobalamin and vinylcobalamin and their implications for vitamin B12-catalyzed reductive dechlorination of chlorinated alkenes

scientific article published in February 2005

Protein Radicals in Enzyme Catalysis

scientific article published on 01 April 1998

Protein Radicals in Enzyme Catalysis. [Chem. Rev. 1998, 98, 705minus sign762

scientific article published on 01 November 1998

Radical-mediated enzymatic methylation: a tale of two SAMS

scientific article

Rapid Discovery of Glycocins through Pathway Refactoring in Escherichia coli

scientific article published on 18 September 2018

Rapid Screening of Lanthipeptide Analogs via In-Colony Removal of Leader Peptides in Escherichia coli

scientific article published on 12 September 2018

Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid

scientific article published on 01 January 2007

Recent developments in pyridine nucleotide regeneration.

scientific article

Reconstitution and Substrate Specificity of the Radical S-Adenosyl-methionine Thiazole C-Methyltransferase in Thiomuracin Biosynthesis.

scientific article

Regeneration of cofactors for use in biocatalysis

scientific article published on December 2003

Relaxing the nicotinamide cofactor specificity of phosphite dehydrogenase by rational design

scientific article published in October 2003

Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway

scientific article published on 17 June 2013

Ribonucleotide reductases: radical enzymes with suicidal tendencies

scientific article published on 01 December 1995

Ribosomal Natural Products, Tailored To Fit.

scientific article published on 6 July 2017

Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era.

scientific article published on 2 March 2017

Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis

scientific article published on 10 May 2013

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

scientific article

Selenocysteine derivatives for chemoselective ligations

scientific article

Selenocysteine positional variants reveal contributions to copper binding from cysteine residues in domains 2 and 3 of human copper chaperone for superoxide dismutase.

scientific article published on December 2008

Site-directed mutagenesis of active site residues of phosphite dehydrogenase

scientific article

Site-selective conjugation of thiols with aziridine-2-carboxylic acid-containing peptides

scientific article published in October 2004

SpaC and NisC, the cyclases involved in subtilin and nisin biosynthesis, are zinc proteins

scientific article published in November 2003

Stereochemistry of Hydride Transfer by Group III Alcohol Dehydrogenases Involved in Phosphonate Biosynthesis

scientific article

Stereospecific Radical-Mediated B12-Dependent Methyl Transfer by the Fosfomycin Biosynthesis Enzyme Fom3

scientific article published on 10 July 2018

Structural Characterization and Bioactivity Analysis of the Two-Component Lantibiotic Flv System from a Ruminant Bacterium

scientific article published on 28 January 2016

Structural and Mechanistic Insights into C-P Bond Hydrolysis by Phosphonoacetate Hydrolase

scientific article

Structural basis for methylphosphonate biosynthesis.

scientific article

Structural characterization of a pentadienyl radical intermediate formed during catalysis by prostaglandin H synthase-2.

scientific article published in April 2001

Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2

scientific article (publication date: 11 October 2002)

Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria

scientific article

Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin H synthase-1 and -2.

scientific article published on 27 November 2010

Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.

scientific article published on 20 November 2017

Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS.

scientific article

Structure and Function of Phosphonoacetaldehyde Dehydrogenase: The Missing Link in Phosphonoacetate Formation

scientific article

Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin

scientific article

Structure and mechanism of lanthipeptide biosynthetic enzymes.

scientific article

Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis.

scientific article

Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB.

scientific article published on 26 October 2014

Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis

scientific article published on 8 February 2016

Structure-Activity Relationships of the S-Linked Glycocin Sublancin

scientific article published on 7 November 2017

Structure-activity relationship studies of the two-component lantibiotic haloduracin

scientific article

Structure-activity relationships of the phosphonate antibiotic dehydrophos

scientific article

Sublancin is not a lantibiotic but an S-linked glycopeptide

scientific article

Substrate Recognition by the Class II Lanthipeptide Synthetase HalM2

scientific article published on 15 April 2020

Substrate Specificity of the Lanthipeptide Peptidase ElxP and the Oxidoreductase ElxO

scientific article

Substrate activation by iron superoxo intermediates

scientific article

Substrate control in stereoselective lanthionine biosynthesis

scientific article

Substrate selectivity of the sublancin S-glycosyltransferase.

scientific article

Substrate-assisted Enzymatic Formation of Lysinoalanine in Duramycin

Substrate-assisted enzymatic formation of lysinoalanine in duramycin

scientific article published in October 2018

Synergistic binding of the leader and core peptides by the lantibiotic synthetase HalM2.

scientific article published on 4 February 2015

Synthesis and Bioactivity of Diastereomers of the Virulence Lanthipeptide Cytolysin

scientific article published on 18 November 2016

Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin

scientific article

Synthesis and characterization of chlorinated alkenylcobaloximes to probe the mechanism of vitamin B(12)-catalyzed dechlorination of priority pollutants

scientific article published in January 2002

Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases

scientific article

Synthesis of 2-amino-3-fluoroacrylic acid containing peptides.

scientific article

Synthesis of 7-thiaarachidonic acid as a mechanistic probe of prostaglandin H synthase-2.

scientific article

Synthesis of Antibiotics and Related Molecules

scientific article published on 01 July 2018

Synthesis of a selenocysteine-containing peptide by native chemical ligation

scientific article published on 01 May 2001

Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase

scientific article

Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean

scientific article

Synthesis of nonproteinogenic amino acids to probe lantibiotic biosynthesis

scientific article published on August 2005

Synthesis of site-specifically labeled arachidonic acids as mechanistic probes for prostaglandin H synthase

scientific article published on 01 February 2004

Temperature-Independent Kinetic Isotope Effects as Evidence for a Marcus-like Model of Hydride Tunneling in Phosphite Dehydrogenase

scientific article published on 07 October 2019

The Enterococcal Cytolysin Synthetase Coevolves with Substrate for Stereoselective Lanthionine Synthesis.

scientific article published on 27 June 2016

The Enzymology of Prochlorosin Biosynthesis.

scientific article

The Fellowship of the Rings: Macrocyclic Antibiotic Peptides Reveal an Anti-Gram-Negative Target

scientific article published on 07 January 2020

The antibiotic dehydrophos is converted to a toxic pyruvate analog by peptide bond cleavage in Salmonella enterica.

scientific article

The cyclooxygenase reaction mechanism

scientific article

The dehydratase activity of lacticin 481 synthetase is highly processive

scientific article published on February 2006

The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold

scientific article

The glycosyltransferase involved in thurandacin biosynthesis catalyzes both O- and S-glycosylation

scientific article published on 16 December 2013

The importance of the leader sequence for directing lanthionine formation in lacticin 481.

scientific article published on 21 June 2008

The leader peptide is not required for post-translational modification by lacticin 481 synthetase

scientific article

The many roles of glutamate in metabolism

scientific article published on September 2015

The phosphoenolpyruvate:sugar phosphotransferase system is involved in sensitivity to the glucosylated bacteriocin sublancin.

scientific article

The protein modification repertoire

The selenocysteine-substituted blue copper center: spectroscopic investigations of Cys112SeCys Pseudomonas aeruginosa azurin

scientific article

The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry.

scientific article published on 13 January 2013

Theoretical investigations into the intermediacy of chlorinated vinylcobalamins in the reductive dehalogenation of chlorinated ethylenes

scientific article published in January 2005

Transforming a blue copper into a red copper protein: engineering cysteine and homocysteine into the axial position of azurin using site-directed mutagenesis and expressed protein ligation

scientific article

Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis

scientific article

Tyrosyl radical cofactors

scientific article

Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide.

scientific article

Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster.

scientific article published on 27 December 2013

Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products

scientific article

Use of lantibiotic synthetases for the preparation of bioactive constrained peptides

scientific article published on 19 January 2008

Use of the dehydrophos biosynthetic enzymes to prepare antimicrobial analogs of alaphosphin

scientific article published on 01 January 2019

Using expressed protein ligation to probe the substrate specificity of lantibiotic synthetases

scientific article published in January 2009

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