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List of works by Pascal Kienlen-Campard

A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis

scholarly article

A mouse model of familial amyotrophic lateral sclerosis expressing a mutant superoxide dismutase 1 shows evidence of disordered transport in the vasopressin hypothalamo-neurohypophysial axis

scientific article published on 01 December 1999

APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation

scientific article published on 30 December 2015

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease

scientific article published on 27 January 2016

Adenylosuccinate lyase deficiency: study of physiopathologic mechanism(s).

scientific article published in October 2004

Amyloid Precursor Protein (APP) controls the expression of the transcriptional activator Neuronal PAS Domain Protein 4 (NPAS4) and synaptic GABA release

scientific article published on 17 April 2020

Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

scientific article published on April 2013

Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs

scientific article published on 16 January 2008

Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing

scientific article

Characterization of Pterocarpus erinaceus kino extract and its gamma-secretase inhibitory properties.

scientific article

Conformational changes induced by the A21G Flemish mutation in the amyloid precursor protein lead to increased Aβ production

scientific article published on 23 January 2014

Contribution of Kunitz Protease Inhibitor and Transmembrane Domains to Amyloid Precursor Protein Homodimerization

scientific article published on 10 February 2012

Correlation between beta-amyloid peptide production and human APP-induced neuronal death

scientific article published on July 2002

Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission

scientific article published on 23 March 2017

Depolarization regulates cyclin D1 degradation and neuronal apoptosis: a hypothesis about the role of the ubiquitin/proteasome signalling pathway

scientific article published in February 1999

Epigenetic control of aquaporin 1 expression by the amyloid precursor protein

scientific article published on 17 August 2009

Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty

scientific article

Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer disease

scientific article

Expression of the c-ets1 gene in the hypothalamus and pituitary during rat development

scientific journal article

Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells

scientific article published on October 2002

Fe65 does not stabilize AICD during activation of transcription in a luciferase assay.

scientific article published on 17 July 2007

Gamma-secretase inhibitor activity of a Pterocarpus erinaceus extract

scientific article published on 30 October 2013

Glucocorticoids, but not dopamine, negatively regulate the melanotrophic activity of the rabbit pituitary intermediate lobe

scientific article published on 01 August 1994

Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in Cells

scientific article published on 10 May 2016

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo

scientific article published on 6 January 2016

How to Build and to Protect the Neuromuscular Junction: The Role of the Glial Cell Line-Derived Neurotrophic Factor

scientific article published on 24 December 2020

In vitro screening on β-amyloid peptide production of plants used in traditional medicine for cognitive disorders

scientific article published on 29 July 2010

Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.

scientific article published on May 2006

Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis

scientific article published on 22 February 2002

Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity

scientific article published in November 2006

Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3.

scientific article published on 13 July 2005

Pharmacological, molecular and functional characterization of vasoactive intestinal polypeptide/pituitary adenylate cyclase-activating polypeptide receptors in the rat pineal gland

scientific article published in August 1998

Phosphorylation of APP695 at Thr668 decreases gamma-cleavage and extracellular Abeta

scientific article published on 17 April 2007

Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex

scientific article

Sex-regulated gene dosage effect of PPARα on synaptic plasticity

article

Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.

scientific article

Structural features of the KPI domain control APP dimerization, trafficking, and processing

scientific article published on 15 November 2011

Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo

scientific article

Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease

scientific article published on 6 March 2014

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice

scientific article published on 11 April 2015

What is the role of amyloid precursor protein dimerization?

scientific article

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