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List of works by Florian Lesage

A TREK-1-like potassium channel in atrial cells inhibited by beta-adrenergic stimulation and activated by volatile anesthetics

scientific journal article

A mammalian two pore domain mechano-gated S-like K+ channel

scientific article

A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids.

scientific article

A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression

scientific article published in October 1996

A pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel gating properties

scientific article published in February 1996

AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels

scientific journal article

Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice.

scientific article published on 30 June 2017

Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer's disease model

scientific article

Altered and dynamic ion selectivity of K+ channels in cell development and excitability

scientific article published on 9 July 2014

An immunocytochemical study on the distribution of two G-protein-gated inward rectifier potassium channels (GIRK2 and GIRK4) in the adult rat brain

scientific article published in September 1997

An ion channel chip for diagnosis and prognosis of autoimmune neurological disorders.

scientific article published in December 2013

Antiepileptic popular ketogenic diet: emerging twists in an ancient story

scientific article

Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23.

scientific article

Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43.

scientific article

Association of beta-catenin with the alpha-subunit of neuronal large-conductance Ca2+-activated K+ channels

scholarly article

Behavioral characterization of mice lacking Trek channels ⬇️

scientific article published on September 7, 2012

Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy

scientific journal article

Canaux potassiques, maladies héréditaires et acquises

scientific article published on 15 May 2007

Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney

scientific article

Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain

scientific article (publication date: 10 October 1994)

Comparative expression of the inward rectifier K+ channel GIRK2 in the cerebellum of normal and weaver mutant mice

scientific article

Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity.

scientific article

Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells

scientific article published on September 28, 1992

Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit.

scientific article

Does sumoylation control K2P1/TWIK1 background K+ channels?

scientific article published in August 2007

Dominant negative chimeras provide evidence for homo and heteromultimeric assembly of inward rectifier K+ channel proteins via their N-terminal end.

scientific article published in January 1996

Effects of the level of mRNA expression on biophysical properties, sensitivity to neurotoxins, and regulation of the brain delayed-rectifier K+ channels Kv1.2.

scientific article published in December 1992

Expression and localization of TREK-1 K+ channels in human odontoblasts

scientific article published on 01 July 2003

External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids

scientific article

Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue.

scientific article published on 10 August 2009

Fetal brain hypometabolism during prolonged hypoxaemia in the llama

scientific article

Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels

scientific article

Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels

scientific article published in February 2009

Glucose-induced inhibition: how many ionic mechanisms?

scientific article published on 15 May 2009

Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers.

scientific article published in July 1995

Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins

scientific article published on 24 August 2017

ISK, a slowly activating voltage-sensitive K+ channel. Characterization of multiple cDNAs and gene organization in the mouse

scientific article

Immunolocalization of the arachidonic acid and mechanosensitive baseline traak potassium channel in the nervous system.

scientific article

In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide

scientific article published on 11 April 2016

Inhalational anesthetics activate two-pore-domain background K+ channels

scientific article (publication date: May 1999)

Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome

scientific article published on 24 January 2020

Injection of a K+ channel (Kv1.3) cRNA in fertilized eggs leads to functional expression in cultured myotomal muscle cells from Xenopus embryos

scientific article published on 01 July 1994

International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels

scientific article

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels

scientific article (publication date: December 2003)

Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis

scientific article

Kv1.1 channels act as mechanical brake in the senses of touch and pain

scientific journal article

Localization of a potassium channel gene (KCNE1) to 21q22.1-q22.2 by in situ hybridization and somatic cell hybridization

scientific article

Mapping of Human Potassium Channel Genes TREK-1 (KCNK2) and TASK (KCNK3) to Chromosomes 1q41 and 2p23 ⬇️

scientific article published on August 1, 1998

Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels ⬇️

scientific article published on October 15, 2003

Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel.

scientific article

Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels

scientific article published on 8 March 2012

Membrane potential-regulated transcription of the resting K+ conductance TASK-3 via the calcineurin pathway

scientific article published on 24 July 2006

Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK

scientific article published on 17 December 2018

Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties

scientific article published on 28 March 2016

Molecular physiology of pH-sensitive background K(2P) channels.

scientific article published on December 2011

Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels.

scientific article published on December 1995

Molecular regulations governing TREK and TRAAK channel functions.

scientific article published on September 2011

Mtap2 is a constituent of the protein network that regulates twik-related K+ channel expression and trafficking.

scientific article published in August 2008

Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels

scientific article published in Nature Communications

Neuronal background two-P-domain potassium channels: molecular and functional aspects

scientific article

Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?

scientific article

Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.

scientific article

Physiological roles of heteromerization: focus on the two-pore domain potassium channels

scientific article published on 21 December 2020

Potassium channel silencing by constitutive endocytosis and intracellular sequestration.

scientific article published on 3 December 2009

Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport

scientific article

RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels

scientific article published on April 2002

Receptor-mediated regulation of IsK, a very slowly activating, voltage-dependent K+ channel in Xenopus oocytes.

scientific article published in May 1992

Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels

scientific article

Regulation of a major cloned voltage-gated K+ channel from human T lymphocytes

scientific article published in June 1992

Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules.

scientific article

Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception

article

Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system

scientific article published on 22 May 2013

Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane.

scientific article published on 25 October 2013

Silent but not dumb: how cellular trafficking and pore gating modulate expression of TWIK1 and THIK2.

scientific article

Structure, chromosome localization, and tissue distribution of the mouse twik K+ channel gene

scientific article published in March 1998

Susceptibility of cloned K+ channels to reactive oxygen species

scientific article

Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel.

scientific article published on 31 January 2014

TASK (TWIK-related acid-sensitive K+ channel) is expressed in glomerulosa cells of rat adrenal cortex and inhibited by angiotensin II.

scientific article published in June 2000

TASK, a human background K+ channel to sense external pH variations near physiological pH ⬇️

scientific article published on September 1, 1997

TASK-2 channels contribute to pH sensitivity of retrotrapezoid nucleus chemoreceptor neurons

scientific article

TRAAK is a mammalian neuronal mechano-gated K+ channel.

scientific article

TREK-1 is a heat-activated background K(+) channel

scientific article

TWIK1, a unique background channel with variable ion selectivity.

scientific article published on 19 March 2012

Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels

scientific article

Task2 potassium channels set central respiratory CO2 and O2 sensitivity.

scientific article

Task3 Potassium Channel Gene Invalidation Causes Low Renin and Salt-Sensitive Arterial Hypertension

article

The Thermosensitive Potassium Channel TREK-1 Contributes to Coolness-Evoked Responses of Grueneberg Ganglion Neurons

article

The family of K2P channels: salient structural and functional properties

scientific article published on 22 January 2015

The protein IsK is a dual activator of K+ and Cl- channels.

scientific article published in October 1993

The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size.

scientific article

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