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List of works by Edwin A. Yates

1H and 13C NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives

article

A heparin-like glycosaminoglycan from shrimp containing high levels of 3-O-sulfated D-glucosamine groups in an unusual trisaccharide sequence

scientific article published on 12 March 2014

A highly efficient tree structure for the biosynthesis of heparan sulfate accounts for the commonly observed disaccharides and suggests a mechanism for domain synthesis ⬇️

scientific article published on February 27, 2012

A new approach for heparin standardization: combination of scanning UV spectroscopy, nuclear magnetic resonance and principal component analysis.

scientific article

A non-hemorrhagic hybrid heparin/heparan sulfate with anticoagulant potential.

scientific article

A robust method to quantify low molecular weight contaminants in heparin: detection of tris(2-n-butoxyethyl) phosphate

scientific article published on 14 April 2011

A zinc complex of heparan sulfate destabilises lysozyme and alters its conformation

scientific article published on 3 August 2012

Anaerobe/aerobe environmental flux determines protein expression profiles of Bacteroides fragilis, a redox pathogen

scientific article

Analysis of the fibroblast growth factor receptor (FGFR) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling network.

scientific article published on 13 March 2013

Attachment of glycosaminoglycan oligosaccharides to thiol-derivatised gold surfaces

scientific article published on 11 October 2004

Cations modulate polysaccharide structure to determine FGF-FGFR signaling: a comparison of signaling and inhibitory polysaccharide interactions with FGF-1 in solution

scientific article published in June 2009

Characterisation of the interaction of neuropilin-1 with heparin and a heparan sulfate mimetic library of heparin-derived sugars

scientific article

Characterization of carbohydrate structural features recognized by anti-arabinogalactan-protein monoclonal antibodies.

scientific article

Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships

scientific article published on 3 September 2010

Conformational degeneracy restricts the effective information content of heparan sulfate

scientific article published on 15 February 2010

Construction and use of a library of bona fide heparins employing 1H NMR and multivariate analysis

scientific article

Determining the anti-coagulant-independent anti-cancer effects of heparin

scientific article published on 20 July 2010

Differential scanning fluorimetry measurement of protein stability changes upon binding to glycosaminoglycans: a screening test for binding specificity

scientific article published on May 2010

Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection.

scientific article published on 2 December 2010

Disruption of rosetting in Plasmodium falciparum malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities.

scientific article published on 9 February 2008

Diversification of the structural determinants of fibroblast growth factor-heparin interactions: implications for binding specificity

scientific article

Effect of substitution pattern on 1 H, 13 C NMR chemical shifts and 1 J CH coupling constants in heparin derivatives

scientific article published on 01 October 2000

Engineered bio-active polysaccharides from heparin.

scientific article published in August 2006

Engineered heparins: novel beta-secretase inhibitors as potential Alzheimer's disease therapeutics

scientific article published on 6 March 2008

Enhanced tumorigenic potential of colorectal cancer cells by extracellular sulfatases.

scientific article published on 4 December 2014

Exploiting a (13)C-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils

scientific article

Following Protein–Glycosaminoglycan Polysaccharide Interactions with Differential Scanning Fluorimetry

scientific article published on 01 January 2012

Generating heparan sulfate saccharide libraries for glycomics applications.

scientific article

Glycosaminoglycan origin and structure revealed by multivariate analysis of NMR and CD spectra

article

Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain

scientific article published on 30 April 2020

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase

scientific article published on 6 October 2003

Heparan sulphate, its derivatives and analogues share structural characteristics that can be exploited, particularly in inhibiting microbial attachment.

scientific article published on 05 April 2012

Heparin binding preference and structures in the fibroblast growth factor family parallel their evolutionary diversification

scientific article

Heparin derivatives as inhibitors of BACE-1, the Alzheimer's beta-secretase, with reduced activity against factor Xa and other proteases.

scientific article

Heparin derivatives for the targeting of multiple activities in the inflammatory response

scientific article published on 7 October 2014

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin

scientific article published on 29 April 2020

High-sensitivity visualisation of contaminants in heparin samples by spectral filtering of 1H NMR spectra

scientific article published on 31 January 2011

Highly diverse heparan sulfate analogue libraries: providing access to expanded areas of sequence space for bioactivity screening

scientific article

How To Find a Needle (or Anything Else) in a Haystack: Two-Dimensional Correlation Spectroscopy-Filtering with Iterative Random Sampling Applied to Pharmaceutical Heparin

scientific article published on 24 July 2012

Human (α2→6) and avian (α2→3) sialylated receptors of influenza A virus show distinct conformations and dynamics in solution

scientific article

In a medium containing glucose, lactate carbon is incorporated by gonococci predominantly into fatty acids and glucose carbon incorporation is increased: implications regarding lactate stimulation of metabolism

scientific article published on 01 December 2000

Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives

scientific article published on 18 June 2007

Insights into the human glycan receptor conformation of 1918 pandemic hemagglutinin-glycan complexes derived from nuclear magnetic resonance and molecular dynamics studies.

scientific article

Interactions of heparin/heparan sulfate with proteins: appraisal of structural factors and experimental approaches

scientific article published on 12 January 2004

Interactions of proteins with heparan sulfate

scientific article published in 2024

Lactate carbon does not enter the sugars of lipopolysaccharide when gonococci are grown in a medium containing glucose and lactate: implications in vivo

scientific article

Lactate stimulation of gonococcal metabolism in media containing glucose: mechanism, impact on pathogenicity, and wider implications for other pathogens.

scientific article

MYCN-dependent expression of sulfatase-2 regulates neuroblastoma cell survival

scientific article

Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry

scientific article published on 01 November 2014

Multivariate analysis applied to complex biological medicines

scientific article published on 01 August 2019

N-acylhomoserine lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa

scientific article published on October 2002

New tools for carbohydrate sulfation analysis: heparan sulfate 2--sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors

article

Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein.

scientific article

On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca2+

article

Potential role for Streptococcus gordonii -derived hydrogen peroxide in heme acquisition by Porphyromonas gingivalis

scientific article published on 01 August 2018

Protein-GAG interactions: new surface-based techniques, spectroscopies and nanotechnology probes.

scientific article

Raman and Raman optical activity of glycosaminoglycans

scientific article published on 19 April 2010

Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: toward glycomics profiling.

scientific article published on 13 July 2009

SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins

scientific article published on 30 April 2020

Selective Detection of Protein Secondary Structural Changes in Solution Protein−Polysaccharide Complexes Using Vibrational Circular Dichroism (VCD)

article

SimpleDSFviewer: A tool to analyze and view differential scanning fluorimetry data for characterizing protein thermal stability and interactions

scientific article published on 19 August 2019

Site-specific identification of an aβ fibril-heparin interaction site by using solid-state NMR spectroscopy

scientific article

Site-specific interactions of copper(II) ions with heparin revealed with complementary (SRCD, NMR, FTIR and EPR) spectroscopic techniques

scientific article published on 28 December 2007

Software tool for the structural determination of glycosaminoglycans by mass spectrometry.

scientific article published in December 2008

Specific heparan sulfate structures involved in retinal axon targeting.

scientific article published in January 2002

Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation

scientific article

Sulfated polysaccharides interact with fibroblast growth factors and protect from denaturation

scientific article published on 16 July 2019

Synthesis and X-ray crystallographic structure determination of methyl α-d-galactopyranoside 2,6-bis(sodium sulfate) · 2H2O

Terahertz: dictating the frequency of life. Do macromolecular vibrational modes impose thermal limitations on terrestrial life?

scientific article published in November 2017

The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding

scientific article (preprint)

The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation.

scientific article published on January 2008

The crystal and molecular structure of 2-sulfamino-2-deoxy-alpha-D-glucopyranose sodium salt.2H2O (glucosamine 2-sulfate).

scientific article published in June 1995

The latent ampholytic nature of glycosaminoglycan (GAG) oligosaccharides facilitates their separation by isoelectric focusing

article published in 2010

The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids

article

The redox potential interferes with the expression of laminin binding molecules in Bacteroides fragilis

scientific article published in November 2008

Unravelling Structural Information from Complex Mixtures Utilizing Correlation Spectroscopy Applied to HSQC Spectra

scientific article published on 29 July 2013

Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans.

scientific article published on 19 March 2018

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