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List of works by Helene Faustrup Kildegaard

A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.

scientific article published on November 2016

A Markov chain model for N-linked protein glycosylation--towards a low-parameter tool for model-driven glycoengineering

scientific article published on 29 October 2015

A versatile system for USER cloning-based assembly of expression vectors for mammalian cell engineering

scientific article

Accelerated homology-directed targeted integration of transgenes in Chinese hamster ovary cells via CRISPR/Cas9 and fluorescent enrichment

scientific article published on 9 May 2016

Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool

scientific article published on 22 May 2014

An Online Compendium of CHO RNA-Seq Data Allows Identification of CHO Cell Line-Specific Transcriptomic Signatures

scientific article published on 05 July 2018

Application of CRISPR/Cas9 Genome Editing to Improve Recombinant Protein Production in CHO Cells.

scientific article

Awakening dormant glycosyltransferases in CHO cells with CRISPRa

scientific article published on 12 November 2019

Baicalein Reduces Oxidative Stress in CHO Cell Cultures and Improves Recombinant Antibody Productivity

scientific article

CRISPR/Cas9 as a Genome Editing Tool for Targeted Gene Integration in CHO Cells

scientific article published on 01 January 2019

CRISPR/Cas9-Multiplexed Editing of Chinese Hamster Ovary B4Gal-T1, 2, 3, and 4 Tailors N-Glycan Profiles of Therapeutics and Secreted Host Cell Proteins

article

CRISPR/Cas9-mediated genome engineering of CHO cell factories: Application and perspectives

scientific article published on 09 June 2015

Case study on human α1-antitrypsin: Recombinant protein titers obtained by commercial ELISA kits are inaccurate

scientific article

Cell Factory Engineering

scientific article published on March 2017

Endoplasmic reticulum-directed recombinant mRNA displays subcellular localization equal to endogenous mRNA during transient expression in CHO cells

scientific article published on 14 September 2016

Engineer Medium and Feed for Modulating N-Glycosylation of Recombinant Protein Production in CHO Cell Culture

scientific article published in January 2017

Enhanced Genome Editing Tools For Multi-Gene Deletion Knock-Out Approaches Using Paired CRISPR sgRNAs in CHO Cells

scientific article

Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion

Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1 esterase inhibitor with fully humanized N-glycosylation profiles

scientific article published on 01 December 2018

Glycoengineering of Chinese hamster ovary cells for enhanced erythropoietin N-glycan branching and sialylation

scientific article

Glycoprofiling effects of media additives on IgG produced by CHO cells in fed-batch bioreactors

scientific article published on 29 July 2015

Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients.

scientific article published on 2 February 2018

Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions.

scientific article published on 05 December 2016

Minimizing Clonal Variation during Mammalian Cell Line Engineering for Improved Systems Biology Data Generation

scientific article published on 16 August 2018

Mitigating Clonal Variation in Recombinant Mammalian Cell Lines

scientific article published on 18 March 2019

Modular 5'-UTR hexamers for context-independent tuning of protein expression in eukaryotes

scientific article published on 01 November 2018

Multi-omic profiling -of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

scientific article published on 20 May 2015

Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data

scientific article

One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment

scientific article published on 10 April 2015

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

scientific article

Reduced apoptosis in Chinese hamster ovary cells via optimized CRISPR interference

scientific article published on 02 April 2019

Revealing key determinants of clonal variation in transgene expression in recombinant CHO cells using targeted genome editing

scientific article published on 14 November 2018

Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion

scientific article published on 16 January 2017

Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway

scientific article published on 25 February 2015

Systematic Evaluation of Site-Specific Recombinant Gene Expression for Programmable Mammalian Cell Engineering

scientific article published on 12 March 2019

The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology

scientific article

Toward genome-scale models of the Chinese hamster ovary cells: incentives, status and perspectives

article

USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin

scientific article

Using Titer and Titer Normalized to Confluence Are Complementary Strategies for Obtaining Chinese Hamster Ovary Cell Lines with High Volumetric Productivity of Etanercept

scientific article published on 23 January 2018

Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

scientific article

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