List of works - Ashot Harutyunyan

A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms

scientific article published on 15 March 2009

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

scientific article

A novel germline JAK2 mutation in familial myeloproliferative neoplasms.

scientific article

Allelic imbalance in CALR somatic mutagenesis

scientific article published on 8 January 2015

CALR exon 9 mutations are somatically acquired events in familial cases of essential thrombocythemia or primary myelofibrosis

scientific article published on 19 February 2014

Clinical significance of genetic aberrations in secondary acute myeloid leukemia

scientific article published on 7 August 2012

Common germline variation at the TERT locus contributes to familial clustering of myeloproliferative neoplasms

scientific article published on 26 September 2014

Complex patterns of chromosome 11 aberrations in myeloid malignancies target CBL, MLL, DDB1 and LMO2.

scientific article

Deletions of the transcription factor Ikaros in myeloproliferative neoplasms.

scientific article published on 27 May 2010

Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies.

scientific article

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

scientific article

Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression

scientific article published on 29 April 2011

Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors

scientific article published on 07 January 2014

Germline RBBP6 mutations in familial myeloproliferative neoplasms.

scientific article published on 16 November 2015

H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.

scientific article

H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation

scientific article published on 01 November 2020

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

scientific article published on 19 March 2019

Homologous recombination of wild-type JAK2, a novel early step in the development of myeloproliferative neoplasm.

scientific article

Identification of genomic aberrations associated with disease transformation by means of high-resolution SNP array analysis in patients with myeloproliferative neoplasm.

scientific article published on 22 September 2011

JAK2 or CALR mutation status defines subtypes of essential thrombocythemia with substantially different clinical course and outcomes.

scientific article published on 23 December 2013

LNK mutations in familial myeloproliferative neoplasms.

scientific article published on 23 May 2016

Low rate of calreticulin mutations in refractory anaemia with ring sideroblasts and marked thrombocytosis

scientific article published on 30 January 2014

Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness

scientific article published on 28 June 2019

Paternal lineage analysis supports an Armenian rather than a Central Asian genetic origin of the Hamshenis

scientific article

Patrilocality and recent migrations have little impact on shaping patterns of genetic structure of the Armenian population

scientific article published in August 2009

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

scientific article published on 01 May 2019

Population genetics of familial Mediterranean fever: a review.

scientific article published on 13 June 2007

Rare germline variants in regions of loss of heterozygosity may influence clinical course of hematological malignancies

scientific article published on 17 June 2011

Regionalized autosomal STR profiles among Armenian groups suggest disparate genetic influences

scientific article published on 8 August 2011

Role of Germline Genetic Factors in MPN Pathogenesis ⬇️

scientific article published on August 21, 2012

Somatic mutations of calreticulin in myeloproliferative neoplasms

scientific article

The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

scientific article published on 04 September 2019

The role of the JAK2 GGCC haplotype and the TET2 gene in familial myeloproliferative neoplasms ⬇️

scientific article published on December 20, 2010

p53 lesions in leukemic transformation

scientific article published on 01 February 2011

List of works by Ashot Harutyunyan

A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease

A novel germline JAK2 mutation in familial myeloproliferative neoplasms.

Allelic imbalance in CALR somatic mutagenesis

CALR exon 9 mutations are somatically acquired events in familial cases of essential thrombocythemia or primary myelofibrosis

Clinical significance of genetic aberrations in secondary acute myeloid leukemia

Common germline variation at the TERT locus contributes to familial clustering of myeloproliferative neoplasms

Complex patterns of chromosome 11 aberrations in myeloid malignancies target CBL, MLL, DDB1 and LMO2.

Deletions of the transcription factor Ikaros in myeloproliferative neoplasms.

Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies.

Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms

Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression

Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors

Germline RBBP6 mutations in familial myeloproliferative neoplasms.

H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.

H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

Homologous recombination of wild-type JAK2, a novel early step in the development of myeloproliferative neoplasm.

Identification of genomic aberrations associated with disease transformation by means of high-resolution SNP array analysis in patients with myeloproliferative neoplasm.

JAK2 or CALR mutation status defines subtypes of essential thrombocythemia with substantially different clinical course and outcomes.

LNK mutations in familial myeloproliferative neoplasms.

Low rate of calreticulin mutations in refractory anaemia with ring sideroblasts and marked thrombocytosis

Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness

Paternal lineage analysis supports an Armenian rather than a Central Asian genetic origin of the Hamshenis

Patrilocality and recent migrations have little impact on shaping patterns of genetic structure of the Armenian population

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

Population genetics of familial Mediterranean fever: a review.

Rare germline variants in regions of loss of heterozygosity may influence clinical course of hematological malignancies

Regionalized autosomal STR profiles among Armenian groups suggest disparate genetic influences

Role of Germline Genetic Factors in MPN Pathogenesis ⬇️

Somatic mutations of calreticulin in myeloproliferative neoplasms

The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

The role of the JAK2 GGCC haplotype and the TET2 gene in familial myeloproliferative neoplasms ⬇️

p53 lesions in leukemic transformation