List of works - José M. Frade

A Mutant Variant of E2F4 Triggers Multifactorial Therapeutic Effects in 5xFAD Mice

scientific article published on 07 March 2022

Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation

scientific article published on 01 July 2019

Biochemical evidence of a translocation between 6 RL/7 RL chromosome arms in rye (Secale cereale L.). A genetic map of 6R chromosome

scientific article published on 01 July 1991

Brain-derived neurotrophic factor-dependent cdk1 inhibition prevents G2/M progression in differentiating tetraploid neurons.

scientific article

Cell cycle control of Notch signaling and the functional regionalization of the neuroepithelium during vertebrate neurogenesis.

scientific article published on January 2009

Control of early cell death by BDNF in the chick retina

scientific article published in September 1997

Control of neuronal ploidy during vertebrate development.

scientific article published on January 2011

Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor.

scientific article

Developmentally regulated vitronectin influences cell differentiation, neuron survival and process outgrowth in the developing chicken retina

scientific article published in September 1995

Flow cytometric analysis of DNA synthesis and apoptosis in central nervous system using fresh cell nuclei.

scientific article published in January 2015

Genetic evidence for cell death mediated by nerve growth factor and the neurotrophin receptor p75 in the developing mouse retina and spinal cord.

scientific article published in February 1999

Genetic evidence for p75NTR-dependent tetraploidy in cortical projection neurons from adult mice.

scientific article published in April 2013

Heterogeneity among neuroepithelial cells in the chick retina revealed by immunostaining with monoclonal antibody PM1.

scientific article published in January 1994

Induction of cell death by endogenous nerve growth factor through its p75 receptor

scientific article published in Nature

Instability of Notch1 and Delta1 mRNAs and reduced Notch activity in vertebrate neuroepithelial cells undergoing S-phase.

scientific article published on 26 January 2008

Insulin-like growth factor-I stimulates neurogenesis in chick retina by regulating expression of the alpha 6 integrin subunit

scientific article published in August 1996

Interkinetic nuclear movement in the vertebrate neuroepithelium: encounters with an old acquaintance.

scientific article

Interkinetic nuclear movement may provide spatial clues to the regulation of neurogenesis

scientific article

Introduction of macarpine as a novel cell-permeant DNA dye for live cell imaging and flow cytometry sorting.

scientific article published on 20 October 2015

Laminin-1 selectively stimulates neuron generation from cultured retinal neuroepithelial cells

scientific article published in January 1996

Lateral inhibition and neurogenesis: novel aspects in motion.

scientific article

Microglia-Derived Nerve Growth Factor Causes Cell Death in the Developing Retina

scientific article published on 01 January 1998

Mitochondrial c-Jun NH2-terminal kinase prevents the accumulation of reactive oxygen species and reduces necrotic damage in neural tumor cells that lack trophic support

scientific article published on 8 January 2007

NRAGE and the cycling side of the neurotrophin receptor p75.

scientific article

Nerve growth factor-induced cell cycle reentry in newborn neurons is triggered by p38MAPK-dependent E2F4 phosphorylation

scientific article published on 14 May 2012

Nerve growth factor: two receptors, multiple functions ⬇️

scientific article published on February 1, 1998

Neuronal cell cycle: the neuron itself and its circumstances

scientific article published on January 2015

Neuronal injury external to the retina rapidly activates retinal glia, followed by elevation of markers for cell cycle re-entry and death in retinal ganglion cells

scientific article

Neuronal tetraploidization in the cerebral cortex correlates with reduced cognition in mice and precedes and recapitulates Alzheimer's-associated neuropathology.

scientific article published on 18 April 2017

Neuronal tetraploidy in Alzheimer and aging

scientific article published on 25 October 2017

Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not

scientific journal article

Neurotrophin-3 antibodies disrupt the normal development of the chick retina

scientific article published on 01 July 1996

Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding

scientific journal article

Origin of eukaryotic programmed cell death: a consequence of aerobic metabolism?

scientific article published on September 1997

Primary neurons can enter M-phase

scientific article published on 14 March 2019

Regulation of neuronal differentiation at the neurogenic wavefront.

scientific article published in July 2012

Role of neurotrophins in the control of neural development: neurotrophin-3 promotes both neuron differentiation and survival of cultured chick retinal cells

scientific article published in January 1994

Single mage gene in the chicken genome encodes CMage, a protein with functional similarities to mammalian type II Mage proteins.

scientific article published on 20 March 2007

Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor

scientific article

Somatic tetraploidy in vertebrate neurons: Implications in physiology and pathology.

scientific article

Sortilin participates in light-dependent photoreceptor degeneration in vivo

scientific article

Stabilization of Dll1 mRNA by Elavl1/HuR in neuroepithelial cells undergoing mitosis.

scientific article

Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting

scientific article published on 9 June 2017

Unscheduled re-entry into the cell cycle induced by NGF precedes cell death in nascent retinal neurones

scientific article published on 01 April 2000

p27(Kip1) participates in the regulation of endoreplication in differentiating chick retinal ganglion cells

scientific article

List of works by José M. Frade

A Mutant Variant of E2F4 Triggers Multifactorial Therapeutic Effects in 5xFAD Mice

Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain Inflammation

Biochemical evidence of a translocation between 6 RL/7 RL chromosome arms in rye (Secale cereale L.). A genetic map of 6R chromosome

Brain-derived neurotrophic factor-dependent cdk1 inhibition prevents G2/M progression in differentiating tetraploid neurons.

Cell cycle control of Notch signaling and the functional regionalization of the neuroepithelium during vertebrate neurogenesis.

Control of early cell death by BDNF in the chick retina

Control of neuronal ploidy during vertebrate development.

Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor.

Developmentally regulated vitronectin influences cell differentiation, neuron survival and process outgrowth in the developing chicken retina

Flow cytometric analysis of DNA synthesis and apoptosis in central nervous system using fresh cell nuclei.

Genetic evidence for cell death mediated by nerve growth factor and the neurotrophin receptor p75 in the developing mouse retina and spinal cord.

Genetic evidence for p75NTR-dependent tetraploidy in cortical projection neurons from adult mice.

Heterogeneity among neuroepithelial cells in the chick retina revealed by immunostaining with monoclonal antibody PM1.

Induction of cell death by endogenous nerve growth factor through its p75 receptor

Instability of Notch1 and Delta1 mRNAs and reduced Notch activity in vertebrate neuroepithelial cells undergoing S-phase.

Insulin-like growth factor-I stimulates neurogenesis in chick retina by regulating expression of the alpha 6 integrin subunit

Interkinetic nuclear movement in the vertebrate neuroepithelium: encounters with an old acquaintance.

Interkinetic nuclear movement may provide spatial clues to the regulation of neurogenesis

Introduction of macarpine as a novel cell-permeant DNA dye for live cell imaging and flow cytometry sorting.

Laminin-1 selectively stimulates neuron generation from cultured retinal neuroepithelial cells

Lateral inhibition and neurogenesis: novel aspects in motion.

Microglia-Derived Nerve Growth Factor Causes Cell Death in the Developing Retina

Mitochondrial c-Jun NH2-terminal kinase prevents the accumulation of reactive oxygen species and reduces necrotic damage in neural tumor cells that lack trophic support

NRAGE and the cycling side of the neurotrophin receptor p75.

Nerve growth factor-induced cell cycle reentry in newborn neurons is triggered by p38MAPK-dependent E2F4 phosphorylation

Nerve growth factor: two receptors, multiple functions ⬇️

Neuronal cell cycle: the neuron itself and its circumstances

Neuronal injury external to the retina rapidly activates retinal glia, followed by elevation of markers for cell cycle re-entry and death in retinal ganglion cells

Neuronal tetraploidization in the cerebral cortex correlates with reduced cognition in mice and precedes and recapitulates Alzheimer's-associated neuropathology.

Neuronal tetraploidy in Alzheimer and aging

Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not

Neurotrophin-3 antibodies disrupt the normal development of the chick retina

Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding

Origin of eukaryotic programmed cell death: a consequence of aerobic metabolism?

Primary neurons can enter M-phase

Regulation of neuronal differentiation at the neurogenic wavefront.

Role of neurotrophins in the control of neural development: neurotrophin-3 promotes both neuron differentiation and survival of cultured chick retinal cells

Single mage gene in the chicken genome encodes CMage, a protein with functional similarities to mammalian type II Mage proteins.

Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor

Somatic tetraploidy in vertebrate neurons: Implications in physiology and pathology.

Sortilin participates in light-dependent photoreceptor degeneration in vivo

Stabilization of Dll1 mRNA by Elavl1/HuR in neuroepithelial cells undergoing mitosis.

Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting

Unscheduled re-entry into the cell cycle induced by NGF precedes cell death in nascent retinal neurones

p27(Kip1) participates in the regulation of endoreplication in differentiating chick retinal ganglion cells