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List of works by Marc L. Reitman

2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity

scientific article published on 24 July 2008

A guide to analysis of mouse energy metabolism

scientific article published on 28 December 2011

A lectin-resistant mouse lymphoma cell line is deficient in glucosidase II, a glycoprotein-processing enzyme.

scientific article published in September 1982

A semi-mechanistic model for the effects of a novel glucagon receptor antagonist on glucagon and the interaction between glucose, glucagon, and insulin applied to adaptive phase II design.

scientific article

A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort

scientific article

A-ZIP/F-1 mice lacking white fat: a model for understanding lipoatrophic diabetes

scientific article published on 01 November 2000

Activation of adenosine A2A or A2B receptors causes hypothermia in mice

scientific article published on 13 March 2018

Activation of neuronal adenosine A1 receptors causes hypothermia through central and peripheral mechanisms

scientific article published on 16 December 2020

Adenosine-Related Mechanisms in Non-Adenosine Receptor Drugs

scientific article published on 13 April 2020

Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity

scientific article published in July 2002

Anti-obesity and metabolic efficacy of the β3-adrenergic agonist, CL316243, in mice at thermoneutrality compared to 22°C

scientific article published on 5 June 2015

Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist

scientific article published on 29 October 2010

BRS3 in both MC4R- and SIM1-expressing neurons regulates energy homeostasis in mice

scientific article published on 29 February 2020

Biphasic effect of melanocortin agonists on metabolic rate and body temperature

scientific article (publication date: 5 August 2014)

Body temperature as a mouse pharmacodynamic response to bombesin receptor subtype-3 agonists and other potential obesity treatments

scientific article published on 31 August 2010

Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple species.

scientific article published on 30 August 2011

Bombesin-Like Receptor 3: Physiology of a Functional Orphan

scientific article published on 4 April 2016

Bombesin-like receptor 3 (Brs3) expression in glutamatergic, but not GABAergic, neurons is required for regulation of energy metabolism

scientific article published on 15 September 2017

Bombesin-like receptor 3 regulates blood pressure and heart rate via a central sympathetic mechanism

scientific article published on 22 January 2016

Brs3 neurons in the mouse dorsomedial hypothalamus regulate body temperature, energy expenditure, and heart rate, but not food intake

scientific article published on 22 October 2018

Buprenorphine given after surgery does not alter renal ischemia/reperfusion injury

scientific article published on 01 December 2000

Characterization of adiposity and metabolism in Lmna-deficient mice

scientific article published in March 2002

Characterization of the bombesin-like peptide receptor family in primates.

scientific article published in July 2004

Chromatin Structure and Transcriptional Control Elements of the Erythroid Krüppel-like Factor (EKLF) Gene ⬇️

scientific article published on September 25, 1998

Chromatin structure of transcriptionally active genes

scientific article published on 01 January 1993

Chromosomal Localization and Partial Genomic Structure of the Human Peroxisome Proliferator Activated Receptor-Gamma (hPPARγ) Gene

article

Cloning of the chicken insulin receptor substrate 1 gene

scientific article published in October 1996

Coadministration of Rifampin Significantly Reduces Odanacatib Concentrations in Healthy Subjects

scientific article published on 20 June 2016

Common body mass index-associated variants confer risk of extreme obesity

scientific article

Common body mass index-associated variants confer risk of extreme obesity

Cool(ing) brain stem GABA neurons

scientific article published on 01 October 2019

Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity

scientific article

Demonstration of the heterozygous state for I-cell disease and pseudo-Hurler polydystrophy by assay of N-acetylglucosaminylphosphotransferase in white blood cells and fibroblasts ⬇️

scientific article published on September 1, 1982

Developmental changes in glycoproteins of the chick nervous system

scientific article published in February 1981

Developmental regulation of globin gene expression

scientific article published on January 1, 1992

Diet induction of monocyte chemoattractant protein-1 and its impact on obesity

scientific article published in August 2005

Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice

scientific article published in June 2003

Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

scientific article published on 18 October 2010

Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

scientific article

Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality

scientific article published on 3 October 2011

Discovery of imidazole carboxamides as potent and selective CCK1R agonists

scientific article published on 20 June 2008

Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists

scientific article published on 31 March 2011

Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists

scientific article published on 4 February 2010

Does leptin contribute to diabetes caused by obesity?

scientific article published on 01 November 1996

Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice

scientific article (publication date: 2014)

Effects of insulin on prenylation as a mechanism of potentially detrimental influence of hyperinsulinemia

scientific article published on 01 April 2000

Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes

scientific article published in August 2000

Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men.

scientific article published on 6 July 2016

Enhancer activity of upstream hypersensitive site 2 of the chicken beta-globin cluster is mediated by GATA sites.

scientific article published in December 1994

Evolution of chicken repeat 1 (CR1) elements: evidence for ancient subfamilies and multiple progenitors

scientific article published on November 1994

FGF21 mimetic shows therapeutic promise.

scientific article published on September 2013

FGF21: a missing link in the biology of fasting

scientific article published in June 2007

Fibroblasts from patients with I-cell disease and pseudo-Hurler polydystrophy are deficient in uridine 5'-diphosphate-N-acetylglucosamine: glycoprotein N-acetylglucosaminylphosphotransferase activity.

scientific article published on May 1981

Function of the upstream hypersensitive sites of the chicken beta-globin gene cluster in mice.

scientific article

Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice.

scientific article published in April 2004

Genetics of gene expression and its effect on disease

scientific article (publication date: 27 March 2008)

Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes

scientific article published in March 1999

Glucose and Lipid Homeostasis and Inflammation in Humans Following an Isocaloric Ketogenic Diet

scientific article published on 08 May 2019

Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)

scientific article

Heritability of the Weight Loss Response to Gastric Bypass Surgery ⬇️

scientific article published on August 10, 2011

Hormone-Replacement Therapy for Melanocyte-Stimulating Hormone Deficiency

scientific article published in July 2016

How Does Fat Transition from White to Beige?

scientific article published in July 2017

Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor.

scientific article

Hypothermia in mouse is caused by adenosine A1 and A3 receptor agonists and AMP via three distinct mechanisms

scientific article published on 30 November 2016

Identification of a placental enhancer for the human leptin gene.

scientific article

Identification of functional elements of the chicken epsilon-globin promoter involved in stage-specific interaction with the beta/epsilon enhancer

scientific article published in October 1996

Increased insulin sensitivity in paternal Gnas knockout mice is associated with increased lipid clearance.

scientific article

Increasing skeletal muscle fatty acid transport protein 1 (FATP1) targets fatty acids to oxidation and does not predispose mice to diet-induced insulin resistance.

scientific article

Integration of body temperature into the analysis of energy expenditure in the mouse

scientific article published on 10 March 2015

Lack of responses to a beta3-adrenergic agonist in lipoatrophic A-ZIP/F-1 mice

scientific article published on 01 November 2000

Leptin and diabetes in lipoatrophic mice

scientific article published in Nature

Leptin in the liver: a toxic or beneficial mix?

scientific article

Leptin-replacement therapy for lipodystrophy.

scientific article published in February 2002

Lipoatrophy syndromes: when 'too little fat' is a clinical problem

scientific article published on 01 September 2000

Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass.

scientific article

Lysosomal enzyme phosphorylation. Recognition of a protein-dependent determinant allows specific phosphorylation of oligosaccharides present on lysosomal enzymes

scientific journal article

Lysosomal enzyme targeting. N-Acetylglucosaminylphosphotransferase selectively phosphorylates native lysosomal enzymes

scientific article

Magic bullets melt fat.

scientific article published in June 2004

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

scientific article published on 01 March 2000

Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors

scientific article published on 29 May 2018

Methodologic considerations for measuring energy expenditure differences between diets varying in carbohydrate using the doubly labeled water method

scientific article published on 01 May 2019

Mouse Thermoregulation: Introducing the Concept of the Thermoneutral Point

scientific article published on 01 April 2020

Mouse lymphoma cell lines resistant to pea lectin are defective in fucose metabolism

scientific article published on 01 October 1980

Normal thyroid thermogenesis but reduced viability and adiposity in mice lacking the mitochondrial glycerol phosphate dehydrogenase

scientific article published in July 2002

Of mice and men - environmental temperature, body temperature, and treatment of obesity

scientific article published on 10 May 2018

Opposite effects of background genotype on muscle and liver insulin sensitivity of lipoatrophic mice. Role of triglyceride clearance

scientific article published on 26 November 2002

Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors.

scientific article

Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling

scientific article published on 24 June 2017

Peroxisome proliferator-activated receptor-alpha agonist treatment in a transgenic model of type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis.

scientific article

Pharmacogenetics of metformin response: a step in the path toward personalized medicine

scientific article published on May 2007

Pharmacokinetics and pharmacodynamics of MK-5046, a bombesin receptor subtype-3 (BRS-3) agonist, in healthy patients

scientific article published on 12 December 2011

Physiology and effects of nucleosides in mice lacking all four adenosine receptors

scientific article published on 01 March 2019

Primary sequence, evolution, and repetitive elements of the Gallus gallus (chicken) beta-globin cluster

scientific article published in December 1993

Pyridinesulfonylureas and pyridinesulfonamides as selective bombesin receptor subtype-3 (BRS-3) agonists

scientific article published on 25 February 2011

RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals

scientific article

Rat mitochondrial glycerol-3-phosphate dehydrogenase gene: multiple promoters, high levels in brown adipose tissue, and tissue-specific regulation by thyroid hormone

scientific article published in March 1998

Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3.

scientific article published on 22 January 2014

Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity

scientific article published on 21 January 2010

Regulation of leptin promoter function by Sp1, C/EBP, and a novel factor

scientific article published on 01 March 1998

Regulatory protein action in the neighborhood of chicken globin genes during development

scientific article published on 01 January 1989

Reply to DS Ludwig et al

scientific article published on 01 November 2019

Reply to Letter to the Editor: "No insulating effect of obesity, neither in mice nor in humans"

scientific article published on 01 November 2019

Research highlights from the latest articles in diabetes research

scientific article published on 01 May 2010

Rifampin's acute inhibitory and chronic inductive drug interactions: experimental and model-based approaches to drug-drug interaction trial design.

scientific article

Search for an Endogenous Bombesin-Like Receptor 3 (BRS-3) Ligand Using Parabiotic Mice

scientific article published on 12 November 2015

Site-independent expression of the chicken β A -globin gene in transgenic mice

scientific article published in Nature

Steps in the phosphorylation of the high mannose oligosaccharides of lysosomal enzymes.

scientific article

Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity

scientific article published on 21 February 2010

Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity

scientific article

The carbohydrate-binding specificity of pea and lentil lectins. Fucose is an important determinant

scientific article published on 01 July 1981

The chemical uncoupler 2,4-dinitrophenol (DNP) protects against diet-induced obesity and improves energy homeostasis in mice at thermoneutrality

scientific article

The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization

scientific article published on 24 March 2012

The effect of food intake on gene expression in human peripheral blood

scientific article

The fat and thin of lipin

scientific article published in January 2005

The role of LMNA in adipose: a novel mouse model of lipodystrophy based on the Dunnigan-type familial partial lipodystrophy mutation.

scientific article published on 05 February 2009

Thyroid hormone and other regulators of uncoupling proteins

scientific article published on 01 June 1999

Torpor in mice is induced by both leptin-dependent and -independent mechanisms

scientific article published on December 1999

Transgenic mice lacking white fat: models for understanding human lipoatrophic diabetes.

scientific article

Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes.

scientific article published in June 2001

Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy.

scientific article

Two clonal cell populations (mosaicism) in a 46,XY male with mucolipidosis II (I-cell disease)--an autosomal recessive disorder.

scientific article

UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase. Proposed enzyme for the phosphorylation of the high mannose oligosaccharide units of lysosomal enzymes

scientific article

Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin

scientific article

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks

scientific article

WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice.

scientific article

Weight Loss after Gastric Bypass Is Associated with a Variant at 15q26.1 ⬇️

scientific article published on May 2, 2013

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