List of works - Jeffrey N. Johnston

1,3,4-Oxadiazole and Heteroaromatic-Fused 1,2,4-Triazole Synthesis using Diverted Umpolung Amide Synthesis

scientific article published on 07 August 2017

A Preparation of enantiomerically enriched axially chiral beta-diketimines: synthesis of (-)- and (+)-IAN amine

scientific article published on 14 May 2008

A Unified Approach to the Four Azaindoline Families by Inter-/Intramolecular Annulative Diamination of Vinylpyridines

scientific article published on 17 July 2015

A chiral N-phosphinyl phosphoramide: another offspring for the sage phosphoric acid progenitor ⬇️

scientific article published on February 15, 2011

A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions

scientific article

A diastereo- and enantioselective synthesis of alpha-substituted anti-alpha,beta-diaminophosphonic acid derivatives

scientific article published on 06 August 2008

A diastereo- and enantioselective synthesis of alpha-substituted syn-alpha,beta-diamino acids

scientific article published on 15 April 2008

A formal enantioselective acetate Mannich reaction: the nitro functional group as a traceless agent for activation and enantiocontrol in the synthesis of beta-amino acids

scientific article published on 18 September 2008

A one-pot amidation of primary nitroalkanes

scientific article published on 01 January 2016

Achiral Counterion Control of Enantioselectivity in a Brønsted Acid-Catalyzed Iodolactonization ⬇️

scientific article published on March 30, 2012

Adaptation of a small-molecule hydrogen-bond donor catalyst to an enantioselective hetero-Diels-Alder reaction hypothesized for brevianamide biosynthesis

scientific article

Alkene diamination using electron-rich amines: hypervalent iodine-promoted inter-/intramolecular C-N bond formation

scientific article published on 01 July 2014

Application of an S --> O Allylic Transposition in the Context of a Bridgehead Olefinic System. New Opportunities for the Structural Modification of Bicyclo[6.2.1]undecanes via Transannular Ring Closure.

scientific article published in January 1998

Bifunctional asymmetric catalysis: amplification of Brønsted basicity can orthogonally increase the reactivity of a chiral Brønsted acid.

scientific article published on March 2010

Biomimetic Desymmetrization of a Carboxylic Acid

scientific article

Bronsted acid-promoted olefin aziridination and formal anti-aminohydroxylation

scientific article

Brønsted acid activation of alpha-diazo imide: a syn-selective glycolate Mannich reaction

scientific article published on 14 September 2009

Brønsted acid catalyzed phosphoramidic acid additions to alkenes: diastereo- and enantioselective halogenative cyclizations for the synthesis of C- and P-chiral phosphoramidates

scientific article

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Catalytic, Enantioselective Synthesis of Cyclic Carbamates from Dialkyl Amines by CO2-Capture: Discovery, Development, and Mechanism

scientific article published on 24 December 2018

Catalytic, Enantioselective Synthesis of Stilbene cis-Diamines: A Concise Preparation of (-)-Nutlin-3, a Potent p53/MDM2 Inhibitor

scientific article published on January 2011

Chiral Brønsted Base-Promoted Nitroalkane Alkylation: Enantioselective Synthesis of sec-Alkyl-3-Substituted Indoles ⬇️

scientific article published on November 19, 2010

Chiral proton catalysis of secondary nitroalkane additions to azomethine: synthesis of a potent GlyT1 inhibitor

scientific article

Chiral proton catalysis: a catalytic enantioselective direct aza-Henry reaction.

scientific article

Chiral proton catalysis: enantioselective Brønsted acid catalyzed additions of nitroacetic acid derivatives as glycine equivalents

scientific article published on 07 March 2007

Continuous Platform to Generate Nitroalkanes On-Demand (in situ) using Peracetic Acid-Mediated Oxidation in a PFA Pipes-in-Series Reactor

scientific article published on 19 July 2018

Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid-Base Catalyst with Recycle

scientific article published on February 2016

Diastereo- and enantioselective additions of α-nitro esters to imines for anti-α,β-diamino acid synthesis with α-alkyl-substitution.

scientific article

Discovery of competing anaerobic and aerobic pathways in umpolung amide synthesis allows for site-selective amide 18 O-labeling ⬇️

scientific article published on December 19, 2011

Enantioselective Addition of Bromonitromethane to Aliphatic N-Boc Aldimines Using a Homogeneous Bifunctional Chiral Organocatalyst.

scientific article published on January 2015

Enantioselective Organocatalytic Amine-Isocyanate Capture-Cyclization: Regioselective Alkene Iodoamination for the Synthesis of Chiral Cyclic Ureas

scientific article published on 19 November 2018

Enantioselective Synthesis of D-α-Amino Amides from Aliphatic Aldehydes

scientific article

Enantioselective Synthesis of α-Bromonitroalkanes for Umpolung Amide Synthesis: Preparation of tert-Butyl ((1R)-1-(4-(benzyloxy)phenyl)-2-bromo-2-nitroethyl)carbamate

scientific article

Enantioselective Synthesis of β-Fluoro Amines via β-Amino α-Fluoro Nitroalkanes and a Traceless Activating Group Strategy.

scientific article published on 17 October 2016

Enantioselective and diastereoselective Mukaiyama-Michael reactions catalyzed by bis(oxazoline) copper(II) complexes

scientific article published in May 2001

Enantioselective small molecule synthesis by carbon dioxide fixation using a dual Brønsted acid/base organocatalyst.

scientific article published on 3 June 2015

Enantioselective synthesis of α-oxy amides via Umpolung amide synthesis

scientific article

Evidence for Ion-Templation During Macrocyclooligomerization of Depsipeptides

scientific article published on 22 March 2018

Free radical-mediated aryl amination and its use in a convergent [3 + 2] strategy for enantioselective indoline alpha-amino acid synthesis

scientific article

Free radical-mediated aryl amination: convergent two- and three-component couplings to chiral 2,3-disubstituted indolines

scientific article

Free radical-mediated vinyl amination: access to N,N-dialkyl enamines and their beta-stannyl and beta-thio derivatives

scientific article published on 01 November 2002

Geometric Restraint Drives On- and Off-pathway Catalysis by the Escherichia coli Menaquinol:Fumarate Reductase ⬇️

scientific article

IAN-amines: direct entry to a chiral C(2)-symmetric zirconium(IV) beta-diketimine complex.

scientific article

MDM2 Antagonists Counteract Drug-Induced DNA Damage.

scientific article

Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells

scientific article

Nonconventional carbon additions to azomethines. aryl amination/indoline synthesis by direct aryl radical addition to azomethine nitrogen

scientific article published on 01 April 2001

On the nature of rate acceleration in the synthesis and fragmentation of triazolines by Brønsted acid: secondary catalysis by water (hydronium triflate).

scientific article

On-Demand Complex Peptide Synthesis: An Aspirational (and Elusive?) Goal for Peptide Synthesis.

scientific article published on 14 October 2016

Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition

scientific article

Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease

scientific article

Origins of selectivity in Brønsted acid-promoted diazoalkane-azomethine reactions (the aza-Darzens aziridine synthesis)

scientific article published on 02 March 2011

Oxidative inter-/intermolecular alkene diamination of hydroxy styrenes with electron-rich amines

scientific article published on 05 May 2015

PREPARATION OF ISOPROPYL 2-DIAZOACETYL(PHENYL)CARBAMATE

scientific article

Preparation of (-)-Nutlin-3 using enantioselective organocatalysis at decagram scale.

scientific article published on 15 October 2013

Preparation of H,(4) PyrrolidineQuin-BAM (PBAM).

scientific article

Preparation of a protected phosphoramidon precursor via an H-phosphonate coupling strategy

scientific article published on 28 August 2006

Rapid synthesis of cyclic oligomeric depsipeptides with positional, stereochemical, and macrocycle size distribution control.

scientific article published on 14 December 2016

Silyl imine electrophiles in enantioselective catalysis: a Rosetta Stone for peptide homologation, enabling diverse N-protected aryl glycines from aldehydes in three steps

scientific article

Stereoselective synthesis of complex polycyclic aziridines: use of the Brønsted acid-catalyzed aza-Darzens reaction to prepare an orthogonally protected mitomycin C intermediate with maximal convergency

scientific article published on 24 February 2011

Substituted Imidazoline Synthesis: A Diastereo- and Enantioselective aza-Henry Route to a Human Proteasome Modulator

scientific article published on 15 October 2020

Synthesis of an advanced intermediate en route to the mitomycin natural products.

scientific article published on December 2006

The first azacyclopentenyl carbinyl radical isomerizations (ACCRI): independent use of steric and electronic (polarization) effects as gating elements

scientific article

The inverted ketene synthon: a double umpolung approach to enantioselective β2,3-amino amide synthesis.

scientific article published on 12 November 2018

To protonate or alkylate? Stereoselective Brønsted acid catalysis of C-C bond formation using diazoalkanes.

scientific article published on March 2010

Total synthesis of the Lycopodium alkaloid serratezomine A using free radical-mediated vinyl amination to prepare a β-stannyl enamine linchpin.

scientific article published on 28 December 2012

Total synthesis of the chlorine-containing hapalindoles K, A, and G.

scientific article published on 7 July 2011

Total synthesis of the lycopodium alkaloid (+)-serratezomine A.

scientific article published on March 2009

Umpolung amide synthesis using substoichiometric N-iodosuccinimide (NIS) and oxygen as a terminal oxidant

scientific article

Umpolung reactivity in amide and peptide synthesis

scientific article published on June 2010

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

scientific article published on 21 February 2019

Use of comparative triazolinium triflate fragmentation rates as a tool to assay relative competency of Brønsted bases in N-->N proton transfer.

scientific article published on 17 July 2009

Use of the vicinal element effect for regiochemical control of quinone substitutions and its implication for convergent mitomycin construction

scientific article published on 01 November 2001

VNI cures acute and chronic experimental Chagas disease

scientific article

List of works by Jeffrey N. Johnston

1,3,4-Oxadiazole and Heteroaromatic-Fused 1,2,4-Triazole Synthesis using Diverted Umpolung Amide Synthesis

A Preparation of enantiomerically enriched axially chiral beta-diketimines: synthesis of (-)- and (+)-IAN amine

A Unified Approach to the Four Azaindoline Families by Inter-/Intramolecular Annulative Diamination of Vinylpyridines

A chiral N-phosphinyl phosphoramide: another offspring for the sage phosphoric acid progenitor ⬇️

A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions

A diastereo- and enantioselective synthesis of alpha-substituted anti-alpha,beta-diaminophosphonic acid derivatives

A diastereo- and enantioselective synthesis of alpha-substituted syn-alpha,beta-diamino acids

A formal enantioselective acetate Mannich reaction: the nitro functional group as a traceless agent for activation and enantiocontrol in the synthesis of beta-amino acids

A one-pot amidation of primary nitroalkanes

Achiral Counterion Control of Enantioselectivity in a Brønsted Acid-Catalyzed Iodolactonization ⬇️

Adaptation of a small-molecule hydrogen-bond donor catalyst to an enantioselective hetero-Diels-Alder reaction hypothesized for brevianamide biosynthesis

Alkene diamination using electron-rich amines: hypervalent iodine-promoted inter-/intramolecular C-N bond formation

Application of an S --> O Allylic Transposition in the Context of a Bridgehead Olefinic System. New Opportunities for the Structural Modification of Bicyclo[6.2.1]undecanes via Transannular Ring Closure.

Bifunctional asymmetric catalysis: amplification of Brønsted basicity can orthogonally increase the reactivity of a chiral Brønsted acid.

Biomimetic Desymmetrization of a Carboxylic Acid

Bronsted acid-promoted olefin aziridination and formal anti-aminohydroxylation

Brønsted acid activation of alpha-diazo imide: a syn-selective glycolate Mannich reaction

Brønsted acid catalyzed phosphoramidic acid additions to alkenes: diastereo- and enantioselective halogenative cyclizations for the synthesis of C- and P-chiral phosphoramidates

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Catalytic, Enantioselective Synthesis of Cyclic Carbamates from Dialkyl Amines by CO2-Capture: Discovery, Development, and Mechanism

Catalytic, Enantioselective Synthesis of Stilbene cis-Diamines: A Concise Preparation of (-)-Nutlin-3, a Potent p53/MDM2 Inhibitor

Chiral Brønsted Base-Promoted Nitroalkane Alkylation: Enantioselective Synthesis of sec-Alkyl-3-Substituted Indoles ⬇️

Chiral proton catalysis of secondary nitroalkane additions to azomethine: synthesis of a potent GlyT1 inhibitor

Chiral proton catalysis: a catalytic enantioselective direct aza-Henry reaction.

Chiral proton catalysis: enantioselective Brønsted acid catalyzed additions of nitroacetic acid derivatives as glycine equivalents

Continuous Platform to Generate Nitroalkanes On-Demand (in situ) using Peracetic Acid-Mediated Oxidation in a PFA Pipes-in-Series Reactor

Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid-Base Catalyst with Recycle

Diastereo- and enantioselective additions of α-nitro esters to imines for anti-α,β-diamino acid synthesis with α-alkyl-substitution.

Discovery of competing anaerobic and aerobic pathways in umpolung amide synthesis allows for site-selective amide 18 O-labeling ⬇️

Enantioselective Addition of Bromonitromethane to Aliphatic N-Boc Aldimines Using a Homogeneous Bifunctional Chiral Organocatalyst.

Enantioselective Organocatalytic Amine-Isocyanate Capture-Cyclization: Regioselective Alkene Iodoamination for the Synthesis of Chiral Cyclic Ureas

Enantioselective Synthesis of D-α-Amino Amides from Aliphatic Aldehydes

Enantioselective Synthesis of α-Bromonitroalkanes for Umpolung Amide Synthesis: Preparation of tert-Butyl ((1R)-1-(4-(benzyloxy)phenyl)-2-bromo-2-nitroethyl)carbamate

Enantioselective Synthesis of β-Fluoro Amines via β-Amino α-Fluoro Nitroalkanes and a Traceless Activating Group Strategy.

Enantioselective and diastereoselective Mukaiyama-Michael reactions catalyzed by bis(oxazoline) copper(II) complexes

Enantioselective small molecule synthesis by carbon dioxide fixation using a dual Brønsted acid/base organocatalyst.

Enantioselective synthesis of α-oxy amides via Umpolung amide synthesis

Evidence for Ion-Templation During Macrocyclooligomerization of Depsipeptides

Free radical-mediated aryl amination and its use in a convergent [3 + 2] strategy for enantioselective indoline alpha-amino acid synthesis

Free radical-mediated aryl amination: convergent two- and three-component couplings to chiral 2,3-disubstituted indolines

Free radical-mediated vinyl amination: access to N,N-dialkyl enamines and their beta-stannyl and beta-thio derivatives

Geometric Restraint Drives On- and Off-pathway Catalysis by the Escherichia coli Menaquinol:Fumarate Reductase ⬇️

IAN-amines: direct entry to a chiral C(2)-symmetric zirconium(IV) beta-diketimine complex.

MDM2 Antagonists Counteract Drug-Induced DNA Damage.

Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells

Nonconventional carbon additions to azomethines. aryl amination/indoline synthesis by direct aryl radical addition to azomethine nitrogen

On the nature of rate acceleration in the synthesis and fragmentation of triazolines by Brønsted acid: secondary catalysis by water (hydronium triflate).

On-Demand Complex Peptide Synthesis: An Aspirational (and Elusive?) Goal for Peptide Synthesis.

Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition

Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease

Origins of selectivity in Brønsted acid-promoted diazoalkane-azomethine reactions (the aza-Darzens aziridine synthesis)

Oxidative inter-/intermolecular alkene diamination of hydroxy styrenes with electron-rich amines

PREPARATION OF ISOPROPYL 2-DIAZOACETYL(PHENYL)CARBAMATE

Preparation of (-)-Nutlin-3 using enantioselective organocatalysis at decagram scale.

Preparation of H,(4) PyrrolidineQuin-BAM (PBAM).

Preparation of a protected phosphoramidon precursor via an H-phosphonate coupling strategy

Rapid synthesis of cyclic oligomeric depsipeptides with positional, stereochemical, and macrocycle size distribution control.

Silyl imine electrophiles in enantioselective catalysis: a Rosetta Stone for peptide homologation, enabling diverse N-protected aryl glycines from aldehydes in three steps

Stereoselective synthesis of complex polycyclic aziridines: use of the Brønsted acid-catalyzed aza-Darzens reaction to prepare an orthogonally protected mitomycin C intermediate with maximal convergency

Substituted Imidazoline Synthesis: A Diastereo- and Enantioselective aza-Henry Route to a Human Proteasome Modulator

Synthesis of an advanced intermediate en route to the mitomycin natural products.

The first azacyclopentenyl carbinyl radical isomerizations (ACCRI): independent use of steric and electronic (polarization) effects as gating elements

The inverted ketene synthon: a double umpolung approach to enantioselective β2,3-amino amide synthesis.

To protonate or alkylate? Stereoselective Brønsted acid catalysis of C-C bond formation using diazoalkanes.

Total synthesis of the Lycopodium alkaloid serratezomine A using free radical-mediated vinyl amination to prepare a β-stannyl enamine linchpin.

Total synthesis of the chlorine-containing hapalindoles K, A, and G.

Total synthesis of the lycopodium alkaloid (+)-serratezomine A.

Umpolung amide synthesis using substoichiometric N-iodosuccinimide (NIS) and oxygen as a terminal oxidant

Umpolung reactivity in amide and peptide synthesis

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

Use of comparative triazolinium triflate fragmentation rates as a tool to assay relative competency of Brønsted bases in N-->N proton transfer.

Use of the vicinal element effect for regiochemical control of quinone substitutions and its implication for convergent mitomycin construction

VNI cures acute and chronic experimental Chagas disease