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List of works by Jeffrey Aubé

(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection

scientific article

1,3-allylic strain as a strategic diversification element for constructing libraries of substituted 2-arylpiperidines.

scientific article

3-Substituted Biquinolinium Inhibitors of AraC Family Transcriptional Activator VirF from S. flexneri Obtained Through In Situ Chemical Ionization of 3,4-Disubstituted Dihydroquinolines

scientific article

A Combined Intramolecular Diels–Alder/Intramolecular Schmidt Reaction: Formal Synthesis of (±)-Stenine

scientific article published on 01 November 2002

A New Twist on Amide Solvolysis ⬇️

scientific article published on February 22, 2012

A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition

scientific article

A concomitant allylic azide rearrangement/intramolecular azide-alkyne cycloaddition sequence

scientific article published on 17 March 2014

A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells

scientific article published in February 2001

A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry

scientific article

A tandem Prins/Schmidt reaction approach to marine alkaloids: formal and total syntheses of lepadiformines A and C

scientific article

Ab initio approach to understanding the stereoselectivity of reactions between hydroxyalkyl azides and ketones

scientific article

An Interrupted Schmidt Reaction: C-C Bond Formation Arising from Nitrilium Ion Capture

scientific article published on 02 October 2018

An RNA-binding protein, Hu-antigen R, in pancreatic cancer epithelial to mesenchymal transition, metastasis, and cancer stem cells

scientific article published on 02 September 2020

An efficient computational model to predict protonation at the amide nitrogen and reactivity along the C-N rotational pathway

scientific article published on April 2015

An expeditious total synthesis of (+/-)-stenine

scientific article published on 01 November 2005

Application of the DP4 Probability Method to Flexible Cyclic Peptides with Multiple Independent Stereocenters: The True Structure of Cyclocinamide A

scientific article published on 09 July 2018

Asymmetric Schmidt reaction of hydroxyalkyl azides with ketones.

scientific article

Asymmetric Total Synthesis of Dendrobatid Alkaloids:  Preparation of Indolizidine 251F and Its 3-Desmethyl Analogue Using an Intramolecular Schmidt Reaction Strategy

scientific article (publication date: May 2004)

Asymmetric total synthesis of alkaloids 223A and 6-epi-223A

scientific article published on September 2009

Asymmetric total synthesis of dendrobatid alkaloid 251F.

scientific article

Automated three-component synthesis of a library of γ-lactams.

scientific article

Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA

scientific article published on 09 July 2019

Base-promoted reactions of bridged ketones and 1,3- and 1,4-haloalkyl azides: competitive alkylation vs azidation reactions of ketone enolates

scientific article published in March 2004

Benzylmorpholine analogs as selective inhibitors of lung cytochrome P450 2A13 for the chemoprevention of lung cancer in tobacco users

scientific article published on 12 June 2013

Butitaxel analogues: synthesis and structure-activity relationships

scientific article published on 01 January 1997

Can they imagine the future? A qualitative study exploring the skills employers seek in pharmaceutical sciences doctoral graduates

scientific article published on 09 September 2019

Cation-n control of regiochemistry of intramolecular Schmidt reactions en route to bridged bicyclic lactams

scientific article published on 01 October 2009

Cation-pi control of regiochemistry of intramolecular schmidt reactions en route to bridged bicyclic lactams

scientific article

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe

scientific article published on 4 February 2013

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.

scientific article published in March 2014

Chemistry of bridged lactams and related heterocycles

scientific article

Chemotype-selective modes of action of κ-opioid receptor agonists

scientific article published on 11 October 2013

Copper-catalyzed oxaziridine-mediated oxidation of C-H bonds.

scientific article

Corey-Chaykovsky epoxidation of twisted amides: synthesis and reactivity of bridged spiro-epoxyamines.

scientific article published on September 2009

Correction to "Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis"

scientific article published on 31 October 2019

Design, synthesis, and evaluation of azapeptides as substrates and inhibitors for human rhinovirus 3C protease

scientific article

Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus

scientific article

Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.

scientific article published on 21 June 2017

Development of functionally selective, small molecule agonists at kappa opioid receptors

scientific article

Discovery and Development of Small Molecules That Reduce PNC Prevalence

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.

scientific article

Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response

scientific article

Discovery, Optimization and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist

scientific article published on 28 April 2020

Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase

Domino reactions that combine an azido-Schmidt ring expansion with the Diels-Alder reaction

scientific article published on 01 December 2004

Double conjugate addition of a nitropropionate ester to a quinone monoketal: synthesis of an advanced intermediate to (+/-)-gelsemine.

scientific article published on 12 July 2007

Drug repurposing and the medicinal chemist.

scientific article

Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis

scientific article published on 11 June 2019

Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma

scientific article published on 22 March 2019

Effect of progressive benzyl substitution on the conformations of aminocaproic acid-cyclized dipeptides.

scientific article published in April 2001

Effect of stereochemistry on the transport of Aca-linked β-turn peptidomimetics across a human intestinal cell line ⬇️

scientific article published on September 1, 1997

Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence

scientific article

Explorations of stemona alkaloid-inspired analogues: skeletal modification and functional group diversification

scientific article

Facile C−N Cleavage in a Series of Bridged Lactams

scientific article published in 2005

First asymmetric total synthesis of (+)-sparteine

scientific article published in July 2002

G protein signaling–biased agonism at the κ-opioid receptor is maintained in striatal neurons

article

High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors

scientific article published on 2 September 2015

High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity

scientific article

Highly stereoselective ring expansion reactions mediated by attractive cation-n interactions

scientific article published on January 2008

HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A

scientific article published on 13 December 2019

Hydrolysis of Iminium Ethers Derived from the Reaction of Ketones with Hydroxy Azides: Synthesis of Macrocyclic Lactams and Lactones

Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry

scientific article published in February 2012

Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol

scientific article published on 29 December 2015

In Situ Generation and Intramolecular Schmidt Reaction of Keto Azides in a Microwave‐Assisted Flow Format ⬇️

scientific article published on July 27, 2011

Intramolecular and Intermolecular Schmidt Reactions of Alkyl Azides with Aldehydes.

scientific article

Intramolecular reactions of benzylic azides with ketones: competition between Schmidt and Mannich pathways

scientific article published on 01 February 2001

Lewis acid-mediated reactions of alkyl azides with alpha,beta-unsaturated ketones.

scientific article

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

scientific article published on 01 October 2019

Mechanism of the acid-promoted intramolecular schmidt reaction: theoretical assessment of the importance of lone pair-cation, cation-π, and steric effects in controlling regioselectivity

scientific article

Medium-bridged lactams: a new class of non-planar amides

scientific article published on 11 November 2010

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.

scientific article published in May 2018

Minor withanolides of Physalis longifolia: structure and cytotoxicity.

scientific article

Modular synthesis of cyclic peptidomimetics inspired by gamma-turns

scientific article published on 01 March 2005

Mucosal-associated invariant and γδ T cell subsets respond to initial Mycobacterium tuberculosis infection

scientific article published on 04 October 2018

N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: a Novel Class of Selective, Nonbasic, Nitrogen-Containing κ-Opioid Receptor Ligands

scientific article published on August 2010

Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1.

scientific article published on 10 April 2015

Nonbonded, attractive cation-pi interactions in azide-mediated asymmetric ring expansion reactions

scientific article published on 9 April 2008

Nucleophilic addition to iminium ethers in the preparation of functionalized N-alkyl heterocycles

scientific article

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition

scientific article published on 01 February 2019

Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity

scientific article

Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline

scientific article

Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif

scientific article published on 23 December 2014

Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold.

scientific article

Probing chemical space with alkaloid-inspired libraries

scientific article

Reaction discovery using microfluidic-based multidimensional screening of polycyclic iminium ethers

scientific article

Reactions of cyclopropanone acetals with alkyl azides: carbonyl addition versus ring-opening pathways

scientific article published on 7 November 2007

Reactivity toward deamidation of asparagine residues in beta-turn structures.

scientific article published on September 2000

Reagent-controlled regiodivergent ring expansions of steroids.

scientific article published on 5 March 2018

Rearrangements of bicyclic nitrones to lactams: comparison of photochemical and modified Barton conditions

scientific article published in October 2003

Regiochemical studies of the ring expansion reactions of hydroxy azides with cyclic ketones

scientific article published on 01 June 2000

Regioselective single and double conjugate additions to substituted cyclohexa-2,5-dienone monoacetals

scientific article published on 01 July 2005

Remote control of diastereoselectivity in intramolecular reactions of chiral allylsilanes.

scientific article published on October 2006

Resolution of Carboxylic Acids Using Copper(I)-Promoted Removal of Propargylic Esters under Neutral Conditions ⬇️

scientific article published on April 14, 2011

Revisiting a classic approach to the Aspidosperma alkaloids: an intramolecular Schmidt reaction mediated synthesis of (+)-aspidospermidine.

scientific article published on December 2005

Ring expansive routes to quinolizidine alkaloids: formal synthesis of (-)-lasubine II

scientific article published on 01 December 2003

Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor

scientific article published on 05 July 2017

Single-Cell Transcriptional Profiling Reveals Signatures of Helper, Effector, and Regulatory MAIT Cells during Homeostasis and Activation

scientific article published on 11 February 2022

Small-molecule libraries: naturally inspired oligomers

scientific article published on 24 January 2012

Solution-phase parallel synthesis of a library of delta(2)-pyrazolines

scientific article

Stability of medium-bridged twisted amides in aqueous solutions

scientific article

Stereocontrol in a combined allylic azide rearrangement and intramolecular Schmidt reaction

scientific article published on 10 April 2012

Stereodivergent synthesis of enantioenriched 4-hydroxy-2-cyclopentenones

scientific article published on 20 December 2013

Stereoselective Synthesis of Freidinger Lactams Using Oxaziridines Derived from Amino Acids

scientific article published on 01 February 1997

Stereoselectivity in nucleophilic additions to 3-azidoalkanals.

scientific article

Structural characterization of N-protonated amides: regioselective N-activation of medium-bridged twisted lactams

scientific article

Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2

scientific article published on 24 May 2018

Syntheses of the Stemona alkaloids (+/-)-stenine, (+/-)-neostenine, and (+/-)-13-epineostenine using a stereodivergent Diels-Alder/azido-Schmidt reaction

scientific article published on 09 April 2008

Synthesis and Cytotoxicity of Semisynthetic Withalongolide A Analogues.

scientific article published on November 2013

Synthesis and conformational studies of dipeptides constrained by disubstituted 3-(aminoethoxy)propionic acid linkers

scientific article published in March 2004

Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication.

scientific article published on July 1998

Synthesis and reactivity of bicyclo[3.2.1]octanoid-derived cyclopropanes

scientific article

Synthesis and rearrangement of a bridged thioamide

scientific article published on 30 October 2009

Synthesis and structural study of cyclic 5-aminovaleric acid-linked beta-Ala-beta-Ala dipeptides

scientific article

Synthesis of N-alkyl-octahydroisoquinolin-1-one-8-carboxamide libraries using a tandem Diels-Alder/acylation sequence

scientific article

Synthesis of a small library of diketopiperazines as potential inhibitors of calpain.

scientific article published in June 2005

Synthesis of enantiomerically enriched (R)-5-tert-butylazepan-2-one using a hydroxyalkyl azide mediated ring-expansion reaction

scientific article

Synthesis of the Nonribosomal Peptide Phevalin and Analogs

scientific article published on 01 March 2019

Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU).

scientific article

Synthetic probes for the study of biological function

scientific article published on 15 January 2013

Target Deconvolution of a Multikinase Inhibitor with Antimetastatic Properties Identifies TAOK3 as a Key Contributor to a Cancer Stem Cell-Like Phenotype

scientific article published on 08 August 2019

Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis

scientific article published on 24 April 2020

Temperature dependence of turnover in a Sc(OTf)3-catalyzed intramolecular Schmidt reaction.

scientific article published on June 2015

Three-component synthesis of 1,4-diazepin-5-ones and the construction of gamma-turn-like peptidomimetic libraries

scientific article

Transport characteristics of peptides and peptidomimetics: I. N-methylated peptides as substrates for the oligopeptide transporter and P-glycoprotein in the intestinal mucosa.

scientific article published in April 2001

Transport characteristics of peptides and peptidomimetics: II. Hydroxyethylamine bioisostere-containing peptidomimetics as substrates for the oligopeptide transporter and P-glycoprotein in the intestinal mucosa.

scientific article

Unusual tethering effects in the Schmidt reaction of hydroxyalkyl azides with ketones: cation-pi and steric stabilization of a pseudoaxial phenyl group

scientific article published in November 2003

Use of a tandem Prins/Friedel-Crafts reaction in the construction of the indeno-tetrahydropyridine core of the haouamine alkaloids: formal synthesis of (-)-haouamine A.

scientific article

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