List of works - Robert M. Prins

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

scientific article

Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma

scientific article published on 16 June 2020

An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway

scientific article published on 15 September 2011

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity

scientific article published on 25 February 2013

Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain

scientific article published on 06 February 2008

Bioluminescent imaging of melanoma in live mice

scientific article

CD200 in CNS tumor-induced immunosuppression: the role for CD200 pathway blockade in targeted immunotherapy

scientific article

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

scientific article

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

scientific article published on June 2010

Cellular and vaccine therapeutic approaches for gliomas

scientific article

Central nervous system tumor immunity generated by a recombinant listeria monocytogenes vaccine targeting tyrosinase related protein-2 and real-time imaging of intracranial tumor burden.

scientific article published on January 2006

Characterization of defective CD4-CD8- T cells in murine tumors generated independent of antigen specificity

scientific article published on February 2004

Comparison of glioma-associated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients

scientific article published on February 2013

Contrasting effects of interleukin-2 secretion by rat glioma cells contingent upon anatomical location: accelerated tumorigenesis in the central nervous system and complete rejection in the periphery

scientific article

Correction to: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma.

scientific article

Cytokine responsiveness of CD8(+) T cells is a reproducible biomarker for the clinical efficacy of dendritic cell vaccination in glioblastoma patients.

scientific article

Cytomegalovirus immunity after vaccination with autologous glioblastoma lysate.

scientific article published on July 2008

Cytotoxic T cells infiltrating a glioma express an aberrant phenotype that is associated with decreased function and apoptosis

scientific article

Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas ligand pathway

scientific article published on 7 November 2011

Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment

scientific article published on August 2005

Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase-1 mutation

scientific article

Detection of immune responses after immunotherapy in glioblastoma using PET and MRI.

scientific article published on 5 September 2017

EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy

scientific article

Efficacy of systemic adoptive transfer immunotherapy targeting NY-ESO-1 for glioblastoma

scientific article published on September 2015

Endogenous vaults and bioengineered vault nanoparticles for treatment of glioblastomas: implications for future targeted therapies

scientific article published on 31 May 2012

Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824.

scientific article published on 27 October 2009

Enhanced sensitivity to IL-2 signaling regulates the clinical responsiveness of IL-12-primed CD8(+) T cells in a melanoma model

scientific article

Epithelial membrane protein-2 (EMP2) promotes angiogenesis in glioblastoma multiforme

scientific article published on 9 June 2017

Evidence for Innate and Adaptive Immune Responses in a Cohort of Intractable Pediatric Epilepsy Surgery Patients

article

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma.

scientific article

Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy

scientific article

Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas.

scientific article

Immunosensitization with a Bcl-2 small molecule inhibitor

scientific article published on 20 September 2008

Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma.

scientific article published on 23 January 2017

Immunotherapy for patients with malignant glioma: from theoretical principles to clinical applications

scientific article published on October 2006

Immunotherapy response assessment in neuro-oncology: a report of the RANO working group

scientific article

Implementing liquid biopsies into clinical decision making for cancer immunotherapy

scientific article

Irradiated tumor cell vaccine for treatment of an established glioma. I. Successful treatment with combined radiotherapy and cellular vaccination

scientific article

Irradiated tumor cell vaccine for treatment of an established glioma. II. Expansion of myeloid suppressor cells that promote tumor progression

scientific article published on 6 April 2002

Lentiviral vectors with CMV or MHCII promoters administered in vivo: immune reactivity versus persistence of expression

scientific article published on May 2007

Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI

scientific article published on 04 May 2019

Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients

scientific article (publication date: 2012)

NIMG-56IMMUNOTHERAPY RESPONSE ASSESSMENT IN NEURO-ONCOLOGY (iRANO): A REPORT OF THE RANO WORKING GROUP.

scientific article

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

article

Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy

scientific article

Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen

scientific article published on 23 December 2008

Radial mobility and cytotoxic function of retroviral replicating vector transduced, non-adherent alloresponsive T lymphocytes.

scientific article

SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation

scientific article published on 05 March 2019

The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis

scientific article published on 22 July 2009

The histone deacetylase inhibitor, LBH589, promotes the systemic cytokine and effector responses of adoptively transferred CD8+ T cells

scientific article

Thymic function and output of recent thymic emigrant T cells during intracranial glioma progression

scientific article

Tissue microarray analysis for epithelial membrane protein-2 as a novel biomarker for gliomas.

scientific article published on 8 September 2017

Tumor immunology, immunomics and targeted immunotherapy for central nervous system malignancies

scientific article

Tumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas.

scientific article

Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative immunohistochemistry

scientific article published on 26 February 2019

pH-weighted molecular imaging of gliomas using amine chemical exchange saturation transfer MRI

scientific article

List of works by Robert M. Prins

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma

An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity

Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain

Bioluminescent imaging of melanoma in live mice

CD200 in CNS tumor-induced immunosuppression: the role for CD200 pathway blockade in targeted immunotherapy

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Cellular and vaccine therapeutic approaches for gliomas

Central nervous system tumor immunity generated by a recombinant listeria monocytogenes vaccine targeting tyrosinase related protein-2 and real-time imaging of intracranial tumor burden.

Characterization of defective CD4-CD8- T cells in murine tumors generated independent of antigen specificity

Comparison of glioma-associated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients

Contrasting effects of interleukin-2 secretion by rat glioma cells contingent upon anatomical location: accelerated tumorigenesis in the central nervous system and complete rejection in the periphery

Correction to: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma.

Cytokine responsiveness of CD8(+) T cells is a reproducible biomarker for the clinical efficacy of dendritic cell vaccination in glioblastoma patients.

Cytomegalovirus immunity after vaccination with autologous glioblastoma lysate.

Cytotoxic T cells infiltrating a glioma express an aberrant phenotype that is associated with decreased function and apoptosis

Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas ligand pathway

Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment

Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase-1 mutation

Detection of immune responses after immunotherapy in glioblastoma using PET and MRI.

EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy

Efficacy of systemic adoptive transfer immunotherapy targeting NY-ESO-1 for glioblastoma

Endogenous vaults and bioengineered vault nanoparticles for treatment of glioblastomas: implications for future targeted therapies

Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824.

Enhanced sensitivity to IL-2 signaling regulates the clinical responsiveness of IL-12-primed CD8(+) T cells in a melanoma model

Epithelial membrane protein-2 (EMP2) promotes angiogenesis in glioblastoma multiforme

Evidence for Innate and Adaptive Immune Responses in a Cohort of Intractable Pediatric Epilepsy Surgery Patients

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma.

Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy

Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas.

Immunosensitization with a Bcl-2 small molecule inhibitor

Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma.

Immunotherapy for patients with malignant glioma: from theoretical principles to clinical applications

Immunotherapy response assessment in neuro-oncology: a report of the RANO working group

Implementing liquid biopsies into clinical decision making for cancer immunotherapy

Irradiated tumor cell vaccine for treatment of an established glioma. I. Successful treatment with combined radiotherapy and cellular vaccination

Irradiated tumor cell vaccine for treatment of an established glioma. II. Expansion of myeloid suppressor cells that promote tumor progression

Lentiviral vectors with CMV or MHCII promoters administered in vivo: immune reactivity versus persistence of expression

Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI

Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients

NIMG-56IMMUNOTHERAPY RESPONSE ASSESSMENT IN NEURO-ONCOLOGY (iRANO): A REPORT OF THE RANO WORKING GROUP.

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy

Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen

Radial mobility and cytotoxic function of retroviral replicating vector transduced, non-adherent alloresponsive T lymphocytes.

SPINT2 is hypermethylated in both IDH1 mutated and wild-type glioblastomas, and exerts tumor suppression via reduction of c-Met activation

The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis

The histone deacetylase inhibitor, LBH589, promotes the systemic cytokine and effector responses of adoptively transferred CD8+ T cells

Thymic function and output of recent thymic emigrant T cells during intracranial glioma progression

Tissue microarray analysis for epithelial membrane protein-2 as a novel biomarker for gliomas.

Tumor immunology, immunomics and targeted immunotherapy for central nervous system malignancies

Tumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas.

Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative immunohistochemistry

pH-weighted molecular imaging of gliomas using amine chemical exchange saturation transfer MRI