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List of works by Christoph Stein

3D-wound healing model: influence of morphine and solid lipid nanoparticles

scientific article

A low pKa ligand inhibits cancer-associated pain in mice by activating peripheral mu-opioid receptors

scientific article published on 29 October 2020

A nontoxic pain killer designed by modeling of pathological receptor conformations

scientific article

A randomized, controlled, clinical pilot study assessing the analgesic effect of morphine applied topically onto split-thickness skin wounds

scientific article published on 19 June 2014

A thermosensitive morphine-containing hydrogel for the treatment of large-scale skin wounds

scientific article published on 23 January 2013

Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations

scientific article

Altered cell-mediated immunity and increased postoperative infection rate in long-term alcoholic patients

scientific article published in May 2004

Analgesic effects of a novel pH-dependent μ-opioid receptor agonist in models of neuropathic and abdominal pain

Analgesic efficacy of opioids in chronic pain: recent meta-analyses

scientific article

Analysis of absorption enhancers in epithelial cell models

scientific article published on July 2012

Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons

scientific article published on 9 February 2017

Antinociception by neutrophil-derived opioid peptides in noninflamed tissue--role of hypertonicity and the perineurium.

scientific article

Antinociceptive effects of dynorphin peptides in a model of inflammatory pain.

scientific article

Antinociceptive effects of mu- and kappa-agonists in inflammation are enhanced by a peripheral opioid receptor-specific mechanism

scientific article

Attacking pain at its source: new perspectives on opioids

scientific article (publication date: August 2003)

Author Correction: pKa of opioid ligands as a discriminating factor for side effects

scientific article published on 04 March 2020

B Lymphocytes Express Pomc mRNA, Processing Enzymes and β-Endorphin in Painful Inflammation

scientific article published on 11 November 2016

Barbiturate-induced inhibition of a spinal nociceptive reflex: role of GABA mechanisms and descending modulation.

scientific article published on March 1987

Beta-endorphin, Met-enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis

scientific article

Blockade of intra-articular adrenergic receptors increases analgesic demands for pain relief after knee surgery

scientific article published on 10 April 2010

Breaking the pain barrier

CXCR1/2 ligands induce p38 MAPK-dependent translocation and release of opioid peptides from primary granules in vitro and in vivo

scientific article

Characterization of mu opioid receptor binding and G protein coupling in rat hypothalamus, spinal cord, and primary afferent neurons during inflammatory pain

scientific article

Cholecystokinin inhibits peripheral opioid analgesia in inflamed tissue

scientific article published in January 1998

Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain

scientific article

Co-expression of beta-endorphin with adhesion molecules in a model of inflammatory pain

scientific article published in August 2000

Comment on "Neutrophils: are they hyperalgesic or anti-hyperalgesic?"

scientific article published in October 2006

Control of inflammatory pain by chemokine-mediated recruitment of opioid-containing polymorphonuclear cells

scientific article published in December 2004

Controlling pain by influencing neurogenic pathways

scientific article

Corticotropin releasing factor receptors in inflamed tissue: Autoradiographic identification

Corticotropin-releasing factor in antinociception and inflammation.

scientific article published on March 1997

Cytokine-induced antinociception mediated by opioids released from immune cells

Cytotoxic T cells modulate inflammation and endogenous opioid analgesia in chronic arthritis

scientific article published on 06 February 2017

Different mechanisms of intrinsic pain inhibition in early and late inflammation

scientific article published in August 2003

Dynorphin, a preferential ligand for kappa-opioid receptors, is present in nerve fibers and immune cells within inflamed tissue of the rat.

scientific article published in June 1992

Editorial

scientific article published on 01 June 1997

Effect of interpleural morphine on postoperative pain and pulmonary function after thoracotomy

scientific article published in December 1992

Effects of neurotoxins and hindpaw inflammation on opioid receptor immunoreactivities in dorsal root ganglia

scientific article published in July 1998

Efficacy of peripheral morphine analgesia in inflamed, non-inflamed and perineural tissue of dental surgery patients

scientific article published in April 2001

Emergent biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses

scientific article published on 3 May 2016

Endogenous peripheral antinociception in early inflammation is not limited by the number of opioid-containing leukocytes but by opioid receptor expression

scientific article

Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C.

scientific article published on 14 November 2007

Exploiting Fluorescence Lifetime Plasticity in FLIM: Target Molecule Localization in Cells and Tissues.

scientific article published on 9 August 2011

Expression of corticotropin-releasing factor in inflamed tissue is required for intrinsic peripheral opioid analgesia

scientific article published on June 1996

Fentanyl decreases discharges of C and A nociceptors to suprathreshold mechanical stimulation in chronic inflammation

scientific article published on September 5, 2012

Functional characteristics of the naked mole rat μ-opioid receptor

scientific article

Gene expression and localization of opioid peptides in immune cells of inflamed tissue: functional role in antinociception

scientific article

Human μ receptor: Gene structure, expression, and μ/κ chimeras that define nontransmembrane domains influencing peptide binding affinities

article

Hypoxia following tricuspid valve resection

scientific article published on 01 January 1986

Immune System, Pain and Analgesia

Immune-derived Opioids: Production and Function in Inflammatory Pain

article

Immunohistochemical localization of endomorphin-1 and endomorphin-2 in immune cells and spinal cord in a model of inflammatory pain

scientific article published in May 2002

Immunosuppressive effects of opioids--clinical relevance

scientific article published on 05 July 2011

Impaired nociception and peripheral opioid antinociception in mice lacking both kinin B1 and B2 receptors

scientific article published in February 2012

Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivo

article

Increased numbers of opioid expressing inflammatory cells do not affect intra-articular morphine analgesia

scientific article

Inflammation enhances peripheral mu-opioid receptor-mediated analgesia, but not mu-opioid receptor transcription in dorsal root ganglia

scientific article published in June 1995

Inflammation of the hind limb as a model of unilateral, localized pain: influence on multiple opioid systems in the spinal cord of the rat.

scientific article

Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue

scientific article

Inflammatory-linked changes in CpG island methylation of three opioid peptide genes in a rat model for pain.

scientific article published on 19 January 2018

Influence of pain treatment by epidural fentanyl and bupivacaine on homing of opioid-containing leukocytes to surgical wounds

scientific article published on 15 December 2006

Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue

scientific article

Interleukin-1 -and corticotropin releasing factor-induced release of β-endorphin from immune cells and inhibition of inflammatory pain

Interleukin-1 beta contributes to the upregulation of kappa opioid receptor mrna in dorsal root ganglia in response to peripheral inflammation.

scientific article published on 19 June 2006

Intra-articular morphine for inflammatory pain

scientific article published in November 2006

Intraarticular morphine versus dexamethasone in chronic arthritis

scientific article published on 01 December 1999

Intraarticular opioid-local anesthetic combinations for chronic joint pain

scientific article

Intraperitoneal versus interpleural morphine or bupivacaine for pain after laparoscopic cholecystectomy

scientific article

Involvement of Intra-articular Corticotropin-releasing Hormone in Postoperative Pain Modulation

scientific article published on 01 February 2007

Involvement of capsaicin-sensitive neurones in hyperalgesia and enhanced opioid antinociception in inflammation

scientific article

Involvement of corticotropin-releasing hormone receptor subtypes 1 and 2 in peripheral opioid-mediated inhibition of inflammatory pain

scientific article

Involvement of cytokines, chemokines and adhesion molecules in opioid analgesia.

scientific article

JAK-STAT1/3-induced expression of signal sequence-encoding proopiomelanocortin mRNA in lymphocytes reduces inflammatory pain in rats

scientific article published on 13 November 2012

Knowledge transfer between research and practice

scientific article published on May 1, 2011

Leukocyte-derived opioid peptides and inhibition of pain

scientific article published on March 2006

Liquid chromatography-tandem mass spectrometry for analysis of intestinal permeability of loperamide in physiological buffer

scientific article

Local analgesic effect of endogenous opioid peptides

scientific article

Local inflammation of the rat paw enhances opioid receptor density in paw tissue and their axonal transport in sciatic nerve

Local upregulation of corticotropin-releasing hormone and interleukin-1 receptors in rats with painful hindlimb inflammation

scientific article published on 01 September 1996

Lymphocytes upregulate signal sequence-encoding proopiomelanocortin mRNA and beta-endorphin during painful inflammation in vivo.

scientific article published on 16 January 2007

Methionine-enkephalin-and Dynorphin A-release from immune cells and control of inflammatory pain

scientific article published in September 2001

Methylnaltrexone and opioid analgesia

scientific article published on 16 September 2014

Mobilization of opioid-containing polymorphonuclear cells by hematopoietic growth factors and influence on inflammatory pain

scientific article

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

scientific article published on December 1, 2011

Modulation of peripheral endogenous opioid analgesia by central afferent blockade

scientific article

Modulation of tight junction proteins in the perineurium to facilitate peripheral opioid analgesia

scientific article

Modulation of transient receptor vanilloid 1 activity by transient receptor potential ankyrin 1.

scientific article published on 25 November 2013

Modulation of μ-opioid receptor activation by acidic pH is dependent on ligand structure and an ionizable amino acid residue

scientific article published on 05 December 2019

Motivational effects of opioids in an animal model of prolonged inflammatory pain: alteration in the effects of kappa- but not of mu-receptor agonists

scientific article published in November 1988

Mu-opioid receptor activation modulates transient receptor potential vanilloid 1 (TRPV1) currents in sensory neurons in a model of inflammatory pain

scientific article published on 27 September 2006

Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils

scientific article

Neck and shoulder pain associated with hepatic arterial chemotherapy using an implantable infusion pump

scientific article published in March 1988

Neurogenic painful inflammation

scientific article published on October 2004

Neurokinin-1 receptor antagonists inhibit the recruitment of opioid-containing leukocytes and impair peripheral antinociception

scientific article

New concepts in opioid analgesia

scholarly article by Christoph Stein published 7 September 2018 in Expert Opinion on Investigational Drugs

Non-analgesic effects of opioids: peripheral opioid effects on inflammation and wound healing

scientific article published on January 2012

Novel Opioid Analgesics and Side Effects.

scientific article published on 12 June 2017

Opioid Receptors

scientific article published on 26 August 2015

Opioid receptor signaling, analgesic and side effects induced by a computationally designed pH-dependent agonist.

scientific article

Opioid receptors and opioid peptide-producing leukocytes in inflammatory pain--basic and therapeutic aspects

scientific article

Opioid therapy in chronic non-malignant pain

scientific article published in February 2003

Opioid treatment of chronic nonmalignant pain.

scientific article published on April 1997

Opioid use in chronic noncancer pain: guidelines revisited

scientific article published on October 2010

Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner

scientific article

Opioide und periphere Entzündungsmechanismen

Opioids

article

Opioids and sensory nerves

scientific article

Opioids as novel intra-articular agents for analgesia following arthroscopic knee surgery

scientific article published on 01 January 1994

Opioids for the treatment of arthritis pain

scientific article

Opioids in musculoskeletal pain

scientific article published in December 2008

Opioids in rheumatic diseases

scientific article published on April 2010

Opioids, sensory systems and chronic pain

scientific article published on 13 March 2013

Pain and the immune system.

scientific article published on 08 April 2008

Pain and the immune system: friend or foe?

scientific article published in May 2002

Pain control and the immune system

Pain control by CXCR2 ligands through Ca2+-regulated release of opioid peptides from polymorphonuclear cells

scientific article published on 23 October 2006

Pain control in inflammation governed by selectins

article published in 1998

Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue

scientific article

Pain measurement in animal models

scientific article published in March 2013

Pain therapy - Are there new options on the horizon?

scientific article published on 01 June 2019

Painful inflammation-induced increase in mu-opioid receptor binding and G-protein coupling in primary afferent neurons

scientific article

Peptide neuroanatomy of adjuvant-induced arthritic inflammation in rat

scientific article published on 01 December 1988

Periaqueductal gray stimulation produces a spinally mediated, opioid antinociception for the inflamed hindpaw of the rat.

scientific article

Perineurial defect and peripheral opioid analgesia in inflammation.

scientific article

Perioperative management of the chronic pain patient

Peripheral Opioid Analgesia

scientific article published on 01 August 2003

Peripheral analgesic actions of opioids

scientific article published on April 1, 1991

Peripheral analgesic and antiinflammatory effects of opioids

scientific article published in December 2001

Peripheral antinociceptive effects of exogenous and immune cell-derived endomorphins in prolonged inflammatory pain.

scientific article published in April 2006

Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat.

scientific article published in January 1988

Peripheral mechanisms of opioid analgesia

scientific article

Peripheral mechanisms of opioid antinociception in inflammation: involvement of cytokines.

scientific article

Peripheral mechanisms of pain and analgesia

scientific article published on 31 December 2008

Peripheral morphine analgesia in dental surgery

scientific article published on May 1, 1998

Peripheral non-viral MIDGE vector-driven delivery of beta-endorphin in inflammatory pain

scientific article published on 14 December 2009

Peripheral opioid analgesia.

scientific article

Peripheral opioid analgesia: Basic and clinical aspects

Peripheral opioid receptor blockade increases postoperative morphine demands--a randomized, double-blind, placebo-controlled trial

scientific article published on 18 July 2014

Peripheral opioid receptors mediating antinociception in inflammation. Activation by endogenous opioids and role of the pituitary-adrenal axis.

scientific article published in April 1990

Peripheral opioid receptors.

scientific article published on April 1995

Periphere Opioidrezeptoren und ihre Bedeutung für die postoperative Schmerztherapie

Polyglycerol-opioid conjugate produces analgesia devoid of side effects

scientific article

Potential links between leukocytes and antinociception

Pro-algesic versus analgesic actions of immune cells

scientific article published on October 2003

Production of G protein-coupled receptors in an insect-based cell-free system.

scientific article

Rapid upregulation of mu opioid receptor mRNA in dorsal root ganglia in response to peripheral inflammation depends on neuronal conduction

scientific article published in January 2004

Relative contribution of peripheral versus central opioid receptors to antinociception

scientific article

Research consortium Neuroimmunology and pain in the research network musculoskeletal diseases

scientific article published on 13 April 2018

Schmerz in der postoperativen Phase Medizinische und ökonomische Aspekte

article

Scientific fraud

scientific article

Selectins and integrins but not platelet-endothelial cell adhesion molecule-1 regulate opioid inhibition of inflammatory pain

scientific article published on 24 May 2004

Selective local PMN recruitment by CXCL1 or CXCL2/3 injection does not cause inflammatory pain

scientific article published on 7 March 2006

Subcellular pathways of beta-endorphin synthesis, processing, and release from immunocytes in inflammatory pain

scientific article published on 20 November 2003

Sympathetic activation triggers endogenous opioid release and analgesia within peripheral inflamed tissue

scientific article

Targeting delta opioid receptors for pain treatment: drugs in phase I and II clinical development.

scientific article

Targeting inflammation and wound healing by opioids

scientific article published on 18 April 2013

Targeting pain and inflammation by peripherally acting opioids

scientific article published on 23 September 2013

The German counterpart to McGill Pain Questionnaire

article

The K(+) channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia

scientific article published on July 2013

The control of pain in peripheral tissue by opioids.

scientific article published on June 1995

The other side of the medal: how chemokines promote analgesia.

scientific article published on 07 March 2008

Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception

scientific article

Topical application of local anesthetics and opioids after elective tooth extraction

scientific article published in June 2005

Topical application of morphine for wound healing and analgesia in patients with oral lichen planus: a randomized, double-blind, placebo-controlled study

scientific article published on 28 March 2017

Topical application of morphine gel in inflammatory mucosal and cutaneous lesions

scientific article published in August 2005

Towards safer and more effective analgesia

scientific article published on October 22, 2012

Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: alterations in behavior and nociceptive thresholds

scientific article published on October 1988

What is wrong with opioids in chronic pain?

scientific article published on 01 October 2000

Why is morphine not the ultimate analgesic and what can be done to improve it?

scientific article published on September 2000

[Pain inhibition by opioids-new concepts]

scientific article published on 01 February 2019

[Pain inhibition by opioids-new concepts]

scientific article published on 01 August 2019

beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue

scientific article

pKa of opioid ligands as a discriminating factor for side effects

scientific article published on 18 December 2019