List of works - Anne Simonsen

A comprehensive glossary of autophagy-related molecules and processes (2nd edition)

scientific article

A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body

scientific article published on 4 April 2006

ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration

publication published on 18 February 2022

Actin shapes the autophagosome

scientific article published on 01 September 2015

Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

scientific article

Alfy-dependent elimination of aggregated proteins by macroautophagy: can there be too much of a good thing?

scientific article published on March 2011

Assays to monitor aggrephagy

scientific article published on 31 December 2014

Autophagic degradation of an oncoprotein

scientific article published on 19 October 2010

Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein

scientific article published on 23 June 2010

Autophagy in malignant transformation and cancer progression

scientific article

Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain

scientific article published on 20 September 2016

Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations

scientific article published on 01 January 2018

Autophagy: friend or foe in the treatment of fusion protein-associated leukemias?

scientific article published on 8 October 2013

Autophagy: more than a nonselective pathway

scientific article published on 15 May 2012

Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy

scientific article published on January 2013

Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins

scientific article

Complex Relations Between Phospholipids, Autophagy, and Neutral Lipids

scientific article

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

scientific article published on September 2009

Coupling of HIV-1 Antigen to the Selective Autophagy Receptor SQSTM1/p62 Promotes T-Cell-Mediated Immunity

scientific article

Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy

scientific article

Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes

scientific article published on 18 February 2019

Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy

scientific article published on 13 September 2018

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

scientific article

ESCRT functions in autophagy and associated disease

scientific article published on 11 February 2008

ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors.

scientific article published on 19 January 2016

ESCRT-mediated phagophore sealing during mitophagy

scientific article published on 01 August 2019

Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells

scientific article published on 25 July 2015

FYVE finger proteins as effectors of phosphatidylinositol 3-phosphate

scientific article

FYVE fingers bind PtdIns(3)P

scientific article

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

scientific article

GAK and PRKCD are positive regulators of PRKN-independent mitophagy

scientific article published on 20 October 2021

Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles

scientific article published on 15 April 2007

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

scientific article

HS1BP3 inhibits autophagy by regulation of PLD1.

scientific article published on 25 February 2017

HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels

scientific article published on 22 December 2016

Intracellular distribution of the MHC class II molecules and the associated invariant chain (Ii) in different cell lines

scientific article published on August 1993

LYST affects lysosome size and quantity, but not trafficking or degradation through autophagy or endocytosis

scientific article published on 8 October 2014

Linking lysosomal trafficking defects with changes in aging and stress response in Drosophila

scientific article

Lipids in autophagy: constituents, signaling molecules and cargo with relevance to disease.

scientific article published on 14 January 2012

MITF has a central role in regulating starvation-induced autophagy in melanoma

scientific article published in Scientific Reports

Membrane Trafficking in Autophagy

scientific article published on 21 September 2017

Membrane dynamics in autophagosome biogenesis

scientific article

Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation

scientific article

Modulation of intracellular calcium homeostasis blocks autophagosome formation

scientific article published on 13 August 2013

NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery disease

scientific article published on 11 March 2020

NIPSNAP1 and NIPSNAP2 act as "eat me" signals to allow sustained recruitment of autophagy receptors during mitophagy

scientific article published on 04 July 2019

Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy

scientific article

Organelle biogenesis and autophagy.

scientific article published in March 2012

PX domains: attracted by phosphoinositides

scientific article

Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene

scientific article published on 26 December 2019

Phosphoinositide-binding proteins in autophagy

scientific article

Phosphoinositides and phagocytosis

scientific article published on October 2001

Polarized transport of MHC class II molecules in Madin-Darby canine kidney cells is directed by a leucine-based signal in the cytoplasmic tail of the beta-chain.

scientific article published on September 1999

Pretreatment of Glioblastoma with Bortezomib Potentiates Natural Killer Cell Cytotoxicity through TRAIL/DR5 Mediated Apoptosis and Prolongs Animal Survival

scientific article published on 17 July 2019

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

scientific article published on 6 November 2007

Publisher Correction: Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy.

scientific article published on 29 March 2018

Quantitative analysis of autophagic activity in Drosophila neural tissues by measuring the turnover rates of pathway substrates

scientific article published on January 2008

RAB24 facilitates clearance of autophagic compartments during basal conditions

scientific article

Radiation induces EIF2AK3/PERK and ERN1/IRE1 mediated pro-survival autophagy

scientific article published on 20 March 2019

Receptor protein complexes are in control of autophagy

scientific article

Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain

scientific article published on 17 March 2008

Regulation of endocytic membrane traffic by phosphatidylinositol 3-phosphate

scientific article

Retinoic acid-induced IgG production in TLR-activated human primary B cells involves ULK1-mediated autophagy

scientific article published on January 2015

SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2.

scientific article published on 7 February 2018

SNX18 tubulates recycling endosomes for autophagosome biogenesis.

scientific article published on 29 August 2013

Selective types of autophagy

scientific article published on 21 August 2012

Self-eating from an ER-associated cup.

scientific article published on August 2008

Sorting of MHC class II molecules and the associated invariant chain (Ii) in polarized MDCK cells

scientific article published on March 1997

Stimulating the cell's appetite for itself

scientific article published on 01 June 2007

Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures

scientific article

Syntaxin-16, a putative Golgi t-SNARE

scientific article

TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease

scientific article published on 11 November 2019

TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy

scientific article

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

scientific article

Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells

scientific article

The Rab5 effector EEA1 interacts directly with syntaxin-6

scientific article

The arsenic-based cure of acute promyelocytic leukemia promotes cytoplasmic sequestration of PML and PML/RARA through inhibition of PML body recycling

scientific article

The elimination of accumulated and aggregated proteins: a role for aggrephagy in neurodegeneration

scientific article published on 20 August 2010

The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimer

scientific article

The leucine-based motif DDQxxLI is recognized both for internalization and basolateral sorting of invariant chain in MDCK cells.

scientific article published on May 1998

The role of phosphoinositides in membrane transport

scientific article

The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy

scientific article

The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking

scientific article

Toward the function of mammalian ATG12-ATG5-ATG16L1 complex in autophagy and related processes

scientific article published on 23 May 2019

UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy

scientific article published on 16 October 2010

cAMP-mediated autophagy inhibits DNA damage-induced death of leukemia cells independent of p53.

scientific article

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects.

scientific article

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

scientific article

List of works by Anne Simonsen

A comprehensive glossary of autophagy-related molecules and processes (2nd edition)

A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body

ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration

Actin shapes the autophagosome

Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

Alfy-dependent elimination of aggregated proteins by macroautophagy: can there be too much of a good thing?

Assays to monitor aggrephagy

Autophagic degradation of an oncoprotein

Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein

Autophagy in malignant transformation and cancer progression

Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain

Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations

Autophagy: friend or foe in the treatment of fusion protein-associated leukemias?

Autophagy: more than a nonselective pathway

Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy

Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins

Complex Relations Between Phospholipids, Autophagy, and Neutral Lipids

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

Coupling of HIV-1 Antigen to the Selective Autophagy Receptor SQSTM1/p62 Promotes T-Cell-Mediated Immunity

Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy

Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes

Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

ESCRT functions in autophagy and associated disease

ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors.

ESCRT-mediated phagophore sealing during mitophagy

Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells

FYVE finger proteins as effectors of phosphatidylinositol 3-phosphate

FYVE fingers bind PtdIns(3)P

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

GAK and PRKCD are positive regulators of PRKN-independent mitophagy

Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

HS1BP3 inhibits autophagy by regulation of PLD1.

HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels

Intracellular distribution of the MHC class II molecules and the associated invariant chain (Ii) in different cell lines

LYST affects lysosome size and quantity, but not trafficking or degradation through autophagy or endocytosis

Linking lysosomal trafficking defects with changes in aging and stress response in Drosophila

Lipids in autophagy: constituents, signaling molecules and cargo with relevance to disease.

MITF has a central role in regulating starvation-induced autophagy in melanoma

Membrane Trafficking in Autophagy

Membrane dynamics in autophagosome biogenesis

Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation

Modulation of intracellular calcium homeostasis blocks autophagosome formation

NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery disease

NIPSNAP1 and NIPSNAP2 act as "eat me" signals to allow sustained recruitment of autophagy receptors during mitophagy

Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy

Organelle biogenesis and autophagy.

PX domains: attracted by phosphoinositides

Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene

Phosphoinositide-binding proteins in autophagy

Phosphoinositides and phagocytosis

Polarized transport of MHC class II molecules in Madin-Darby canine kidney cells is directed by a leucine-based signal in the cytoplasmic tail of the beta-chain.

Pretreatment of Glioblastoma with Bortezomib Potentiates Natural Killer Cell Cytotoxicity through TRAIL/DR5 Mediated Apoptosis and Prolongs Animal Survival

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

Publisher Correction: Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy.

Quantitative analysis of autophagic activity in Drosophila neural tissues by measuring the turnover rates of pathway substrates

RAB24 facilitates clearance of autophagic compartments during basal conditions

Radiation induces EIF2AK3/PERK and ERN1/IRE1 mediated pro-survival autophagy

Receptor protein complexes are in control of autophagy

Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain

Regulation of endocytic membrane traffic by phosphatidylinositol 3-phosphate

Retinoic acid-induced IgG production in TLR-activated human primary B cells involves ULK1-mediated autophagy

SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2.

SNX18 tubulates recycling endosomes for autophagosome biogenesis.

Selective types of autophagy

Self-eating from an ER-associated cup.

Sorting of MHC class II molecules and the associated invariant chain (Ii) in polarized MDCK cells

Stimulating the cell's appetite for itself

Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures

Syntaxin-16, a putative Golgi t-SNARE

TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease

TRAF6 mediates ubiquitination of KIF23/MKLP1 and is required for midbody ring degradation by selective autophagy

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition

Targeting autophagy potentiates the apoptotic effect of histone deacetylase inhibitors in t(8;21) AML cells

The Rab5 effector EEA1 interacts directly with syntaxin-6

The arsenic-based cure of acute promyelocytic leukemia promotes cytoplasmic sequestration of PML and PML/RARA through inhibition of PML body recycling