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List of works by Melissa M. Damschroder

A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways

scientific article published on 6 May 2015

Analysis of human and primate CD2 molecules by protein sequence and epitope mapping with anti-human CD2 antibodies

scientific article published in August 2004

Antibody humanization by framework shuffling.

scientific article published in May 2005

Antibody-dependent cell-mediated cytotoxicity effector-enhanced EphA2 agonist monoclonal antibody demonstrates potent activity against human tumors

scientific article published on June 2009

Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia

scientific article published on 02 December 2013

B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody

scientific article published on 6 July 2010

Bi-epitope SPR surfaces: a solution to develop robust immunoassays

scientific article

Crystallization and preliminary X-ray diffraction analysis of the complex between a human anti-interferon antibody fragment and human interferon alpha-2A.

scientific article published on 25 December 2008

Crystallization and preliminary X-ray diffraction analysis of the complex of a human anti-ephrin type-A receptor 2 antibody fragment and its cognate antigen

scientific article

Current approaches to fine mapping of antigen-antibody interactions.

scientific article published on August 2014

Developability assessment of engineered monoclonal antibody variants with a complex self-association behavior using complementary analytical and in silico tools

scientific article published on 15 November 2018

Direct targeting of alphavbeta3 integrin on tumor cells with a monoclonal antibody, Abegrin

scientific article published on December 2006

Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy

scientific article published in PLoS ONE

Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design

scientific article published on 01 May 2019

Framework shuffling of antibodies to reduce immunogenicity and manipulate functional and biophysical properties

scientific article published on 22 January 2007

Generation and Characterization of an IgG4 Monomeric Fc Platform.

scientific article

Identification and characterization of a novel family of pneumococcal proteins that are protective against sepsis

scientific article

Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action

scientific article published on 08 February 2016

Isolation of mutants in a DNA methyltransferase through mcrB-mediated restriction

article

Long-acting antibody ligand mimetics for HER4-selective agonism

scientific article published on 14 October 2020

MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

scientific article published on 01 June 2010

MEDI0639: a novel therapeutic antibody targeting Dll4 modulates endothelial cell function and angiogenesis in vivo

scientific article

Mechanisms of neutralization of a human anti-α-toxin antibody

scientific article published on 10 September 2014

Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineering

scientific article

Modulation of the effector functions of a human IgG1 through engineering of its hinge region

scientific article published on July 2006

Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-α receptor 1 antibody

scientific article published on January 2015

Molecular basis for the antagonistic activity of an anti-CXCR4 antibody

scientific article published on 29 October 2015

Molecular basis for the mechanism of action of an anti-TACE antibody

scientific article published on 9 September 2016

Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein.

scientific article published on 15 March 2018

Process optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule electrostatic interactions

scientific article published on 14 April 2019

Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

scientific article

Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody

scientific article

Structural characterization of a human Fc fragment engineered for extended serum half-life

scientific article

Structural characterization of a mutated, ADCC-enhanced human Fc fragment

scientific article

Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody

scientific article published on 18 April 2018

Targeting CD73 in the tumor microenvironment with MEDI9447.

scientific article published on 11 July 2016

The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA

scientific article (publication date: 2012)

Upregulation of annexin A1 protein expression in the intratumoral vasculature of human non-small-cell lung carcinoma and rodent tumor models

scientific article published on 04 June 2020

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