List of works - Xiongwen Chen

A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle

scientific journal article

Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties

scientific article published in February 2007

Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808

scientific article published on 03 April 2008

Alterations in Early Action Potential Repolarization Causes Localized Failure of Sarcoplasmic Reticulum Ca 2+ Release

scientific article published on 10 February 2005

Blunted cardiac beta-adrenergic response as an early indication of cardiac dysfunction in Duchenne muscular dystrophy

scientific article

Bone marrow cells adopt the cardiomyogenic fate in vivo

scientific article

Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes

scientific article published on 02 October 2008

Ca2+ influx-induced sarcoplasmic reticulum Ca2+ overload causes mitochondrial-dependent apoptosis in ventricular myocytes

scientific article published on 6 October 2005

Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure

scientific article published in September 2007

CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes

scientific article published on 16 July 2009

Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat.

scientific article published on 7 September 2007

Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy

scientific article published on 25 November 2010

Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction

scientific article published on 10 April 2012

Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling

scientific article published on 25 October 2012

Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart

scientific article published on 11 April 2017

Cellular basis of abnormal calcium transients of failing human ventricular myocytes

scientific article published on 20 February 2003

Circulating 'lncRNA OTTHUMT00000387022' from monocytes as a novel biomarker for coronary artery disease

scientific article published on 7 February 2016

Compartmentalization of β-adrenergic signals in cardiomyocytes

scientific article

Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice

scientific article published on December 2011

Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity

scientific article

G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure

scientific article

GDF11 does not rescue aging-related pathological hypertrophy

scientific article

GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice

scientific journal article

How to Improve the Survival of Transplanted Mesenchymal Stem Cell in Ischemic Heart?

scientific article

Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction

scientific article published on 2 February 2012

Increased expression of Syne1/nesprin-1 facilitates nuclear envelope structure changes in embryonic stem cell differentiation.

scientific article published on 23 August 2011

Increasing T-type calcium channel activity by β-adrenergic stimulation contributes to β-adrenergic regulation of heart rates

scientific article published on 23 December 2017

Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction

scientific article published on 29 July 2010

Inhibition of angiotensin II Gq signaling augments beta-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure

scientific article published on 30 September 2008

Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes

scientific article (publication date: June 2015)

Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts.

scientific article

Intracellular sodium determines frequency-dependent alterations in contractility in hypertrophied feline ventricular myocytes

scientific article published on 29 September 2006

L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices

scientific article published in September 2002

LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation.

scientific article

Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes

scientific article published on 25 January 2008

Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction

scientific article published on March 2015

Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias

scientific article published on 26 November 2015

Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts

scientific article published on 9 April 2012

Plasma long non-coding RNA, CoroMarker, a novel biomarker for diagnosis of coronary artery disease

scientific article published on 11 June 2015

Potential of cardiac stem/progenitor cells and induced pluripotent stem cells for cardiac repair in ischaemic heart disease

scientific article

Prolyl Hydroxylase Domain Protein 2 Silencing Enhances the Survival and Paracrine Function of Transplanted Adipose-Derived Stem Cells in Infarcted Myocardium ⬇️

scientific article published on May 21, 2013

Protease-activated receptor 4 deficiency offers cardioprotection after acute ischemia reperfusion injury

scientific article

Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach

scientific article published on 25 June 2009

Protein kinase D3 is a pivotal activator of pathological cardiac hypertrophy by selectively increasing the expression of hypertrophic transcription factors

scientific article published on 4 October 2011

Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation

scientific article published on 21 March 2008

Regulated Overexpression of the A 1 -Adenosine Receptor in Mice Results in Adverse but Reversible Changes in Cardiac Morphology and Function

scientific article published on 06 November 2006

Regulation of L-type calcium channel by phospholemman in cardiac myocytes

scientific article

Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model

scientific article published on 23 June 2017

Repair of the injured adult heart involves new myocytes potentially derived from resident cardiac stem cells

scientific article published on 31 March 2011

Role of STIM1 (Stromal Interaction Molecule 1) in Hypertrophy-Related Contractile Dysfunction

scientific article published on 7 June 2017

STIM1 elevation in the heart results in aberrant Ca²⁺ handling and cardiomyopathy

scientific article

T-type Ca²⁺ channels regulate the exit of cardiac myocytes from the cell cycle after birth.

scientific article published on 04 June 2013

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

scientific article

The δA isoform of calmodulin kinase II mediates pathological cardiac hypertrophy by interfering with the HDAC4-MEF2 signaling pathway

scientific journal article

Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction

scientific article

alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice

scientific article published on 16 November 2009

β-Adrenergic stimulation increases Cav3.1 activity in cardiac myocytes through protein kinase A

scientific article

List of works by Xiongwen Chen

A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle

Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties

Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808

Alterations in Early Action Potential Repolarization Causes Localized Failure of Sarcoplasmic Reticulum Ca 2+ Release

Blunted cardiac beta-adrenergic response as an early indication of cardiac dysfunction in Duchenne muscular dystrophy

Bone marrow cells adopt the cardiomyogenic fate in vivo

Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes

Ca2+ influx-induced sarcoplasmic reticulum Ca2+ overload causes mitochondrial-dependent apoptosis in ventricular myocytes

Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure

CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes

Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat.

Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy

Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction

Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling

Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart

Cellular basis of abnormal calcium transients of failing human ventricular myocytes

Circulating 'lncRNA OTTHUMT00000387022' from monocytes as a novel biomarker for coronary artery disease

Compartmentalization of β-adrenergic signals in cardiomyocytes

Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice

Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity

G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure

GDF11 does not rescue aging-related pathological hypertrophy

GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice

How to Improve the Survival of Transplanted Mesenchymal Stem Cell in Ischemic Heart?

Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction

Increased expression of Syne1/nesprin-1 facilitates nuclear envelope structure changes in embryonic stem cell differentiation.

Increasing T-type calcium channel activity by β-adrenergic stimulation contributes to β-adrenergic regulation of heart rates

Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction

Inhibition of angiotensin II Gq signaling augments beta-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure

Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes

Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts.

Intracellular sodium determines frequency-dependent alterations in contractility in hypertrophied feline ventricular myocytes

L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices

LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation.

Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes

Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction

Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias

Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts

Plasma long non-coding RNA, CoroMarker, a novel biomarker for diagnosis of coronary artery disease

Potential of cardiac stem/progenitor cells and induced pluripotent stem cells for cardiac repair in ischaemic heart disease

Prolyl Hydroxylase Domain Protein 2 Silencing Enhances the Survival and Paracrine Function of Transplanted Adipose-Derived Stem Cells in Infarcted Myocardium ⬇️

Protease-activated receptor 4 deficiency offers cardioprotection after acute ischemia reperfusion injury

Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach

Protein kinase D3 is a pivotal activator of pathological cardiac hypertrophy by selectively increasing the expression of hypertrophic transcription factors

Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation

Regulated Overexpression of the A 1 -Adenosine Receptor in Mice Results in Adverse but Reversible Changes in Cardiac Morphology and Function

Regulation of L-type calcium channel by phospholemman in cardiac myocytes

Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model

Repair of the injured adult heart involves new myocytes potentially derived from resident cardiac stem cells

Role of STIM1 (Stromal Interaction Molecule 1) in Hypertrophy-Related Contractile Dysfunction

STIM1 elevation in the heart results in aberrant Ca²⁺ handling and cardiomyopathy

T-type Ca²⁺ channels regulate the exit of cardiac myocytes from the cell cycle after birth.

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

The δA isoform of calmodulin kinase II mediates pathological cardiac hypertrophy by interfering with the HDAC4-MEF2 signaling pathway

Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction

alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice

β-Adrenergic stimulation increases Cav3.1 activity in cardiac myocytes through protein kinase A