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List of works by Raphael Kopan

A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates

scientific article published on April 2006

A garden of Notch-ly delights

scientific article published on 01 September 2006

A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.

scientific article published on 4 April 2016

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

scientific article published on 17 October 2003

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

scientific article (publication date: 8 April 1999)

A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development

scientific article published on 13 July 2004

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

scientific article

Alagille, Notch, and robustness: why duplicating systems does not ensure redundancy

scientific article

Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation.

scientific article

Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensing enhancers.

scientific article published on 27 September 2017

Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization

scientific article

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin

scientific article (publication date: 2010)

Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes.

scientific article published on 04 July 2007

Cancer linked to Alzheimer disease but not vascular dementia

scientific article

Chromatin-based mechanisms of renal epithelial differentiation

scientific article

Chronic itch development in sensory neurons requires BRAF signaling pathways

scientific article

Circulating TSLP associates with decreased wheezing in non-atopic preschool children: data from the URECA birth cohort

scientific article

Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins

scientific article

Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation

scientific article published on 15 August 2009

Developmental signaling. Vertebrate ligands for Notch.

scientific article published on September 1995

Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells

scientific article

Differentiation and gene regulation: toward a holistic understanding of animal development: intercellular communication and transcriptional regulation are two sides of the same coin

scientific article published on 01 October 2002

Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells

scientific journal article

Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization.

scientific article published on 23 September 2004

Elevated Epidermal Thymic Stromal Lymphopoietin Levels Establish an Antitumor Environment in the Skin ⬇️

scientific article published on October 16, 2012

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

scientific article published in June 2000

Epidermal ADAM17 is dispensable for notch activation

scientific article published on 3 April 2013

Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.

scientific article published on July 2009

Evidence for a physical interaction between presenilin and Notch

scientific article

F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation

scientific journal article

FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.

scientific article

Gamma -secretase inhibitors repress thymocyte development

scientific article

Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney

scientific journal article

Gamma-secretase: proteasome of the membrane?

scientific article

Genetic mosaic analysis indicates that the bulb region of coat hair follicles contains a resident population of several active multipotent epithelial lineage progenitors.

scientific article published on February 2002

Hamartin regulates cessation of mouse nephrogenesis independently of Mtor

scientific article published on 21 May 2018

In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea

scientific article

Inhibition of granulocytic differentiation by mNotch1.

scientific article published on November 1996

Intramembrane proteolysis: theme and variations.

scientific article

Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan

scientific article published in October 2015

Long-range, nonautonomous effects of activated Notch1 on tissue homeostasis in the nail

scientific article published in November 2003

Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice

scientific article

Making new kidneys: On the road from science fiction to science fact.

scientific article published on December 2016

Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE

scientific article published on February 2007

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

scientific article

Molecular insights into segmentation along the proximal-distal axis of the nephron.

scientific article published on 13 June 2007

Monitoring Notch activation in cultured mammalian cells: luciferase complementation imaging assays.

scientific article

Monitoring Notch activation in cultured mammalian cells: transcriptional reporter assays

scientific article

NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells

scientific article published on 22 December 2007

Nephron progenitor cells: shifting the balance of self-renewal and differentiation

scientific article published on January 2014

Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway

scientific journal article

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

scientific article

Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition

scientific article

Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation

scientific article published on 05 October 2020

Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells

scientific article

Notch pathway is dispensable for adipocyte specification

scientific article published on 01 September 2004

Notch signal strength controls cell fate in the haemogenic endothelium

scientific article

Notch signaling

scientific article published on 01 October 2012

Notch signaling in bulge stem cells is not required for selection of hair follicle fate.

scientific article published on 11 February 2009

Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development.

scientific article

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

scientific article published on 24 February 2008

Notch signaling regulates gastric antral LGR5 stem cell function.

scientific article published on 12 August 2015

Notch signaling: from the outside in

scientific article (publication date: 15 December 2000)

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

scientific article

Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice.

scientific article

Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord

scientific article published in January 2006

Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.

scientific article published on 17 January 2007

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

scientific journal article

Notch: Architect, Landscaper, and Guardian of the Intestine ⬇️

scientific article published on June 12, 2011

Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development

scientific article

Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1

scientific article (publication date: 2012)

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

scientific article published in July 2004

Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window

scientific article published on September 2009

Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch.

scientific article published on 3 October 2006

RNF4-Dependent Oncogene Activation by Protein Stabilization.

scientific article published on September 2016

Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy.

scientific article published on 21 November 2016

Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS)

scientific article published on October 2009

Real-time imaging of notch activation with a luciferase complementation-based reporter.

scientific article

Regulated intramembrane proteolysis takes another twist

scientific article published in November 2001

Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets

scientific article published on 10 June 2021

Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity

scientific article

Selective blockade of transport via SERCA inhibition: the answer for oncogenic forms of Notch?

scientific article published in March 2013

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

scientific article published on February 1996

Signalling downstream of activated mammalian Notch

scientific article

Simple copy number determination with reference query pyrosequencing (RQPS).

scientific article published in September 2010

Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma

scientific article

SnapShot: notch signaling pathway

scientific article published on 01 March 2007

SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers

scientific article

SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers

scientific article published on 01 October 2016

Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands

scientific article

Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

scientific article

Synthesis and possible role of proteoglycans during Volvox development

scientific article published on 01 April 1985

The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force

scientific article published on May 2017

The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development

scientific article published on 29 February 2016

The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.

scientific article published in September 2005

The Notch transcription activation complex makes its move

scientific article published on 01 March 2006

The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation

scientific article

The anatomical distribution of genetic associations.

scientific article

The black box illuminated: signals and signaling

scientific article

The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage.

scientific article

The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold.

scientific article

The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development

scientific journal article

The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis

scientific article published on 10 June 2015

The role of Notch signaling in specification of podocyte and proximal tubules within the developing mouse kidney.

scientific article

Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2.

scientific article

Three-dimensional structure of the γ-secretase complex

scientific article published on 09 March 2006

rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse

scientific article

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