List of works - Andrew J. Beavil

A range of C∊3–C∊4 interdomain angles in IgE Fc accommodate binding to its receptor CD23

scientific article

A small-molecule activator of kinesin-1 drives remodeling of the microtubule network

scientific article published on 11 December 2017

Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42

scientific article

Allergen specificity of IgG4-expressing B cells in patients with grass pollen allergy undergoing immunotherapy

scientific article published on 13 May 2012

Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.

scientific article

Analysis of the interaction between RGD-expressing adenovirus type 5 fiber knob domains and alphavbeta3 integrin reveals distinct binding profiles and intracellular trafficking.

scientific article published on September 2006

Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

scientific article published on 17 January 2017

Attenuation of IgE affinity for FcepsilonRI radically reduces the allergic response in vitro and in vivo

scientific article published on 13 August 2008

Bent Domain Structure of Recombinant Human IgE-Fc in Solution by X-ray and Neutron Scattering in Conjunction with an Automated Curve Fitting Procedure

article

Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E

scientific article

Characterisation of an engineered trastuzumab IgE antibody and effector cell mechanisms targeting HER2/neu-positive tumour cells.

scientific article

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.

scientific article

Conformational plasticity at the IgE-binding site of the B-cell receptor CD23

scientific article

Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc RI

scientific article

Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields.

scientific article published on 11 September 2017

Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcɛRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity.

scientific article published on 16 May 2011

Heterogeneous Glycosylation of Immunoglobulin E Constructs Characterized by Top-Down High-Resolution 2-D Mass Spectrometry†

scientific article published on 01 March 2000

Human immunoglobulin E flexes between acutely bent and extended conformations.

scientific article

IgE Trimers Drive SPE-7 Cytokinergic Activity

scientific article published on 15 August 2017

IgE binds asymmetrically to its B cell receptor CD23

scientific article

Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class

scientific article published on 28 March 2015

Mapping of the CD23 Binding Site on Immunoglobulin E (IgE) and Allosteric Control of the IgE-FcϵRI Interaction ⬇️

scientific article published on July 19, 2012

Monitoring the systemic human memory B cell compartment of melanoma patients for anti-tumor IgG antibodies

scientific article (publication date: 2011)

Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application.

scientific article published on 03 December 2011

Soluble CD23 controls IgE synthesis and homeostasis in human B cells.

scientific article

Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody

scientific article published in Scientific Reports

Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor

article

Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition

article published in the Proceedings of the National Academy of Sciences of the United States of America

Synthesis and incorporation into cyclic peptides of tolan amino acids and their hydrogenated congeners: construction of an array of A-B-loop mimetics of the Cε3 domain of human IgE.

scientific article published on 7 March 2012

Synthesis of the C19 methyl ether of aspercyclide A via germyl-Stille macrocyclisation and ELISA evaluation of both enantiomers following optical resolution

scientific article published on 15 August 2011

The biology of IGE and the basis of allergic disease

scientific article

The crystal structure of IgE Fc reveals an asymmetrically bent conformation

scientific article

The crystal structure of rabbit IgG-Fc

scientific article

Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.

scientific article

Total synthesis of (+/-)-aspercyclide A and its C19 methyl ether

scientific article published on 23 December 2009

List of works by Andrew J. Beavil

A range of C∊3–C∊4 interdomain angles in IgE Fc accommodate binding to its receptor CD23

A small-molecule activator of kinesin-1 drives remodeling of the microtubule network

Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42

Allergen specificity of IgG4-expressing B cells in patients with grass pollen allergy undergoing immunotherapy

Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.

Analysis of the interaction between RGD-expressing adenovirus type 5 fiber knob domains and alphavbeta3 integrin reveals distinct binding profiles and intracellular trafficking.

Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling

Attenuation of IgE affinity for FcepsilonRI radically reduces the allergic response in vitro and in vivo

Bent Domain Structure of Recombinant Human IgE-Fc in Solution by X-ray and Neutron Scattering in Conjunction with an Automated Curve Fitting Procedure

Ca2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin E

Characterisation of an engineered trastuzumab IgE antibody and effector cell mechanisms targeting HER2/neu-positive tumour cells.

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.

Conformational plasticity at the IgE-binding site of the B-cell receptor CD23

Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc RI

Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields.

Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcɛRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity.

Heterogeneous Glycosylation of Immunoglobulin E Constructs Characterized by Top-Down High-Resolution 2-D Mass Spectrometry†

Human immunoglobulin E flexes between acutely bent and extended conformations.

IgE Trimers Drive SPE-7 Cytokinergic Activity

IgE binds asymmetrically to its B cell receptor CD23

Inhibition of allergen-dependent IgE activity by antibodies of the same specificity but different class

Mapping of the CD23 Binding Site on Immunoglobulin E (IgE) and Allosteric Control of the IgE-FcϵRI Interaction ⬇️

Monitoring the systemic human memory B cell compartment of melanoma patients for anti-tumor IgG antibodies

Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application.

Soluble CD23 controls IgE synthesis and homeostasis in human B cells.

Structural basis for selective inhibition of immunoglobulin E-receptor interactions by an anti-IgE antibody

Structure based design and characterization of peptides that inhibit IgE binding to its high-affinity receptor

Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition

Synthesis and incorporation into cyclic peptides of tolan amino acids and their hydrogenated congeners: construction of an array of A-B-loop mimetics of the Cε3 domain of human IgE.

Synthesis of the C19 methyl ether of aspercyclide A via germyl-Stille macrocyclisation and ELISA evaluation of both enantiomers following optical resolution

The biology of IGE and the basis of allergic disease

The crystal structure of IgE Fc reveals an asymmetrically bent conformation

The crystal structure of rabbit IgG-Fc

Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.

Total synthesis of (+/-)-aspercyclide A and its C19 methyl ether