Search filters

List of works by Juan Valcárcel

A simple principle to explain the evolution of pre-mRNA splicing

scientific article

A splicing mastermind for EMT

scientific article

Alternative Splicing and Cancer ⬇️

scientific article published on May 20, 2012

Alternative pre-mRNA splicing: the logic of combinatorial control

scientific article (publication date: August 2000)

Alternative splicing and genome complexity

scientific article

Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodgkin lymphoma cells.

scientific article

Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells

scientific article

Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1-associated proteins in alternative pre-mRNA splicing.

scientific article

Breaking the second genetic code

scientific article published in Nature

Building specificity with nonspecific RNA-binding proteins

scientific article

CPEB1 coordinates alternative 3′-UTR formation with translational regulation

scientific article published in Nature

Chromatin's thread to alternative splicing regulation

scientific article published on 03 August 2013

Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR.

scientific article published on 15 September 2014

Competition by the masses

scientific article published in August 2013

Corrigendum: Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks

scholarly article published in Genome Research

Corrigendum: Relationship between nucleosome positioning and progesterone-induced alternative splicing in breast cancer cells.

scientific article published on July 2015

Decrypting the genome's alternative messages

scientific article published on 21 March 2009

Degradation of cellular mRNA during influenza virus infection: its possible role in protein synthesis shutoff

scientific article published in March 1992

Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP

scientific article

Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins

scientific article (publication date: 26 May 1995)

Distinct regulatory programs establish widespread sex-specific alternative splicing in Drosophila melanogaster.

scientific article

Diversity of vertebrate splicing factor U2AF35: identification of alternatively spliced U2AF1 mRNAS.

scientific article published on 19 April 2004

Dual function for U2AF(35) in AG-dependent pre-mRNA splicing

scientific article published on November 2001

Dynamics of alternative splicing during somatic cell reprogramming reveals functions for RNA-binding proteins CPSF3, hnRNP UL1, and TIA1

scientific article published on 03 June 2021

Elisa Izaurralde 1959–2018

scholarly article by Matthias Hentze published in June 2018

Erratum to: Promoter-like epigenetic signatures in exons displaying cell type-specific splicing

scientific article published on 18 March 2016

Estimating rates of alternative splicing in mammals and invertebrates

article

Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing

scientific article

Functional association of nuclear protein 4.1 with pre-mRNA splicing factors

scientific article

Functional splicing network reveals extensive regulatory potential of the core spliceosomal machinery

scientific article published on 04 December 2014

Genome-wide analysis of alternative pre-mRNA splicing

scientific article

Genome-wide identification of Fas/CD95 alternative splicing regulators reveals links with iron homeostasis

scientific article published on 04 December 2014

Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophila cells

scientific article published on 29 January 2009

Haploinsufficiency, rather than the effect of an excessive production of soluble CD95 (CD95{Delta}TM), is the basis for ALPS Ia in a family with duplicated 3' splice site AG in CD95 intron 5 on one allele

scientific article published on 3 May 2005

Heterogeneity of the mutation rates of influenza A viruses: isolation of mutator mutants ⬇️

scientific article published on April 1, 1992

In vitro correction of a pseudoexon-generating deep intronic mutation in LGMD2A by antisense oligonucleotides and modified small nuclear RNAs.

scientific article published on 07 August 2013

Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3' splice site AG.

scientific article published in December 1999

Interaction of U2AF65 RS region with pre-mRNA branch point and promotion of base pairing with U2 snRNA [corrected]

scientific article published on 01 September 1996

Intron Removal Requires Proofreading of U2AF/3' Splice Site Recognition by DEK

scientific article published in Science

Isolated pseudo-RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition

scientific article

Kinetic role for mammalian SF1/BBP in spliceosome assembly and function after polypyrimidine tract recognition by U2AF.

scientific article

Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks

scientific article

Molecular basis of differential 3' splice site sensitivity to anti-tumor drugs targeting U2 snRNP.

scientific article published on 13 December 2017

Molecular biology. A splicing magic bullet

scientific article

Molecular biology: spliceosome meets telomerase.

scientific article

Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF

scientific article

Multiple forms of the U2 small nuclear ribonucleoprotein auxiliary factor U2AF subunits expressed in higher plants

scientific article published in December 1998

Mutations primarily alter the inclusion of alternatively spliced exons

scientific article published on 28 October 2020

Nuclear transport of influenza virus polymerase PA protein.

scientific article

Nucleocytoplasmic shuttling of heterodimeric splicing factor U2AF

scientific article (publication date: 20 April 2001)

Nucleosome positioning as a determinant of exon recognition

scientific article

Optimization of oligonucleotide-based DNA microarrays.

scientific article

Post-transcriptional regulation: the dawn of PTB.

scientific article

Powering a two-stroke RNA engine

scientific article published in July 2007

Promoter-like epigenetic signatures in exons displaying cell type-specific splicing

scientific article published on 23 October 2015

RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation

scientific article published on December 2013

RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition.

scientific article

RNA processing: Redrawing the map of charted territory

scientific article published on 01 December 2009

RNA splicing contributes to the generation of mature mRNAs of Borna disease virus, a non-segmented negative strand RNA virus

scientific article published on October 1994

RNA. Prescribing splicing

scientific article published on January 2015

RNAtomy of the Spliceosome's heart

scientific article published on 24 September 2013

Reconstruction of composite regulator-target splicing networks from high-throughput transcriptome data

scientific article

Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

scientific article published on March 2011

Regulation of FAS exon definition and apoptosis by the Ewing sarcoma protein

scientific article published on 10 May 2014

Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definition

scientific article

Regulation of alternative pre-mRNA splicing

scientific article

Relationship between nucleosome positioning and progesterone-induced alternative splicing in breast cancer cells

scientific article

Role of six single nucleotide polymorphisms, risk factors in coronary disease, in OLR1 alternative splicing

scientific article published on 22 April 2015

Sequential recognition of the pre-mRNA branch point by U2AF65 and a novel spliceosome-associated 28-kDa protein

scientific article

Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45

scientific article (publication date: 3 May 2002)

Splicing together sister chromatids

scientific article

Strict 3' splice site sequence requirements for U2 snRNP recruitment after U2AF binding underlie a genetic defect leading to autoimmune disease

scientific article published on 13 January 2011

Structural basis for the recognition of spliceosomal SmN/B/B' proteins by the RBM5 OCRE domain in splicing regulation

scientific article

Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1

scientific article

Sudemycin K: A Synthetic Antitumor Splicing Inhibitor Variant with Improved Activity and Versatile Chemistry.

scientific article published in December 2016

Switch in 3' splice site recognition between exon definition and splicing catalysis is important for sex-lethal autoregulation.

scientific article

Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers

article

Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.

scientific article published on 21 December 2017

Targeting of U2AF65 to sites of active splicing in the nucleus

scientific article

The Drosophila fl(2)d gene, required for female-specific splicing of Sxl and tra pre-mRNAs, encodes a novel nuclear protein with a HQ-rich domain

scientific article

The Drosophila splicing regulator sex-lethal directly inhibits translation of male-specific-lethal 2 mRNA

scientific article

The Spliceosome: The Ultimate RNA Chaperone and Sculptor

scientific article

The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing

scientific article

The complete local genotype-phenotype landscape for the alternative splicing of a human exon

scientific article published on 10 May 2016

The conserved RNA recognition motif 3 of U2 snRNA auxiliary factor (U2AF 65) is essential in vivo but dispensable for activity in vitro

scientific article

The expanding transcriptome: the genome as the 'Book of Sand'

scientific article

The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches

scientific article

The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA.

scientific article published in March 1993

The spliceosome as a target of novel antitumour drugs

scientific article

The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites

scientific article

Tumor suppressor properties of the splicing regulatory factor RBM10.

scientific article published on 6 February 2016

Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein

scientific article published on 08 May 2007

U2 small nuclear ribonucleoprotein particle (snRNP) auxiliary factor of 65 kDa, U2AF65, can promote U1 snRNP recruitment to 5' splice sites

scientific article

U2AF-homology motif interactions are required for alternative splicing regulation by SPF45

scientific article

U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction

scientific article (publication date: 15 July 1997)

Unweaving the meanings of messenger RNA sequences

scientific article published on July 2006

Viral cell biology: Influenza raids the splicing store

scientific article published on 24 June 2016

hnRNP A1 proofreads 3' splice site recognition by U2AF.

scientific article

Paulina is supported by:

About Paulina

Help