List of works - Robin Leatherbarrow

A combined proton and phosphorus-31 nuclear magnetic resonance investigation of the combining site of M603, a phosphocholine-binding myeloma protein

scientific article published on 01 September 1982

A conserved cis peptide bond is necessary for the activity of Bowman-Birk inhibitor protein.

scientific article published in August 2002

A continuous assay for foot-and-mouth disease virus 3C protease activity

scientific article

A fluorescence-based assay for N-myristoyltransferase activity

scientific article published on 14 October 2011

A study of the specificity of barley chymotrypsin inhibitor 2 by cysteine engineering of the P1 residue

scientific article published in May 1998

A two-step mechanism for the folding of actin by the yeast cytosolic chaperonin.

scientific article published on 5 November 2010

Analysis of calibration methodologies for solvent effects in drug discovery studies using evanescent wave biosensors

scientific article

Analysis of molecular recognition using optical biosensors.

scientific article

Analysis of protein-protein interactions by using droplet-based microfluidics

scientific article published in July 2009

Binding energy and catalysis: a lesson from protein engineering of the tyrosyl-tRNA synthetase

article

Binding of complement subcomponent Clq to mouse IgGl, IgG2a AND IgG2b: A novel Clq binding assay

scientific article published on 01 April 1984

Bovine dopamine beta-hydroxylase, primary structure determined by cDNA cloning and amino acid sequencing.

scientific article published on July 1990

Carbon-13 NMR study of the effects of mutation on the tryptophan dynamics in chymotrypsin inhibitor 2: correlations with structure and stability

article

Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major

scientific article published on June 2006

Comparing experimental and computational alanine scanning techniques for probing a prototypical protein–protein interaction

scientific article published on 23 July 2010

Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity

scientific article published on 14 January 2005

Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N -Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)

scientific article

Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease

scientific article published on 17 December 2013

Design of a small peptide-based proteinase inhibitor by modeling the active-site region of barley chymotrypsin inhibitor 2

scientific article published on 01 November 1991

Design, synthesis and analysis of novel bicyclic and bifunctional protease inhibitors

scientific article published in September 2004

Designer catalytic antibodies

scientific article published in Nature

Development of small molecules to target the IgE:FcεRI protein-protein interaction in allergies

scientific article

Diversification of the IgG molecule by oligosaccharides ⬇️

scientific article published on December 1, 1991

Droplet dispensing in digital microfluidic devices: Assessment of long-term reproducibility

scientific article published on 6 April 2012

Effect of osmolytes on the exchange rates of backbone amide protons in proteins.

scientific article

Expression and kinetic characterization of barley chymotrypsin inhibitors 1a and 1b.

scientific article published in June 1994

Foot-and-mouth disease virus 3C protease: recent structural and functional insights into an antiviral target

scientific article published on 14 August 2006

Imaging of proteins by scanning tunnelling microscopy

scientific article published on 01 July 1992

Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins

scientific article published in July 2007

Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides

scientific article published in February 2002

Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides: creation of a new tri-functional inhibitor

scientific article published on December 2004

Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate

scientific article

Introduction of the new dipeptide isostere 7-endo-BtA as reverse turn inducer in a Bowman-Birk proteinase inhibitor: synthesis and conformational analysis.

scientific article published in June 2001

Investigation of transition-state stabilization by residues histidine-45 and threonine-40 in the tyrosyl-tRNA synthetase

scientific article published on 01 December 1987

Kinetics of Protein-Protein Interactions at the Surface of an Optical Biosensor

scientific article published on 01 October 1995

Membrane enhanced peptide synthesis

scientific article published on 02 March 2010

Metal ion dependence of phosphorothioate ATP analogues in the Bacillus stearothermophilus tyrosyl-tRNA synthetase reaction

scientific article published in February 1990

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.

scientific article published in December 2007

N-Myristoyl transferase-mediated protein labelling in vivo

scientific article published on 12 May 2008

N-myristoyltransferase: a prospective drug target for protozoan parasites

scientific article published on March 2008

Peptide mimics of the Bowman-Birk inhibitor reactive site loop

scientific article

Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold

scientific article published in October 2009

Protein engineering

scientific article published on 01 October 1986

Reagent-controlled stereoselective synthesis of lignan-related tetrahydrofurans

scientific article published in October 2004

Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor scaffolds

scientific article

Role of arginine 67 in the stabilization of chymotrypsin inhibitor 2: examination of amide proton exchange rates and denaturation thermodynamics of an engineered protein

scientific article published on 01 July 1990

Role of tyrosines in the combining site of the dinitrophenyl-binding IgA myeloma M315: specific nitration and high-resolution proton nuclear magnetic resonance studies

scientific article published on 01 October 1982

Second-Order Kinetic Analysis of IAsys Biosensor Data: Its Use and Applicability ⬇️

scientific article published on October 1, 1998

Solution Structure of a Novel C2-Symmetrical Bifunctional Bicyclic Inhibitor Based on SFTI-1

scientific article published on 01 September 2005

Specific N-terminal protein labelling: use of FMDV 3C pro protease and native chemical ligation

scientific article published on 25 June 2008

Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis

scientific article published on 25 October 2006

Structure of immunoglobulin G by scanning tunnelling microscopy.

scientific article

Structure-activity relationships in engineered proteins: analysis of use of binding energy by linear free energy relationships

scientific article published in September 1987

Synthesis and bio-assay of RCM-derived Bowman-Birk inhibitor analogues

scientific article published on 24 December 2003

Synthesis of the C19 methyl ether of aspercyclide A via germyl-Stille macrocyclisation and ELISA evaluation of both enantiomers following optical resolution

scientific article published on 15 August 2011

Synthetic peptide mimics of the Bowman-Birk inhibitor protein.

scientific article published in July 2001

The (1)H-NMR solution structure of the antitryptic core peptide of Bowman-Birk inhibitor proteins: a minimal canonical loop

scientific article

The conserved P1' Ser of Bowman-Birk-type proteinase inhibitors is not essential for the integrity of the reactive site loop

scientific article published in August 2003

The effect of aglycosylation on the binding of mouse IgG to staphylococcal protein A

article

The role of threonine in the P 2 position of bowman-birk proteinase inhibitors: studies on P 2 variation in cyclic peptides encompassing the reactive site loop 1 1Edited by A. R. Fersht ⬇️

scientific article published on September 18, 1998

The structural basis of a conserved P2 threonine in canonical serine proteinase inhibitors

scientific article

Total synthesis of (+/-)-aspercyclide A and its C19 methyl ether

scientific article published on 23 December 2009

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach ⬇️

scientific article

List of works by Robin Leatherbarrow

A combined proton and phosphorus-31 nuclear magnetic resonance investigation of the combining site of M603, a phosphocholine-binding myeloma protein

A conserved cis peptide bond is necessary for the activity of Bowman-Birk inhibitor protein.

A continuous assay for foot-and-mouth disease virus 3C protease activity

A fluorescence-based assay for N-myristoyltransferase activity

A study of the specificity of barley chymotrypsin inhibitor 2 by cysteine engineering of the P1 residue

A two-step mechanism for the folding of actin by the yeast cytosolic chaperonin.

Analysis of calibration methodologies for solvent effects in drug discovery studies using evanescent wave biosensors

Analysis of molecular recognition using optical biosensors.

Analysis of protein-protein interactions by using droplet-based microfluidics

Binding energy and catalysis: a lesson from protein engineering of the tyrosyl-tRNA synthetase

Binding of complement subcomponent Clq to mouse IgGl, IgG2a AND IgG2b: A novel Clq binding assay

Bovine dopamine beta-hydroxylase, primary structure determined by cDNA cloning and amino acid sequencing.

Carbon-13 NMR study of the effects of mutation on the tryptophan dynamics in chymotrypsin inhibitor 2: correlations with structure and stability

Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major

Comparing experimental and computational alanine scanning techniques for probing a prototypical protein–protein interaction

Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity

Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N -Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)

Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease

Design of a small peptide-based proteinase inhibitor by modeling the active-site region of barley chymotrypsin inhibitor 2

Design, synthesis and analysis of novel bicyclic and bifunctional protease inhibitors

Designer catalytic antibodies

Development of small molecules to target the IgE:FcεRI protein-protein interaction in allergies

Diversification of the IgG molecule by oligosaccharides ⬇️

Droplet dispensing in digital microfluidic devices: Assessment of long-term reproducibility

Effect of osmolytes on the exchange rates of backbone amide protons in proteins.

Expression and kinetic characterization of barley chymotrypsin inhibitors 1a and 1b.

Foot-and-mouth disease virus 3C protease: recent structural and functional insights into an antiviral target

Imaging of proteins by scanning tunnelling microscopy

Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins

Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides

Inhibition of human beta-tryptase by Bowman-Birk inhibitor derived peptides: creation of a new tri-functional inhibitor

Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate

Introduction of the new dipeptide isostere 7-endo-BtA as reverse turn inducer in a Bowman-Birk proteinase inhibitor: synthesis and conformational analysis.

Investigation of transition-state stabilization by residues histidine-45 and threonine-40 in the tyrosyl-tRNA synthetase

Kinetics of Protein-Protein Interactions at the Surface of an Optical Biosensor

Membrane enhanced peptide synthesis

Metal ion dependence of phosphorothioate ATP analogues in the Bacillus stearothermophilus tyrosyl-tRNA synthetase reaction

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.

N-Myristoyl transferase-mediated protein labelling in vivo

N-myristoyltransferase: a prospective drug target for protozoan parasites

Peptide mimics of the Bowman-Birk inhibitor reactive site loop

Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold

Protein engineering

Reagent-controlled stereoselective synthesis of lignan-related tetrahydrofurans

Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor scaffolds

Role of arginine 67 in the stabilization of chymotrypsin inhibitor 2: examination of amide proton exchange rates and denaturation thermodynamics of an engineered protein

Role of tyrosines in the combining site of the dinitrophenyl-binding IgA myeloma M315: specific nitration and high-resolution proton nuclear magnetic resonance studies

Second-Order Kinetic Analysis of IAsys Biosensor Data: Its Use and Applicability ⬇️

Solution Structure of a Novel C2-Symmetrical Bifunctional Bicyclic Inhibitor Based on SFTI-1

Specific N-terminal protein labelling: use of FMDV 3C pro protease and native chemical ligation

Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis

Structure of immunoglobulin G by scanning tunnelling microscopy.

Structure-activity relationships in engineered proteins: analysis of use of binding energy by linear free energy relationships

Synthesis and bio-assay of RCM-derived Bowman-Birk inhibitor analogues

Synthesis of the C19 methyl ether of aspercyclide A via germyl-Stille macrocyclisation and ELISA evaluation of both enantiomers following optical resolution

Synthetic peptide mimics of the Bowman-Birk inhibitor protein.

The (1)H-NMR solution structure of the antitryptic core peptide of Bowman-Birk inhibitor proteins: a minimal canonical loop

The conserved P1' Ser of Bowman-Birk-type proteinase inhibitors is not essential for the integrity of the reactive site loop

The effect of aglycosylation on the binding of mouse IgG to staphylococcal protein A

The role of threonine in the P 2 position of bowman-birk proteinase inhibitors: studies on P 2 variation in cyclic peptides encompassing the reactive site loop 1 1Edited by A. R. Fersht ⬇️

The structural basis of a conserved P2 threonine in canonical serine proteinase inhibitors

Total synthesis of (+/-)-aspercyclide A and its C19 methyl ether

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach ⬇️