List of works - Atsushi Tajima

A Targeted Genetic Association Study of the Rare Type of Osteomyelitis

scientific article published on 24 January 2020

A de novo mutation of the LDL receptor gene as the cause of familial hypercholesterolemia identified using whole exome sequencing

scientific article published on 22 December 2015

A haplotype spanning two genes, ELN and LIMK1, decreases their transcripts and confers susceptibility to intracranial aneurysms.

scientific article

A homozygous mutation of VWA3B causes cerebellar ataxia with intellectual disability

scientific article published on 8 July 2015

A new targeted capture method using bacterial artificial chromosome (BAC) libraries as baits for sequencing relatively large genes

scientific article published on 12 July 2018

A nonsynonymous variant of IL1A is associated with endometriosis in Japanese population

scientific article published on 2 May 2013

A partial nuclear genome of the Jomons who lived 3000 years ago in Fukushima, Japan

scientific article

A replication study of a candidate locus for follicle-stimulating hormone levels and association analysis for semen quality traits in Japanese men

scientific article published on 30 June 2016

A successful case of neoadjuvant chemotherapy and radical hysterectomy during pregnancy for advanced uterine cervical cancer accompanied by neonatal erythroderma

scientific article published on 25 July 2018

A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis

scientific article

A toddler with phylloid-type pigmentary mosaicism and ambiguous genitalia resulting from trisomy 14 induced by a der(Y)t(Y;14)

scientific article published on 25 September 2020

ANRIL is implicated in the regulation of nucleus and potential transcriptional target of E2F1 ⬇️

scientific article published on September 1, 2010

Aberrant DNA methylation of blood in schizophrenia by adjusting for estimated cellular proportions

scientific article

An association study of four candidate loci for human male fertility traits with male infertility

scientific article published on 23 April 2015

An independent validation study of three single nucleotide polymorphisms at the sex hormone-binding globulin locus for testosterone levels identified by genome-wide association studies

scientific article published on 14 June 2017

Ancient Jomon genome sequence analysis sheds light on migration patterns of early East Asian populations

scientific article published on 25 August 2020

Association Analysis of Genes Involved in the Maintenance of the Integrity of the Extracellular Matrix with Intracranial Aneurysms in a Japanese Cohort

article

Association Between Serum 25-Hydroxyvitamin D Concentrations and Chronic Pain: Effects of Drinking Habits

scientific article published on 19 November 2020

Association of TUSC1 and DPF3 gene polymorphisms with male infertility.

scientific article published on 3 October 2017

Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study

scientific article

Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort

scientific article

Association of the growth hormone receptor gene polymorphisms with mandibular height in a Korean population

scientific article

Blood diagnostic biomarkers for major depressive disorder using multiplex DNA methylation profiles: discovery and validation

scientific article

COL6A1, the candidate gene for ossification of the posterior longitudinal ligament, is associated with diffuse idiopathic skeletal hyperostosis in Japanese

scientific article published on 01 October 2005

CRISPR/Cas9-mediated gene knockout in the mouse brain using in utero electroporation

scientific article

Calcium Signaling Pathway Is Associated with the Long-Term Clinical Response to Selective Serotonin Reuptake Inhibitors (SSRI) and SSRI with Antipsychotics in Patients with Obsessive-Compulsive Disorder

scientific article

Characterization of the antinociceptive effects of TRK-820 in the rat

scientific article published on 01 January 2000

Clinical and genetic characteristics of abnormal glucose tolerance in Japanese women in the first year after gestational diabetes mellitus

scientific article published on 26 October 2018

Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project

scientific article published on 04 October 2010

Comprehensive Genetic Exploration of Fused Teeth by Whole Exome Sequencing

scientific article published in 2022

Construction of a combinatorial pipeline using two somatic variant calling methods for whole exome sequence data of gastric cancer

scientific article

Cumulative effect of the plasma total homocysteine-related genetic variants on schizophrenia risk

scientific article published on 17 October 2016

DNA methylation signatures of peripheral leukocytes in schizophrenia.

scientific article published on 9 September 2012

De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity

scientific article

Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis.

scientific article published in May 2018

Differential effects of chromosome 9p21 variation on subphenotypes of intracranial aneurysm: site distribution.

scientific article published in July 2010

Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia.

scientific article published on 14 March 2017

Elevated peripheral blood glutamate levels in major depressive disorder.

scientific article published on 6 April 2018

Erratum: An independent validation study of three single nucleotide polymorphisms at the sex hormone-binding globulin locus for testosterone levels identified by genome-wide association studies

scientific article published on 14 June 2017

Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia

scientific article published on 19 March 2019

Evaluating the performance of Affymetrix SNP Array 6.0 platform with 400 Japanese individuals

scientific article

Evaluation of an association between plasma total homocysteine and schizophrenia by a Mendelian randomization analysis.

scientific article published on 26 July 2015

Exploration of genetic factors determining cleft side in a pair of monozygotic twins with mirror-image cleft lip and palate using whole-genome sequencing and comparison of craniofacial morphology

scientific article published on 19 August 2018

Folding of the Cerebral Cortex Requires Cdk5 in Upper-Layer Neurons in Gyrencephalic Mammals.

scientific article published in August 2017

Foretinib overcomes entrectinib resistance associated with the NTRK1 G667C mutation in NTRK1 fusion-positive tumor cells in a brain metastasis model.

scientific article published on 20 February 2018

Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression.

scientific article published on 12 September 2017

Further evidence for an association between mandibular height and the growth hormone receptor gene in a Japanese population

scientific article published in October 2009

Gene expression in a canine basilar artery vasospasm model: a genome-wide network-based analysis.

scientific article published on 08 May 2008

Gene expression profile for predicting survival in advanced-stage serous ovarian cancer across two independent datasets

scientific article

Gene expression profiling reveals distinct molecular signatures associated with the rupture of intracranial aneurysm

scientific article published on 17 June 2014

Genetic background of people in the Dominican Republic with or without obese type 2 diabetes revealed by mitochondrial DNA polymorphism

scientific article published on 5 August 2004

Genetic origins of the Ainu inferred from combined DNA analyses of maternal and paternal lineages

scientific article

Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy

scientific article published on 12 December 2019

Genome-wide association study identifies ERBB4 on 2q34 as a novel locus associated with sperm motility in Japanese men.

scientific article published on 16 February 2018

Genome-wide association study of intracranial aneurysm identifies three new risk loci

scientific article

Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels

scientific article published on 27 April 2020

Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms

scientific article published on 08 July 2010

Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility

scientific article

Germline copy number variations in BRCA1-associated ovarian cancer patients.

scientific article published on 7 December 2010

Hepatic microRNA expression is associated with the response to interferon treatment of chronic hepatitis C

scientific article

High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway.

scientific article published on 12 January 2012

IFN-γ and TNF-α synergistically induce microRNA-155 which regulates TAB2/IP-10 expression in human mesangial cells.

scientific article

Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia.

scientific article published on 23 February 2017

Identification of independent risk loci for Graves' disease within the MHC in the Japanese population

scientific article published on 08 September 2011

Identification of novel candidate loci for anorexia nervosa at 1q41 and 11q22 in Japanese by a genome-wide association analysis with microsatellite markers

scientific article published on 14 August 2009

In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy of targeted drugs.

scientific article published on 10 November 2017

Is there any evidence for linkage on chromosome 17cen in affected Japanese sib-pairs with an intracranial aneurysm?

scientific article

Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation.

scientific article

Lack of replication of four candidate SNPs implicated in human male fertility traits: a large-scale population-based study

scientific article published on 23 April 2015

Localized astrogenesis regulates gyrification of the cerebral cortex

scientific article published on 11 March 2022

Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia.

scientific article

Meta-analysis of association studies between DISC1 missense variants and schizophrenia in the Japanese population

scientific article published on 15 August 2012

Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population

scientific article published on 16 September 2010

Mitochondrial DNA polymorphisms in Yunnan nationalities in China

scientific article published in January 2001

Moderate alcohol consumption is associated with impaired insulin secretion and fasting glucose in non-obese non-diabetic men

scientific article published on 10 September 2020

NFKBIL1 confers resistance to experimental autoimmune arthritis through the regulation of dendritic cell functions.

scientific article published in May 2011

Next-generation sequencing analysis identifies genomic alterations in pathological morphologies: A case of pulmonary carcinosarcoma harboring EGFR mutations

scientific article published on 31 May 2018

No association between the COMT Val158Met polymorphism and the long-term clinical response in obsessive-compulsive disorder in the Japanese population

scientific article published on 26 May 2015

Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease

scientific article published on 23 August 2018

Orthognathic surgery induces genome-wide changes longitudinally in DNA methylation in saliva

scientific article published on 15 November 2018

Plasma total homocysteine is associated with DNA methylation in patients with schizophrenia.

scientific article published on 26 April 2013

Potent antinociceptive effects of TRK-820, a novel kappa-opioid receptor agonist

scientific article (publication date: 1999)

Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory functions and neurogenesis.

scientific article published on 25 January 2017

Regulation of the hepatitis C virus genome replication by miR-199a.

scientific article

Replication study and meta-analysis of human nonobstructive azoospermia in Japanese populations

scientific article published on 11 April 2013

Retinoic acid-inducible gene-I (RIG-I) is induced by IFN-{gamma} in human mesangial cells in culture: possible involvement of RIG-I in the inflammation in lupus nephritis

scientific article published on 18 February 2010

Separate mechanisms of long-term potentiation in two input systems to CA3 pyramidal neurons of rat hippocampal slices as revealed by the whole-cell patch-clamp technique

scientific article published in November 1991

Sex differences of leukocytes DNA methylation adjusted for estimated cellular proportions.

scientific article published on 25 June 2015

Specific molecular signatures of non-tumor liver tissue may predict a risk of hepatocarcinogenesis

scientific article published on 18 June 2014

Susceptibility loci for intracranial aneurysm in European and Japanese populations

scientific article

Sustained clonal hematopoiesis by HLA-lacking hematopoietic stem cells without driver mutations in aplastic anemia

scientific article published on 01 May 2018

Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms.

scientific article

TRIM39 and RNF39 are associated with Behçet's disease independently of HLA-B∗51 and -A∗26

scientific article published on 27 September 2010

TRIM39R, but not TRIM39B, regulates type I interferon response

scientific article published on 23 May 2013

TRK-820, a selective kappa-opioid agonist, produces potent antinociception in cynomolgus monkeys

scientific article published in March 2001

The ATF6β-calreticulin axis promotes neuronal survival under endoplasmic reticulum stress and excitotoxicity

scientific article published on 22 June 2021

The alanine/threonine polymorphism of the alpha-1-antichymotrypsin (SERPINA3) gene and ruptured intracranial aneurysms in the Japanese population

scientific article published on 12 September 2006

The history of human populations in the Japanese Archipelago inferred from genome-wide SNP data with a special reference to the Ainu and the Ryukyuan populations.

scientific article

The impact of next-generation sequencing technologies on HLA research

scientific article (publication date: November 2015)

The prehistoric peopling of Southeast Asia

scientific article

The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families

scientific article

Using endothelial nitric oxide synthase gene polymorphisms to identify intracranial aneurysms more prone to rupture in Japanese patients

scientific article published on 01 November 2006

Whole-exome sequencing analysis of supernumerary teeth occurrence in Japanese individuals.

scientific article published on 26 January 2017

Whole-genome sequencing in a pair of monozygotic twins with discordant cleft lip and palate subtypes

scientific article published on 10 July 2018

Zebrafish Numb homologue: phylogenetic evolution and involvement in regulation of left-right asymmetry

scientific article published on 15 May 2006

List of works by Atsushi Tajima

A Targeted Genetic Association Study of the Rare Type of Osteomyelitis

A de novo mutation of the LDL receptor gene as the cause of familial hypercholesterolemia identified using whole exome sequencing

A haplotype spanning two genes, ELN and LIMK1, decreases their transcripts and confers susceptibility to intracranial aneurysms.

A homozygous mutation of VWA3B causes cerebellar ataxia with intellectual disability

A new targeted capture method using bacterial artificial chromosome (BAC) libraries as baits for sequencing relatively large genes

A nonsynonymous variant of IL1A is associated with endometriosis in Japanese population

A partial nuclear genome of the Jomons who lived 3000 years ago in Fukushima, Japan

A replication study of a candidate locus for follicle-stimulating hormone levels and association analysis for semen quality traits in Japanese men

A successful case of neoadjuvant chemotherapy and radical hysterectomy during pregnancy for advanced uterine cervical cancer accompanied by neonatal erythroderma

A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis

A toddler with phylloid-type pigmentary mosaicism and ambiguous genitalia resulting from trisomy 14 induced by a der(Y)t(Y;14)

ANRIL is implicated in the regulation of nucleus and potential transcriptional target of E2F1 ⬇️

Aberrant DNA methylation of blood in schizophrenia by adjusting for estimated cellular proportions

An association study of four candidate loci for human male fertility traits with male infertility

An independent validation study of three single nucleotide polymorphisms at the sex hormone-binding globulin locus for testosterone levels identified by genome-wide association studies

Ancient Jomon genome sequence analysis sheds light on migration patterns of early East Asian populations

Association Analysis of Genes Involved in the Maintenance of the Integrity of the Extracellular Matrix with Intracranial Aneurysms in a Japanese Cohort

Association Between Serum 25-Hydroxyvitamin D Concentrations and Chronic Pain: Effects of Drinking Habits

Association of TUSC1 and DPF3 gene polymorphisms with male infertility.

Association of common polymorphisms with gestational diabetes mellitus in Japanese women: A case-control study

Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort

Association of the growth hormone receptor gene polymorphisms with mandibular height in a Korean population

Blood diagnostic biomarkers for major depressive disorder using multiplex DNA methylation profiles: discovery and validation

COL6A1, the candidate gene for ossification of the posterior longitudinal ligament, is associated with diffuse idiopathic skeletal hyperostosis in Japanese

CRISPR/Cas9-mediated gene knockout in the mouse brain using in utero electroporation

Calcium Signaling Pathway Is Associated with the Long-Term Clinical Response to Selective Serotonin Reuptake Inhibitors (SSRI) and SSRI with Antipsychotics in Patients with Obsessive-Compulsive Disorder

Characterization of the antinociceptive effects of TRK-820 in the rat

Clinical and genetic characteristics of abnormal glucose tolerance in Japanese women in the first year after gestational diabetes mellitus

Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project

Comprehensive Genetic Exploration of Fused Teeth by Whole Exome Sequencing

Construction of a combinatorial pipeline using two somatic variant calling methods for whole exome sequence data of gastric cancer

Cumulative effect of the plasma total homocysteine-related genetic variants on schizophrenia risk

DNA methylation signatures of peripheral leukocytes in schizophrenia.

De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity

Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis.

Differential effects of chromosome 9p21 variation on subphenotypes of intracranial aneurysm: site distribution.

Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia.

Elevated peripheral blood glutamate levels in major depressive disorder.

Erratum: An independent validation study of three single nucleotide polymorphisms at the sex hormone-binding globulin locus for testosterone levels identified by genome-wide association studies

Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia

Evaluating the performance of Affymetrix SNP Array 6.0 platform with 400 Japanese individuals

Evaluation of an association between plasma total homocysteine and schizophrenia by a Mendelian randomization analysis.

Exploration of genetic factors determining cleft side in a pair of monozygotic twins with mirror-image cleft lip and palate using whole-genome sequencing and comparison of craniofacial morphology

Folding of the Cerebral Cortex Requires Cdk5 in Upper-Layer Neurons in Gyrencephalic Mammals.

Foretinib overcomes entrectinib resistance associated with the NTRK1 G667C mutation in NTRK1 fusion-positive tumor cells in a brain metastasis model.

Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression.

Further evidence for an association between mandibular height and the growth hormone receptor gene in a Japanese population

Gene expression in a canine basilar artery vasospasm model: a genome-wide network-based analysis.

Gene expression profile for predicting survival in advanced-stage serous ovarian cancer across two independent datasets

Gene expression profiling reveals distinct molecular signatures associated with the rupture of intracranial aneurysm

Genetic background of people in the Dominican Republic with or without obese type 2 diabetes revealed by mitochondrial DNA polymorphism

Genetic origins of the Ainu inferred from combined DNA analyses of maternal and paternal lineages

Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy

Genome-wide association study identifies ERBB4 on 2q34 as a novel locus associated with sperm motility in Japanese men.

Genome-wide association study of intracranial aneurysm identifies three new risk loci

Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels

Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms

Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility

Germline copy number variations in BRCA1-associated ovarian cancer patients.

Hepatic microRNA expression is associated with the response to interferon treatment of chronic hepatitis C

High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway.

IFN-γ and TNF-α synergistically induce microRNA-155 which regulates TAB2/IP-10 expression in human mesangial cells.

Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia.

Identification of independent risk loci for Graves' disease within the MHC in the Japanese population

Identification of novel candidate loci for anorexia nervosa at 1q41 and 11q22 in Japanese by a genome-wide association analysis with microsatellite markers

In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy of targeted drugs.

Is there any evidence for linkage on chromosome 17cen in affected Japanese sib-pairs with an intracranial aneurysm?

Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation.

Lack of replication of four candidate SNPs implicated in human male fertility traits: a large-scale population-based study

Localized astrogenesis regulates gyrification of the cerebral cortex

Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia.

Meta-analysis of association studies between DISC1 missense variants and schizophrenia in the Japanese population

Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population

Mitochondrial DNA polymorphisms in Yunnan nationalities in China

Moderate alcohol consumption is associated with impaired insulin secretion and fasting glucose in non-obese non-diabetic men

NFKBIL1 confers resistance to experimental autoimmune arthritis through the regulation of dendritic cell functions.

Next-generation sequencing analysis identifies genomic alterations in pathological morphologies: A case of pulmonary carcinosarcoma harboring EGFR mutations

No association between the COMT Val158Met polymorphism and the long-term clinical response in obsessive-compulsive disorder in the Japanese population

Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease