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List of works by Joaquim Bosch-Barrera

A phase Ib trial of continuous once-daily oral afatinib plus sirolimus in patients with epidermal growth factor receptor mutation-positive non-small cell lung cancer and/or disease progression following prior erlotinib or gefitinib.

scientific article published on 22 March 2017

A randomized, phase 2 evaluation of the CHK1 inhibitor, LY2603618, administered in combination with pemetrexed and cisplatin in patients with advanced nonsquamous non-small cell lung cancer

scientific article published on 06 March 2017

Adult onset Still's disease after first cycle of pemetrexed and gemcitabine for non-small cell lung cancer.

scientific article published on 13 November 2008

An olive oil phenolic is a new chemotype of mutant isocitrate dehydrogenase 1 (IDH1) inhibitors

scientific article published on 01 March 2019

Anti-protozoal and anti-bacterial antibiotics that inhibit protein synthesis kill cancer subtypes enriched for stem cell-like properties

scientific article published on 13 May 2015

Assessment of ALK status by FISH on 1000 Spanish non-small cell lung cancer patients.

scientific article published in December 2014

Author Correction: STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

scientific article published on 01 September 2018

BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer

scientific article

BRCA1 haploinsufficiency cell-autonomously activates RANKL expression and generates denosumab-responsive breast cancer-initiating cells

scientific article

Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells

scientific article

Combination of gefitinib and olaparib versus gefitinib alone in EGFR mutant non-small-cell lung cancer (NSCLC): A multicenter, randomized phase II study (GOAL)

scientific article published on 03 October 2020

Comprehensive cross-platform comparison of methods for non-invasive EGFR mutation testing: Results of the RING observational trial

scientific article published on 26 October 2020

Computational de-orphanization of the olive oil biophenol oleacein: Discovery of new metabolic and epigenetic targets

scientific article published on 29 May 2019

Costs and ethical issues related to first-line treatment of metastatic non-small-cell lung cancer: considerations from a public healthcare system perspective

article

Costs of bevacizumab and pemetrexed for advanced non-squamous NSCLC in Italy and Germany

scientific article published on 04 November 2010

Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells

scientific article published on April 2012

Direct antitumour activity of zoledronic acid: preclinical and clinical data

scientific article

EphA2 receptor activation with ephrin-A1 ligand restores cetuximab efficacy in NRAS-mutant colorectal cancer cells

scientific article published on 30 May 2017

Ethics competences in the undergraduate medical education curriculum: the Spanish experience.

scientific article published on October 2016

Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A

scientific article published on 19 July 2019

First-Line Lorlatinib or Crizotinib in Advanced ALK-Positive Lung Cancer

scientific article published on 01 November 2020

Hepatic breast cancer dissemination after an iatrogenic hepatic laceration during talc pleurodesis: a case report.

scientific article

IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations

scientific article published on January 2013

Id1 and Id3 co-expression correlates with clinical outcome in stage III-N2 non-small cell lung cancer patients treated with definitive chemoradiotherapy.

scientific article published on 11 January 2013

Immune-related adverse events and atypical radiological response with checkpoint inhibitor immunotherapy in an elderly patient with high PD-L1 expressing lung adenocarcinoma

scientific article published on 31 August 2018

Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell Monolayers ⬇️

scientific article published on 31 March 2019

Lung cancer symptoms at diagnosis: results of a nationwide registry study

scientific article published on 01 November 2020

Metabolomic mapping of cancer stem cells for reducing and exploiting tumor heterogeneity

scientific article published on 15 October 2017

Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation

scientific article published on 06 November 2018

Metformin inhibits RANKL and sensitizes cancer stem cells to denosumab

scientific article

Metformin lowers the threshold for stress-induced senescence: a role for the microRNA-200 family and miR-205.

scientific article published on 15 March 2012

Metformin-induced preferential killing of breast cancer initiating CD44+CD24−/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts ⬇️

scientific article published on April 1, 2012

Metformin: Multi-faceted protection against cancer ⬇️

scientific article published on December 1, 2011

Monitoring EGFR-T790M mutation in serum/plasma for prediction of response to third-generation EGFR inhibitors in patients with lung cancer.

scientific article

Neoadjuvant Chemoradiotherapy Treatment for a Classic Biphasic Pulmonary Blastoma with High PD-L1 Expression.

scientific article

Next-generation Sequencing for ALK and ROS1 Rearrangement Detection in Patients With Non-small-cell Lung Cancer: Implications of FISH-positive Patterns

scientific article published on 26 February 2019

Oncobiguanides: Paracelsus' law and nonconventional routes for administering diabetobiguanides for cancer treatment

scientific article published on May 2014

Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype.

scientific article published on May 2015

Paraneoplastic limbic encephalitis in a male with squamous cell carcinoma of the lung

scientific article published on 11 November 2014

Polycaprolactone Electrospun Scaffolds Produce an Enrichment of Lung Cancer Stem Cells in Sensitive and Resistant EGFRm Lung Adenocarcinoma

scientific article published on 22 October 2021

Primary bone lymphoma of the mandible and thyroid incidentaloma identified by FDG PET/CT: a case report

scientific article published on 26 June 2009

Probable drug-drug interaction between erlotinib and amiodarone causes severe neurotoxicity in a patient with advanced lung cancer.

scientific article published on 7 February 2018

Response of brain metastasis from lung cancer patients to an oral nutraceutical product containing silibinin

scientific article published on 03 March 2016

Revisiting silibinin as a novobiocin-like Hsp90 C-terminal inhibitor: Computational modeling and experimental validation

scientific article published on 26 June 2019

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

scientific article published on 11 June 2018

STAT3-targeted treatment with silibinin overcomes the acquired resistance to crizotinib in ALK-rearranged lung cancer

scientific article published on 18 October 2016

Sensory-motor axonal peripheral neuropathy in an advanced breast cancer patient treated with ixabepilone

scientific article published in November 2009

Silibinin administration improves hepatic failure due to extensive liver infiltration in a breast cancer patient

article published in 2014

Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients

scientific article published on 07 June 2020

Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy

scientific article

Silibinin is a direct inhibitor of STAT3.

scientific article published on 13 April 2018

Silibinin meglumine, a water-soluble form of milk thistle silymarin, is an orally active anti-cancer agent that impedes the epithelial-to-mesenchymal transition (EMT) in EGFR-mutant non-small-cell lung carcinoma cells

scientific article published on August 2013

Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo

scientific article published on January 2013

Somatic DICER1 mutations in adult-onset pulmonary blastoma.

scientific article

Stem cell-like ALDH(bright) cellular states in EGFR-mutant non-small cell lung cancer: a novel mechanism of acquired resistance to erlotinib targetable with the natural polyphenol silibinin

scientific article published on 17 September 2013

Stem cells and cancer: elucidating the origin of the cancer stem cell

scientific article published in April 2007

Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

scientific article published on 11 April 2022

Successful empirical erlotinib treatment of a mechanically ventilated patient newly diagnosed with metastatic lung adenocarcinoma

scientific article published on 24 July 2014

Synthetic lethal interaction of cetuximab with MEK1/2 inhibition in NRAS-mutant metastatic colorectal cancer

scientific article published on 12 September 2016

Targeting STAT3 with silibinin to improve cancer therapeutics

scientific article

Teaching Bioethics to Students of Medicine with Problem-Based Learning (PBL)

scientific article published in May 2015

The Medical Oncology resident mentor: situation and workload

scientific article published on 30 July 2018

The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells

scientific article published on 13 May 2020

The extra virgin olive oil phenolic oleacein is a dual substrate-inhibitor of catechol-O-methyltransferase

scientific article published on 29 March 2019

The multimodal management of locally advanced N2 non-small cell lung cancer: is there a role for surgical resection? A single institution's experience

scientific article published on 20 July 2012

Toxic epidermal necrolysis related to pemetrexed and carboplatin with vitamin B12 and folic acid supplementation for advanced non-small cell lung cancer

scientific article published on 14 September 2009

Transcriptional upregulation of HER2 expression in the absence of HER2 gene amplification results in cetuximab resistance that is reversed by trastuzumab treatment.

scientific article

Tumor Cell-Intrinsic Immunometabolism and Precision Nutrition in Cancer Immunotherapy

scientific article published on 02 July 2020

Zoledronic acid in lung cancer with bone metastases: a review ⬇️

scientific article published on April 1, 2013

[Ethical dilemmas in the medical practice in 2010: reflexions around the results of a survey to 10,000 physicians]

scientific article published on 01 January 2011

[Insulin and insulin-like growth factor pathway, a new targeted therapy in oncology]

scientific article published on 01 September 2009

[Visual hallucinations and unusual pain related to hypomagnesemia in an advanced cancer patient]

scientific article published on 01 September 2010

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