List of works - Xavier León

A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model

scientific article published on 19 April 2022

A retrospective analysis of the outcome of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck refractory to a platinum-based chemotherapy

scientific article published on 01 September 2005

Absence of disruptive TP53 mutations in high-risk human papillomavirus-driven neck squamous cell carcinoma of unknown primary

scientific article published on 15 August 2019

An anatomical study of anastomoses between the laryngeal nerves.

scientific article

CKMT1 and NCOA1 expression as a predictor of clinical outcome in patients with advanced-stage head and neck squamous cell carcinoma.

scientific article published on 30 October 2015

Ceratocricoid muscle: an embryological and anatomical study

scientific article published on 01 May 2009

Classification of parotidectomies: a proposal of the European Salivary Gland Society

scientific article

Comparison of chi-squared automatic interaction detection classification trees vs TNM classification for patients with head and neck squamous cell carcinoma

scientific article published on 01 March 2012

Comparison of the Radiation Therapy Oncology Group recursive partitioning classification and Union Internationale Contre le Cancer TNM classification for patients with head and neck carcinoma

scientific article

Competing mortality in oropharyngeal carcinoma according to human papillomavirus status

scientific article published on 14 December 2018

Delayed carotid blow-out syndrome: a new complication of chemoradiotherapy treatment in pharyngolaryngeal carcinoma

scientific article published on 11 September 2012

Distinctive Expression and Amplification of Genes at 11q13 in Relation to HPV Status with Impact on Survival in Head and Neck Cancer Patients

article

Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma

scientific article published on 12 December 2018

Elective treatment of the neck for second primary tumors of the head and neck

scientific article published on 6 July 2013

Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients.

scientific article published on 24 August 2015

Etiología y tratamiento de la parálisis laríngea: estudio retrospectivo de 108 pacientes

scientific article published on 27 April 2014

Expression of IL-1α correlates with distant metastasis in patients with head and neck squamous cell carcinoma

scientific article published on 9 October 2015

Expression of the CXCL12/CXCR4 chemokine axis predicts regional control in head and neck squamous cell carcinoma.

scientific article

Extended deep inferior epigastric artery perforator flap for head and neck reconstruction: a clinical experience with 100 patients

scientific article published on 10 November 2010

External validation of a risk group defined by recursive partitioning analysis in patients with head and neck carcinoma treated with surgery and postoperative radiotherapy

scientific article

External validation of sTWEAK as a prognostic noninvasive biomarker for head and neck squamous cell carcinoma.

scientific article published on 17 December 2015

Foramen thyroideum: a comparative study in embryos, fetuses, and adults

scientific article published on 01 August 1997

Gene expression signatures and molecular markers associated with clinical outcome in locally advanced head and neck carcinoma.

scientific article

HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients

scientific article published on 28 January 2016

High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma

scientific article published on 31 October 2013

Human papillomavirus as prognostic marker with rising prevalence in neck squamous cell carcinoma of unknown primary: A retrospective multicentre study.

scientific article published on 10 February 2017

Impact of total laryngectomy on return to work.

scientific article published on 17 May 2017

Incidence and significance of clinically unsuspected thyroid tissue in lymph nodes found during neck dissection in head and neck carcinoma patients

scientific article published on 01 March 2005

Indications and results of extended total laryngectomy with en-bloc resection of overlying cervical skin

scientific article published on 26 July 2019

Influence of the persistence of tobacco and alcohol use in the appearance of second neoplasm in patients with a head and neck cancer. A case-control study

scientific article

Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2.

scientific article published on 4 February 2012

Is dissection of level V necessary in patients with T(2)-T(4)N(0) supraglottic cancer?

scientific article published on 01 March 2004

Ku70 predicts response and primary tumor recurrence after therapy in locally advanced head and neck cancer.

scientific article published in September 2008

Laryngeal cancer in non-smoking and non-drinking patients

journal article; published in Acta Oto-Laryngologica in 2004

Low blood levels of sTWEAK are related to locoregional failure in head and neck cancer.

scientific article published on 26 May 2014

Management of recurrent head and neck cancer: variables related to salvage surgery

scientific article published on 17 May 2016

Metachronous second primary tumours in the aerodigestive tract in patients with early stage head and neck squamous cell carcinomas

scientific article published on 13 May 2005

Nasopharyngeal carcinoma: 30-year experience of a single institution in a non-endemic area

scientific article published on 24 January 2017

Oral cavity colon adenocarcinoma metastases: case report with surgical approach and review of more than 30 years literature

scientific article published on 28 July 2020

Oral cavity, pharynx and larynx nodules.

scientific article published on 7 April 2016

Organ preservation in laryngeal and hypopharyngeal cancer

scientific article

Overexpression of the nuclear factor-kappa B (p65) in association with local failure in patients with head and neck carcinoma undergong radiotherapy or chemoradiotherapy.

scientific article published on 16 March 2012

Overview of the efficacy of cetuximab in recurrent and/or metastatic squamous cell carcinoma of the head and neck in patients who previously failed platinum-based therapies

scientific article published in June 2008

Parotid incidentaloma identified by positron emission/computed tomography: when to consider diagnoses other than warthin tumor

scientific article

Parotidectomies in benign parotid tumours: "Sant Pau" surgical extension classification

scientific article

Potential structures that could be confused with a nonrecurrent inferior laryngeal nerve: an anatomic study

scientific article published on 01 January 2008

Pretreatment count of peripheral neutrophils, monocytes, and lymphocytes as independent prognostic factor in patients with head and neck cancer

scientific article

Prognostic capacity of Systemic Inflammation Response Index (SIRI) in patients with head and neck squamous cell carcinoma

scientific article published on 21 November 2019

Prognostic factors in head and neck squamous cell carcinoma: Comparison of CHAID decision trees technology and cox analysis ⬇️

scientific article published on June 19, 2012

Prognostic role of MMP-9 expression in head and neck carcinoma patients treated with radiotherapy or chemoradiotherapy.

scientific article

Prognostic role of extracapsular spread in planned neck dissection after chemoradiotherapy

article

Prognostic significance of extracapsular spread in isolated neck recurrences in head and neck squamous cell carcinoma patients

scientific article published on 10 August 2016

Prognostic value of CD45 transcriptional expression in head and neck cancer.

scientific article published on 25 November 2017

Prostacyclin-synthase expression in head and neck carcinoma patients and its prognostic value in the response to radiotherapy

scientific article published on January 2015

Prostaglandin E(2) pathway in head and neck squamous cell carcinoma

scientific article published in September 2008

Reconstruction of oral cavity defects with FAMM (facial artery musculomucosal) flaps. Our experience

scientific article published on 15 January 2015

Recurrent laryngeal squamous cell carcinoma: rTNM versus composite laryngeal recurrence staging system. Proposal for a modification of the CLRSS to improve patient classification

scientific article published in July 2008

Relationship between response to induction chemotherapy and disease control in patients with advanced laryngeal carcinoma included in an organ preservation protocol.

scientific article published on 27 March 2017

Reply to letter to the editor

scientific article published on 26 July 2014

Results of an organ preservation protocol with induction chemotherapy and radiotherapy in patients with locally advanced laryngeal carcinoma

scientific article published on 18 February 2004

Salvage surgery after local recurrence in patients with head and neck carcinoma treated with chemoradiotherapy or bioradiotherapy

scientific article published on 13 November 2014

Salvage surgery after locoregional failure in head and neck carcinoma patients treated with chemoradiotherapy.

scientific article published on 19 August 2010

Second, third, and fourth head and neck tumors. A progressive decrease in survival

scientific article published on 6 February 2012

Selective dissection of levels II-III with intraoperative control of the upper and middle jugular nodes: A therapeutic option for the no neck

scientific article published on 01 June 2001

Stomal recurrence in head and neck cancer patients with temporary tracheostomy

scientific article published on 03 March 2014

Supracricoid laryngectomy as salvage surgery after failure of radiation therapy

scientific article published on 13 February 2007

The combined use of EFS, GPX2, and SPRR1A expression could distinguish favorable from poor clinical outcome among epithelial-like head and neck carcinoma subtypes

scientific article published on 16 January 2019

The effect of waiting time on local control and survival in head and neck carcinoma patients treated with radiotherapy

scientific article

The prognostic value of pretreatment platelet count in patients with head and neck squamous cell carcinoma

scientific article published on 8 July 2016

The role of HPV on the risk of second primary neoplasia in patients with oropharyngeal carcinoma

scientific article published on 2 December 2016

Total or subtotal glossectomy with microsurgical reconstruction: functional and oncological results

scientific article published on 23 September 2011

Tumor cells induce COX-2 and mPGES-1 expression in microvascular endothelial cells mainly by means of IL-1 receptor activation.

scientific article published on 26 January 2011

Validation of the pathological classification of lymph node metastasis for head and neck tumors according to the 8th edition of the TNM Classification of Malignant Tumors.

scientific article published on 18 May 2017

Variability in nerve patterns of the adductor muscle group supplied by the recurrent laryngeal nerve.

scientific article

Variability of the nerve supply patterns of the human posterior cricoarytenoid muscle.

scientific article

Weighted lymph node ratio: New tool in the assessment of postoperative staging of the neck dissection in HPV-negative head and neck squamous cell carcinoma patients

scientific article published on 26 June 2020

[Larynx transplant: a therapeutic option for the 21st century? Literature review]

scientific article published on 01 March 2008

[Results of an organ conservation protocol in patients with locally advanced laryngeal tumours]

scientific article published on 01 May 2009

uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy

scientific article

List of works by Xavier León

A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model

A retrospective analysis of the outcome of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck refractory to a platinum-based chemotherapy

Absence of disruptive TP53 mutations in high-risk human papillomavirus-driven neck squamous cell carcinoma of unknown primary

An anatomical study of anastomoses between the laryngeal nerves.

CKMT1 and NCOA1 expression as a predictor of clinical outcome in patients with advanced-stage head and neck squamous cell carcinoma.

Ceratocricoid muscle: an embryological and anatomical study

Classification of parotidectomies: a proposal of the European Salivary Gland Society

Comparison of chi-squared automatic interaction detection classification trees vs TNM classification for patients with head and neck squamous cell carcinoma

Comparison of the Radiation Therapy Oncology Group recursive partitioning classification and Union Internationale Contre le Cancer TNM classification for patients with head and neck carcinoma

Competing mortality in oropharyngeal carcinoma according to human papillomavirus status

Delayed carotid blow-out syndrome: a new complication of chemoradiotherapy treatment in pharyngolaryngeal carcinoma

Distinctive Expression and Amplification of Genes at 11q13 in Relation to HPV Status with Impact on Survival in Head and Neck Cancer Patients

Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma

Elective treatment of the neck for second primary tumors of the head and neck

Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients.

Etiología y tratamiento de la parálisis laríngea: estudio retrospectivo de 108 pacientes

Expression of IL-1α correlates with distant metastasis in patients with head and neck squamous cell carcinoma

Expression of the CXCL12/CXCR4 chemokine axis predicts regional control in head and neck squamous cell carcinoma.

Extended deep inferior epigastric artery perforator flap for head and neck reconstruction: a clinical experience with 100 patients

External validation of a risk group defined by recursive partitioning analysis in patients with head and neck carcinoma treated with surgery and postoperative radiotherapy

External validation of sTWEAK as a prognostic noninvasive biomarker for head and neck squamous cell carcinoma.

Foramen thyroideum: a comparative study in embryos, fetuses, and adults

Gene expression signatures and molecular markers associated with clinical outcome in locally advanced head and neck carcinoma.

HPV Involvement in Head and Neck Cancers: Comprehensive Assessment of Biomarkers in 3680 Patients

High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma

Human papillomavirus as prognostic marker with rising prevalence in neck squamous cell carcinoma of unknown primary: A retrospective multicentre study.

Impact of total laryngectomy on return to work.

Incidence and significance of clinically unsuspected thyroid tissue in lymph nodes found during neck dissection in head and neck carcinoma patients

Indications and results of extended total laryngectomy with en-bloc resection of overlying cervical skin

Influence of the persistence of tobacco and alcohol use in the appearance of second neoplasm in patients with a head and neck cancer. A case-control study

Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2.

Is dissection of level V necessary in patients with T(2)-T(4)N(0) supraglottic cancer?

Ku70 predicts response and primary tumor recurrence after therapy in locally advanced head and neck cancer.

Laryngeal cancer in non-smoking and non-drinking patients

Low blood levels of sTWEAK are related to locoregional failure in head and neck cancer.

Management of recurrent head and neck cancer: variables related to salvage surgery

Metachronous second primary tumours in the aerodigestive tract in patients with early stage head and neck squamous cell carcinomas

Nasopharyngeal carcinoma: 30-year experience of a single institution in a non-endemic area

Oral cavity colon adenocarcinoma metastases: case report with surgical approach and review of more than 30 years literature

Oral cavity, pharynx and larynx nodules.

Organ preservation in laryngeal and hypopharyngeal cancer

Overexpression of the nuclear factor-kappa B (p65) in association with local failure in patients with head and neck carcinoma undergong radiotherapy or chemoradiotherapy.

Overview of the efficacy of cetuximab in recurrent and/or metastatic squamous cell carcinoma of the head and neck in patients who previously failed platinum-based therapies

Parotid incidentaloma identified by positron emission/computed tomography: when to consider diagnoses other than warthin tumor

Parotidectomies in benign parotid tumours: "Sant Pau" surgical extension classification

Potential structures that could be confused with a nonrecurrent inferior laryngeal nerve: an anatomic study

Pretreatment count of peripheral neutrophils, monocytes, and lymphocytes as independent prognostic factor in patients with head and neck cancer

Prognostic capacity of Systemic Inflammation Response Index (SIRI) in patients with head and neck squamous cell carcinoma

Prognostic factors in head and neck squamous cell carcinoma: Comparison of CHAID decision trees technology and cox analysis ⬇️

Prognostic role of MMP-9 expression in head and neck carcinoma patients treated with radiotherapy or chemoradiotherapy.

Prognostic role of extracapsular spread in planned neck dissection after chemoradiotherapy

Prognostic significance of extracapsular spread in isolated neck recurrences in head and neck squamous cell carcinoma patients

Prognostic value of CD45 transcriptional expression in head and neck cancer.

Prostacyclin-synthase expression in head and neck carcinoma patients and its prognostic value in the response to radiotherapy

Prostaglandin E(2) pathway in head and neck squamous cell carcinoma

Reconstruction of oral cavity defects with FAMM (facial artery musculomucosal) flaps. Our experience

Recurrent laryngeal squamous cell carcinoma: rTNM versus composite laryngeal recurrence staging system. Proposal for a modification of the CLRSS to improve patient classification

Relationship between response to induction chemotherapy and disease control in patients with advanced laryngeal carcinoma included in an organ preservation protocol.

Reply to letter to the editor

Results of an organ preservation protocol with induction chemotherapy and radiotherapy in patients with locally advanced laryngeal carcinoma

Salvage surgery after local recurrence in patients with head and neck carcinoma treated with chemoradiotherapy or bioradiotherapy

Salvage surgery after locoregional failure in head and neck carcinoma patients treated with chemoradiotherapy.

Second, third, and fourth head and neck tumors. A progressive decrease in survival

Selective dissection of levels II-III with intraoperative control of the upper and middle jugular nodes: A therapeutic option for the no neck

Stomal recurrence in head and neck cancer patients with temporary tracheostomy

Supracricoid laryngectomy as salvage surgery after failure of radiation therapy

The combined use of EFS, GPX2, and SPRR1A expression could distinguish favorable from poor clinical outcome among epithelial-like head and neck carcinoma subtypes

The effect of waiting time on local control and survival in head and neck carcinoma patients treated with radiotherapy

The prognostic value of pretreatment platelet count in patients with head and neck squamous cell carcinoma

The role of HPV on the risk of second primary neoplasia in patients with oropharyngeal carcinoma

Total or subtotal glossectomy with microsurgical reconstruction: functional and oncological results

Tumor cells induce COX-2 and mPGES-1 expression in microvascular endothelial cells mainly by means of IL-1 receptor activation.

Validation of the pathological classification of lymph node metastasis for head and neck tumors according to the 8th edition of the TNM Classification of Malignant Tumors.

Variability in nerve patterns of the adductor muscle group supplied by the recurrent laryngeal nerve.

Variability of the nerve supply patterns of the human posterior cricoarytenoid muscle.

Weighted lymph node ratio: New tool in the assessment of postoperative staging of the neck dissection in HPV-negative head and neck squamous cell carcinoma patients

[Larynx transplant: a therapeutic option for the 21st century? Literature review]

[Results of an organ conservation protocol in patients with locally advanced laryngeal tumours]

uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy