Search filters

List of works by Akihito Ishigami

17β-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-30

scientific article published on 19 October 2011

A selective NFkappaB inhibitor, DHMEQ, reduced atherosclerosis in ApoE-deficient mice

scientific article published on 01 December 2006

Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease.

scientific article

Absorption and excretion of ascorbic acid alone and in acerola (Malpighia emarginata) juice: comparison in healthy Japanese subjects

scientific article published on 01 January 2011

Accumulation of citrullinated proteins by up-regulated peptidylarginine deiminase 2 in brains of scrapie-infected mice: a possible role in pathogenesis

scientific article

Acerola (Malpighia emarginata DC.) Juice Intake Suppresses UVB-Induced Skin Pigmentation in SMP30/GNL Knockout Hairless Mice

scientific article

Age-associated changes in the transcriptomes of non-cultured adipose-derived stem cells from young and old mice assessed via single-cell transcriptome analysis

scientific article published on 25 November 2020

Age-associated decrease of senescence marker protein-30/gluconolactonase in individual mouse liver cells: Immunohistochemistry and immunofluorescence

scientific article published on 14 October 2014

Age-related change in the degradation rate of ovalbumin microinjected into mouse liver parenchymal cells

scientific article published on 01 February 1990

Age-related changes in DNA synthesis stimulated by epinephrine and isoproterenol in primary cultured rat hepatocytes

scientific article published on 01 February 1994

Age-related changes of dopamine, noradrenaline and adrenaline in adrenal glands of mice

scientific article published on 31 August 2012

Age-related oxidant stress with senescence marker protein-30 deficiency plays a pivotal role in coronary artery spasm

scientific article published on 01 March 2013

All-trans retinoic acid increases peptidylarginine deiminases in a newborn rat keratinocyte cell line.

scientific article published on June 1996

Anti-aging research using SMP30/GNL knockout mice

scientific article published in January 2010

Anti-inflammatory activity of SMP30 modulates NF-κB through protein tyrosine kinase/phosphatase balance

scientific article published on 15 November 2014

Ascorbic acid deficiency affects genes for oxidation-reduction and lipid metabolism in livers from SMP30/GNL knockout mice

scientific article published on 3 April 2014

Ascorbic acid deficiency leads to epidermal atrophy and UVB-induced skin pigmentation in SMP30/GNL knockout hairless mice

scientific article published on 12 April 2012

Ascorbic acid depletion enhances expression of the sodium-dependent vitamin C transporters, SVCT1 and SVCT2, and uptake of ascorbic acid in livers of SMP30/GNL knockout mice

scientific article published in February 2010

Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts.

scientific article published on 7 December 2012

Ascorbic acid levels in various tissues, plasma and urine of mice during aging.

scientific article published in January 2012

Ascorbic acid prevents protein oxidation in livers of senescence marker protein-30/gluconolactonase knockout mice

scientific article published on 10 October 2013

Attenuated phagocytosis of secondary necrotic neutrophils by macrophages in aged and SMP30 knockout mice.

scientific article

Bioavailability of vitamin C from mashed potatoes and potato chips after oral administration in healthy Japanese men.

scientific article published on 15 September 2011

Citrullination preferentially proceeds in glomerular Bowman's capsule and increases in obstructive nephropathy

scientific article published in July 2005

Coffee consumption in aged mice increases energy production and decreases hepatic mTOR levels

scientific article published on 7 January 2017

Coronary artery spasm related to thiol oxidation and senescence marker protein-30 in aging

scientific article published on 19 February 2013

Detection of deiminated proteins in rat skin: probing with a monospecific antibody after modification of citrulline residues

scientific article published on 01 August 1995

Determination of dehydroascorbic acid in mouse tissues and plasma by using tris(2-carboxyethyl)phosphine hydrochloride as reductant in metaphosphoric acid/ethylenediaminetetraacetic acid solution

scientific article published in January 2010

Development of a new distyrylbenzene-derivative amyloid-β-aggregation and fibril formation inhibitor.

scientific article published on January 2012

Developmental and age-related changes of peptidylarginine deiminase 2 in the mouse brain

scientific article published in March 2010

Dibutyl phthalate impairs neural progenitor cell proliferation and hippocampal neurogenesis

scientific article published on 25 April 2019

Dietary ascorbic acid restriction in GNL/SMP30-knockout mice unveils the role of ascorbic acid in regulation of somatic and visceral pain sensitivity

scientific article published on 01 March 2019

Effect of ascorbic acid deficiency on catecholamine synthesis in adrenal glands of SMP30/GNL knockout mice.

scientific article

Effect of dietary restriction on the degradation of proteins in senescent mouse liver parenchymal cells in culture

scientific article published on 01 December 1990

Effect of vitamin C depletion on UVR-B induced cataract in SMP30/GNL knockout mice

scientific article published on 06 December 2011

Effect of vitamin C depletion on age-related hearing loss in SMP30/GNL knockout mice

scientific article published on 4 September 2009

Effects of ascorbic acid deficiency on protein and lipid oxidation in livers from SMP30/GNL knockout mice

scientific article published in January 2013

Effects of vitamin C deficiency on the skin of the senescence marker protein-30 (SMP30) knockout mouse

scientific article published on 29 May 2009

Effects of vitamin C on cytotherapy-mediated muscle regeneration

scientific article published on 8 October 2012

Elevated levels of 4-hydroxynonenal-histidine Michael adduct in the hippocampi of patients with Alzheimer's disease

scientific article published in August 2009

Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.

scientific article

Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease

scientific article published on 28 November 2009

Hepatoprotective effect of Arazyme on CCl4-induced acute hepatic injury in SMP30 knock-out mice

scientific article

High dietary intake of vitamin C suppresses age-related thymic atrophy and contributes to the maintenance of immune cells in vitamin C-deficient senescence marker protein-30 knockout mice

scientific article published on 22 January 2015

Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin

scientific article

Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice.

scientific article published on 14 August 2008

Implication of p53-dependent cellular senescence related gene, TARSH in tumor suppression.

scientific article

Importance of research on peptidylarginine deiminase and citrullinated proteins in age-related disease.

scientific article published on July 2010

Inactivation kinetics of horseradish peroxidase microinjected into hepatocytes from mice of various ages

scientific article published on 01 December 1988

Increased and type II-specific expression of peptidylarginine deiminase in activated microglia but not hyperplastic astrocytes following kainic acid-evoked neurodegeneration in the rat brain

scientific article

Insufficient ascorbic acid intake during gestation induces abnormal cardiac dilation in fetal and neonatal SMP30/GNL knockout mice

scientific article published on 05 February 2013

Involvement of peptidylarginine deiminase-mediated post-translational citrullination in pathogenesis of sporadic Creutzfeldt-Jakob disease

scientific article

Lepr(db/db) Mice with senescence marker protein-30 knockout (Lepr(db/db)Smp30(Y/-)) exhibit increases in small dense-LDL and severe fatty liver despite being fed a standard diet

scientific article

Microglial expression of peptidylarginine deiminase 2 in the prenatal rat brain.

scientific article published on 20 June 2007

Modulation of gene expression of SMP-30 by LPS and calorie restriction during aging process.

scientific article

Myasthenia gravis experimentally induced with muscle-specific kinase

scientific article

Neuroprotective and Anti-Inflammatory Effects of Evernic Acid in an MPTP-Induced Parkinson’s Disease Model

scientific article published in 2021

Nuclear localization of senescence marker protein-30, SMP30, in cultured mouse hepatocytes and its similarity to RNA polymerase.

scientific article

Over-expression of Senescence Marker Protein-30 decreases reactive oxygen species in human hepatic carcinoma Hep G2 cells.

scientific article published on October 2009

Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice.

scientific article published on November 2011

Pathophysiological significance of senescence marker protein-30.

scientific article published on July 2010

Pathophysiological significances of citrullinated proteins in geriatric diseases

scientific article

Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases

scientific article published in July 2012

Potato chip intake increases ascorbic acid levels and decreases reactive oxygen species in SMP30/GNL knockout mouse tissues

scientific article

Protective effect of pre- and post-vitamin C treatments on UVB-irradiation-induced skin damage

scientific article published in Scientific Reports

Protein deimination in the rat brain after kainate administration: citrulline-containing proteins as a novel marker of neurodegeneration.

scientific article

Radiation-induced gastrointestinal syndrome is exacerbated in vitamin C-insufficient SMP30/GNL knockout mice

scientific article published on 04 July 2020

Reduced aqueous humour ascorbic-acid concentration in women with smaller anterior chamber depth

scientific article published in Scientific Reports

SMP30 deficiency causes increased oxidative stress in brain

scientific article published on 28 February 2006

SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span.

scientific article published in March 2004

Senescence marker protein 30 deficiency increases Parkinson's pathology by impairing astrocyte activation.

scientific article

Senescence marker protein 30 has a cardio-protective role in doxorubicin-induced cardiac dysfunction

scientific article

Senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and diastolic dysfunction

scientific article published on 9 August 2013

Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis.

scientific article

Senescence marker protein-30 (SMP30) deficiency impairs myocardium-induced dilation of coronary arterioles associated with reactive oxygen species

scientific article published on 29 April 2013

Senescence marker protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells.

scientific article

Senescence marker protein-30 as a novel antiaging molecule.

scientific article published in June 2004

Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver

scientific article published in July 2004

Senescence marker protein-30 knockout mouse as a novel murine model of senile lung

scientific article published in March 2004

Senescence marker protein-30 knockout mouse as an aging model

scientific article published in June 2004

Senescence marker protein-30 knockout mouse liver is highly susceptible to tumor necrosis factor-alpha- and Fas-mediated apoptosis

scientific journal article

Senescence marker protein-30 protects mice lungs from oxidative stress, aging, and smoking

scientific article published on 25 May 2006

Senescence marker protein-30/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetes

scientific article

Senescence marker protein-30/gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion.

scientific article published on 24 November 2009

Senescence marker protein-30/gluconolactonase expression in the mouse ovary during gestation

scientific article published in January 2013

Senescence marker protein-30/superoxide dismutase 1 double knockout mice exhibit increased oxidative stress and hepatic steatosis

scientific article

Smad3 deficiency ameliorates hepatic fibrogenesis through the expression of senescence marker protein-30, an antioxidant-related protein

scientific article

Structural basis of the γ-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase

scientific article

The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells

scientific article published on 27 October 2017

The redox-sensitive DNA binding sites responsible for age-related downregulation of SMP30 by ERK pathway and reversal by calorie restriction

scientific article published on 01 March 2006

Time course of vitamin C distribution and absorption after oral administration in SMP30/GNL knockout mice

scientific article published on 13 August 2010

Two novel sandwich ELISAs identify PAD4 levels and PAD4 autoantibodies in patients with rheumatoid arthritis

scientific article published on 18 September 2012

Uric acid levels in tissues and plasma of mice during aging

scientific article published on 01 January 2012

Vitamin C and vitamin E double-deficiency increased neuroinflammation and impaired conditioned fear memory

scientific article published on 08 January 2019

Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice

scientific article published in May 2010

Vitamin C deficiency causes muscle atrophy and a deterioration in physical performance

scientific article published on 20 March 2019

Vitamin C deficiency increases the binucleation of hepatocytes in SMP30 knock-out mice

scientific article published on November 2010

Vitamin C depletion increases superoxide generation in brains of SMP30/GNL knockout mice

scientific article

Vitamin C is not essential for carnitine biosynthesis in vivo: verification in vitamin C-depleted senescence marker protein-30/gluconolactonase knockout mice

scientific article

Vitamin C prevents cigarette smoke-induced pulmonary emphysema in mice and provides pulmonary restoration.

scientific article published in February 2014

[Advanced approaches to anti-aging --use of aging model animals--]

scientific article published on 01 January 2010

cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I

scientific article

Paulina is supported by:

About Paulina

Help