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List of works by Rosa M. Reguera

2-Alkynoic fatty acids inhibit topoisomerase IB from Leishmania donovani

scientific article

A chronic bioluminescent model of experimental visceral leishmaniasis for accelerating drug discovery

scientific article published on 14 February 2019

A novel active DNA topoisomerase I in Leishmania donovani.

scientific article published on 19 November 2002

A pentapeptide signature motif plays a pivotal role in Leishmania DNA topoisomerase IB activity and camptothecin sensitivity

scientific article published on 18 September 2012

Alterations in the glutathione-redox balance induced by the bio-insecticide Spinosad in CHO-K1 and Vero cells

scientific article published in August 2007

Alterations of the glutathione-redox balance induced by metals in CHO-K1 cells.

scientific article published in July 2002

Alterations on polyamine content and glutathione metabolism induced by different concentrations of paraquat in CHO-K1 cells

scientific article published on 01 June 2000

Analysis of genetic elements regulating the methionine adenosyltransferase gene in Leishmania infantum

article

Antileishmanial activity and tubulin polymerization inhibition of podophyllotoxin derivatives on Leishmania infantum

scientific article published on 28 June 2017

Antileishmanial effect of new indeno-1,5-naphthyridines, selective inhibitors of Leishmania infantum type IB DNA topoisomerase.

scientific article published on 9 September 2016

Appraisal of a Leishmania major strain stably expressing mCherry fluorescent protein for both in vitro and in vivo studies of potential drugs and vaccine against cutaneous leishmaniasis

scientific article

Axenic interspecies and intraclonal hybrid formation in Leishmania: Successful crossings between visceral and cutaneous strains

scientific article published on 09 February 2022

Basal cytotoxicity of four insect sex pheromones in CHO-K1 cells

scientific article published on February 2002

Biochemical Pharmacology: Polyamine-mediated Heart Hypertrophy Induced by Clenbuterol in the Mouse

scientific article published on 01 January 1998

Changes in glutathione-redox balance induced by hexachlorocyclohexane and lindane in CHO-K1 cells

scientific article published on November 2002

Changes in the glutathione-redox balance induced by the pesticides heptachlor, chlordane, and toxaphene in CHO-K1 cells

scientific article published in December 2000

Characterization of a methionine adenosyltransferase over-expressing strain in the trypanosomatid Leishmania donovani

scientific article published on 22 September 2005

Characterization of the 5' region of the Leishmania infantum LORIEN/MAT2 gene cluster and role of LORIEN flanking regions in post-transcriptional regulation.

scientific article published on 28 March 2008

Characterizing the bi-subunit type IB DNA topoisomerase of Leishmania parasites; a novel scenario for drug intervention in trypanosomatids

scientific article

Cloning expression and characterization of methionine adenosyltransferase in Leishmania infantum promastigotes

scientific article published on 6 November 2001

Current status on prevention and treatment of canine leishmaniasis

scientific article published on 12 July 2016

Cyclodiene organochlorine insecticide-induced alterations in the sulfur-redox cycle in CHO-K1 cells

scientific article published in November 2001

DNA topoisomerase I from parasitic protozoa: a potential target for chemotherapy.

scientific article

Deletion study of DNA topoisomerase IB from Leishmania donovani: searching for a minimal functional heterodimer.

scientific article

Drug discovery technologies: Caenorhabditis elegans as a model for anthelmintic therapeutics

scientific article published on 13 March 2020

Early alterations of polyamine metabolism induced after acute administration of clenbuterol in mouse heart

scientific article

First Total Synthesis of -Phenyl 6 Fatty Acids and their Leishmanicidal and Anticancer Properties.

scientific article

First evidence of intraclonal genetic exchange in trypanosomatids using two Leishmania infantum fluorescent transgenic clones

scientific article (publication date: September 2014)

First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the leishmania topoisomerase IB enzyme

scientific article

Fluorinated analogues of L-ornithine are powerful inhibitors of ornithine decarboxylase and cell growth of Leishmania infantum promastigotes

scientific article published on 01 January 1995

Gene disruption of the DNA topoisomerase IB small subunit induces a non-viable phenotype in the hemoflagellate Leishmania major

scientific article

Gimatecan and other camptothecin derivatives poison Leishmania DNA-topoisomerase IB leading to a strong leishmanicidal effect.

scientific article published in March 2013

Identification and characterization of the regions involved in the nuclear translocation of the heterodimeric leishmanial DNA topoisomerase IB.

scientific article

Improved Efficiency of Ibuprofen by Cationic Carbosilane Dendritic Conjugates.

scientific article published on 17 August 2016

Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis

scientific article

Infection with arginase-deficient Leishmania major reveals a parasite number-dependent and cytokine-independent regulation of host cellular arginase activity and disease pathogenesis

scientific article

Infrared fluorescent imaging as a potent tool for in vitro, ex vivo and in vivo models of visceral leishmaniasis

scientific article (publication date: March 2015)

Interaction of cationic diamidines with Leishmania infantum DNA

scientific article published on 01 July 1998

Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection

scientific article

Leishmania donovani methionine adenosyltransferase. Role of cysteine residues in the recombinant enzyme.

scientific article

Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase

scientific article published on 01 August 2011

Leishmania major lacking arginase (ARG) are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice

scientific article published on 20 January 2009

Molecular and functional characterization of adenylate kinase 2 gene from Leishmania donovani.

scientific article

Muscle and serum changes with salbutamol administration in aerobically exercised rats

scientific article published on 01 May 2000

Mutational analysis of methionine adenosyltransferase from Leishmania donovani.

scientific article

Mutational study of the "catalytic tetrad" of DNA topoisomerase IB from the hemoflagellate Leishmania donovani: Role of Asp-353 and Asn-221 in camptothecin resistance

scientific article

New approaches from nanomedicine for treating leishmaniasis.

scientific article

Novel Very Long-Chain α-Methoxylated Δ5,9 Fatty Acids from the Sponge Asteropus niger Are Effective Inhibitors of Topoisomerases IB.

scientific article published on 22 December 2015

Novel findings on trypanosomatid chemotherapy using DNA topoisomerase inhibitors

scientific article published on June 2009

PEGylated Dendritic Polyglycerol Conjugate Delivers Doxorubicin to the Parasitophorous Vacuole in Leishmania infantum Infections

scientific article published on 6 July 2017

Plasma and Muscle Polyamine Levels in Aerobically Exercised Rats Treated with Salbutamol

scientific article published on 01 September 1998

Polyamine transport in parasites: a potential target for new antiparasitic drug development.

scientific article

Putrescine uptake inhibition by aromatic diamidines in leishmania infantum promastigotes

scientific article published on 01 May 1994

RNA interference in Trypanosoma brucei: a high-throughput engine for functional genomics in trypanosomatids?

scientific article published on 2 July 2007

Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis

scientific article published on 20 October 2011

S -ADENOSYLMETHIONINE SYNTHESIS IN LEISHMANIA INFANTUM PROMASTIGOTES

scientific article published on 01 January 1999

S-Adenosylmethionine in protozoan parasites: functions, synthesis and regulation

scientific article published on 20 December 2006

Structural determinants of putrescine uptake inhibition produced by cationic diamidines in the model of trypanosomatid Crithidia fasciculata.

scientific article published in December 1996

Structural insights on the small subunit of DNA topoisomerase I from the unicellular parasite Leishmania donovani

scientific article published on 31 July 2007

Substituted 1,5-naphthyridine derivatives as novel antileishmanial agents. Synthesis and biological evaluation

scientific article published on 18 April 2018

Synthesis of marine α-methoxylated fatty acid analogs that effectively inhibit the topoisomerase IB from Leishmania donovani with a mechanism different from that of camptothecin

scientific article published on 30 September 2013

Target-based vs. phenotypic screenings in Leishmania drug discovery: A marriage of convenience or a dialogue of the deaf?

scientific article

Targeting atypical trypanosomatid DNA topoisomerase I.

scientific article published on August 2006

The Pharmacology of Leishmaniasis ⬇️

scientific article published on April 1, 1998

The first total synthesis of the (±)-17-methyl-trans-4,5-methyleneoctadecanoic acid and related analogs with antileishmanial activity.

scientific article

The transcriptome of Leishmania major in the axenic promastigote stage: transcript annotation and relative expression levels by RNA-seq.

scientific article

Trypanosomatids see the light: recent advances in bioimaging research

scientific article published on 22 September 2014

Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery

scientific article

Type I DNA topoisomerase from protozoan pathogens as a potential target for anti-tumoral drugs

scientific article published in January 2007

Yeast-based systems for tropical disease drug discovery

article published in 2016

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