List of works - Kasper B. Hansen

(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology.

scientific article published in April 2003

4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues

scientific article published on May 2010

A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.

scientific article published on 5 October 2010

Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist

scientific article published on 5 December 2017

Binding of ArgTX-636 in the NMDA receptor ion channel

scientific article published on 24 May 2014

Control of assembly and function of glutamate receptors by the amino-terminal domain.

scientific article

Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators".

scientific article published on 4 March 2015

Crystal Structure and Pharmacological Characterization of a Novel N-Methyl-D-aspartate (NMDA) Receptor Antagonist at the GluN1 Glycine Binding Site

scientific article

Design and Synthesis of 2,3- trans-Proline Analogues as Ligands for Ionotropic Glutamate Receptors and Excitatory Amino Acid Transporters

scientific article published on 24 May 2019

Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators.

scientific article

Development of 2'-substituted (2S,1'R,2'S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-d-aspartic acid receptor agonists

scientific article published on 9 May 2013

Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of <i>N</i>-Methyl-d-aspartate Receptors

scientific article published on 16 December 2020

Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors.

scientific article

FLIPR assays of intracellular calcium in GPCR drug discovery.

scientific article

Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy

scientific article published on January 2014

Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors

scientific article published on 02 November 2019

GluN1 splice variant control of GluN1/GluN2D NMDA receptors

scientific article

Glutamate receptor ion channels: structure, regulation, and function

scientific article

Glutamate receptors: mechanistic twists and turns

scientific article published on 01 September 2014

How glutamate receptor subunits mix and match: details uncovered

scientific article published on 01 July 2011

Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists

scientific article

Ionotropic glutamate-like receptor 2 binds D-serine and glycine

scientific article

Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.

scientific article

Modal gating of GluN1/GluN2D NMDA receptors

scientific article published on 8 April 2013

Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium

scientific article

Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.

scientific article

Novel 3-carboxy- and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists: design, synthesis, and pharmacological characterization

scientific article published on September 2010

Partial agonists and subunit selectivity at NMDA receptors

scientific article published on December 2010

Stereocontrolled synthesis and pharmacological evaluation of azetidine-2,3-dicarboxylic acids at NMDA receptors

scientific article published on January 2009

Stereoselective Synthesis of New (2S,3R)-3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid Analogues Utilizing a C(sp3)-H Activation Strategy and Structure-Activity Relationship Studies at the Ionotropic Glutamate Receptors

scientific article published on 17 February 2020

Structural Determinants of Agonist Efficacy at the Glutamate Binding Site of N-Methyl-D-Aspartate Receptors

scientific article

Structural and Mechanistic Determinants of a Novel Site for Noncompetitive Inhibition of GluN2D-Containing NMDA Receptors ⬇️

scientific article published on March 9, 2011

Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits

scientific article published on 31 July 2017

Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.

scientific article

Structure, function, and allosteric modulation of NMDA receptors

scientific article published on 23 July 2018

Subtype-Specific Agonists for NMDA Receptor Glycine Binding Sites.

scientific article published on 17 May 2017

Subunit-selective allosteric inhibition of glycine binding to NMDA receptors

scientific article published in May 2012

Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors

scientific article published on 10 July 2007

Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid

scientific article published in February 2007

Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids

scientific article

The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.

scientific article published in September 2004

The use ofXenopusoocytes in drug screening ⬇️

scientific article published on January 18, 2011

Tweaking agonist efficacy at N-methyl-D-aspartate receptors by site-directed mutagenesis.

scientific article published on 30 August 2005

Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands

scientific article published on 18 April 2019

Xenopus oocyte electrophysiology in GPCR drug discovery

scientific article published in January 2009

List of works by Kasper B. Hansen

(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology.

4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues

A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.

Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist

Binding of ArgTX-636 in the NMDA receptor ion channel

Control of assembly and function of glutamate receptors by the amino-terminal domain.

Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators".

Crystal Structure and Pharmacological Characterization of a Novel N-Methyl-D-aspartate (NMDA) Receptor Antagonist at the GluN1 Glycine Binding Site

Design and Synthesis of 2,3- trans-Proline Analogues as Ligands for Ionotropic Glutamate Receptors and Excitatory Amino Acid Transporters

Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators.

Development of 2'-substituted (2S,1'R,2'S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-d-aspartic acid receptor agonists

Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of <i>N</i>-Methyl-d-aspartate Receptors

Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors.

FLIPR assays of intracellular calcium in GPCR drug discovery.

Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy

Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors

GluN1 splice variant control of GluN1/GluN2D NMDA receptors

Glutamate receptor ion channels: structure, regulation, and function

Glutamate receptors: mechanistic twists and turns

How glutamate receptor subunits mix and match: details uncovered

Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists

Ionotropic glutamate-like receptor 2 binds D-serine and glycine

Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.

Modal gating of GluN1/GluN2D NMDA receptors

Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium

Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.

Novel 3-carboxy- and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists: design, synthesis, and pharmacological characterization

Partial agonists and subunit selectivity at NMDA receptors

Stereocontrolled synthesis and pharmacological evaluation of azetidine-2,3-dicarboxylic acids at NMDA receptors

Stereoselective Synthesis of New (2S,3R)-3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid Analogues Utilizing a C(sp3)-H Activation Strategy and Structure-Activity Relationship Studies at the Ionotropic Glutamate Receptors

Structural Determinants of Agonist Efficacy at the Glutamate Binding Site of N-Methyl-D-Aspartate Receptors

Structural and Mechanistic Determinants of a Novel Site for Noncompetitive Inhibition of GluN2D-Containing NMDA Receptors ⬇️

Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits

Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.

Structure, function, and allosteric modulation of NMDA receptors

Subtype-Specific Agonists for NMDA Receptor Glycine Binding Sites.

Subunit-selective allosteric inhibition of glycine binding to NMDA receptors

Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors

Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid

Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids

The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.

The use ofXenopusoocytes in drug screening ⬇️

Tweaking agonist efficacy at N-methyl-D-aspartate receptors by site-directed mutagenesis.

Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands

Xenopus oocyte electrophysiology in GPCR drug discovery