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List of works by Shozeb Haider

A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer

scientific article published on 16 June 2015

A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands.

scientific article published on 25 May 2010

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex

scientific article

A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome

scientific article

A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes

scientific article

A novel mutation in HSD11B2 causes apparent mineralocorticoid excess in an Omani kindred.

scientific article published on 15 August 2016

A novel small-molecule inhibitor of IL-6 signalling.

scientific article

A rare CYP21A2 mutation in a congenital adrenal hyperplasia kindred displaying genotype-phenotype nonconcordance

scientific article published on 20 August 2015

A structural analysis of G-quadruplex/ligand interactions.

scientific article published on 26 May 2011

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.

scientific article

Anthrax SET protein: a potential virulence determinant that epigenetically represses NF-κB activation in infected macrophages

scientific article

Biaryl polyamides as a new class of DNA quadruplex-binding ligands.

scientific article

Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif

scientific article published on 28 June 2010

Bisphosphonates inactivate human EGFRs to exert antitumor actions

scientific article

Blocking FSH induces thermogenic adipose tissue and reduces body fat.

scientific article published on 24 May 2017

Boronic acid inhibitors of the class A β-lactamase KPC-2

scientific article published on 27 April 2018

Can We Execute Reliable MM-PBSA Free Energy Computations of Relative Stabilities of Different Guanine Quadruplex Folds?

scientific article

Carbazole Derivatives' Binding to c-KIT G-Quadruplex DNA

Carbazole ligands as c-myc G-quadruplex binders

scientific article published on 23 March 2018

Clinical, genetic, and structural basis of apparent mineralocorticoid excess due to 11β-hydroxysteroid dehydrogenase type 2 deficiency

scientific article published on 11 December 2017

Clinical, genetic, and structural basis of congenital adrenal hyperplasia due to 11β-hydroxylase deficiency

scientific article published on 22 February 2017

Conformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale.

scientific article

Conformational dynamics of the ligand-binding domain of inward rectifier K channels as revealed by molecular dynamics simulations: toward an understanding of Kir channel gating.

scientific article published on 4 March 2005

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands.

scientific article published on 9 October 2017

De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus

scientific article published on 05 July 2018

Defining the architecture of KPC-2 Carbapenemase: identifying allosteric networks to fight antibiotics resistance

scientific article published in Scientific Reports

Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly

scientific article published on 28 February 2014

Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor

scientific article published on 07 October 2019

Dominant Driving Forces in Human Telomere Quadruplex Binding-Induced Structural Alterations.

scientific article published on June 2015

Dynamic Profiling of β-Coronavirus 3CL M<sup>pro</sup> Protease Ligand-Binding Sites

scientific article published on 14 June 2021

Electrostatic Switching Controls Channel Dynamics of the Sensor Protein VirB10 in A. tumefaciens Type IV Secretion System

scientific article published on 04 February 2020

Enhancement of antiviral immunity by small molecule antagonist of suppressor of cytokine signaling

scientific article

Epitope-specific monoclonal antibodies to FSHβ increase bone mass

scientific article published on 12 February 2018

Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding.

scientific article

Evaluation of the taste-masking effects of (2-hydroxypropyl)-β-cyclodextrin on ranitidine hydrochloride; a combined biosensor, spectroscopic and molecular modelling assessment

scientific article published on 17 January 2018

Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus

scientific article published on 19 October 2020

Exploring the Dynamics of Propeller Loops in Human Telomeric DNA Quadruplexes Using Atomistic Simulations.

scientific article

Extended molecular dynamics of a c-kit promoter quadruplex

scientific article

First-in-class humanized FSH blocking antibody targets bone and fat

scientific article published on 30 October 2020

Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.

scientific article published on 13 January 2005

Functional and Modeling Studies of the Transmembrane Region of the TRPM8 Channel

scientific article published in November 2015

Functional characterisation of missense variations in the Kir4.1 potassium channel (KCNJ10) associated with seizure susceptibility.

scientific article

G-Quadruplexes (GQU).

scientific article

HSV-1-induced SOCS-1 expression in keratinocytes: use of a SOCS-1 antagonist to block a novel mechanism of viral immune evasion

scientific article published on 19 June 2009

Holliday Junctions Formed from Human Telomeric DNA

scientific article published on 30 October 2018

Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis.

scientific article published on 2 August 2007

Improvement of the activity of the anti-HIV-1 integrase aptamer T30175 by introducing a modified thymidine into the loops.

scientific article published on 10 May 2018

Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors

scientific article published on 20 September 2019

Ion channel gates: comparative analysis of energy barriers.

scientific article

Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes

scientific article published on 05 September 2019

Mechanism of glucocerebrosidase activation and dysfunction in Gaucher disease unraveled by molecular dynamics and deep learning

scientific article published on 26 February 2019

Molecular dynamics of HIV1-integrase in complex with 93del - a structural perspective on the mechanism of inhibition.

scientific article

Molecular dynamics simulation approaches to K channels: conformational flexibility and physiological function.

scientific article published in March 2005

Molecular dynamics simulations of inwardly rectifying (Kir) potassium channels: a comparative study

scientific article published on 28 February 2007

Molecular dynamics studies of the STAT3 homodimer:DNA complex: relationships between STAT3 mutations and protein-DNA recognition

scientific article published on 3 May 2012

Mutations disrupting neuritogenesis genes confer risk for cerebral palsy

scientific article published on 28 September 2020

Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation

scientific article published on 18 December 2018

Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis

scientific article published on 10 July 2019

N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines.

scientific article published in November 2013

Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths

scientific article published on 26 May 2020

New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity

scientific article

On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis

scientific article published on 2 February 2011

Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of the Phosphomimetic S39E Mutant

scientific article published on 04 November 2019

Recessive Inheritance of Congenital Hydrocephalus With Other Structural Brain Abnormalities Caused by Compound Heterozygous Mutations in ATP1A3

scientific article published on 26 September 2019

Regioselective glycosylation of novobiocin alters activity.

scientific article

Reply to Graham et al.: In silico atomistic coordinates and molecular dynamics simulation trajectories of the glucocerebrosidase-saposin C complex

scientific article published on 01 June 2019

Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass

scientific article published on 08 June 2020

Repurposing of Tranilast for Potential Neuropathic Pain Treatment by Inhibition of Sepiapterin Reductase in the BH4 Pathway

scientific article published on 10 July 2019

Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer

scientific article

SET domain-mediated lysine methylation in lower organisms regulates growth and transcription in hosts.

scientific article published on 25 February 2016

Selective recognition of c-MYC Pu22 G-quadruplex by a fluorescent probe

scientific article published on 01 March 2019

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

scientific article published on 13 November 2009

Signal transduction mechanism of a peptide mimetic of interferon-gamma.

scientific article published on May 2004

Simulations of a protein translocation pore: SecY

scientific article published on 01 October 2006

Structural Dynamics of Lateral and Diagonal Loops of Human Telomeric G-Quadruplexes in Extended MD Simulations

scientific article published on 28 September 2018

Structure-based design of selective high-affinity telomeric quadruplex-binding ligands.

scientific article

Surface area accessibility and the preferred topology of telomeric DNA quadruplex-ligand complexes

scientific article published on 30 May 2011

Synergistic Effect of Chlorogenic Acid and Caffeic Acid with Fosfomycin on Growth Inhibition of a Resistant Listeria monocytogenes Strain

scientific article published on 23 March 2020

Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule.

scientific article

Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule.

scientific article published on 22 January 2018

Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands

scientific article published on 8 April 2008

Tetra-end-linked oligonucleotides forming DNA G-quadruplexes: a new class of aptamers showing anti-HIV activity

article

The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis

scientific article published on 29 May 2019

The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: Biophysical and molecular modeling studies

scientific article published in 2011

The use of a quantitative structure-activity relationship (QSAR) model to predict GABA-A receptor binding of newly emerging benzodiazepines

scientific article published on 22 December 2017

Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.

scientific article published on 18 January 2008

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